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Infections of Chlamydia trachomatis and Mycoplasma hominis as Risk Factors for Abnormal Cervical Cells Mardhia, Mardhia; Effiana, Effiana; Irsan, Abror; Natalia, Diana; Rahmayanti, Sari; Indarti, Junita; Rachmadi, Lisnawati; Yasmon, Andi
Makara Journal of Health Research Vol. 22, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Cervical cancer is the fourth most common cancer among women across the world. Recent studies have shown that cervical cancer is not only caused by persistent infection of human papillomavirus (HPV), but sexually transmitted infections (STIs) also play a role in the pathogenesis of abnormal cervical cells. STIs frequently occur with no specific symptoms, such as the infections caused by Chlamydia trachomatis and Mycoplasma hominis. Asymptomatic STIs could lead to persistent infection. Persistent infections caused by STIs have been hypothesised to increase the access of HPV into the deeper cervical tissue and cause cervical cell abnormalities. Therefore, we conducted this study to assess the association between C. trachomatis and M. hominis infections and abnormal cervical cells. Methods: A cross-sectional study was performed on 58 outpatients at the Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Abnormal cervical cells were detected by a liquid-based cytology Pap smear, and bacterial identification was done by conducting conventional duplex polymerase chain reaction (PCR). Results: 58 patients, 14 (24.1%) showed abnormal cervical cells, whereas 44 (75.9%) patients showed normal cervical cells. The conventional duplex PCR demonstrated a positive result for C. trachomatis and M. hominis bacterial infections in only 1 (7.1%) and 2 (14.3%) patients with abnormal cervical cells, respectively. The statistical analysis revealed no significant association between the bacterial infections and the abnormal cervical cytology in the patients (p > 0.05). Conclusions: Infections caused by C. trachomatis and/or M. hominis were not associated with abnormal cervical cells.
The Antifungal Effect of Kesum Leaf (Polygonum minus Huds) in Ethanol Extract on Microsporum gypseum Liauw, Josephine Johan; Rizki, Syarifah Nurulyanti; Natalia, Diana; Mahyarudin, Mahyarudin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): June 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1258.247 KB) | DOI: 10.30659/sainsmed.v12i1.4448

Abstract

Introduction: Dermatophytosis or tinea is a disease found in the keratinized tissues caused by dermatophytes. The prolonged use of antifungal drugs has adverse effects on humans. Kesum leaves (Polygonum minus Huds) contains the secondary metabolite properties which can act as anti-fungi. Objective: This study aimed to determine the antifungal activity of ethanol extract of kesum leaves in inhibiting the Microsporum gypseum.Methods: Phytochemical analysis was performed using a test tube method and thin layer chromatography. The antifungal activity test used a disc diffusion method with the extract concentrations of 5%, 10%, 20%, 40%, and 80%. Kesum leaves macerated using ethanol 96% solvent. Itraconazole 8µl/disk and DMSO4 were respectively used as positive and negative control. Results: Phytochemical analysis on the ethanol extract of kesum leaves showed the secondary metabolite groups of flavonoids, alkaloids, terpenoids, phenolics, and saponins. Ethanol extract of kesum leaves did not form an inhibitory zone on the growth of Microsporum gypseum. Meanwhile in the positive control, in the form of itraconazole 8 µl/disk, the inhibition zone was formed around the disc with a mean value of 37.5 mm.Conclusion: Ethanol extract of kesum leaves (Polygonum minus Huds) has no antifungal activity against the growth of Microsporum gypseum.
Patofisiologi Jantung pada Latihan Fisik Berat Handoko, Willy; Natalia, Diana
Jurnal Ilmu Keolahragaan Vol 7, No 1 (2024): JURNAL ILMU KEOLAHRAGAAN
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jilo.v7i1.77959

Abstract

Latihan fisik yang rutin dapat menyebabkan beberapa perubahan fisiologis yang menguntungkan pada tubuh dan efektif dalam pencegahan dan bersifat terapeutik pada berbagai jenis penyakit kronik, seperti penyakit jantung koroner, hipertensi, gagal jantung, obesitas, depresi dan diabetes melitus. Meskipun bermanfaat, latihan fisik, sama halnya dengan obat"“obatan farmasi memiliki batas maksimum. Latihan fisik yang dilakukan secara berlebihan akan mempunyai dampak negatif (seperti trauma musculoskeletal atau stres kardiovaskuler) yang lebih besar daripada manfaatnya
Threat of zoonotic malaria and strategy to overcome in Kalimantan (Indonesian Borneo) bordering Malaysian Borneo Natalia, Diana; Handoko, Willy; Rahmayanti, Sari; Wahyudi, Tri; Abdul Rashid, Ayu Akida; Divis, Paul Cliff Simon
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.208-218

