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Rahmat Firman Septiyanto, Rahmat Firman
Jurusan Pendidikan Fisika FKIP UNTIRTA
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Journal : Indonesia Natural Research Pharmaceutical Journal (INRPJ)

 1 
LIPID EXTRACT OF GRACILARIA SP. AS AN ANTI-APOPTOTIC CANDIDATE FOR CANCER THERAPY Isriyanti Affifah; Rahmat Firman Septiyanto; Fida Madayanti Warganegara
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 8, No 1 (2023)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v8i1.6809

Abstract

It has been claimed that an Indonesian seaweed lipid extract possesses antibacterial properties. The mitochondrial pathway reported that a long fatty acid (more than 10 carbon atoms), which is known as the major component in seaweed lipid extract, acts as an apoptotic agent. It has also been claimed that unsaturated fatty acids can prevent apoptosis. on this study, we investigated the role of an Indonesian seaweed lipid extract on the mitochondrial pathway of apoptosis. Lipid isolation was the first step of the study, which was carried out using centrifugation and a chloroform-methanol-phosphate buffer 2:1:0,8. Rotary evaporators were used to separate the lipid extract from its solvent. Dry weight Gracilaria sp. yield extraction was 21,8%. By using several centrifugation techniques in SET buffer (0,25 M Sucrose, 0,5 mmol EDTA, and 10 mmol/L Tris base), pH 7,4, mitochondria were recovered from rat liver. By adding 10% (v/v) lipid extract to a suspension of mitochondria, toxicity testing from the lipid extract was undertaken. By using light microscopy, mitochondrial morphological damage was seen. Gracilaria sp. exhibits strong apoptotic activity.
Co-Authors Akbar Hanif Dawam Akbar Hanif Dawam Abdullah Akbar Hanif Dawam Abdullah Akbar Hanif Dawam Abdullah Akbar Hanif Dawam Abdullah Alfarouqy, Ahmad Haekal Amalia, Rizkika Anang Suryana Andri Suherman Andri Suherman Asep Saefullah Asep Saefullah Asep Saefullah Atifah Alya Ramadhina Agustin Atika Diah Isnaeni Putri Ayu, Widya Purbo Kusumaning Azmar, Azmar Bunbun Bundjali Dina Rahmi Darman Dinda Aulia Oktaviana Fatah Sulaiman Fauziah, Siti Sepiyanti Fida Madayanti Warganegara Fida Madayanti Warganegara Firmanul Catur Wibowo Fitri, Amelia Febriana Guntara, Yudi Guntara, Yudi Firman Hanif Akbar Dawam Abdullah Indri Sari Utami Irah Namirah Isriyanti Affifah, Isriyanti Junitasari, Junitasari Kurnia, Selvi M, Yus Rama Denny Masitoh Mangsur Mukhtar, Yus Rama Denny Mustaqim, Ilham Namirag, Irah Nisa Sa'diah Novita Aulia Safitri Prayoga, Adam Fori PUTRI HANDAYANI Qothrunnada, Qothrunnada Rahmat Awaludin Salam Rifdah Hanifah Sinda Intandiana Siti Nala Farihah Syamsul Hidayat Syamsul Hidayat Utami, Indri Sari Utami, Indri Sari Widyawati, Dian Yayat Ruhiat Yudi Guntara Yus Rama Denny Yusifa, Agni Yuvita Oktarisa, Yuvita