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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Scholaria: Jurnal Pendidikan dan Kebudayaan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Journal of Pharmaceutical Care Anwar Medika Academia Open Journal of Community Practice and Social Welfare (JaCiPS) Indonesian Community Journal Sainsbertek Jurnal Ilmiah Sains & Teknologi Abdimas Indonesian Journal Prosiding Seminar Nasional Universitas Ma Chung Jurnal Kesehatan dr. Soebandi Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas KOPEMAS Khidmat: Journal Community Service
Godeliva Adriani Hendra
Universitas Ma Chung
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Academia Open

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Antibiotics and Antivirals in COVID-19: Clinical Outcomes Godeliva Adriani Hendra; Monika Turnip; FX. Haryanto Susanto
Academia Open Vol 8 No 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.6662

Abstract

The clinical manifestations of COVID-19 disease are mainly caused by an irregular host response associated with excessive expression of inflammatory markers. Patients with mild, moderate, and severe symptoms of COVID-19 with or without comorbidities use a combination of antiviral drugs and antibiotics. This study aimed to determine the relationship between the use of antiviral drugs and antibiotics on the clinical outcomes of COVID-19 patients. The research design used a cross-sectional study with retrospective data collection. The inclusion criteria were COVID-19 patients hospitalized at Panti Waluya Sawahan Malang Hospital with or without comorbidities, positive RT-PCR results, and receiving antibiotic and antiviral therapy. The clinical outcome is a patient improvement if the length of stay is 14 days, and the patient worsens if it is >14 days. There is no relationship between antibiotics and antiviral drugs on the clinical outcomes of COVID-19 patients (p>0,05). Highlights: Excessive expression of inflammatory markers contributes to the clinical manifestations of COVID-19. Combination therapy of antiviral drugs and antibiotics is commonly used for COVID-19 patients. The study found no significant relationship between the use of antibiotics and antiviral drugs and the clinical outcomes of COVID-19 patients Keywords: antibiotics, antiviruses, COVID-19, clinical improvement, clinical deterioration
Exploring Prescription Patterns and Patient Characteristics in Antiepileptic Therapy: A Retrospective Observational Study Aditya, Martanty; Hendra, Godeliva Adriani; Maitreya, Putera
Academia Open Vol 8 No 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.7268

Abstract

This retrospective observational study aimed to provide an overview of prescribed antiepileptic therapy utilization and patient profiles. Conducted at a Neurology Polyclinic, data from December 2022 to January 2023 were analyzed descriptively. Among 35 eligible patients, the majority were male (68.57%), aged 15-25 years (48.57%), with long-standing epilepsy (54.28%), and absence of recent seizures (54.28%) and comorbidities (62.85%). Monotherapy was employed for 51.43%, while 48.57% received combination therapy. Phenytoin emerged as the most frequently prescribed monotherapy (25.71%), and valproic acid combined with phenytoin was the prominent combination (14.28%). This study highlights the prevalence of phenytoin and valproic acid usage, suggesting the need for further investigation into their efficacy and implications for epilepsy management. Highlights: Diverse Prescription Patterns: The study reveals a range of antiepileptic therapy prescriptions, with phenytoin and valproic acid being the predominant choices in both single and combination forms. Patient Profiles and Demographics: The analysis focuses on male-dominated respondents aged 15-25 years, emphasizing the importance of understanding patient characteristics for tailored epilepsy management strategies. Implications for Treatment Strategies: The findings underscore the significance of evaluating the efficacy and clinical implications of commonly prescribed antiepileptic drugs, guiding clinicians in optimizing epilepsy treatment regimens. Keywords: Antiepileptic therapy, Prescription patterns, Patient characteristics, Epilepsy management, Combination therapy.
Co-Authors Aditya Nirwana Amar Ma’ruf Stya Bakti Aprilia, Devi Ratna Aprillia Dian Partisia Bakti, Amar Ma'ruf Stya Bila, Naura Syifa Salsa Choirunniza, Aqidatun Naffiah Chresiani Destianita Yoedistira Dhanang Prawira Nugraha Dhita Rizki Amalia Elvina Agus Eva Monica Eva Monica Eva Monica, Eva F.X. Haryanto Susanto Fibe Yulinda Cesa Ike Yossy Herawati Ismaurasi, Marcelina Fransisca Alecia Khoiroh, Afifatul Krisdia, Tuswatul Anggi Maitreya, Putera Martanty Aditya, Martanty Monica, Eva Monika Turnip Nawawi, Achmad Zulkifli Nugraha, Dhanang Prawira Pramesti, Agatha Tri Endha Putri Devy Septya Rahadi, Theresa Dhea Lonika Rehmadanta Sitepu Rinda Puspita Sari Rollando, Rollando Sabrina Handayani Tambun Salsabila Rohadatul Aisy Sentosa, Revin Adis shida, Fika sham Sintia Dina Pranata Suhul Raos Kumawula Ing Gustyas Suliati, Hinda Susanto, FX. Haryanto Wilujeng, Lilis Lestari Windra Swastika Windra Swastika Yulianda, Leli Dwi Yulis Mitra Reformasika