Articles
<![CDATA[Number of polymorphonuclear leucocytes in the endocervical discharge smear examination as diagnostic test for chlamydial cervicitis ]]>
<![CDATA[Satiti Retno Pudjiati, Satiti Retno Pudjiati]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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<![CDATA[The chlamydial servicitis is the most prevalent sexually transmitted disease among child-bearing age women and usually asymtomatic in nature, so it is difficult to be diagnosed early and to be eradicated. The laboratory methods for supporting its clinical diagnosis, whether in vitro cultivation or automatic technique, are not only complicated but also expensive. The simplest laboratory testing, especially for primary clinical service with !imitated in laboratory equipment, is achieved by counting the total number of polymorphonuclear leucocytes of endoservical exudate. Unfortunately, the cut off point varied from one country to another. In Indonesia, this cut off point has not determined yet. The purpose of this study was to develop simple and efficient diagnostic test for diagnosing chlamydial cervicitis, by searching the cut off point of a number of polymorphonuclear leucocytes in the endocervical discharge smear examination stained with Gram. The subjects of this study were female sex workers; 44 were from the Clinic of Griya Lentera PKBI Yogyakarta and 36 were from Sanggrahan Resosialisation Yogyakarta. Gynecologic examination, laboratory examination with Gram staining and C. trachomatis antigen detection using Test Pack Chlamydia were done on all subjects. The results indicated that the cut off point of the number of polymorphonuclear leucocyte in diagnosing chlamydial cervicitis is 10 with 60 % sensitivity, 76.67 % specificity, 81 % PPV (positive predictive value) and 53.49 % NPV (negative predictive value).Key words: chlamydial cervicitis - Grams stain - polymorphonuclear leucocyte - test pack chlamydia -female sex workers.]]>
<![CDATA[Herpes simplex encephalitis (A review) ]]>
<![CDATA[Satiti Retno Pudjiati, Herning Setijowati]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008) ]]>
Publisher : <![CDATA[Universitas Gadjah Mada ]]>
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<![CDATA[Herpes simplex encephalitis (HSEI is an inflammation of the brain caused by herpes simpleks virus (HSVI. HSE includes serious types. HSE can influence all age group, but most common in those under 20 and over 40 years old. Clinical diagnosis based on clinical presentation, laboratory examination of cerebrospinal fluid (CSFI, even by computerized tomography scan (CT-scan)/magnetic resonance imaging (MRII, electro encephalogram (EEGI is difficult that resulted in nonspecific diagnosis. Polymerase chain reaction (PCRI, and brain biopsy are the best diagnostic test. The main treatment of HSE is non spesific i.e. acyclovir. An early management may decrease the risk of mortality from 80% - 25%. While without treatment the mortality.can reach 70-80% and the prognosis might unfavourable.Key words: encephalitis - HSE - CSF - CT-scan - MRI - EEG]]>
<![CDATA[Association between sexual orientation and sexual contact with the incidence of human immunodeficiency virus (HIV) infection in Dr. Sardjito General Hospital, Yogyakarta ]]>
<![CDATA[Imtihani, Hajar]]>;
<![CDATA[Pudjiati, Angela Satiti Retno]]>;
<![CDATA[Luthfiandi, Mochammad Rifky]]>;
<![CDATA[Susetiati, Devi Artami]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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<![CDATA[Anal intercourse has been known to have a high risk of human immunodeficiency virus (HIV) transmission. The objective of this study was to evaluate the relationship between sexual orientation and the mode of sexual contact with the incidence of HIV infection. This was observational analytic study with cross sectional design. Subjects were new male patient who visited sexually transmitted infection (IMS) clinics at Dr. Sardjito General Hospital, Yogyakarta during 2016. Data were obtained from medical records. The HIV status was established from HIV rapid test and enzyme-linked fluorescent assay (ELFA). Data were analyzed using descriptive test and Pearson’s chi-squared test with significance level of p< 0.05. Among 167 subjects, 47.91% were in the age group 17 - 25 years old. Forty subjects (24%) had HIV positive status. The majority of subjects were heterosexuals (111 subjects (66.47%)), 43 subjects (25.75%) were homosexuals, and 13 subjects (7.8%) were bisexuals. HIV positive subjects were more common in homosexual groups than were heterosexual and bisexual (p]]>
