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All Journal Medula Jurnal Analis Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks JURNAL KESEHATAN: JURNAL ILMIAH MULTI SCIENCES Jurnal EduHealth Sains Medisina Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
DWi Aulia Ramdini
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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MEKANISME AKSI DAN EFIKASI OBAT-OBATAN BOTANI YANG BERPOTENSI DALAM PENGOBATAN ALTERNATIF UNTUK FIBROID UTERUS Tiara Sekar; Rodiani; DWi Aulia Ramdini
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.483

Abstract

Uterine fibroids are benign gynecologic tumors that develop from the myometrium and become entangled in the majority of women. The available pharmacological treatments are useful for reducing the size of the fibroids and relieving the symptoms of uterine fibroids. However, these pharmacological agents are said to be unaffordable for most people and are also associated with considerable side effects. Therefore, botanical medicines stole the attention in the last decade because of their therapeutic effectiveness accompanied by affordable costs and comparable and stronger therapeutic efficacy, with fewer side effects. The aim of this review is to provide information regarding the mechanisms by which various botanical drugs possess uterine anti-fibroid activity. The source search method is carried out through several trusted websites such as Pubmed, Science Direct, and Google Scholar. Based on the literature that has been identified, five botanical drugs were found which will be discussed in this review. These botanical drugs will be explained their mechanism of action in carrying out uterine anti-fibroid activity which has the potential as an alternative treatment for uterine fibroids.
Literatur Review: Efek Samping Penggunaan Obat Hipertensi Sekar Anastry Putri; Dwi Aulia Ramdini; Afriyani; M. Fitra Wardhana
Medula Vol 13 No 4 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.773

Abstract

Hypertension is a major risk factor for cardiovascular disease. Hypertension also has another term, namely "silent killer" which can be interpreted that it is not uncommon for people with hypertension to find it difficult to realize or even not to feel the warning symptoms of their disease. Treatment for hypertensive patients is a treatment therapy that needs to be done in the long term or for life. The problem often occurs in the treatment of chronic diseases that require long-term treatment such as hypertension because there are still many patients who do not comply with the treatment therapy they should be undergoing. One of the causes of non-compliance is the presence of patients who experience side effects from treatment. A drug side effect is an unwanted event and is detrimental to the patient as a result of drug use. Side effects that often occur in amlodipine therapy are: palpitations, flushing, ankle edema, hypotension, headache and nausea. Captropil can cause hyperkalemia and dry cough. Side effects of beta blockers that can occur are insomnia, hallucinations and depression. Clonidine can cause side effects such as dry mouth with symptoms of dry and cracked lips. Treatment with hydrochlorothiazide generally causes complaints related to side effects of the drug including frequent urination, feeling weak and wanting to faint, and abnormal heart rate. The use of diuretics can cause increased levels of uric acid or hyperuricemia resulting in deposition of uric acid, acute arthritis, nephrolithiasis.
Pengaruh Metode Ekstraksi Terhadap Persen Rendemen dan Kadar Fenolik Ekstrak Tanaman yang Berpotensi sebagai Antioksidan Nungky Pawarti; Muhammad Iqbal; Dwi Aulia Ramdini; Citra Yuliyanda
Medula Vol 13 No 4 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.774

Abstract

Antioxidants are chemical compounds with various structures that bind free radicals. Antioxidants can inhibit oxidation reactions even at low concentrations. Antioxidant reactions with free radicals also occur in the body. Antioxidants will bind to free radicals and turn them into less reactive compounds so that cells and organs in the body will be protected from oxidative stress which can trigger various diseases. Identification of antioxidants is done by extracting natural plant materials. The methods often used in extraction include maceration, soxhletation, reflux and percolation. Different extraction processes will affect the type and quality of the compounds produced. The factors that influence the success of the extraction are the type of dissolution, the ratio of the amount of solvent, particle size, temperature, time and method of extraction. Secondary metabolite compounds which are thermolabile will experience an increase in levels with increasing temperature. However, the levels of metabolite compounds will decrease with the addition of higher temperatures. Heating helps metabolite compounds that are insoluble at room temperature to be dissolved maximally so that the extraction process can run well. The amount of active substance produced in extraction will affect the percent yield value. The percent yield value is needed to determine the amount of extract produced during the extraction. The yield data also has a close relationship with the active compounds in a sample. The higher the yield value, the more active compounds contained in the sample.
Faktor-Faktor yang Mempengaruhi Penggunaan Obat Herbal dan Obat Tradisional pada Pasien Hipertensi Sahanaz Zaqiyah Darozah; Dwi Aulia Ramdini; Afriyani; Oktafany
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1012

Abstract

The use of traditional medicine derived from various types of plants has become a culture and tradition in Indonesia. It is primarily used for treating metabolic and degenerative diseases, with hypertension being one of the notable examples. Hypertension stands as a leading cause of premature death worldwide. The global incidence of hypertension in 2015 reached 1.13 billion, with a prevalence ranging between 30-45%. Currently, approximately 75-80% of the world's population with hypertension decide to use herbal medicines because they can be tolerated by the body and have fewer associated side effects. The utilization of herbal and traditional medicines is widespread across various countries, including 29.4% in Iran, 21% in South Africa, 75.6% in Tanzania, 30.6% in Malaysia, and 54%-78% in Indonesia. Therefore, this article discusses factors influencing the use of herbal and traditional medicines among hypertensive patients. Factors known to influence the utilization of these medicines include gender, age, education, occupation, and medication adherence. Health professionals have to be concerned about herbal and traditional medicines use in hypertensive patients to ensure that the treatment is safe, effective, and minimizes the risk of side effects and drug interactions.
Co-Authors Afriyani Afriyani Afriyani Anastasya Dian Nurrarti Arini Puspita Sari Asep Sukohar Audry Lintang Hasanuddin Baehaqi Citra Yuliyanda Citra Yuliyanda Pardilawati Eka Ananda Laksana Putri Era Yesica Damanik Ervina Damayanti Evy Afriyani Fitri Dwi Antari Fredison Fredison Ihsanti Dwi Rahayu Lilik Koernia Wahidah M. Fitra Wardhana Maria Tuntun Mesa Sukmadani Rusdi Mirza Junando Muhammad Fitra Wardhana Sayoeti Nungky Pawarti Nurhayati Nurhayati Oktafany Oktafany Oktafany Oktafany, Oktafany Ramadhan Triyandi Rasmi Zakiah Oktarlina Rodiani Sahanaz Zaqiyah Darozah Salsabila Zaneta Aurelia Sekar Anastry Putri SITI AMINAH Siti Khalimatus Sa'diah Suharmanto Tiara Sekar Widyaningrum, Diah Ayu Yasmin Al Illyyin Zahra Fadilatusya'adah