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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) E-Jurnal Medika Udayana Media Kesehatan Masyarakat Indonesia Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) Bali Anatomy Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Biomedika
Cokorda Agung Wahyu Purnamasidhi
Tropical And Infectious Diseases Division, Internal Medicine Department, Universitas Udayana, Bali, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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Comorbid Diseases and Outcomes of Critically Ill COVID-19 Patients Admitted to an Indonesian Intensive Care Unit from May to October 2021 Siahaan, Katrin Wilentina; Somia, I Ketut Agus; Utama, I Made Susila; Dian, Ni Made Dewi; Gayatri, Anak Agung Ayu Yuli; Purnamasidhi, Cokorda Agung Wahyu; Merati, Ketut Tuti Parwati
Current Internal Medicine Research and Practice Surabaya Journal Vol. 5 No. 2 (2024): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v5i2.54859

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The spread of COVID-19 has become a worldwide health threat, with 583,038,110 cases and a death toll of 6,416,023. This study attempted to determine the relationship of age, sex, and comorbid diseases with the outcomes of critically ill COVID-19 patients at Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, Indonesia. Methods: This analytic study employed a retrospective approach, analyzing secondary data from medical records using a purposive sampling method. The research included univariate analysis, bivariate analysis using the chi-square test, and multivariate analysis using a general linear model performed with the assistance of IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA). A statistical analysis result with a p-value of less than 0.05 was deemed significant. Results: A total of 264 critically ill COVID-19 patients were hospitalized in the Intensive Care Unit of Prof. Dr. IGNG Ngoerah Central General Hospital from May to October 2021. Comorbid diseases were present in 215 patients. The comorbid diseases that had the greatest impact on increasing mortality were diabetes mellitus, hypertension, kidney disease, and cardiovascular disease (p=0.000–0.006, 95% CI). Conclusion: Age and sex do not have any significant relationship with the outcomes of critically ill COVID-19 patients. Meanwhile, comorbid diseases, such as diabetes mellitus, hypertension, and renal and cardiovascular diseases, pose a significant impact on the mortality rate of critically ill COVID-19 patients.   Highlights: 1. This study investigated patients who were critically ill with COVID-19 to determine the relationship between age, sex, comorbidities, and patient outcomes. 2. The findings of this study may provide additional data on the impact of comorbidities on the severity of COVID-19, which can be valuable to prevent mortality due to the infection.
Beban Tas Siswa di Sekolah Dasar Saraswati 5 Denpasar Harkitasari, Saktivi; Dewi Manuaba, Ida Ayu Laxmi Ananda; Primayanti, I Dewa Ayu Inten Dwi; Purnamasidhi, Cokorda Agung Wahyu
Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) Vol 6 No 2 (2020): Volume 6 No 2 Desember 2020
Publisher : Program Studi Magister Ergonomi Fisiologi Kerja Pascasarjana Universitas Udayana Denpasar Bekerjasama dengan Perhimpunan Ergonomi Indonesia (PEI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JEI.2020.v06.i02.p09

Abstract

The use of school bags without ergonomics design, miscarriage school bag, excessive bag load and carrying bags with long duration could be risk of disrupting the musculoskeletal system. The aim of this research is to know the frequency of bag load category of elementary students at SD Saraswati 5 Denpasar according to class, age, gender and weight of respondent. This research method was a descriptive cross-sectional study conducted at SD Saraswati 5 Denpasar. The sample in this study was selected by systematic random sampling. There were 86 respondents who carried load of bag of medium category amounted to 40 (46.5%) student, heavy bag category tend to carried by grade 3 student amounted to 12 (54.5%), male and female students carried the same bag load that is the moderate category 40 (46.5%) and the group with the mildest weight among other groups tend to carried heavy bag category amounted to 16 (55.2%). The conclusion is Students of Elementary School Saraswati 5 Denpasar more often carry the bag burden of the medium category. More heavy bag load categories are carried by students aged 7 years - 9 years. Groups of students with the lightest weight tend to carry heavy bag loads.
External Validation of AI-powered GeNose C19 to Diagnose Volatile Organic Compounds in COVID-19 Patients Tested at Udayana University Academic Hospital Purnamasidhi, Cokorda Agung Wahyu; Darwinata, Agus Eka; Utama, I Made Susila; Merati, Ketut Tuti Parwati; Harkitasari, Saktivi; Junior, Darren; Diksha, I Gusti Ngurah Ariestha Satya; Suteja, Richard Christian
Biomedika Vol 16, No 2 (2024): Biomedika Agustus 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i2.3940