<![CDATA[The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions ]]>
<![CDATA[Agung Pranoto]]>;
<![CDATA[Satiti Retno Pudjiati]]>;
<![CDATA[Yohanes Widodo Wirohadidjojo]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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<![CDATA[Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.]]>
<![CDATA[Herpes simplex encephalitis (A review) ]]>
<![CDATA[Herning Setijowati Satiti Retno Pudjiati]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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<![CDATA[Herpes simplex encephalitis (HSEI is an inflammation of the brain caused by herpes simpleks virus (HSVI. HSE includes serious types. HSE can influence all age group, but most common in those under 20 and over 40 years old. Clinical diagnosis based on clinical presentation, laboratory examination of cerebrospinal fluid (CSFI, even by computerized tomography scan (CT-scan)/magnetic resonance imaging (MRII, electro encephalogram (EEGI is difficult that resulted in nonspecific diagnosis. Polymerase chain reaction (PCRI, and brain biopsy are the best diagnostic test. The main treatment of HSE is non spesific i.e. acyclovir. An early management may decrease the risk of mortality from 80% - 25%. While without treatment the mortality.can reach 70-80% and the prognosis might unfavourable.Key words: encephalitis - HSE - CSF - CT-scan - MRI - EEG]]>
<![CDATA[Number of polymorphonuclear leucocytes in the endocervical discharge smear examination as diagnostic test for chlamydial cervicitis ]]>
<![CDATA[Satiti Retno Pudjiati Satiti Retno Pudjiati]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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<![CDATA[The chlamydial servicitis is the most prevalent sexually transmitted disease among child-bearing age women and usually asymtomatic in nature, so it is difficult to be diagnosed early and to be eradicated. The laboratory methods for supporting its clinical diagnosis, whether in vitro cultivation or automatic technique, are not only complicated but also expensive. The simplest laboratory testing, especially for primary clinical service with !imitated in laboratory equipment, is achieved by counting the total number of polymorphonuclear leucocytes of endoservical exudate. Unfortunately, the cut off point varied from one country to another. In Indonesia, this cut off point has not determined yet. The purpose of this study was to develop simple and efficient diagnostic test for diagnosing chlamydial cervicitis, by searching the cut off point of a number of polymorphonuclear leucocytes in the endocervical discharge smear examination stained with Gram. The subjects of this study were female sex workers; 44 were from the Clinic of Griya Lentera PKBI Yogyakarta and 36 were from Sanggrahan Resosialisation Yogyakarta. Gynecologic examination, laboratory examination with Gram staining and C. trachomatis antigen detection using Test Pack Chlamydia were done on all subjects. The results indicated that the cut off point of the number of polymorphonuclear leucocyte in diagnosing chlamydial cervicitis is 10 with 60 % sensitivity, 76.67 % specificity, 81 % PPV (positive predictive value) and 53.49 % NPV (negative predictive value).Key words: chlamydial cervicitis - Gram's stain - polymorphonuclear leucocyte - test pack chlamydia -female sex workers.]]>
<![CDATA[Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients ]]>
<![CDATA[Epi Panjaitan]]>;
