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All Journal Jurnal Kesehatan Masyarakat (IKESMA) JMM (Jurnal Masyarakat Mandiri) Indonesian Journal of Cardiology Heart Science Journal Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Jurnal Neuroanestesi Indonesia Narra X Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Teuku Heriansyah, Teuku
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Exploring the Relationship Between Comprehensive Respiratory Assessment and Intra-Extracardiac Biomarkers in Heart Failure Rehabilitation Triangto, Kevin; Radi, Basuni; Siswanto, Bambang B.; Tambunan, Tresia FU.; Heriansyah, Teuku; Harahap, Alida R.; Kekalih, Aria; Katsukawa, Hajime; Santoso, Anwar
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.248

Abstract

Introduction: Heart failure with reduced ejection fraction (HFrEF) is well-known as a systemic disease that involves cardiac and extracardiac issues, with respiratory function playing on of the key role in rehabilitation prognosis. Biomarkers such as soluble suppression of tumorigenicity 2 (sST2), myostatin, miRNA-133, and NT-proBNP indicate disease progression. Notably, sST2, which is also produced by the lungs, predicts heart failure outcomes. This study examines the relationship between comprehensive respiratory assessments (e.g., diaphragmatic ultrasonography, spirometry) and intra-extracardiac biomarkers to improve rehabilitation strategies. Methods: Sixty-nine HFrEF patients underwent respiratory evaluations, including diaphragmatic ultrasonography, spirometry, chest expansion measurements, and a six-minute walking test (6MWT). Biomarkers assessed were sST2, myostatin, miRNA-133, and NT-proBNP. Associations between respiratory parameters and biomarkers were analyzed using t-tests and correlation analyses. Results: The median age was 56 years, and 33 (47.82%) of the subjects had diaphragmatic dysfunction, resulting in poorer 6MWT performance (378.03±58.15 m vs 409.75±63.65 m, p=0.017) and other parameters. Superior chest expansion negatively correlated with sST2 (r=−0.387, p=0.001) and positively with miRNA-133 (r=0.442, p<0.001). Similar results were found for inferior chest expansion. No significant correlations were observed for other biomarkers. Conclusion: This study highlights strong associations between chest expansion and sST2/miRNA-133, suggesting that incorporating respiratory assessments and training into HFrEF rehabilitation could enhance outcomes by addressing cardiorespiratory insufficiencies. Given sST2's predictive value for heart failure prognosis, these findings support a multi-component rehabilitation strategy incorporating respiratory training, such as aerobic and inspiratory muscle exercises, to enhance cardiopulmonary outcomes. This integrated approach offers promise for future HFrEF rehabilitation protocols.
Co-Authors Achdiat Agoes Adam, Erika Adi Purnawarman, Adi Aldri Frinaldi Amanda, Febrina Ambari, Ade Meidian Anwar Santoso Aria Kekalih Arifah, Medisa Roro Putri Nur Badai Bhatara Tiksnadi Bambang Budi Siswanto Bashori, Ahmad A. Basuni Radi Buchari Desandri, Dwita Desandri, Dwita Rian Djanggan Sargowo Dwiputra, Bambang Ekawati, Wahyu Elvira Sari Dewi Enitan, Seyi S. Erwinanto, Erwinanto Faradilla, Rizka Fithriany Fitra, Maha Gusti, Naufal Hadi, Tjut F. Hamny Sofyan Harahap, Alida R. Harahap, Alida Rosita Herlina Dimiati, Herlina Inda Lestari, Inda Indriyani, Damayanti Jannah, Riska Raudhatul Jasa, Zafrullah Kany Kamarlis, Reno K. Katsukawa, Hajime Kristianingrum, Niko Dima Kumboyono Kumboyono Kurniawan, Ferry D. Lestari, Nova D. Liza Salawati, Liza Machfud, Savinka Salsabiela Iriana Maimun Syukri, Maimun Marfuah Marfuah Mudatsir Mudatsir Muhammad Ridwan Munawarah, Iffah Munirwan, Haris Nina Widasari novia, rizki Novita Novita Nurjani Nursuhaida, Haffa Syafana Pintaningrum, Yusra Putra, Magma Purnawan Putri, Cut JE. Renan Sukmawan Riswandha, Sofyan Rita Zahara, Rita Saputra, Irwan Saputra, Jefri Dwi Sari, Indah P. Satuman Satuman Septi Nurhayati Sri Soenarti Subkhan, Muhammad Suciana Sunanto Ng Syamsiar, Syamsiar Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Taufiks, Nasyaruddin H. Taufiqurrahman Taufiqurrahman Titin A Wihastuti, Titin A Triangto, Kevin Wicaksono, Sony Wicaksono, Sony Hilal Yanti, Budi Yuliezar Perwira Dara, Yuliezar Perwira Yuvhendmindo, Shahcoga L. ZAHRA, RITA