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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana The Indonesian Biomedical Journal Narra J Journal Of World Science Davar: Jurnal Teologi SENTRI: Jurnal Riset Ilmiah Jurnal Widya Medika Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Paulus Sugianto, Paulus
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Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Studi Penggunaan Kombinasi Obat Fenitoin dan Natrium Valproat terhadap Serum Magnesium dan Jumlah Kejang pada Pasien Epilepsi di RSUD DR. Soetomo Sambono, Vonneth Glorya; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 7 No. 1 (2020): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i1.2392

Abstract

Epilepsy is a clinical condition that is recognized by the pattern of seizures ranging from neurological development status according to age, history of seizures, and prognosis. Clinical research in humans and animals shows that magnesium deficiency can cause seizures. Drug therapy in epilepsy patients can be done by monotherapy and polytherapy. The combination of phenytoin and sodium valproate can be used as a polytherapy. The purpose of this study was to describe the serum magnesium levels and the number of seizures in epilepsy patients who received phenytoin and sodium valproate using a descriptive method prospectively. The parameters used are the conditions of the patient while receiving treatment. Ten epilepsy patients which treated with combination therapy of phenytoin and sodium valproate were used for this research.The results showed that the highest dose used in polytherapy was phenytoin 500 mg and sodium valproate 500 mg 2 x 1 po. The highest normal magnesium level was 2.21 mg / dL (10%). The highest number of seizures was 7 times a month (10%) and no adverse drug interactions occured. Phenytoin and sodium valproate therapy can minimize the number of seizures but do not affect the patient's magnesium level.
VITAMIN B SUPPLEMENTATION IN GERIATRIC PATIENTS: A POTENTIAL STRATEGY TO MANAGING HYPERHOMOCYSTEINEMIA IN CEREBROVASCULAR DISEASE Meryana, Meryana,; Sugianto, Paulus; Erwin, Ferdinand; Jaya, David Karunia
JURNAL WIDYA MEDIKA Vol. 10 No. 2 (2024): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v10i2.6024

Abstract

Homocysteine is a non-essential amino acid produced in the biosynthesis pathway between methionine and cysteine. Its levels tend to rise with age due to physiological, lifestyle, and nutritional factors. Elevated homocysteine can induce oxidative stress, inflammation, and endothelial dysfunction, which are critical in the development of cerebrovascular diseases. These mechanisms involve increased free radicals, decreased antioxidant enzyme activity, and enhanced inflammatory responses. Specifically, elevated homocysteine heightens oxidative stress and inflammation by increasing pro-inflammatory cytokines and decreasing anti-inflammatory cytokines, leading to endothelial cell damage and apoptosis. Supplementation with vitamins B6, B9, and B12 has been shown to lower homocysteine levels and reduce the risk of ischemic stroke. However, there is currently no established guideline for the appropriate dosing of these vitamins.
Pengaruh Corporate Risk, Profitabilitas terhadap Tax Avoidance pada Perusahaan Properti dan Real Estate yang Terdaftar di Bursa Efek Indonesia Barus, Irene Sukma Lestari; Winiasih, Shelma Alya; Sugianto, Paulus; Mulyati, Yati
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 10 (2025): SENTRI : Jurnal Riset Ilmiah, Oktober 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i10.4628

Abstract

This study aims to determine how the influence of Corporate Risk, profitability, on Tax Avoidance on property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023. This research is motivated by the unstable condition of the company, which sometimes has an increase and a decrease in the variable Corporate Risk and profitability. The method of data collection used in this study is the documentation method. The sample determination technique used in this study is a purposive sampling technique. The number of samples in this study amounted to 92 property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023. The method of analysis used in this study is regression analysis of panel data at the significance level of 5%. The Program used in analyzing data is Eviews. The results of the study partially show that Corporate Risk (X1) has no effect on Tax Avoidance in property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023. Profitability (X2) affects Tax Avoidance in property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023, while simultaneously showing that Corporate Risk and profitability affect Tax Avoidance in property and Real Estate companies listed on the Indonesia Stock Exchange in 2019-2023.
Can't be Overlooked: A Case Report of Pansinusitis Causing a Rare and Life-Threatening Cavernous Sinus Thrombosis Puspanadi, Theresa; Sugianto, Paulus; Limantara, Edward; Metaputra, Teguh Filbert
Journal of World Science Vol. 4 No. 11 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i11.1536