<![CDATA[Satiti Retno Pudjiati]]>;
<![CDATA[Agnes Sri Siswati]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 04 (2014) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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DOI: 10.19106/JMedScie004604201401
<![CDATA[Human immunodefiiency virus (HIV) infection and aquired immunodeficiency syndrome (AIDS)cause a progressive depletion of CD4+ T cell populations accompanied by progressive impairmentof cellular immunity and increasing susceptibility to opportunistic infections. Seborrheic dermatitisis one of the most common skin opportunistic infections on HIV/AIDS patients. Malasseziaspecies is bilieved as the causative of seborrheic dermatitis. The aim of the study was to evaluatelow CD4+ T cell counts as risk factor for Malassezia sp. infection in HIV/AIDS patients. This wasan observational study with cross-sectional design conducted on HIV/AIDS patients who attendedin Department of Dermatology and Venereology, Faculty of Medicine Universitas Gadjah Mada/Dr Sardjito General Hospital, Yogyakarta and met the inclusion and exclusion criteria. Culture ofMalassezia sp. was conducted in Department of Microbiology and classified as high (>100 CFU/tape) and low (<100 CFU/tape) density colonies. CD4+ T cell counts were measured in Departmentof Clinical Pathology and classified as high (>200 cells/mm3) and low (<200 cells/mm3) CD4+ Tcell counts. A total of 83 subjects with HIV/AIDS comprising 54 (65.1%) males and 29 (34.9%)females aged 20 - >60 years were involved in the study. The number of Malassezia sp. colonyon subjects with high and low CD4+ T cell counts were 31.55 ± 26.21 and 25.2 ± 33.89 CFU/tape, respectively. No significantly relationship between between CD4+ T cell count and Malasseziasp. colony number was observed in the study (p=0.607; 95%CI=0.04-5.19; RP=0.452). Inconclusion, low CD4+ T cell counts is not risk factor for Malassezia sp. infection in HIV/AIDSpatients.]]>
<![CDATA[Association between HLA-B alleles and nevirapine-induced allergies among Indonesian HIV patients ]]>
<![CDATA[Angela Satiti Retno Pudjiati]]>;
<![CDATA[Dyah Ayu Mira Oktarina]]>;
<![CDATA[Hardyanto Soebono]]>;
<![CDATA[Saihas Sauda]]>;
<![CDATA[Dewi Kartikawati Paramita]]>;
<![CDATA[Iwan Dwiprahasto]]>;
<![CDATA[Zubairi Djoerban]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 4 (2016) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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DOI: 10.19106/JMedSci004804201604
<![CDATA[This study aimed to investigate the association between human leukocyte antigen-B(HLA-B) alleles and nevirapine allergy in HIV patients in Indonesia. A case control studywas conducted involving 147 HIV patients comprising of 50 patients with and 97patients without nevirapine allergy as control. The HLA-B allele typing was conducted byusing polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP),followed by sequencing. Bivariate analysis using Chi-square (X2) test and multivariatelogistic regression with significance level at p<0.05 were applied to analysis the data.Among 147 subjects, 34 with HLA-B alleles were identified. Bivariable analysis showedthat HLA-B*58 allele was the most significant risk factor for the nevirapine allergy (OR= 3.67; 95% CI: 1.79 to 7.54), while HLA-B*35 allele was a protective factor (OR =0.18; 95% CI: 0.08 to 0.42). Multivariate logistic regression analysis showed that youngmen and HLA-B*58 allele were the significant risk factors of nevirapine allergy (OR: 4.63;95% CI: 2.02 to 10.61), while older women with the HLA-B*35 was able to reducethe risk of nevirapine allergy approximately 81% (OR: 0.19; 95% CI: 0.08 to 0.49). Inconclusion, young male with the HLA-B*58 allele are the high risk factor for nevirapineallergy in Indonesian HIV patients.]]>
<![CDATA[Correlation between CD4 cell counts with mucocutaneous manifestations: study of HIV patients in Dr. Sardjito General Hospital, Yogyakarta ]]>
<![CDATA[Satiti Retno Pudjiati]]>;
<![CDATA[Nadia Akita Dewi]]>;
