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Serum Procalcitonin (PCT) Level In Acute Kidney Injury (AKI) In Critical Patients: Acute Kidney Injury (AKI) In Critical Patients Iwan Tona, Azwar; Syukri, Maimun
Journal of Society Medicine Vol. 1 No. 2 (2022): November
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.923 KB) | DOI: 10.47353/jsocmed.v1i2.8

Abstract

Early prediction and avoidance of aggravation of AKI will be useful in identifying patients at risk of developing a higher degree of AKI. Many studies have been conducted to prevent AKI and find biomarkers to predict AKI. Many studies have identified biomarkers of AKI, such as neutrophil-associated lipocalin (NGAL), cystatin C, interleukin-18, and tissue inhibitors of metalloproteinase-2 (TIMP-2). Yet few have investigated the role of PCT as a predictor of AKI. The pathophysiological mechanisms that explain the association between serum PCT and AKI remain unclear. Various inflammatory responses are thought to play a role in the AKI development. PCT acts as a chemoattractant in the ​​inflammation area and causes more monocytes to invade the ​​inflammation. PCT is initially produced in adherent monocytes and then contributes to an increase in circulating PCT by attracting parenchymal cells as they attach directly to activated monocytes. High PCT levels ultimately act as a direct chemoattractant to monocyte counts.
Burnout and study engagement among medical students during COVID-19 pandemic: A cross-sectional study in Aceh, Indonesia Al-Gunaid, Seba; Syukri, Maimun; Kurniawan , Ferry D.; Rizal, Syamsul; Novirianthy, Rima
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.165

Abstract

Medical students are particularly vulnerable to burnout due to the demanding and resource-constrained nature of their training. Burnout negatively impacts academic and personal well-being, potentially impacting future professional practice and patient care. To date, no studies have examined burnout prevalence among medical students in Aceh. The aim of this study was to determine the association between burnout and academic engagement among medical students at Syiah Kuala University, as well as the relationship with age, sex, and year of study. This cross-sectional study was conducted among medical students in Aceh, Indonesia, between October 1, 2021, and March 13, 2022. Total sampling was employed to select study participants. Data were collected using an e-questionnaire using the Oldenburg Burnout Inventory questionnaire adapted for students (OLBI-S) and Utrecht Work Engagement Scale for Students (UWES-S-9) for academic engagement. The total number of participants was 286 students. Most participants were female (n=202, 70.6%), while male students were 84 (29.3%). The prevalence of burnout was 36% (n=102). Gender (p=0.65) and study year (p=0.62) were not associated with disengagement, a subscale of the OLBI-S. Similarly, exhaustion scores did not differ significantly by gender (p=0.48) or study year (p=0.28). In conclusion, fewer than half of the medical students experienced burnout during the COVID-19 pandemic, with no association found between burnout and gender or study year.
Effect of Hydroxychloroquine Therapy on Hematology and Ocular Manifestations of Systemic Lupus Erythematosus Patients Muhsin, Muhsin; Sylvawani, Mahriani; Abdullah, Vera; Nilawati, Enny; Riswan, Muhammad; Abdullah, Abdullah; Syukri, Maimun
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1181.1

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects women and has various clinical manifestations involving multiple organs. The use of hydroxychloroquine (HCQ) provides some advantages. This study aimed to analyze hematological and ocular effects following short-term HCQ administration in SLE patients. A cross-sectional study was conducted from April to July 2022 at Zainoel Abidin Hospital, Banda Aceh, Indonesia, involving 23 female SLE patients. Blood laboratory parameters were assessed, and an ophthalmologist performed ocular examinations. The study showed an average hemoglobin of 11.6 g/dL. Other blood laboratory results were within normal limits. The mean duration of SLE diagnosis and HCQ use was 21.0 months and 9.7 months, respectively. There was no correlation between HCQ use duration and hematological parameters (hemoglobin, leukocytes, and thrombocytes; p values 0.38, 0.14, and 0.62, respectively). This study showed that only one SLE patient taking HCQ for less than five years had ocular problems. The prevalence of ocular and hematological effects in SLE patients treated with HCQ for less than five years is minimal.
Renal function and potassium changes in HFrEF patients treated with ACEI vs. ARNI: A prospective cohort study among Acehnese, Indonesia Munawarah, Iffah; Heriansyah, Teuku; Syukri, Maimun; Purnawarman, Adi; Buchari
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.10