Abstract

Indonesia aims to eradicate malaria by 2030. Indonesia has the second highest disease burden in the WHO South-East Asia region, after India, accounting for 9% of all malaria cases in 2024. Malaria cases have dropped dramatically due to national strategic plans and programs, and the Indonesian Ministry of Health has certified several districts as malaria-free zones. Malaria cases in Kalimantan (Indonesian Borneo), have declined during the last two decades. Nearly all regencies within these provinces have been declared as having low malaria endemic status (API<1 per 1000 people), except for one regency in East Kalimantan Province, which showed a high endemicity level (API>5 per 1000 people). This reduced incidence, however, contrasts sharply with the zoonotic infection caused by the simian parasite Plasmodium knowlesi, which is prevalent in Malaysian Borneo. Only a few cases of P. knowlesi infection have been reported in South and Central Kalimantan Province since 2010. This difference between Kalimantan, Indonesia and Borneo, Malaysia appears contradictory given that both regions have a similar epidemiological risk of zoonotic malaria infection and share the same natural habitat. The references were tracked using various databases, such as Google Scholar, PubMed (MEDLINE) and other sources (Google engine and manual searching using a reference list). This review’s objective was to describe current malaria and zoonotic malaria, mosquito vector prevalence, and the available data from case reports along the Kalimantan border in Indonesia during the malaria elimination phase, compared with malaria distribution in the neighbouring country, Malaysian Borneo.
Isolation and Characterization of Cellulose Microfibril (MFC) from Gracilaria sp. with Different Quality Grades Nurhayati; Irianto, Hari Eko; Supriyanto, Agus; Kusumawati, Rinta; Basmal, Jamal; Munifah, Ifah; Setiawati, Natalia Prodiana; Kusumaningrum, Wida Banar; Amanda, Putri; Roziafanto, Ahmad Nandang; Riastuti, Rini; Chalid, Muchamad
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.712-724

Abstract

The cellulose found in Gracilaria sp. has not been utilized optimally. This study investigated the characteristics of cellulose and cellulose microfibril (MFC) isolated from three grades of Gracilaria sp. Descriptive tests were performed to determine the quality of eachgrade, including observations on moisture content, ashcontent, CAW,andimpurities. The extraction process involved separating agar from Gracilaria sp., isolating cellulose using 10% NaOH, and bleaching cellulose with 3% NaOCl. The bleached cellulose was then ultrasonicated to produce MFC. Characterization was performed using FTIR, XRD, PSA, STA, DSC, and py-GC/MS. FTIR analysis indicated similar peaks for both cellulose forms but only differed in transmittance intensity. The crystallinity index from XRD analysis was 22–39% for raw Gracilaria sp., 25–46% for cellulose, and 68–89% for MFC. The particle size distribution of MFC mostly ranged between 200–500 nm, with 63.16% frequency. TG analysis showed cellulose decomposition with a Tonset of 231–260oC and a Tmax of 318–326oC. DSC analysis revealed that sonication enhances the polymer structure’s crystallization compared to pre-sonicated cellulose and raw material. The py-GC/MS analysis showed that D-allose and n-Hexadecanoic acid were the major components.
Formulation of nutritious biscuits fortified with minced catfish and Ulva sp for malnourished children Setiawati, Natalia Prodiana; Fateha, Fateha; Supriyanto, Agus; Mardiyana, Indri; Nurhayati, Nurhayati; Sihono, Sihono; Suryaningrum, Th. Dwi
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 20, No 2 (2025): August 2025
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.1039

Abstract

Stunting is a critical problem that deserves attention and has become a global problem. The approach to reducing stunting is to provide nutritious supplementary food in the form of biscuits for children, especially those who are malnourished. The purpose of this study is to formulate nutritious biscuits enriched with minced catfish as a source of amino acids and Ulva sp as a source of dietary fiber. Design expert software (DX13) ® was used to analyze sensory data gathered from a hedonic scale assessment with 25 trained panelists to determine the best formulation for the fortified biscuit product. Taste and texture were among the sensory qualities that were assessed. In addition, physical aspects such as hardness and color (L, a, and b) are analyzed to determine the quality of the biscuit formula. The best formulas based on sensory evaluation and physical analysis undergo further analysis of their nutritional composition, including proximate analysis and amino acid profile.The best quality products found are biscuits fortified with a formula consisting of 33% wheat flour, 14% chopped catfish, and 1% Ulva flour.The state of the art of this research is the development of functional biscuits fortified with a combination of animal protein (catfish) and dietary fiber as well as antioxidants form Ulva sp., using an RSM-based formulation optimization approach to produce a highly nutritious product that isacceptable to children.
Perlindungan Informasi Data Diri Anak Yang Terpublikasi Karena Ketidakpatuhan Pedoman Penulisan Putusan MA Di PN Tenggarong Natalia, Diana; Sudiro, Amoury Adi
JURNAL SYNTAX IMPERATIF : Jurnal Ilmu Sosial dan Pendidikan Vol. 5 No. 1 (2024): Jurnal Syntax Imperatif: Jurnal Ilmu Sosial dan Pendidikan
Publisher : CV RIFAINSTITUT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-imperatif.v5i1.349