<![CDATA[Sekar Sari Arum Palupi]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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DOI: 10.19106/JMedSci005001201805
<![CDATA[Mucocutaneous disorders often seen in HIV patients with varying morbidity. The HIVprogression is characterized by the declining of CD4 cell counts and emergence ofmucocutaneous manifestations. The aim of the study was to evaluate the relationshipbetween CD4 cell counts with mucocutaneous manifestations in HIV patients. This wasa cross-sectional study based on medical records at Dr. Sardjito General Hospital duringthe period January 2011-December 2015. Data of patient’s age, sex, risk factors oftransmission, most mucocutaneous manifestations and CD4 cell count were gathered. Thecorrelation between CD4 cell counts with muscocutaneous manifestations were analyzedusing chi-square test. A total 928 patients were involved in the study. More than half ofthe patients were male (65.4%) and mostly, the patients aged 20-29 years (38.69%).The main risk factors for HIV transmission were unsafe sex (75%). The highest CD4 cellcounts was 1094 cells/mm3 and the lowest was 1 cell/mm3. We found 306 cases ofmucocutaneous manifestations. The most mucocutaneous manifestations was a fungalinfection (40.4%) with the highest infection type was oral candidiasis(33.8%); then noninfection(28%) with the highest type was drug eruption(35.9%); and tumors(0.5%) thatwas only Kaposi sarcoma cases. We also found sexually transmitted infections (STIs)(18.85%) with the highest cases was condyloma acuminata (49.3%). Statistical analysisshowed a significantly relationship between CD4 cell counts with a fungal infection(p <0.0001; OR= 3.8; 95% CI: 2.29 - 6.30), viral infection (p =0.0031; OR= 0.4;95% CI: 0.24-0.74) and parasitic infection (p=0.043; OR= 0.2; 95% CI: 0.06-0.61).In conclusion, alteration in CD4 cell counts affects opportunistic infections occurencein HIV patients. Lower CD4 cell counts (<200 cells/mm3) increases the risk of fungalinfection as much as 3.8 times. Higher CD4 cell counts (>200 cells/mm3) increases therisk of viral infection by about 2.5 times and parasitic infections as much as 5 times.]]>
<![CDATA[The role of Malassezia sp, sebum level and Trans Epidermal Water Loss (TEWL) toward the dandruff severity between hijab and non hijab wearing subjects ]]>
<![CDATA[Kristiana Etnawati]]>;
<![CDATA[Agnes Sri Siswati]]>;
<![CDATA[Satiti Retno Pudjiati]]>;
<![CDATA[Devi Artami Susetiati]]>;
<![CDATA[Dwi Retno Adiwinarni]]>;
<![CDATA[Affendi Purbananto]]>
<![CDATA[ Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018) ]]>
Publisher : <![CDATA[Journal of the Medical Sciences (Berkala Ilmu Kedokteran) ]]>
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DOI: 10.19106/JMedScie/0050032018011
<![CDATA[Dandruff is a common symptom in adolescence, which possibly due to increasing ofMalassezia sp. colonization, sebum level as well as skin hydration. Wearing hijab ispredicted to increase the humidity and sebum level lead to increase the number ofMalassezia sp. and dandruff severity. A case-control study was conducted on 19 femalewith dandruff who wear hijab and 19 female with dandruff who do not wear hijab, agebetween 18 and 27 years old. The dandruff severity was defined clinically using ascoring system (0-100), only subjects with minimum score of 28 will be included in thisstudy. The sebum and trans epidermal water loss (TEWL) levels were measured withSebumeter and Tewameter from Courage Khazaka. The Malassezia sp. was examinedusing microscopic examination of the squama and culture in the Saboraud medium.There were no significant differences found between hijab and non-hijab groups fordandruff severity. No difference found between two groups for sebum level, Malasseziasp. number microscopically, and Malassezia sp. colonization. Only TEWL level in hijabgroup that was found to be higher than non-hijab group. Wearing hijab does not increasethe dandruff severity, sebum level and colonization number of Malassezia sp. Wearinghijab is found to increase the TEWL level.]]>
