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HUBUNGAN ANTARA NILAI BONE MINERAL DENSITY DENGAN SKOR KUALITAS HIDUP PADA LANSIA Hernanda Haudzan Hakim; Lusiana Batubara; Faizah Fulyani
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 1 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar belakang : Seiring dengan bertambahnya usia, lansia mengalami penurunan nilai bone mineral density, sehingga menimbulkan berbagai macam keluhan. Keluhan yang ditimbulkan antara lain adalah perubahan bentuk tubuh, nyeri kronik dan patah tulang. Keluhan-keluhan tersebut dapat mempengaruhi aktivitas lansia sehari-hari terutama pada aspek fisik, psikologis, sosial dan lingkungan, sehingga diperkirakan penurunan nilai bone mineral density ini juga akan berdampak pada kualitas hidup lansia. Tujuan : Mengetahui hubungan antara nilai bone mineral density dengan skor kualitas hidup pada lansia. Metode : Penelitian ini merupakan penelitian observasional analitik dengan pendekatan belah lintang. Sampel dalam penelitian ini adalah 42 lansia wanita di berbagai posyandu lansia di Kota Semarang seperti Posyandu Lansia Cinde, Posyandu Lansia Tegalsari, Posyandu Lansia Mahoni, Posyandu Lansia Genuk, dan Posyandu Lansia Dewi Sartika. Pengambilan data bone mineral density dilakukan di Rumah Sakit Telogorejo Kota Semarang dengan menggunakan alat bone densitometry, sedangkan penilaian terhadap skor kualitas hidup dilakukan dengan menggunakan kuesinoer WHOQOL. Penelitian dilakukan selama periode Juni-September 2018. Hubungan antara bone mineral density dengan kualitas hidup diteliti dengan menggunakan analisis bivariat. Hasil : Rerata nilai bone mineral density pada lansia adalah 0,907±0,15 g/cm2 dan rerata skor kualitas hidup total adalah 294,79±43,60. Uji Shapiro-Wilk menunjukan sebaran data yang normal, sehingga dilakukan analisis korelasi menggunakan uji pearson. Hasil analisis menunjukan tidak terdapat korelasi bermakna (p>0,05) antara nilai bone mineral density dengan skor kualitas hidup pada lansia. Simpulan : Tidak ada hubungan antara nilai bone mineral density dengan kualitas hidup lansia secara keseluruhanKata kunci : Bone Mineral Density, Kualitas Hidup, WHOQOL.

Effect of Superoxide Dismutase (SOD) Supplementation on Plasma Levels of Malondialdehyde (MDA), Total Cholesterol and LDL Cholesterol in the Elderly Dwi Ngestiningsih; Rejeki Andayani Rahayu; Lusiana Batubara
Journal of Biomedicine and Translational Research Vol 5, No 2 (2019): December 2019
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v5i2.4679

Background: Several various physiological functions in elderly people are diminished due to cell or tissue damage. One of the probable causes are oxidative stress yielded by free radicals.Oxidative stress (ROS) induce lipid peroxidation in endothelial cell membrane, which generates atherosclerotic plaque. In a state of oxidative stress, MDA level will increased. The purpose of this study is to determine the effect of SOD supplementation on MDA, total cholesterol and LDL cholesterol plasma levels in the elderly.Methods: This study was open label, a randomized control trial. Subjects were elderly people aged > 60 years (median 75, 60-82 ys, male 10 (24,4%)) institutionalized at Social Rehabilitation Unit Pucang Gading Semarang, Indonesia. The treatment group consisted of 16 people, received SOD (GlisodinR) 1 capsule (250 IU) 1 hour before meals, plus exercise scheduled for 8 weeks. The control group consisted of 15 people, received placebo, and exercise. Plasma MDA levels were examined using TBARS method, while total cholesterol and LDL cholesterol were examined using CHOD-PAP method.Results: This study show a reduction of plasma MDA levels in the treatment group compare to control group ( p = 0.062 ). A significant reduction of total cholesterol and LDL cholesterol levels in the treatment group were found (before 190.00 and 131.47 g/dl, after 182.27 and 121.93 g/dl, p = 0.005 and 0.001).Conclusion: The SOD supplementation significantly reduce Total Cholesterol and LDL level, but not MDA level in the elderly.

Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women Innawati Jusup; Lusiana Batubara; Dwi Ngestiningsih; Faizah Fulyani; Devina Afraditya Paveta; Putri Theresia Lemmo Ate Bancin
Molecular and Cellular Biomedical Sciences Vol 5, No 1 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i1.157

