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All Journal BALI MEDICAL JOURNAL (BMJ) Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Ilmu dan Teknologi Kesehatan J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Medical and Health Science Journal Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ilmiah Kesehatan Majalah Biomorfologi (Biomorphology Journal) Jurnal Kesehatan Tambusai Folia Medica Indonesiana
Nurul Wiqoyah, Nurul
Departement Of Microbiology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Antibacterial Activity Test of Green Betel Leaf Extract (Piper betle Linn.) against Methicillin-Sensitive Staphylococcus aureus Manaf, Syifa Az Zahrah; Wiqoyah, Nurul; Setiawati, Yuani
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.131-139

Abstract

Highlights Green betel leaf extract, particularly cultivated in Batu City, can inhibit and kill MSSA. Green betel leaf extract, particularly cultivated in Batu City, can be developed into a new alternative treatment as an effective antibiotic to kill MSSA bacteria.   ABSTRACT Background: Asia is one of the regions with the highest prevalence rates of Staphylococcus aureus (S. aureus) infection. Green betel leaves (Piper betle Linn.) have been shown to possess antibacterial potential due to their active compound content. Objective: To investigate whether betel leaf extract affects methicillin-sensitive Staphylococcus aureus (MSSA). Material and Method: This research was a descriptive experimental study focusing on the antibacterial activity test of green betel leaf extract against MSSA. The MSSA bacteria used were bacterial preparations in the Microbiology Laboratory of the Faculty of Medicine, Universitas Airlangga. The green betel leaf extract was obtained in 2023 in Batu City, East Java, Indonesia. The antibacterial activity test technique used was the dilution test. The tool used in data processing was Microsoft Excel. Results: Germs were found in the dilution test, particularly in tubes with concentrations of 50 mg/mL. The study also highlighted that no growth of germs was found based on the results obtained for the increase of MSSA on agar plates at concentrations of 800 mg/mL, 600 mg/mL, 400 mg/mL, and 200 mg/mL. The study also found that the growth of MSSA germs was at 100 mg/mL and 50 mg/mL. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of green betel leaf extract against MSSA were 100 mg/mL and 200 mg/mL, respectively. Conclusion: The extract of green betel leaves, particularly cultivated in Batu City, East Java, Indonesia has been shown to possess antibacterial activity, which can inhibit and kill MSSA bacteria. Further research is needed on the antibacterial activity of green betel leaf extract against other bacterial species.
Sepsis-3 and its Assesment Tools (Sofa and Qsofa): Historical Evolution, Clinical Utility and Criticisms Bhagaskara, Pandya; Wiqoyah, Nurul
Jurnal Ilmiah Kesehatan Vol 17 No 2 (2025): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

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Abstract

Sepsis remains a major global health problem with high morbidity and mortality. Over the past three decades, evolving consensus definitions have sought to improve diagnostic accuracy and patient outcomes. The latest definition, Sepsis-3, defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, with the Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) as key tools. This review outlines the historical development of sepsis definitions, examines the role of SOFA and qSOFA, and summarizes their strengths and criticisms. Sepsis-3 marked a shift from inflammation-based to organ dysfunction–centered criteria. Evidence shows that SOFA is highly accurate for prognosis in intensive care, while qSOFA is useful for bedside risk stratification outside the ICU. Both outperform systemic inflammatory response syndrome (SIRS) in specificity, though SOFA requires laboratory parameters and qSOFA shows reduced sensitivity. Some authors argue SIRS should not be entirely discarded due to its early recognition value. In conclusion, Sepsis-3 advanced the standardization of sepsis definitions, yet challenges remain, and this article was written to provide a concise overview of its evolution, utility, and ongoing debates. Keywords: Sepsis-3, SOFA, qSOFA, SIRS, sepsis definitions
Profil Spesies Candida Dan Pola Kepekaan Antijamur Pada Pasien Candidemia Darah di Unit Mikrobiologi Klinik RSUD Dr.Soetomo periode 2020-2023 Faizah, Wardatun; Wiqoyah, Nurul; Ervianti, Evy; Endraswari, Pepy Dwi
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.23799