Abstract

In search for potential alternatives to RT-PCR, Gadjah Mada University developed GeNose C19 which was deemed to have high sensitivity, specificity, PPV, and NPV. The objective of this study is to contribute to the development of GeNose C19 by means of external validation conducted in Udayana University Academic Hospital, Bali. This was a cross-sectional study conducted on adults above 17 years old. Demographic variables, symptoms, vaccination status, GeNose C19 results, and RT-PCR results were measured. We analyzed the sensitivity, specificity, PPV, and NPV using respective appropriate formulas and the impact of other variables gathered towards accuracy by means of Chi-squared test, Mann-Whitney U test and independent-samples T test. The results showed that the subjects included in this study were 50.8% female and had a mean (IQR) age of 23.0 (21.0-27.5) years old. Only three subjects (2.5%) showed COVID-19-related symptoms such as cough (1.7%), flu (0.8%), fever (0.8%), and headache (0.8%). GeNose C19 yields a sensitivity of 83.1%, a specificity of 73.6%, PPV of 79.4%, and NPV of 78.0%. There were no variables that significantly affect the accuracy of GeNose C19. Further study is still required to validate GeNose C19’s performance in different environmental conditions and multiple different races.
Genetic Mutations and Polymorphisms Related to Severity, Mortality, and Antibody-Dependent Enhancement of Dengue Virus (DENV) Infection: A Literature Review Purnamasidhi, Cokorda Agung Wahyu; Junior, Darren; Satya Diksha, I Gusti Ngurah Ariestha; Hiranandini Prawista, I Gusti Ayu Maha; Guptha, I Dewa Gede Agung Siwa; Pratyaksa, I Gusti Ngurah Dinda; Indratmo, Novea; Suteja, Richard Christian; Harkitasari, Saktivi
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.70457

Abstract

The dengue virus (DENV) is a blood-borne Flavivirus transmitted through vectors and ranks as the fastest-spreading tropical disease globally. Dengue infection could exhibit mild to severe symptoms depending on various factors. Antibody-dependent enhancement (ADE) is a cross-reactive phenomenon between different DENV strains that clinicians should be aware of, as it leads to a higher incidence of dengue with warning signs and severe dengue. On the molecular level, many genes contribute to the severity and pathophysiology of ADE. Mutations and polymorphisms in these genes could alter the course of dengue infection. This article aims to comprehensively review studies that measure the impact of dengue-related genetic mutations and polymorphisms on the severity, mortality, and ADE of DENV infection. We performed a literature review to identify relevant articles on PubMed, Science Direct, Europe PMC, and Google Scholar. The review examines polymorphisms across multiple gene families: Fcγ receptors, cytokines (TNF-α, TGF-β1, IL-10), immune regulatory genes (MICB, PLCE1, RIPK2), antigen-presenting machinery (DC-SIGN, TAP), and host defense mechanisms (VDR, CTLA-4, MBL, HPA). These genetic variations have population-specific effects and may confer both protection in some populations and increased susceptibility to severe outcomes of dengue in others. The effects of these polymorphisms are context-dependent and differ according to the phase of infection, ethnicity, and gene-gene interactions. Overall, it could be concluded that aside from external factors, polymorphisms on human genes regulating mechanisms and components related to dengue infection have been extensively discussed to play a role in the overall clinical outcome.
UNDERSTANDING LEVEL OF PKK BANJAR PURWA SANTHI BENOA ON MEDICAL MASK WASTE MANAGEMENT AND STRENGTHENING HEALTH PROTOCOLS IN CONTROLLING COVID-19 INFECTION I Komang Hotra Adiputra; Kadek Diana Harmayani; Ni Made Susilawathi; Cokorda Agung Wahyu Purnamasidhi; Komang Ayu Witarini; I Wayan Arya Biantara; I Dewa Made Sukrama; I Gede Purna Weisnawa; Jerry; Putu Kintan Wulandari; Darren Junior; Dewa Ayu Fony Prema Shanti; I Dewa Ayu Agung Warmadewanthi
INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY VOLUME 6, NUMBER 1, APRIL 2023
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/urbanenvirotech.v6i1.15335

Abstract

The increase in mask waste and a lack of understanding about the management of single-use mask waste raises the potential for environmental pollution and COVID-19 transmission. Aim: This study aimed to assess the level of understanding of medical mask waste management and strengthening health protocols in controlling COVID-19 infection in Banjar Purwa Santhi, Benoa, Badung Regency. Methodology and Results: A cross-sectional method and descriptive study design were used with a sample of 100 respondents selected via stratified sampling. The research and service activities at Banjar Purwa Santhi Benoa include public campaign and assessment of the level understanding of medical mask waste management. Based on univariate analysis, 91% of respondents know that mask waste contains hazardous and toxic substances. If mask waste is disposed carelessly, 98% of respondents stated that it can pollute the environment, and 98% of respondents also stated that it has the potential to become a means of transmitting COVID-19. However, 85% of respondents disposed of the masks in the household trash. Conclusion, significance and impact study: Respondents had a good level of knowledge about health protocols and mask waste management but have not separated masks from household waste. By holding the community service activity, it is hoped that changes in community behavior will occur.
Functional Gait Assessment to Predict the Risk of Falls in Elderly Saktivi Harkitasari; Cokorda Agung Wahyu Purnamasidhi; RA Tuty Kuswardhani
WMJ (Warmadewa Medical Journal) Vol 3 No 1 (2018): May 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.1.369.6-14

