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All Journal The Indonesian Biomedical Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh eJournal Kedokteran Indonesia The Journal of Society Medicine (JSOCMED) Narra X Indonesian Journal of Case Reports Trends in Infection and Global Health
Maimun Syukri, Maimun
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Serum Procalcitonin (PCT) Level In Acute Kidney Injury (AKI) In Critical Patients: Acute Kidney Injury (AKI) In Critical Patients Iwan Tona, Azwar; Syukri, Maimun
Journal of Society Medicine Vol. 1 No. 2 (2022): November
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.923 KB) | DOI: 10.47353/jsocmed.v1i2.8

Abstract

Early prediction and avoidance of aggravation of AKI will be useful in identifying patients at risk of developing a higher degree of AKI. Many studies have been conducted to prevent AKI and find biomarkers to predict AKI. Many studies have identified biomarkers of AKI, such as neutrophil-associated lipocalin (NGAL), cystatin C, interleukin-18, and tissue inhibitors of metalloproteinase-2 (TIMP-2). Yet few have investigated the role of PCT as a predictor of AKI. The pathophysiological mechanisms that explain the association between serum PCT and AKI remain unclear. Various inflammatory responses are thought to play a role in the AKI development. PCT acts as a chemoattractant in the ​​inflammation area and causes more monocytes to invade the ​​inflammation. PCT is initially produced in adherent monocytes and then contributes to an increase in circulating PCT by attracting parenchymal cells as they attach directly to activated monocytes. High PCT levels ultimately act as a direct chemoattractant to monocyte counts.
Burnout and study engagement among medical students during COVID-19 pandemic: A cross-sectional study in Aceh, Indonesia Al-Gunaid, Seba; Syukri, Maimun; Kurniawan , Ferry D.; Rizal, Syamsul; Novirianthy, Rima
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.165

Abstract

Medical students are particularly vulnerable to burnout due to the demanding and resource-constrained nature of their training. Burnout negatively impacts academic and personal well-being, potentially impacting future professional practice and patient care. To date, no studies have examined burnout prevalence among medical students in Aceh. The aim of this study was to determine the association between burnout and academic engagement among medical students at Syiah Kuala University, as well as the relationship with age, sex, and year of study. This cross-sectional study was conducted among medical students in Aceh, Indonesia, between October 1, 2021, and March 13, 2022. Total sampling was employed to select study participants. Data were collected using an e-questionnaire using the Oldenburg Burnout Inventory questionnaire adapted for students (OLBI-S) and Utrecht Work Engagement Scale for Students (UWES-S-9) for academic engagement. The total number of participants was 286 students. Most participants were female (n=202, 70.6%), while male students were 84 (29.3%). The prevalence of burnout was 36% (n=102). Gender (p=0.65) and study year (p=0.62) were not associated with disengagement, a subscale of the OLBI-S. Similarly, exhaustion scores did not differ significantly by gender (p=0.48) or study year (p=0.28). In conclusion, fewer than half of the medical students experienced burnout during the COVID-19 pandemic, with no association found between burnout and gender or study year.
Perbandingan Rasio Albumin Kreatinin Urin Sebelum Dan Setelah Puasa Pada Penyakit Ginjal Diabetik: Comparison of Urinary Creatinine Albumin Ratio Before and After Fasting in Diabetic Kidney Disease Hasan, Desi Salwani; Syukri, Maimun; Balqis, Ummu; Suhanda, Rachmad
Journal of Medical Science Vol 6 No 2 (2025): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v6i2.246

Abstract

Pembatasan asupan kalori selama berpuasa dapat menurunkan berat badan, namun juga memiliki risiko perburukan fungsi ginjal pada pasien dengan penyakit ginjal diabetik. Rasio albumin kreatinin merupakan salah satu penanda perburukan fungsi ginjal.  Penelitian ini bertujuan untuk mengetahui perbandingan rasio albumin kreatinin urin sebelum dan setelah berpuasa pada pasien penyakit ginjal diabetik. Penelitian ini merupakan penelitian cohort prospektif yang dilakukan mulai 1 Maret 2024-31 Mei 2024 di Poliklinik Endokrin dan poliklinik ginjal Hipertensi Rumah sakit dr Zainoel Abidin, melibatkan subyek penyakit ginjal diabetik yang menjalani puasa Ramadhan minimal 7 hari berturut, usia > 18 tahun, proteinuria +1 atau lebih berdasarkan urinalisis dan kriteria ekslusi adalah sindroma nefrotik atau penyaki glomerulus dan lupus eritematosus sistemik. Perbandingan kadar albumin kreatinin rasio sebelum dan setelah puasa Ramadhan menggunakan uji T-test berpasangan bila distribusi data normal dan uji Wilcoxon bila distribusi data tidak normal dengan tingkat signifikansi pengambilan keputusan pada p<0.05. Penelitian melibat 37 subyek dengan penyakit ginjal diabetik, laki laki lebih banyak dari Perempuan (54,1 %) dengan rerata usia 51,41±9,39 tahun. Median Rasio Albumin kreatinin sebelum puasa Ramadhan adalah 1359(10,57-12442) mg dan 1015(7,89-9764) mg setelah 7 hari menjalani puasa. Perbandingan rasio albumin kreatinin urin pada pasien penyakit ginjal diabetik sebelum dan sesudah puasa Ramadhan tidak menunjukkan perbedaan yang bermakna secara statistik dengan nilai P 0,140. Simpulan: terdapat penurunan rasio albumin kreatinin namun tidak berbeda secara statistik.
Effect of Hydroxychloroquine Therapy on Hematology and Ocular Manifestations of Systemic Lupus Erythematosus Patients Muhsin, Muhsin; Sylvawani, Mahriani; Abdullah, Vera; Nilawati, Enny; Riswan, Muhammad; Abdullah, Abdullah; Syukri, Maimun
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1181.1