Abstract

Penelitian ini bertujuan untuk mengetahui dan menganalisis bentuk pelanggaran hukum terkait pelindungan data diri anak sebagai korban/pelaku/saksi yang terlibat masalah hukum di Indonesia, terutama anak sebagai korban/pelaku/saksi anak pada Direktori Putusan Mahkamah Agung Republik Indonesia (DPMARI) di Pengadilan Negeri Tenggarong. Salah satu hak anak yang sangat wajib kita jaga adalah kerahasiaan informasi data diri anak apabila terlibat masalah hukum, terutama untuk anak yang menjadi korban/pelaku/saksi yang masih dibawah umur. Metode penelitian yang digunakan adalah yuridis normatif dengan pendekatan perundang-undangan dan analisis deskriptif. Penelitian ini menunjukkan bahwa meski sudah ada peraturan hukum yang melarang publikasi informasi data diri anak sebagai korban/pelaku/saksi, namun pada kenyataannya masih ditemukan ketidaksesuaian peraturan berupa pencantuman informasi data diri anak sebagai korban/pelaku/saksi pada salinan putusan di laman website DPMARI Pengadilan Negeri Tenggarong. Hal ini tentunya melanggar hak kerahasiaan informasi data diri anak dan perlu mendapat perhatian serta langkah perbaikan ke depannya
AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN KRATOM (Mitragyna speciosa) TERHADAP JAMUR Microsporum canis Susanto, Dhessy; Natalia, Diana; Widiyantoro, Ari
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 3 No. 3 (2022)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v3i3.2481

Abstract

The world population experiencing dermatophytosis has reached 20%. Dermatophytosis is an infection caused by dermatophyte fungi. The prevalence in Asia reaches 35.6%. One of the fungi that causes dermatophytosis is Microsporum canis. Microsporum canis is known to be resistant to antifungal drugs. Kratom (Mitragyna speciosa) is a plant originating from Southeast Asia and in Indonesia it is often found in the Kapuas Hulu area, West Kalimantan. Kratom leaves are widely used as herbal medicine and have secondary metabolite compounds that have the potential to be used as antifungals. This study aims to determine the antifungal activity of ethanol extract of kratom leaves (Mitragyna speciosa) on the growth of Microsporum canis. Phytochemical screening was carried out using the Thin Layer Chromatography (TLC) scanner method and spray testing to determine the secondary metabolite compounds of the extract being tested. The test extract was made in concentrations of 5%, 10%, 15%, 20%, 25%, 50%, 75%, and 90% (w/v) with ethanol as a solvent. 8 µg itraconazole discs were used as a positive control and 10% DMSO was used as a negative control. Antifungal activity testing was carried out using the disc diffusion method by measuring the fungal growth inhibition zone. The ethanol extract of kratom leaves contains secondary metabolite compounds, namely alkaloids, terpenoids, steroids, flavonoids and tannins with the most dominant groups of alkaloid and tannin compounds. The results showed that there was no growth inhibition zone for Microsporum canis at all extract concentrations tested. The ethanol extract of kratom leaves does not have antifungal activity against the growth of Microsporum canis.
The Influence of Acid and Cooking Methods on The Quality of Fish Meal Processed from by-products of Catfish Fillet Processing Suryaningrum, Theresia Dwi; Ellya, Ellya; Fateha, Fateha; Setiawati, Natalia Prodiana; Mardiyana, Indri; Supriyanto, Agus; Nurhayati, Nurhayati; Giyatmi, Giyatmi
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 18, No 3 (2023): December 2023
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.800

Abstract

Catfish fillet processing produces a by-product dominated by heads (25- 28%) and bones (11-13%). This study aims to process fish meal from by- products of catfish using different treatments, namely soaking in a 4% formic acid solution (F) and a 4% hydrochloric acid solution (H), as well as cooking techniques involving boiling (R) and steaming (K). Observations were made on the yield, pH, proximate analysis, calcium content, NPN (non-protein nitrogen), TBA (thiobarbituric acid), microbiological tests, sensory evaluation, and amino acid profiles. The research showed that soaking in acid caused a decrease in pH, protein content, and TBA and increased the fat content of the resulting fish meal. The optimal treatment for the highest quality fish meal is steaming without acid treatment. In this treatment, the protein content meet  the requirements of the SNI 01.2725.01.2013 as grade 3 fish meal, with a yield of 22.83%, a pH of 6.86, a moisture content of 6.2 ± 0.3%, an ash content  of 27.33 ± 0.7%, and a protein content of 45.5 ± 1.3%. Analysis of the amino acid profile of fish meal from that treatment showed a better amino acid composition compared to commercial fish meal. The fish meal  contained essential amino acids in sufficient quantities, with higher levels compared to the amino acid standards set by FAO/WHO 2013 for human nutritional needs, and met the requirements as a nutritional ingredient for fish and livestock feed.