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septa surya wahyudi, septa surya
Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : eJournal Kedokteran Indonesia

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Effect of Low-Dose Chlorpyrifos on Hepatocyte Necrosis and Serum Albumin Levels in Wistar Rats Abrori, Cholis; Dwisaraswati, Salma Aulia; Wahyudi, Septa Surya; Rumastika, Nindya Shinta; Rachmania, Sheilla; Wisudanti, Desie Dwi; Sakinah, Elly Nurus; Komariah, Cicih; Supangat, Supangat
eJournal Kedokteran Indonesia Vol. 13 No. 2 (2025): Vol 13, No. 2 - Agustus 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1003.1

Abstract

Chlorpyrifos is a broad-spectrum organophosphate pesticide that also causes various health problems. The active metabolite of chlorpyrifos can increase free radicals in the body, especially in the liver and kidneys. The continuous increase in free radicals will cause an imbalance between free radicals and oxidants, triggering oxidative stress. Oxidative stress stimulates mitochondrial dysfunction, resulting in changes in the hepatocyte shape and serum albumin levels. This study aimed to determine the effect of chlorpyrifos on the hepatic histopathology scores and serum albumin levels of Wistar rats. Experimental research was conducted at the Faculty of Medicine, University of Jember in May-December 2024. A total of 12 male Wistar rats were divided into two groups. The control group was given normal saline (+5% Tween 20), and the chlorpyrifos group was given chlorpyrifos + normal saline (+5% Tween 20) orally for 7 days. On the 8th day, all animals were euthanized with ketamine-xylazine, hepatic organs, and blood were taken intracardiac. Preparations were made using HE staining, and serum albumin levels were checked using a photometer. The results showed that hepatic histopathology scores assessed by the Manja Roenigk method and serum albumin levels had significant differences between the groups metabolized. Seven days of chlorpyrifos exposure can increase hepatocyte necrosis and decrease serum albumin levels.
Co-Authors A.A. Ketut Agung Cahyawan W Adelia Handoko Al Munawir Alfina kamelia fakhriyah Alif Kufari Ancah Caesarina Novi Marchianti Aris Prasetyo Aziz, Ayu Munawaroh Bagus Hermansyah Bagus Indra Kusuma Bi’izzyk, Avie Baldana Cholis Abrori, Cholis Cicih Komariah Desie Dwi Wisudanti Dhiemas Trisyuananda Eniestama Diayu Putri Akhita Dina Helianti Dini Agustina Doddy M Soebadi Dwisaraswati, Salma Aulia Edy Junaidi El Milla, Kardiana Izza Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Haniefah, Yumna Rifda Heni Fatmawati I Nyoman Insan Parisudha Ika Rahmawati Sutejo Inke Kusumastuti Insani, Ain Yuanita Janu, Libri Wira Indra Jauhar Firdaus Kholid, Akbar Fakhrudin Kristianingrum Dian Sofiana Kristianningrum Dian Sofiana Kurnia Putra, Prayoga Triyadi Laksmi Indreswari Made Devi Desyana Arisandi Miftakhul Huda Muhammad Aqib Husni Fadhli Muhammad Hasan Pipiet Wulandari Pralampita, Pulong Wijang Prasetyo, Aris Probosutiksna, Nuno Febrian Probosutiksna, Nuno Febrian Radiva Eryadana, Aqshal Rahma Illa Putri Utami Rayyan, Muhammad Isra Rafidin Rosita Dewi Rumastika, Nindya Shinta Ryan Ravi Is Syahputra Sheilla Rachmania, Sheilla Soetojo Soetojo Sri Weli Teguh Pujo Sakti Suci Rizalah I Sunaryo Hardjowijoto Supangat Supangat Supangat Supangat Sutejo, Ika Rahmwati Tarmono Djojodimedjo Tristianti, Farmitalia Nisa Widjajana, Desy Pratiwi Winanda, Leony Agnes Savira Yuli Hermansyah Yunita Wulansari Zahrah Febianti Zulfahmi Muslim