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All Journal Jurnal Abmas Negeri (JAGRI) Public Health and Safety International Journal (PHASIJ) Journal of Training and Community Service Adpertisi West Science Social and Humanities Studies JIMAD : Jurnal Ilmiah Multidisiplin Journal of Tecnologia Quantica Journal of Biomedical and Techno Nanomaterials Journal of World Future Medicine, Health and Nursing Journal Emerging Technologies in Education
Dito Anurogo
Universitas Muhammadiyah Makassar
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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BIOETHICAL CHALLENGES IN THE USE OF NANO-MEDICINE FOR DEGENERATIVE DISEASE THERAPY Lucas Lima; Clara Mendes; Roya Zahir; Dito Anurogo
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i2.3926

Abstract

The emergence of nano-medicine has introduced transformative approaches for the treatment of degenerative diseases, including Parkinson’s, Alzheimer’s, and osteoarthritis. These technologies enable targeted drug delivery, enhanced bioavailability, and improved therapeutic precision. Despite clinical potential, ethical challenges related to patient comprehension, informed consent, and long-term safety remain underexplored, particularly for vulnerable populations affected by cognitive decline. Understanding these challenges is critical for aligning technological innovation with bioethical principles. This study aims to investigate the bioethical issues arising from the use of nano-medicine in degenerative disease therapy and to identify strategies that enhance ethical implementation in clinical practice. The research further seeks to develop a conceptual framework to guide ethical decision-making in emerging medical technologies. A qualitative exploratory design was employed, including fifteen participants comprising clinicians, patients, and regulatory authorities. Data were collected through semi-structured interviews, direct observation of clinical interactions, and document analysis of protocols and consent forms. Thematic coding and triangulation were applied to elucidate patterns in ethical practices, communication strategies, and institutional oversight. Findings indicate that patient comprehension varies significantly with age and cognitive status, while clinician strategies and institutional protocols influence ethical adherence. Iterative consent processes and technological support enhance transparency, autonomy, and responsible clinical practice.
IMPLEMENTING DIGITAL TWINS FOR CANCER THERAPY SIMULATION: GENETIC-BASED MEDICAL PERSONALIZATION Siri Lek; Lucas Lima; Pedro Silva; Dito Anurogo
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 4 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i4.4202

Abstract

because substantial genetic heterogeneity, dynamic tumor evolution, and variable treatment responses limit the effectiveness of standardized clinical protocols. This study aimed to evaluate the implementation of Digital Twins for cancer therapy simulation and to examine their contribution to genetic-based medical personalization and clinical decision support. A mixed-methods sequential explanatory design was employed involving 480 patients treated at tertiary oncology centers. Quantitative analyses included descriptive statistics, structural equation modeling, survival analysis, mediation and moderation analyses, whereas qualitative evidence was obtained through semi-structured interviews, clinical observations, multidisciplinary case reviews, and document analysis. Findings demonstrated that Digital Twin-assisted treatment planning significantly improved simulation accuracy, treatment response prediction, therapeutic precision, physician decision confidence, and multidisciplinary coordination while reducing anticipated adverse treatment events. Results indicate that Digital Twin technology provides a comprehensive precision oncology framework by integrating computational intelligence, genomic medicine, and real-time clinical information to optimize individualized cancer therapy, improve evidence-based decision-making, and enhance long-term patient outcomes while supporting the broader implementation of personalized medicine.
Gamification and Student Well-being: Exploring the Psychological Impact of Game-Based Learning Adiyati Fathu Roshonah; Nong Chai; Rustiyana Rustiyana; Dito Anurogo
Journal Emerging Technologies in Education Vol. 3 No. 4 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jete.v3i4.2573

Abstract

Background. The increasing integration of digital learning environments has accelerated the adoption of gamification as a pedagogical approach to enhance engagement and student well-being. Contemporary education faces growing challenges related to academic stress, low motivation, and diminished emotional resilience among learners. Purpose. This research investigates the psychological effects of game-based learning, focusing on how gamification elements such as rewards, competition, collaboration, and feedback affect students’ emotional states, motivation, and perceived well-being.   Method. The study aims to bridge the gap between cognitive engagement and affective learning outcomes by empirically examining the psychological dynamics fostered by gamified educational experiences. A mixed-method design was employed, combining quantitative data from 320 undergraduate students across four universities and qualitative interviews with 24 participants. Results. Instruments included validated scales measuring intrinsic motivation, emotional engagement, and academic well-being. Data analysis was conducted using structural equation modeling (SEM) to identify causal relationships between gamification components and psychological indicators. Conclusion. The study concludes that gamification serves not only as a motivational tool but also as a psychological support mechanism in learning environments.
Co-Authors Abdul Rahman Rahim Adiningrat, Andi Arifwangsa Andi Weri Sompa Clara Mendes Emdat Suprayitno Faidul Adziem Gamar Abdullah Hermansyah Hermansyah I Ketut Dian Lanang Triana Jeane L.I. Sumarauw Loso Judijanto Lucas Lima Luis Santos Maria Clara Reyes Mohamad Firdaus Muhammad Nur Abdi Muntasir, Muntasir Ni Nyoman Sri Wirayuni Nong Chai Noorhani Dyani Laksmi Nur Hasanah Pedro Silva Pong Krit Rahmat Pannyiwi Rezqiqah Aulia Rahmat Roshonah, Adiyati Fathu Roya Zahir Rustiyana, Rustiyana Samantha Gonzales Siri Lek Sisilia Prima Yanuaria Buka Sri Kubillawati, Suarni, Agusdiwana Yocki Yuanti