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All Journal Public Health of Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Manarang HOSPITAL MAJAPAHIT (JURNAL ILMIAH KESEHATAN POLITEKNIK KESEHATAN MAJAPAHIT) ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal IDAMAN (Induk Pemberdayaan Masyarakat Pedesaan) Journal of Holistics and Health Sciences (JHHS) Jurnal Pengabdian kepada Masyarakat Hospital Majapahit : Jurnal Ilmiah Kesehatan Politeknik Kesehatan Mojokerto Journal of Education Research Prima Wiyata Health Jurnal Pengabdian Masyarakat Bangsa PEDAMAS (Pengabdian Kepada Masyarakat) JPK : Jurnal Penelitian Kesehatan Journal of Indonesian Health Policy and Administration Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) Jurnal Penelitian Keperawatan Strada Jurnal Ilmiah Kesehatan (SJIK) Medica Majapahit
Hany Aryani Puspita
Bachelor Of Nursing Science Program, College Of Health Sciences Of Husada Jombang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Decreased Insulin and Interleukin-6 Levels in Rattus Norvegicus Model of Polycystic Ovary Syndrome-Insulin Resistance Treated with a High Protein Diet Hany Aryani Puspita; Zerly Agrisidan; Wahyu Anjas Sari
Journal of Ners and Midwifery Vol 11 No 2 (2024)
Publisher : STIKes Patria Husada Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26699/jnk.v11i2.ART.p209-215

Abstract

Hypercaloric in women of childbearing age is one of the causes of polycystic ovary syndrome (PCOS) with insulin resistance. Increased inflammation (tumor factor necrosis-α (TNF-α) and interleukin-6 (IL-6)) is the impact of endocrine and metabolic disorders involved due to metabolic syndrome, obesity, and diabetes mellitus. This study aims to evaluate whether a high-protein diet can reduce insulin and interleukin-6 levels, which are key indicators of polycystic ovary syndrome, and whether these changes can help in the treatment of the syndrome. This study used a prepost test only control design, true experimental, with a total sample of 6 female Rattus norvegicus rats aged 2–3 years (150–200 g). It consists of 4 groups, namely the negative control group (K-), the positive control group (K+), the treatment group (P), and the group without treatment (P-). The study examined the rat blood serum ELISA measurement of insulin and IL-6 levels. Anova test results of IL-6 levels (p = 0.002). Post-hoc test results of group K- and group P (p = 0.002), group K + and group P (p = 0.037), group K- and group K + (p = 0.437). The Anova test results of insulin levels between groups found a significant difference (p = 0.001). Post-hoc test of insulin levels of group K- and group P (p = 0.002), group K- and group K+ (p = 0.000), and group K+ with group P (p = 0.356). In group K and group P, the results of the ANOVA and post hoc tests on IL-6 levels and insulin levels with the provision of a high-protein diet show significant differences. This study suggests that a high-protein diet may be an effective therapeutic alternative in reducing the symptoms of polycystic ovary syndrome, especially in controlling high insulin and interleukin-6 levels.
Modulating Inflammation in PCOS: The Role of a High-Protein, Low-Carb Diet in Reducing IL-6 and TNF-α Hany Puspita Aryani; Lilis Suryani; Sugiyanta
Public Health of Indonesia Vol. 12 No. 1 (2026): January - March
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v12i1.1316

