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All Journal Public Health of Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) HOSPITAL MAJAPAHIT (JURNAL ILMIAH KESEHATAN POLITEKNIK KESEHATAN MAJAPAHIT) ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal IDAMAN (Induk Pemberdayaan Masyarakat Pedesaan) Journal of Holistics and Health Sciences (JHHS) Jurnal Pengabdian kepada Masyarakat Hospital Majapahit : Jurnal Ilmiah Kesehatan Politeknik Kesehatan Mojokerto Journal of Education Research Prima Wiyata Health Jurnal Pengabdian Masyarakat Bangsa PEDAMAS (Pengabdian Kepada Masyarakat) JPK : Jurnal Penelitian Kesehatan Journal of Indonesian Health Policy and Administration Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) Jurnal Penelitian Keperawatan Strada Jurnal Ilmiah Kesehatan (SJIK) Medica Majapahit
Hany Aryani Puspita
Program Studi Sarjana Keperawatan, Sekolah Tinggi Ilmu Kesehatan Husada Jombang, Jombang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Modulating Inflammation in PCOS: The Role of a High-Protein, Low-Carb Diet in Reducing IL-6 and TNF-α Aryani, Hany Puspita; Suryani, Lilis; Sugiyanta
Public Health of Indonesia Vol. 12 No. 1 (2026): January - March
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v12i1.1316

Abstract

Background: Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder characterized by insulin resistance and low-grade inflammation, marked by elevated cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Nutritional modulation may play a role in managing these inflammatory markers. Objective: This study aimed to assess the effect of a low-carbohydrate high-protein (RKTP) diet on IL-6 and TNF-α levels in a PCOS-insulin resistance rat model. Methods: This experimental study used a post-test only control group design involving 18 female Rattus norvegicus rats. The rats were divided into three groups: negative control (K−), positive control (K+; PCOS-insulin resistance induced by testosterone propionate), and treatment (P; PCOS-insulin resistance treated with RKTP diet composed of 40% carbohydrates, 30% protein, and 30% fat). The intervention lasted 48 days. Serum levels of IL-6 and TNF-α were measured using ELISA. Data were analyzed using ANOVA, Kruskal-Wallis, and Mann-Whitney tests. Results: The treatment group experienced a significant reduction in IL-6 levels compared to the positive control (p = 0.038) and negative control (p = 0.002). TNF-α levels also significantly decreased in the treatment group (mean = 4.17) compared to the negative control group (mean = 8.83), with a Mann-Whitney test p-value of 0.025. These findings suggest an anti-inflammatory effect of the RKTP diet in PCOS-induced insulin resistance. Conclusion: A high-protein, low-carbohydrate diet effectively reduced inflammatory cytokines in PCOS-insulin resistant rats, suggesting potential as a non-pharmacologic intervention in PCOS management. Keywords: RKTP diet; PCOS-RI; IL-6 Levels; TNF-α Levels
Red Ginger as a Potential SDG-3 Herbal Therapy: Molecular and Flow Cytometry Evaluation of CD4, CD8, and CD62L Lymphocyte Modulation in PCOS-Induced Rattus norvegicus Mudrikatin, Siti; Aryani, Hany Puspita; Setyowati, Risha
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13687

Abstract

Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine disorder associated with hyperandrogenism, inflammation, and immune system dysfunction. Elevated levels of testosterone are known to affect lymphocyte profiles and contribute to the inflammatory processes in PCOS. The aim of this study was to evaluate the impact of red ginger extract (Zingiber officinale var. rubrum) on lymphocyte subpopulations in a testosterone-induced PCOS rat model. This experimental study involved 30 female Rattus norvegicus divided randomly into five groups: a normal control, a PCOS control (testosterone-induced without treatment), and three PCOS treatment groups receiving different doses of red ginger extract. PCOS induction was done using testosterone propionate. Following the treatment period, lymphocyte subpopulation analysis was performed using flow cytometry based on the CD4⁺, CD8⁺, and CD62L⁺ surface markers. The results indicated significant differences in the expression of CD4⁺, CD8⁺, and CD62L⁺ among all red ginger treatment groups compared to the PCOS control group (p < 0.05), suggesting an immunomodulatory effect of red ginger. In conclusion, the administration of red ginger extract was able to modulate the lymphocyte subpopulation profile in the PCOS model, potentially contributing to controlling immune responses associated with hyperandrogenism.
Co-Authors Barir, Baroroh Barir Budi Santoso Budi Santoso Budiman Budiman Copertino Tna’auni, Yoseph Dian Anggraini, Rista Dwi Uswatun Sholikhah Elly Rustanti Enny Puspita Enny Puspita Ermawati Ermawati Farida, Siti Nur Fatmawati, Elis Fatmawati, Zeny Gevi Melliya Sari Hanis Kusumawati Rahayu Karisma Dwi Ana Lilis Suryani Lukman Waris Najah Soraya Nia Putri, Diah Pitaloka Risha Setyowati Rista Dian Anggraini Rosita, Yoga Rustanti, Elly Rustanti Rustanti, Ely Semi Semi, Semi Siti Mudrikatin Sri Wulandari Sugiyanta Sukati Sarmin Sulistiawati Sylvie Puspita Sylvie Puspita Wahyu Anjas Sari Warda Anil Masyayih Wati, Dwi Retno Widjiati Widjiati Widjiati Zerly Agrisidan