Abstract

Sinusitis is a prevalent, mostly favorable medical condition. However, in rare cases, inadequately treated sinusitis can lead to devastating and life-threatening complications, such as cavernous sinus thrombosis (CST). We present the case of a 41-year-old woman presenting with diplopia and ophthalmoplegia, ptosis, facial paresthesia, and less common facial paresis. Diagnostic imaging–including magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and digital subtraction angiography (DSA) confirmed bilateral CST secondary to untreated pansinusitis. Cultures of sinus drainage revealed uncommon pathogens: Staphylococcus epidermidis and Chryseobacterium indologenes. A multidisciplinary approach involving intravenous antibiotics, anticoagulation, and functional endoscopic sinus surgery (FESS) resulted in significant clinical improvement. This case highlights the critical need for accurate diagnosis, timely and prudent intervention, and enhanced public health education to prevent potentially life-threatening complications of untreated sinusitis. Moreover, it contributes novel insights into the atypical microbiological profile and neurological manifestations of CST.
Konsep keselamatan Universalisme, Calvinisme dan Armenianisme serta implementasinya di GKSI Betlehem ITC Kuningan Jakarta Suparyadi, Zakharia; Sugianto, Paulus; Triono, Yohanes Eko; Yusuf, Hartono
Davar : Jurnal Teologi Vol 6, No 1 (2025): Juni
Publisher : Sekola Tinggi Teologi Sangkakala Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55807/davar.v6i1.216

Abstract

ABSTRACTSalvation is a crucial aspect of human life, especially in relation to life after death. Each religion has a different understanding of how to attain salvation, including Christianity, which embraces diverse theological perspectives such as Universalism, Calvinism, and Arminianism. These three perspectives are often debated because each has its own foundation and interpretation of God's Word. However, based on biblical truth, the most harmonious view is Arminianism, which affirms that salvation is a gift from God through faith in Jesus Christ, but requires a human response of faith, repentance, and ongoing faithfulness.This study aims to explain the biblical concept of salvation and its application to GKSI Bethlehem ITC Kuningan Jakarta. The method used is a qualitative method with a descriptive approach and inductive analysis to explore in-depth theological understanding based on biblical sources. The results show that salvation is a free gift from God given through faith in Jesus Christ, not the result of human effort, but rather a work of God's grace through Christ's death and resurrection. However, humans still have a responsibility to respond to this gift with faith, repentance, and ongoing faithfulness. Keywords: Salvation, Universalism, Calvinism, Arminianism, Grace of God. ABSTRAK Keselamatan merupakan aspek yang sangat penting dalam kehidupan manusia, terutama dalam kaitannya dengan kehidupan setelah kematian. Setiap agama memiliki pemahaman berbeda tentang cara memperoleh keselamatan, termasuk dalam kekristenan yang memiliki beragam pandangan teologis seperti Universalisme, Calvinisme, dan Arminianisme. Ketiga pandangan ini sering menjadi perdebatan karena masing-masing memiliki dasar dan penafsiran terhadap firman Tuhan yang berbeda. Namun, berdasarkan kebenaran Alkitab pandangan yang paling selaras adalah Arminianisme, yang menegaskan bahwa keselamatan merupakan anugerah Allah melalui iman kepada Yesus Kristus, tetapi menuntut tanggapan manusia berupa iman, pertobatan, dan kesetiaan yang terus-menerus.Penelitian ini bertujuan untuk menjelaskan konsep keselamatan menurut Alkitab dan penerapannya bagi GKSI Betlehem ITC Kuningan Jakarta. Metode yang digunakan adalah metode kualitatif dengan pendekatan deskriptif dan analisis induktif untuk menggali pemahaman teologis secara mendalam berdasarkan sumber-sumber Alkitabiah. Hasil penelitian menunjukkan bahwa keselamatan adalah anugerah Allah yang diberikan secara cuma-cuma melalui iman kepada Yesus Kristus, bukan hasil usaha manusia, melainkan karya kasih karunia Allah melalui kematian dan kebangkitan Kristus. Namun demikian, manusia tetap memiliki tanggung jawab untuk merespons anugerah tersebut dengan iman, pertobatan, dan kesetiaan yang berkelanjutan. Kata kunci: Keselamatan, Universalisme, Calvinisme, Arminianisme, Anugerah Allah
Co-Authors Andi Alfian Zainuddin Andi Asadul Islam Andi Kurnia Bintang, Andi Kurnia Barus, Irene Sukma Lestari Chatarina Umbul Wahyuni David, Bryan Elisabeth Kasih Erwin, Ferdinand Fidiana, Fidiana Hatta, Mohammad Ilsa Hunaifi, Ilsa Imam Subadi Jaya, David Karunia Latuasan, Ivana Rahayu Latuasan, Ivana Rahayu Limantara, Edward Machin, Abdulloh Meryana, Meryana, Metaputra, Teguh Filbert Muhammad Hamdan Muhammad Ikbal Ngakan Made Rai Widjaja Nugraha, Priya Paat, Vicky B.G.D Palupi, Imas R. Pardede, Sabrina Melisa Pardede, Sabrina Melisa Puspanadi, Theresa Rahmarini, Edfina Sambono, Vonneth Glorya Sanjiwani, Kadek Siska Febri Simanjuntak, Erwin Sudarmono Sirly Nabireta Maharani Ganing, Sirly Nabireta Stepanus, Stepanus Suparyadi, Zakharia Surpa, Rio Tasti Susana, Mulyani Tammasse, Jumraini Triono, Yohanes Eko Wahid, Isra' Wahyuning Hadi, Deby Wahyuninghadi, Debi Widjiati Widjiati, Widjiati Winiasih, Shelma Alya Yati Mulyati, Yati Yusuf, Hartono