Abstract

Background: Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder characterized by insulin resistance and low-grade inflammation, marked by elevated cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Nutritional modulation may play a role in managing these inflammatory markers. Objective: This study aimed to assess the effect of a low-carbohydrate high-protein (RKTP) diet on IL-6 and TNF-α levels in a PCOS-insulin resistance rat model. Methods: This experimental study used a post-test only control group design involving 18 female Rattus norvegicus rats. The rats were divided into three groups: negative control (K−), positive control (K+; PCOS-insulin resistance induced by testosterone propionate), and treatment (P; PCOS-insulin resistance treated with RKTP diet composed of 40% carbohydrates, 30% protein, and 30% fat). The intervention lasted 48 days. Serum levels of IL-6 and TNF-α were measured using ELISA. Data were analyzed using ANOVA, Kruskal-Wallis, and Mann-Whitney tests. Results: The treatment group experienced a significant reduction in IL-6 levels compared to the positive control (p = 0.038) and negative control (p = 0.002). TNF-α levels also significantly decreased in the treatment group (mean = 4.17) compared to the negative control group (mean = 8.83), with a Mann-Whitney test p-value of 0.025. These findings suggest an anti-inflammatory effect of the RKTP diet in PCOS-induced insulin resistance. Conclusion: A high-protein, low-carbohydrate diet effectively reduced inflammatory cytokines in PCOS-insulin resistant rats, suggesting potential as a non-pharmacologic intervention in PCOS management. Keywords: RKTP diet; PCOS-RI; IL-6 Levels; TNF-α Levels
Ginger-Lemon-Honey Plus Vitamin B6 for Nausea and Vomiting In First-Trimester Pregnancy: A Three-Group Quasi-Experimental Study Sukati Sarmin; Wardani Arista Kusuma; Aryani Hany Puspita; Fatmawati Zany
Jurnal Kesehatan Manarang Vol 12 No 2 (2026): August 2026
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v12i2.2307

Abstract

Nausea and vomiting are common symptoms experienced by pregnant women during the first trimester, primarily associated with hormonal and physiological changes. Ginger, lemon, honey, and vitamin B6 have been widely used as complementary approaches to alleviate pregnancy-related nausea and vomiting. This study aimed to evaluate and compare the effectiveness of three interventions: ginger-lemon-honey, ginger-lemon-honey combined with vitamin B6, and vitamin B6 alone in reducing nausea and vomiting among pregnant women with emesis gravidarum. A quasi-experimental study with a three-group pretest-posttest design was conducted among 45 first-trimester pregnant women experiencing nausea and vomiting. Participants were selected using purposive sampling and allocated into three intervention groups: ginger-lemon-honey, ginger-lemon-honey plus vitamin B6, and vitamin B6 alone. Nausea and vomiting severity was assessed before and after the intervention using the Pregnancy-Unique Quantification of Emesis (PUQE-24) scale. Data were analyzed using univariate analysis, one-way ANOVA, and ANCOVA to evaluate differences between groups after adjustment for baseline scores. All three intervention groups demonstrated a significant reduction in nausea and vomiting following the intervention (p < 0.001). The ginger-lemon-honey plus vitamin B6 group showed the lowest adjusted mean PUQE-24 score of 6.002 (95% CI [5.4–6.5]), followed by the ginger-lemon-honey group with an adjusted mean of 7.590 (95% CI [7.0–8.1]), and the vitamin B6 group with an adjusted mean of 9.342 (95% CI [8.8–9.8]). These findings indicate that the combined ginger-lemon-honey and vitamin B6 intervention resulted in the lowest adjusted PUQE-24 score compared with either intervention alone. The combination of ginger, lemon, honey, and vitamin B6 was more effective in reducing nausea and vomiting among first-trimester pregnant women with emesis gravidarum than ginger-lemon-honey or vitamin B6 alone. This combined intervention may provide a comprehensive complementary approach through mechanisms involving gastrointestinal, neurological, psychological, and metabolic pathways.
Co-Authors Barir, Baroroh Barir Budi Santoso Budi Santoso Copertino Tna’auni, Yoseph Dian Anggraini, Rista Dwi Uswatun Sholikhah Elly Rustanti Enny Puspita Enny Puspita Ermawati Ermawati Farida, Siti Nur Fatmawati Zany Fatmawati, Elis Fatmawati, Zeny Gevi Melliya Sari Hanis Kusumawati Rahayu Karisma Dwi Ana Lilis Suryani Lukman Waris Najah Soraya Nia Putri, Diah Pitaloka Risha Setyowati Rista Dian Anggraini Rosita, Yoga Rustanti, Elly Rustanti Rustanti, Ely Semi Semi, Semi Siti Mudrikatin Sri Wulandari Sugiyanta Sukati Sarmin Sukati Sarmin Sulistiawati Sylvie Puspita Sylvie Puspita Wahyu Anjas Sari Warda Anil Masyayih Wardani Arista Kusuma Wati, Dwi Retno Widjiati Widjiati, Widjiati Zerly Agrisidan