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All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Syntax Literate: Jurnal Ilmiah Indonesia JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Bioscientist : Jurnal Ilmiah Biologi Sciences of Phytochemistry Journal of Natural Product for Degenerative Diseases
Yati Sumiyati, Yati
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Colocasia esculenta L. Extract Increase Growth and Motility of Rotenone Induced Zebrafish (Danio rerio) Larvae Stunting Model Furqon, Muhammad; Kumala, Shirly; Farida, Yunahara; Zaidan, Sarah; Sumiyati, Yati
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.10670

Abstract

This study aims to determine the effect of Colocasia esculenta L on the growth and motility of zebrafish (Danio rerio) larvae after induction of rotenone as a stunting model. The Zebrafish have divided 3 groups i.e Normal (embryonic medium without rotenone induction), Negative Control (embryonic medium with rotenone induction), and Treatment Groups (embryonic medium with rotenone induction and Colocasia esculenta extracts, dose 30-60-90 ppm). The stunting model is designed by induction of 12.5 ppb rotenone to Zebrafish larvae. The growth of the larvae was observed by using a microscope to measure the body and head length. Evaluation of motility was carried out by recording the movement of the fish for 1 minute, and the pace was analyzed by using Video Tracker. The evaluations were observed at 3, 6, 9 dpf (day post-fertilization). Colocasia Esculenta Extract (CEE) groups have higher body lengths compared to the Negative Control Group. The lengths were 125.4 µm for CEE30, 119.4 µm for CEE60, and 121.4 µm CEE90 while the length for the Negative Control Group was 118.3 µm at 9 dpf. However, there were no different values for the ratio of head length to body length of all groups. The ratio was 1:6 at 3 dpf, and 1:4 at 6 and 9 dpf. Moreover, the motility was higher in CEE groups compared to the Negative Control at 3, 6, 9 dpf. The body length and motility of Zebrafish larvae higher compare to the Negative Control Group showing the potential of Colocasia esculenta extract on growth and enhancement of motoric activity.
Analisis Drug Related Problems Pasien Depresi di Rumah Sakit Jiwa Marzoeki Mahdi Bogor Triwulan I 2024 Anantaningtyas, Laora Ratna; Sumiyati, Yati; Utami R., Hesty; Prasetiyawan, Prasetiyawan
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 01 Juli 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v22i1.25315

Abstract

Masalah terkait obat lazim terjadi pada pengobatan jiwa termasuk depresi yang dapat menyebabkan morbiditas dan mortalitas pasien. Tujuan penelitian ini untuk menganalisis kejadian DRP pada pasien depresi. Penelitian ini merupakan studi cross sectional dengan pengambilan data secara prospektif. Subyek penelitian adalah seluruh pasien depresi di poliklinik Cemas & Depresi periode Januari sampai Maret 2024 yang memenuhi kriteria inklusi. Pada penelitian ini dilakukan analisis faktor yang diprediksi berpotensi menyebabkan DRP terdiri dari karakteristik demografi dan klinis menggunakan uji regresi logistik. Analisis DRP menggunakan Pharmaceutical Care Network Europe (PCNE) V9.1. Jumlah sampel penelitian sebanyak 173 pasien. Pada penelitian ini pasien jenis kelamin terbanyak yaitu perempuan (68,2%); rata-rata usia 38,4 tahun; dengan pendidikan tinggi (72,8%) dan tidak bekerja (57,2%). Lama pengobatan rata-rata 22 bulan; jumlah obat rata-rata 3 item; dan tanpa penyakit penyerta (86.1%). Antidepresan yang paling sering diresepkan adalah sertralin (62,9%) dan sebanyak 91% merupakan terapi kombinasi dengan kombinasi terbanyak adalah sertralin-clobazam-lorazepam (22%). Terdapat 655 DRP dengan 194 DRP aktual (29,6%) dan 461 DRP Potensial (70,4%). Secara keseluruhan DRP paling banyak terkait potensi interaksi obat sebanyak 59%; durasi pengobatan terlalu lama sebanyak 21,2%; terkait kepatuhan minum obat sebanyak 8,4%; dosis obat terlalu rendah sebanyak 6,1% dan penyebab lain sebanyak 5,3%. Antidepresan yang sering menyebabkan DRP adalah amitriptilin 35,7%. Obat yang sering menyebabkan DRP adalah lorazepam sebanyak 36,4% dan clobazam 33,8%.  Karakteristik pasien yang berpengaruh signifikan (p value < 0,05) terhadap kejadian DRP adalah usia (p value 0,035; odds ratio 1,044; 95% CI 1,003-1,087); jumlah obat (p value 0,000; odds ratio 3,206; 95% CI 1,951-5,268) dan lama pengobatan (p value 0,007; odds ratio 1,035; 95% CI 1,009-1,061).
Co-Authors Anantaningtyas, Laora Ratna Arief, Ilham Asti, Windi Fachry Abda El Rahman Farida, Yunahara Fauzia Noprima Okta Fernandez, Itha Gumilar Adhi Nugroho Indra Kusuma Kurniati, Rizki Kurniawan, Affandi Lim, Helsa Lina Karlina Mulatsari, Esti Ni Made Dwi Sandhiutami Okta, Fauzia Noprima Prasetiyawan, Prasetiyawan Priyanti, Ike Ari Ramadaniati, Hesty Utami Ros Sumarny S. Mardiko, Etty Sarnianto, Prih Sembiring, Rinawati Shirly Kumala Suherman, Sandra Loretta Suri, Nurma Syahputri, Devina Harti Utami R., Hesty Warni Warni, Warni Yesi Desmiaty, Yesi Zaidan, Sarah