Abstract

Background: Renin-Angiotensin-Aldosterone System (RAAS) acceleration commonly occur in Heart Failure (HF). Drugs such as Angiotensin-Converting Enzyme Inhibitors (ACEI) and Angiotensin Receptor-Neprilysin Inhibitors (ARNI) become essential part of HF treatment. Long-term consumption may impair kidney function and potassium imbalance, which could potentially limit the therapy, therefore we conducted this study to assess the effects of ACEI and ARNI on renal function and potassium level in Indonesian patients with heart failure with reduced ejection fraction (HFrEF), as no local studies exist. Method: A prospective cohort was performed in Banda Aceh, which comprise of 40 ACEI and 40 ARNI patients on standard therapy. Left ventricular ejection fraction (LVEF), serum creatinine level then converted into estimated Glomerular Filtration Rate (eGFR), and serum potassium level were measured at baseline and after 3 months into the therapy. Independent t-test was applied to compare groups. Result: Both ARNI and ACEI groups showed significant improvement in eGFR (p < 0.005). The intergroup difference was 11 mg/dL (p = 0.038) showed that ACEI had a better outcome in eGFR improvement compare with ARNI. Potassium rose slightly in both groups, with an intergroup difference of 0.082 mmol/L (p = 0.623), indicating no meaningful difference. Conclusion: Both ACEI and ARNI improved eGFR after 3 months, with a modest potassium increase.
Hubungan Adekuasi Hemodialsis dan Kadar Natrium Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) dengan Efusi Pleura Transudat pada Penyakit Ginjal Kronik Abdullah; Reza Tandi, Teuku Muhammad; Syukri, Maimun; Salwani, Desi; Cassandra, Amelia
Journal of Medical Science Vol 7 No 1 (2026): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v7i1.228

Abstract

Penyakit ginjal kronis (PGK) masih menjadi masalah kesehatan global. Riset Kesehatan Dasar (Riskesdas) menunjukkan peningkatan prevalensi PGK di Indonesia dari 0,2 menjadi 0,38 % (2013-2018). Hemodialisis (HD) merupakan salah satu modalitas terapi pengganti ginjal pada penyakit ginjal kronik tahap akhir (PGTA). Efusi pleura sering dijumpai pada pasien PGTA yang menjalani HD. Pada PGTA yang belum HD terdapat 3% efusi pleura dan 31,85% yang telah menjalani HD. Mekanisme efusi pleura pada PGTA  dianggap berkaitan erat dengan kondisi kelebihan cairan dan HD yang tidak optimal. N-terminal prohormone-brain natriuretic peptide (NT-proBNP) dianggap dapat mendeteksi kondisi kelebihan cairan dan evaluasi adekuasi HD berkala perlu dilakukan pada pasien HD. Karena itu, peneliti tertarik untuk meneliti bagaimana hubungan Adekuasi Hemodialisis dan Kadar NT-proBNP terhadap jenis Efusi Pleura Pada Pasien PGK. Penelitian bersifat analitik dengan pendekatan cross sectional dan menggunakan total sampling mulai 1 April 2024 hingga 31 Juli 2024 yang dilakukan di RSUD dr. Zainoel Abidin Banda Aceh. Penelitian ini melibatkan pasien efusi pleura yang menjalani HD di RSUZA. Variabel bebas pada penelitian ini adalah Adekuasi HD (Kt/V) dan Kadar NT-proBNP dan variabel terikat Efusi Pleura.  Uji normalitas menggunakan Shapiro wilk. Hubungan antar variabel diuji menggunakan Pearson correlation test bila distribusi data normal atau uji Spearman correlation test distribusi data tidak normal. Hasil penelitian menunjukkan NT-proBNP memiliki hubungan yang signifikan terhadap Efusi Pleura Transudat dengan nilai p=0,762 di tingkat kepercayaan 99%. Adekuasi HD tidak memiliki hubungan yang signifikan terhadap efusi pleura transudat dengan nilai p= -0,134.