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All Journal JBIO: jurnal biosains (the journal of biosciences) Indonesian Journal of Pharmaceutical Science and Technology Biology, Medicine, & Natural Product Chemistry Journal of Indonesian Dental Association B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal AKAL: Abdimas dan Kearifan Lokal Jurnal Kedokteran Gigi Terpadu JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Abdimas Kesehatan Terpadu Jurnal Pengabdian Masyarakat Trimedika
Soesanto, Sheila
Department Of Pharmacology, Faculty Of Dentistry, Universitas Trisakti, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Transportation Other

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Antibiofilm of Arumanis Mango Leaves (Mangifera indica L.) Ethanol Extract Against Staphylococcus aureus in vitro Evangelista Rachel Hepziba; Sheila Soesanto; Armelia Sari Widyarman
Journal of Indonesian Dental Association Vol. 5 No. 2 (2022): October
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v5i2.846

Abstract

Introduction: Staphylococcus aureus is a pathogen bacteria that forms biofilm and induces acute inflammation associated with dentoalveolar abscess, which needs antibiotics such as amoxicillin for the treatment. Due to antibiotic resistance and various side effects, natural ingredients are needed as an alternative treatment. Arumanis mango leaves (Mangifera indica L.) contains mangiferin, flavonoid, and tannin which are expected to inhibit the growth of Staphylococcus aureus and its biofilm formation. Objective: The aim of this study was to determine the antibacterial and antibiofilm effects of Mangifera indica L. leaves against Staphylococcus aureus in vitro. Methods: This study was in vitro laboratory experiment with post test only control group design. Antibacterial test was carried out by plate count method and antibiofilm test was carried out by microtiter plate biofilm assay method. Staphylococcus aureus ATCC 25923 was cultured in BHI broth in 37oC for 24h with anaerobic condition. The present study used ethanol extract of Mangifera indica L. leaves in 6 different concentrations: 3,125%, 6,25%, 12,5%, 25%, 50%, and 100%. Amoxicillin was used as positive control and DMSO 10% used as negative control. Data was analyzed with Shapiro-wilk test, One-way ANOVA test, and post hoc Tukey HSD test with p<0,05 as the level of significance. Results: The most effective concentration to inhibit the growth of Staphylococcus aureus was 100% extract compared to negative control (p<0,05). The most effective concentration against Staphylococcus aureus biofilm formation was 100% extract in 3hr incubation compared to negative control (p<0,05). Conclusion: Ethanol extract of Mangifera indica L. leaves has been shown in vitro to have antibacterial and antibiofilm properties against Staphylococcus aureus.
Co-Authors Albert Alvina Alvina Armelia Sari Widyarman Aryadi Beby Sophiana, Beby Sophiana Cokro, Wilbert Alvin Genesis Eddy Eddy Elly Herwana, Elly Evangelista Rachel Hepziba Graciela, Audria Halim, Johni Hartanto, Firstine Hartanto Hartanto, Firstine Kelsi Henry Tedja, Christian Hepziba, Evangelista Rachel Joice Viladelvia Kalumpiu, Joice Viladelvia Joko Kusnoto Kurniasari Kurniasari, Kurniasari Liem, Maria Barbie Natassya, Priska Naufal, Nafia Syifa Octarina Octarina Octarina Pratama Sarwono, Aditya Rahmi Amtha Septifionna, Haura Agni Sudarmi, Elisabeth Thebez, Vanessa Angela Widyarman, Armelia Sari Wijaya, Johanna A. YENNY YENNY Yonathan, Dick Yuliasari, Hani