Abstract

Aging process represents the natural process which is inevitable. It is caused by a biological factor that goes naturally resulting in the anatomical, biochemical and physiological changes. The natural changes contribute to falling in elderly. The objective of this study was to assess the falling prediction in elderly by using Functional Gait Assessment. This study used a cross-sectional research design with falling prediction as the variable. Forty-three elderly in Panti Werdha Wana Seraya (aged 60-103 years, - mean of 77.48 ± 1.61), selected according to the inclusion criteria, were included in the study. The data were collected using Functional Gait Assessment and analyzed both descriptively and statistically. The results showed that the elderly had a high risk of falls. Functional Gait Assessment showed that 41 of 43 subjects scored
COVID-19 Traveler Policy in Migrant Worker: How it Helped Shape Distinct Clusters During the Early Phases of the Pandemic Saktivi Harkitasari; Richard Christian Suteja; Giovanca Verentzia Purnama; I Komang Hotra Adiputra; Jerry; I Gede Purna Weisnawa; Cokorda Agung Wahyu Purnamasidhi
WMJ (Warmadewa Medical Journal) Vol 8 No 1 (2023): May 2023
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.8.1.6214.1-8

Abstract

Though COVID-19 caught healthcare authorities worldwide off guard, several countries successfully dampened the morbidity and mortality curve by imposing strict biosecurity protocols. We would like to observe the effect of healthcare policies enforced in correlation to the formation of new clusters during early phases of the pandemic, thereby providing statistical justification for laws enforced by authorities. With access to medical records from Udayana University Hospital, a tertiary COVID-19 referral health center, we then observe epidemiological data of patients admitted and their admission date in correlation to dates where major changes in national COVID-19 protocols were established. We found a double distinctive curve that is mainly made of two distinct demographic groups: migrant workers and private employees. We found that during March 2020, when strict travel protocols are yet to be imposed, the viral introduction was mostly carried by returning migrant workers. Sporadic cases emerged, though soon vanishing due to the enforcement of quarantine protocols. Subsequently, in June 2020, a work-from-office setting was adopted, where some offices perform at a capacity higher than allowed. This incites the formation of new office-linked clusters. After this period, no recognizable pattern found due to massive local transmission affecting all layers of society. However, it can be concluded that COVID-19 law does shape the curve, and strict protocols may end the pandemic sooner. Keywords: COVID-19, Migrant Workers, Health Policy, Private Employee
Co-Authors Adiputra, I Komang Hotra Agus Eka Darwinata Akatsu, Haruko Anak Agung Ayu Yuli Gayatri Anom Suardika Darren Junior Dewa Ayu Fony Prema Shanti Dewi Manuaba, Ida Ayu Laxmi Ananda Dian, Ni Made Dewi Diksha, I Gusti Ngurah Ariestha Satya Divasta, I G Mahapraja Florensia, Maria Gayatri, Anak Agung Ayu Yuli Giovanca Verentzia Purnama Guptha, I Dewa Gede Agung Siwa Haruko Akatsu Hiranandini Prawista, I Gusti Ayu Maha I Dewa Ayu Agung Warmadewanthi I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Dewa Made Sukrama I Dewa Nyoman Wibawa I Gde Haryo Ganesha I Gede Purna Weisnawa I Kadek Swastika I Ketut Agus Somia I Ketut Mariadi I Komang Hotra Adiputra I Komang Hotra Adiputra I Made Ady Wirawan I Made Jawi I Made Sudarmaja I Made Susila Utama I Nyoman Gede Narendra Yanakusuma I Wayan Arya Biantara I Wayan Putu Sutirta Yasa Indratmo, Novea Jerry Jerry Junior, Darren Kadek Diana Harmayani Karya, I Kadek Jony Dwi Ketut Tuti Parwati Merati Komang Ayu Witarini Krisnawardani K, Cokorde Istri Yuliandari Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Made Dewi Dian Sukmawati Ni Made Susilawathi Paramita, Ni Putu Pradnya Pratiwi, Cokorda Agung Pratyaksa, I Gusti Ngurah Dinda Pujawan, I Made Naris Purnama, Giovanca Verentzia Putu Kintan Wulandari R. A.T. Kuswardhani Richard Christian Suteja Saktivi Harkitasari, Saktivi Satya Diksha, I Gusti Ngurah Ariestha Shanti, Dewa Ayu Fony Prema Siahaan, Katrin Wilentina Suastika, Luh Oliva Saraswati Suteja, Richard Christian Tirtha Yasa, I Nyoman Wawan Utama, I Made Susila Weisnawa, I Gede Purna Wulandari, Putu Kintan Yenny Kandarini