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects women and has various clinical manifestations involving multiple organs. The use of hydroxychloroquine (HCQ) provides some advantages. This study aimed to analyze hematological and ocular effects following short-term HCQ administration in SLE patients. A cross-sectional study was conducted from April to July 2022 at Zainoel Abidin Hospital, Banda Aceh, Indonesia, involving 23 female SLE patients. Blood laboratory parameters were assessed, and an ophthalmologist performed ocular examinations. The study showed an average hemoglobin of 11.6 g/dL. Other blood laboratory results were within normal limits. The mean duration of SLE diagnosis and HCQ use was 21.0 months and 9.7 months, respectively. There was no correlation between HCQ use duration and hematological parameters (hemoglobin, leukocytes, and thrombocytes; p values 0.38, 0.14, and 0.62, respectively). This study showed that only one SLE patient taking HCQ for less than five years had ocular problems. The prevalence of ocular and hematological effects in SLE patients treated with HCQ for less than five years is minimal.
Trends in CTGF Expression in Renal and Chorioretinal Tissues Following Metformin and SGLT2 Inhibitor Treatment in Diabetic Rats Syukri, Maimun; Zaini, Lia Meuthia; Kartasasmita, Arief Sjamsulaksan; Gondhowiardjo, Tjahjono Darminto; Lesmana, Ronny; Mulya, Putri Nabillah
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3886

Abstract

BACKGROUND: Connective tissue growth factor (CTGF) plays a central role in fibrotic processes affecting both renal and retinal tissues in diabetes. Although sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to exert renoprotective and antifibrotic effects, their impact on CTGF expression in renal and retinal tissues has not been clearly established. This preliminary study was conducted to evaluate whether SGLT2 inhibitors (SGLT2i) could influence CTGF expression in the kidneys and eyes of diabetes-induced rats.METHODS: After two weeks of adaptation, 24 rats were randomized and distributed equally into four groups (n=6 each): 1) Healthy Control, healthy rats without diabetic induction; 2) Negative Control, diabetic rats induced with streptozotocin (STZ) without treatment; 3) Metformin Group, diabetic rats treated with metformin; and 4) SGLT2i Group, diabetic rats treated with empagliflozin. Following eight weeks of intervention, CTGF expression was analyzed by Western blot in renal tissue (right kidney) and chorioretinal tissue (right eye). Four samples per group yielded analyzable bands and were included in the final quantification.RESULTS: In renal tissue, CTGF levels (mean±SD) were highest in Negative Control Group (0.81±0.06). Both the Metformin Group (0.58±0.14) and SGLT2i Group (0.57±0.33) demonstrated a trend toward reduced CTGF expression. In chorioretinal tissue, CTGF values were relatively similar across groups (Healthy Control: 0.67±0.05; Negative Control: 0.63±0.12), with Metformin Group (0.61±0.12) and SGLT2i Group (0.64±0.22) showing a modest reduction trend.CONCLUSION: In diabetic rats, CTGF expression levels are markedly increased. Following treatment with metformin and SGLT2i, CTGF expression demonstrates a noticeable reduction trend.KEYWORDS: SGLT2 inhibitor, metformin, connective tissue growth factor, cellular communication network factor 2, renal, retina
Co-Authors Abdullah Abdullah Abdullah, Vera Agung Pranata Al-Gunaid, Seba Al-Muchtari, Teuku AZ. Arief S. Kartasasmita Ayulinda, Arianisah P. Beočanin, Anđelija Darmawi . Erianza, Dava Gondhowiardjo, Tjahjono Darminto Hanifah Yusuf Harapan Harapan Hasan, Desi Salwani Hasan, Maryatun Herlina Dimiati, Herlina Ichsan Ichsan Idroes, Ghifari Maulana Iwan Tona, Azwar Jayawarsa, A.A. Ketut Kamil, Qatrunnada Kartasasmita, Arief Sjamsulaksan Kurnia F. Jamil Kurniawan , Ferry D. Lia Meuthia Zaini, Lia Meuthia Liansyah, Tita M. Maelani, Imelda Mahmud , Nissa N. Marty Mawarpury Mudatsir , Mudatsir Mudatsir Mudatsir Muhammad Yani, Muhammad Muhsin Muhsin Mulya, Putri Nabillah Nilawati, Enny Nurjannah Nurjannah Oktari, Rina S. Putri, Widia Rachmad Suhanda Redwood-Campbell, Lynda Renaldi, Teuku Rima Novirianthy Rinaldi Idroes Riswan, Muhammad Ronny Lesmana Rudi Kurniawan Samsul Anwar Sari, Etika Soehartati Gondhowiardjo Sofyan, Sarwo E. Syamsul Rizal Sylvawani, Mahriani Teuku Rizky Noviandy Tjahjono D. Gondhowiardjo Tona, Azwar Iwan Ummu Balqis Usman, Said Yusni Yusni Yusni Yusni Zaini, Lia M.