Abstract

Candida spp fungal infections. can attack the circulatory system (can be known as candidemia or blood infection by the fungus Candida spp.). Patients in the intensive care unit (ICU) or emergency unit (IGD) with long-term air-conditioned conditions resulting in Candida spp. can grow more easily and increase the risk of fungal infections. This study aims to evaluate the profile of Candida spp. as well as patterns of sensitivity to antifungals in patients with blood candidemia in the Clinical Microbiology Unit of Dr. RSUD. Soetomo during the 2020-2023 period. This research method involves analysis of medical record data of patients diagnosed with blood candidemia, with a retrospective descriptive research type. The research samples were isolate data, used were clinical specimens that can cause candidiasis in the vagina, oral cavity and urogenital tract. The sample size in this study was as large as the data from isolates originating from a total of clinics in the time period. The results of this study provide a comprehensive picture regarding the distribution of Candida spp. the most commonly encountered, as well as the pattern of sensitivity to certain antifungals in patients with blood candidemia in the Dr. Hospital environment. Soetomo. It is hoped that the information obtained from this study will provide better guidance in the management and selection of appropriate therapy for patients affected by blood candidemia in the future.
Antibiotic-Producing Streptomyces sp. Isolated from the Soil of a Mangrove Ecosystem Retnowati, Wiwin; Mertaniasih, Ni Made; Purwanta, Marijam; Wiqoyah, Nurul; , Atika; Maharani, Sekar; Mahdani, Wilda
Folia Medica Indonesiana Vol. 59, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. The unexplored soil of mangrove ecosystems in Surabaya, Indonesia, has the potential to be home to biodiversity, including Streptomyces sp. that can produce antibiotics. 2. Streptomyces sp. has antibacterial properties against Gram-positive and Gram-negative bacteria, and the duration of incubation plays a critical role in regulating the antibacterial activity. Abstract A mangrove ecosystem in Surabaya, Indonesia, has a high salinity, pH, potassium, phosphorus, and nitrate contents. This ecosystem comprises a mixture of sand, dust, mud, and clay, which has the potential to be a conducive environment for the isolation of Streptomyces. The importance of Streptomyces in biotechnology lies in its ability to produce bioactive secondary metabolites, which represent a valuable reservoir of antibiotics. This research aimed to assess the antibiotic activity exhibited by Streptomyces sp. isolated from the soil of a mangrove ecosystem in Wonorejo, Surabaya, Indonesia. The analysis focused on the potential of Streptomyces sp. to produce antibiotics that work against Gram-positive bacteria (i.e., Staphylococcus aureus ATCC 25923 and Bacillus subtilis) as well as Gram-negative bacteria (i.e., Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Salmonella Typhimurium). The antibacterial activity test was conducted using the modified agar diffusion method. Observations were performed to identify any clear zone formation around the Streptomyces sp. agar colonies with a diameter of 0.8 cm and a height of 3 mm. The clear zone diameter was measured every 24 hours during the 10-day incubation period to assess the diversity of antibacterial activity. The antibacterial profile of Streptomyces sp. exhibited varying levels of activity against different bacterial strains in the tests conducted. The inhibition zone diameters demonstrated the highest levels of activity in Bacillus subtilis (15.9 mm) on day 7, Staphylococcus aureus (27.6 mm) on day 2, Pseudomonas aeruginosa (24.3 mm) on day 7, Escherichia coli (29.2 mm) on day 5, and Salmonella Typhimurium (27.5 mm) on day 7. The results indicated that Streptomyces sp. had inhibitory effects against Gram-positive bacteria as well as Gram-negative bacteria. In conclusion, Streptomyces sp. is a source of biodiversity found in the soil of mangrove ecosystems and has the ability to produce antibiotics.
Edukasi Resistensi Antimikroba pada Siswa SMA: Upaya Membangun Kesadaran Penggunaan Antibiotik yang Bijak: Upaya Membangun Kesadaran Penggunaan Antibiotik yang Bijak Koendhori, Eko Budi; Dwi Endraswari, Pepy; Kusumaningrum, Deby; Mahmudatul Muna, Nafdzu; Juniastuti, Juniastuti; Wiqoyah, Nurul; Retno Wahyunitisari, Manik; J. Setiabudi, Rebekah; Wiwin Retnowati; Setiawan, Firman; Alimsardjono, Lindawati
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 10 No 3 (2025): J-Dinamika
Publisher : Politeknik Negeri Jember

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Abstract

Latar Belakang: Resistensi antimikroba merupakan salah satu ancaman kesehatan global yang dapat meningkatkan angka kesakitan, kematian, dan biaya pelayanan kesehatan. Edukasi tentang penggunaan antibiotik yang bijak perlu diberikan sejak usia sekolah agar siswa dapat menjadi agen perubahan di masyarakat.Tujuan: Meningkatkan pengetahuan siswa SMA mengenai antibiotik dan resistensi antimikroba melalui edukasi interaktif.Metode: Kegiatan dilaksanakan pada 97 siswa SMA Al-Uswah Surabaya dengan metode seminar, diskusi, dan lomba media edukasi (video/poster). Evaluasi dilakukan melalui kuesioner pre-test dan post-test dengan 10 pertanyaan terkait antibiotik dan resistensi antimikroba. Analisis dilakukan dengan menghitung persentase jawaban benar dan peningkatan pengetahuan.Hasil: Rata-rata skor post-test meningkat dibandingkan pre-test. Peningkatan tertinggi pada pertanyaan mekanisme resistensi antibiotik (34,5%), terendah pada pemahaman dasar antibiotik (3,9%). Normalized gain (g=0,44) menunjukkan kategori peningkatan sedang.Kesimpulan: Edukasi interaktif efektif meningkatkan pemahaman siswa tentang resistensi antimikroba. Kegiatan serupa perlu dilanjutkan secara berkelanjutan dan diperluas ke sekolah lain.
Co-Authors , Atika Agnes Dwi Sis Perwitasari, Agnes Dwi Sis Alimsardjono, Lindawati Arifa Mustika Atika Bhagaskara, Pandya Deby Kusumaningrum Dwi Endraswari, Pepy Eko Budi Koendhori, Eko Budi Evy Ervianti Faizah, Wardatun Fanny Gunawan Fikri Sasongko Widyatama Indiastuti, Danti Nur Juniastuti Juniastuti Lifindra, Billy Yanssen Lindarto, Wira Widjaya Maharani, Sekar Mahdani, Wilda Mahmudatul Muna, Nafdzu Manaf, Syifa Az Zahrah Muhammad Ansori Muna, Nafdzu Makhmudatul Ni Made Mertaniasih Nur Rochmah, Nur Pepy Dwi Endraswari, Pepy Dwi Priyo Budi Purwono Purwanta, Marijam Rebekah Setiabudi, Rebekah Retno Wahyunitisari, Manik S. Soedarsono Salwa Putri Qurrotuaini Saputra, Pandit Bagus Tri Sardjono, Lindawati Alim Sekar Maharani Setiawan, Firman Setyarini, Wahyu Suhintam Pusarawati Ulfa Dwi Karisma Vermasari, Naritha Wahyunitisari, Manik Retno Wayan Tunas Artama Wilda Mahdani Willy Sandhika Wiwin Retnowati Yuani Setiawati