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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana The Indonesian Biomedical Journal Narra J Davar: Jurnal Teologi SENTRI: Jurnal Riset Ilmiah Jurnal Widya Medika Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Paulus Sugianto, Paulus
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Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Other

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Studi Penggunaan Kombinasi Obat Fenitoin dan Natrium Valproat terhadap Serum Magnesium dan Jumlah Kejang pada Pasien Epilepsi di RSUD DR. Soetomo Sambono, Vonneth Glorya; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2392

Abstract

Epilepsy is a clinical condition that is recognized by the pattern of seizures ranging from neurological development status according to age, history of seizures, and prognosis. Clinical research in humans and animals shows that magnesium deficiency can cause seizures. Drug therapy in epilepsy patients can be done by monotherapy and polytherapy. The combination of phenytoin and sodium valproate can be used as a polytherapy. The purpose of this study was to describe the serum magnesium levels and the number of seizures in epilepsy patients who received phenytoin and sodium valproate using a descriptive method prospectively. The parameters used are the conditions of the patient while receiving treatment. Ten epilepsy patients which treated with combination therapy of phenytoin and sodium valproate were used for this research.The results showed that the highest dose used in polytherapy was phenytoin 500 mg and sodium valproate 500 mg 2 x 1 po. The highest normal magnesium level was 2.21 mg / dL (10%). The highest number of seizures was 7 times a month (10%) and no adverse drug interactions occured. Phenytoin and sodium valproate therapy can minimize the number of seizures but do not affect the patient's magnesium level.
VITAMIN B SUPPLEMENTATION IN GERIATRIC PATIENTS: A POTENTIAL STRATEGY TO MANAGING HYPERHOMOCYSTEINEMIA IN CEREBROVASCULAR DISEASE Meryana, Meryana,; Sugianto, Paulus; Erwin, Ferdinand; Jaya, David Karunia
JURNAL WIDYA MEDIKA Vol. 10 No. 2 (2024): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i2.6024

Abstract

Homocysteine is a non-essential amino acid produced in the biosynthesis pathway between methionine and cysteine. Its levels tend to rise with age due to physiological, lifestyle, and nutritional factors. Elevated homocysteine can induce oxidative stress, inflammation, and endothelial dysfunction, which are critical in the development of cerebrovascular diseases. These mechanisms involve increased free radicals, decreased antioxidant enzyme activity, and enhanced inflammatory responses. Specifically, elevated homocysteine heightens oxidative stress and inflammation by increasing pro-inflammatory cytokines and decreasing anti-inflammatory cytokines, leading to endothelial cell damage and apoptosis. Supplementation with vitamins B6, B9, and B12 has been shown to lower homocysteine levels and reduce the risk of ischemic stroke. However, there is currently no established guideline for the appropriate dosing of these vitamins.
Pengaruh Corporate Risk, Profitabilitas terhadap Tax Avoidance pada Perusahaan Properti dan Real Estate yang Terdaftar di Bursa Efek Indonesia Barus, Irene Sukma Lestari; Winiasih, Shelma Alya; Sugianto, Paulus; Mulyati, Yati
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 10 (2025): SENTRI : Jurnal Riset Ilmiah, Oktober 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i10.4628

Abstract

This study aims to determine how the influence of Corporate Risk, profitability, on Tax Avoidance on property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023. This research is motivated by the unstable condition of the company, which sometimes has an increase and a decrease in the variable Corporate Risk and profitability. The method of data collection used in this study is the documentation method. The sample determination technique used in this study is a purposive sampling technique. The number of samples in this study amounted to 92 property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023. The method of analysis used in this study is regression analysis of panel data at the significance level of 5%. The Program used in analyzing data is Eviews. The results of the study partially show that Corporate Risk (X1) has no effect on Tax Avoidance in property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023. Profitability (X2) affects Tax Avoidance in property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023, while simultaneously showing that Corporate Risk and profitability affect Tax Avoidance in property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023.
Co-Authors Andi Alfian Zainuddin Andi Asadul Islam Andi Kurnia Bintang, Andi Kurnia Barus, Irene Sukma Lestari David, Bryan Elisabeth Kasih Erwin, Ferdinand Fidiana, Fidiana Hatta, Mohammad Ilsa Hunaifi, Ilsa Imam Subadi, Imam Jaya, David Karunia Latuasan, Ivana Rahayu Latuasan, Ivana Rahayu Machin, Abdulloh Meryana, Meryana, Muhammad Hamdan Muhammad Ikbal Ngakan Made Rai Widjaja Nugraha, Priya Paat, Vicky B.G.D Palupi, Imas R. Pardede, Sabrina Melisa Pardede, Sabrina Melisa Rahmarini, Edfina Sambono, Vonneth Glorya Sanjiwani, Kadek Siska Febri Simanjuntak, Erwin Sudarmono Sirly Nabireta Maharani Ganing, Sirly Nabireta Stepanus, Stepanus Surpa, Rio Tasti Susana, Mulyani Tammasse, Jumraini Wahid, Isra' Wahyuning Hadi, Deby Wahyuninghadi, Debi Widjiati Widjiati, Widjiati Winiasih, Shelma Alya Yati Mulyati, Yati