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Sepsis-3 and its Assesment Tools (Sofa and Qsofa): Historical Evolution, Clinical Utility and Criticisms Bhagaskara, Pandya; Wiqoyah, Nurul
Jurnal Ilmiah Kesehatan Vol 17 No 2 (2025): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

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Sepsis remains a major global health problem with high morbidity and mortality. Over the past three decades, evolving consensus definitions have sought to improve diagnostic accuracy and patient outcomes. The latest definition, Sepsis-3, defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, with the Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) as key tools. This review outlines the historical development of sepsis definitions, examines the role of SOFA and qSOFA, and summarizes their strengths and criticisms. Sepsis-3 marked a shift from inflammation-based to organ dysfunction–centered criteria. Evidence shows that SOFA is highly accurate for prognosis in intensive care, while qSOFA is useful for bedside risk stratification outside the ICU. Both outperform systemic inflammatory response syndrome (SIRS) in specificity, though SOFA requires laboratory parameters and qSOFA shows reduced sensitivity. Some authors argue SIRS should not be entirely discarded due to its early recognition value. In conclusion, Sepsis-3 advanced the standardization of sepsis definitions, yet challenges remain, and this article was written to provide a concise overview of its evolution, utility, and ongoing debates. Keywords: Sepsis-3, SOFA, qSOFA, SIRS, sepsis definitions

Antibacterial Activity Test of Green Betel Leaf Extract (Piper betle Linn.) against Methicillin-Sensitive Staphylococcus aureus Manaf, Syifa Az Zahrah; Wiqoyah, Nurul; Setiawati, Yuani
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.131-139

Highlights Green betel leaf extract, particularly cultivated in Batu City, can inhibit and kill MSSA. Green betel leaf extract, particularly cultivated in Batu City, can be developed into a new alternative treatment as an effective antibiotic to kill MSSA bacteria. ABSTRACT Background: Asia is one of the regions with the highest prevalence rates of Staphylococcus aureus (S. aureus) infection. Green betel leaves (Piper betle Linn.) have been shown to possess antibacterial potential due to their active compound content. Objective: To investigate whether betel leaf extract affects methicillin-sensitive Staphylococcus aureus (MSSA). Material and Method: This research was a descriptive experimental study focusing on the antibacterial activity test of green betel leaf extract against MSSA. The MSSA bacteria used were bacterial preparations in the Microbiology Laboratory of the Faculty of Medicine, Universitas Airlangga. The green betel leaf extract was obtained in 2023 in Batu City, East Java, Indonesia. The antibacterial activity test technique used was the dilution test. The tool used in data processing was Microsoft Excel. Results: Germs were found in the dilution test, particularly in tubes with concentrations of 50 mg/mL. The study also highlighted that no growth of germs was found based on the results obtained for the increase of MSSA on agar plates at concentrations of 800 mg/mL, 600 mg/mL, 400 mg/mL, and 200 mg/mL. The study also found that the growth of MSSA germs was at 100 mg/mL and 50 mg/mL. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of green betel leaf extract against MSSA were 100 mg/mL and 200 mg/mL, respectively. Conclusion: The extract of green betel leaves, particularly cultivated in Batu City, East Java, Indonesia has been shown to possess antibacterial activity, which can inhibit and kill MSSA bacteria. Further research is needed on the antibacterial activity of green betel leaf extract against other bacterial species.

Sepsis-3 and its Assesment Tools (Sofa and Qsofa): Historical Evolution, Clinical Utility and Criticisms Bhagaskara, Pandya; Wiqoyah, Nurul
Jurnal Ilmiah Kesehatan Vol 17 No 2 (2025): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Sepsis remains a major global health problem with high morbidity and mortality. Over the past three decades, evolving consensus definitions have sought to improve diagnostic accuracy and patient outcomes. The latest definition, Sepsis-3, defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection, with the Sequential Organ Failure Assessment (SOFA) and quick SOFA (qSOFA) as key tools. This review outlines the historical development of sepsis definitions, examines the role of SOFA and qSOFA, and summarizes their strengths and criticisms. Sepsis-3 marked a shift from inflammation-based to organ dysfunction–centered criteria. Evidence shows that SOFA is highly accurate for prognosis in intensive care, while qSOFA is useful for bedside risk stratification outside the ICU. Both outperform systemic inflammatory response syndrome (SIRS) in specificity, though SOFA requires laboratory parameters and qSOFA shows reduced sensitivity. Some authors argue SIRS should not be entirely discarded due to its early recognition value. In conclusion, Sepsis-3 advanced the standardization of sepsis definitions, yet challenges remain, and this article was written to provide a concise overview of its evolution, utility, and ongoing debates. Keywords: Sepsis-3, SOFA, qSOFA, SIRS, sepsis definitions

Profil Spesies Candida Dan Pola Kepekaan Antijamur Pada Pasien Candidemia Darah di Unit Mikrobiologi Klinik RSUD Dr.Soetomo periode 2020-2023 Faizah, Wardatun; Wiqoyah, Nurul; Ervianti, Evy; Endraswari, Pepy Dwi
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.23799

Candida spp fungal infections. can attack the circulatory system (can be known as candidemia or blood infection by the fungus Candida spp.). Patients in the intensive care unit (ICU) or emergency unit (IGD) with long-term air-conditioned conditions resulting in Candida spp. can grow more easily and increase the risk of fungal infections. This study aims to evaluate the profile of Candida spp. as well as patterns of sensitivity to antifungals in patients with blood candidemia in the Clinical Microbiology Unit of Dr. RSUD. Soetomo during the 2020-2023 period. This research method involves analysis of medical record data of patients diagnosed with blood candidemia, with a retrospective descriptive research type. The research samples were isolate data, used were clinical specimens that can cause candidiasis in the vagina, oral cavity and urogenital tract. The sample size in this study was as large as the data from isolates originating from a total of clinics in the time period. The results of this study provide a comprehensive picture regarding the distribution of Candida spp. the most commonly encountered, as well as the pattern of sensitivity to certain antifungals in patients with blood candidemia in the Dr. Hospital environment. Soetomo. It is hoped that the information obtained from this study will provide better guidance in the management and selection of appropriate therapy for patients affected by blood candidemia in the future.

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