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All Journal Jurnal Ilmu Pertanian Indonesia The Journal of Pure and Applied Chemistry Research JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA ALCHEMY Jurnal Penelitian Kimia Jurnal Pendidikan Kimia (JPKim) QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Jurnal Kartika Kimia Journal of Science Innovare EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal AbdiMas Nusa Mandiri Charity : Jurnal Pengabdian Masyarakat Rudence: Rural Development for Economic Resilience Helium: Journal of Science and Applied Chemistry Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif
Diana Widiastuti
Universitas Pakuan
Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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In-Vitro and In-Silico Study: The Anti-Inflammatory Activity of Ethanol Extract from Cogon Grass Roots (Imperata cylindrica L. Warnasih, Siti; Hasanah, Uswatun; Simalango, Siska Juliani; Mulyati, Ade Heri; Widiastuti, Diana
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.264-276

Abstract

Background: Inflammation is a protective reaction triggered by harmful substances, microbes, or physical trauma. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat inflammation, though they have certain drawbacks, such as the potential for chronic kidney failure and unfavorable gastrointestinal side effects. Therefore, alternative treatments are needed. Cogon grass (Imperata cylindrica L.) roots contain secondary metabolites that may offer potential for inflammation treatment. Objective: This study aims to investigate the potential of secondary metabolites from cogon grass roots as anti-inflammatory agents, both in vitro using protein denaturation inhibition techniques and in silico against the COX-1 and COX-2 enzyme receptors. Methods: Molecular docking of COX-1 (PDB ID 6Y3C) and COX-2 (PDB ID 1PXX) using AutoDock Tool 1.5.6 was used to test the anti-inflammatory activity. In parallel, the in vitro technique involved spectrophotometric denaturation inhibition of the BSA (bovine serum albumin) protein. Results: The in silico results showed that the cyclovalone ligand exhibited the highest interaction and stability, with Gibbs free energies of -9.3 kcal/mol against COX-1 and -9.8 kcal/mol against COX-2, compared to the control ligand diclofenac, which had Gibbs free energies of -6.5 kcal/mol against COX-1 and -8.5 kcal/mol against COX-2. The 30% ethanol extract of cogon grass roots demonstrated anti-inflammatory activity in the in vitro analysis, with an IC50 value of 71.79 µg/mL. Conclusions: These preliminary findings suggest that the ethanol extract of cogon grass roots contains cyclovalone compounds with potential as anti-inflammatory agents.
Co-Authors Ade Heri Mulyati Ade Heri Mulyati Ade Heri Mulyati Ade Heri Mulyati, Ade Heri Adhimah, Novy Nur Agus Taufiq Akhwan Triadi Ani Iryani Aqilah, Siti Azizah, Briantine Siti Nur Benedicta, Glisten Madeleine Dwi Febriantini Eka Herlina Eka Herlina Eka Herlina Eka Herlina Esya Juniar Fajar Anggraeni Fajar Dwi Fauzi Hidayat Farah Dinna Farida Nuraeni Farida Nuraeni Fatwa Rachmawati Annissa Haritsa, Angel Aulia Herman, Herman LAKSMI AMBARSARI Lathifah, Suci Siti Leny Heliawati Linda Jati Kusumawardani Maharani Farah Dhifa Dg Masikki Matius Paundanan Muhammad Fathurrahman Muhammad Fathurrahman Muhammad Rivai Muthia Septiani Novy Nur Adhimah Nunung Kurniasih, Nunung Pham Van Hung Purwantiningsih Sugita Putry Sri Ratih Ratih, Putry Sri Septiani, Muthia Sherin Nurhafidza Ahmad Simalango, Siska Juliani Siska Elisahbet Sinaga Siska Elisahbet Sinaga Siti Warmasih Siti Warnasih Supratman, Lilis Sutanto . Sutanto _ Tri Panji Usep Suhendar Uswatun Hasanah Uswatun Hasanah Vina Amalia, Vina Yulian Syahputri Zahra Sahara Maharani Zuniar Subastian