Background: Osteoporosis is one of chronic degenerative diseases especially in postmenopausal women, characterized by a decreased bone mass due to imbalance activity between osteoblasts and osteoclasts. Recently, oxidative stress is believed to play an important role in osteoporosis pathogenesis. Oxidative stress is commonly considered as the consequence of an imbalance between pro and antioxidants species, which results in damage in the affected tissue. Malondialdehyde (MDA) is frequently used as a biomarker of oxidative stress in many health problems since MDA is produced at high levels during lipid peroxidation. Meanwhile, glutathione is well known as one of antioxidant which against oxidative stress by preserving its homeostasis in the reduced form of glutathione sulfhydryl (GSH) and the oxidized form of glutathione disulphide (GSSG). This study was aimed to determine the association between MDA, GSH/GSSG ratio and bone mineral density (BMD) in postmenopausal women.Materials and method: We conducted a cross-sectional study in 40 postmenopausal women. MDA and GSH/GSSG ratio were assessed by enzyme-linked immunosorbent assay (ELISA). Bone mineral density (BMD) was obtained from secondary data. The statistical analysis was conducted using Spearman rho’s correlation test.Results: Based on the test, we didn’t found significant correlation between MDA and BMD (r=-0.054, p=0.741), but we found significant moderate correlation between GSH/GSSG ratio (r=0.436, p=0.005) and BMD in postmenopausal women. Conclusion: There was no correlation between MDA and BMD in postmenopausal women. However, there was significant moderate correlation between GSH/GSSG ratio and BMD in postmenopausal women.Keywords: MDA, GSH/GSSG ratio, BMD, osteoporosis

English language Andrew - Johan; Regina Oktavia; Lusiana Batubara; Dwi Ngestiningsih; Innawati Jusup
JOMIS (Journal of Midwifery Science) Vol 5 No 2 (2021): JOMIS (Journal Of Midwifery Science)
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jomis.v5i2.1697

Background: Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) are increased in tissue damage. Ashitaba contains many compounds that can reduce serum SGOT and SGPT levels. Objective: This study was proposed to prove that giving Ashitaba extract could reduce serum SGOT and SGPT levels in rats exposed to burn injury. Methods: This study used a posttest only control group design with 20 rats as samples. All research samples were treated with second-degree burns and were divided into 2 different groups, the treatment group (given Ashitaba extract 300 mg /kg BW) and the control group. The blood serum was analyzed for SGOT and SGPT test on the 2nd, 8th, and 14th days. For statistical analysis, the Wilcoxon test used to analyze the levels of serum SGOT and SGPT. Results: There was no significant difference in serum SGOT and SGPT levels between the control and treatment groups on the 2nd, 8th, and 14th days Conclusion: Ashitaba extract could not reduce serum SGOT and SGPT levels in rats exposed to burn injury.

Air Pollution Exposure and Physical Exhaustion in Relation to GSH:GSSG Ratio of Online-Based Motorcycle Drivers Nabilla Nurcahya Junior; Dodik Pramono; Fathur Nur Kholis; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.33245

Background: Online motorcycle drivers work more than 10 hours a day, surpassing the international working hour regulations. Working hours are directly proportional to air pollution exposure generating reactive oxygen species (ROS). On the other hand, physical exercise also contributes to the generation of ROS due to greater oxygen utilization by mitochondria. The ratio of GSH to GSSG represents the oxidative stress level in body tissues.Objective: This study aimed to analyze the relationship between the length of air pollution exposure and the level of physical exhaustion to GSH:GSSG ratio of online motorcycle drivers.Methods: This research was a cross-sectional study of 16 male online motorcycle drivers. The GSH:GSSG ratio was assessed by ELISA with cyclic DTNB reaction principle. Length of air pollution exposure and level of physical exhaustion data were obtained from the interview. Statistical analysis was done to determine the correlation between variables.Results: The mean GSH:GSSG ratio in studied population is 0.69 ± 0.26, lower than 1 value of GSH:GSSG ratio represents high oxidative stress condition. Based on the correlation test, there are no correlation between length of air pollution exposure (r = -0.464, p = 0.070) and level of physical exhaustion (r = -0.439, p = 0.089) to GSH:GSSG ratio in online motorcycle drivers.Conclusion: Our findings suggested that online motorcycle drivers have a high level of oxidative stress, length of air pollution exposure, and status of physical exhaustion, which is not associated with the GSH:GSSG ratio.

Air Pollution Exposure Duration and Its Correlation with Triglyceride, HDL, and Atherogenic Index in Online Motorcycle Drivers Adrian Stefanus Herawan; Edward Kurnia Setiawan Limijadi; Donna Hermawati; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.33794

Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin.

The Correlation Between The Use Of Face Moisturizers On The Incidence Of Acne Vulgaris Due To Masks Ashauma Aksanul Muttaqin; Ari Budi Himawan; Lusiana Batubara; Widyawati Widyawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 4 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i4.35080

Background: Acne vulgaris or widely known as acne, is a skin disease in the form of inflammation of the pilosebaceous unit characterized by the appearance of comedones, papules, pustules, and nodules. Due to the Coronavirus disease 2019 (COVID-19) pandemic, masks have become personal protective equipment (PPEs), commonly used by health workers and the general public. The combination of friction, repeated pressure, sweat, or stress on the skin from wearing the mask causes acne or an exacerbation of existing acne. Meanwhile, the use of facial moisturizer can maintain skin moisture and help the repair process of the structure of the skin barrier.Objective: This study aims to determine the relationship between the use of facial moisturizers and the incidence of acne vulgaris due to masks.Methods: This study is an analytical observational study with a cross-sectional design. The subjects in this study amounted to 44 people who were nurses at the Diponegoro National Hospital who had approved the informed consent form, filled out a complete questionnaire, and included the research criteria. The research sample was selected using purposive sampling. The diagnosis of acne vulgaris was made by doctor-in-charge based on the subject's face photo. The statistical test used is Fischer's Exact Test.Results: Based on data analysis using Fischer's Exact Test, the results showed no significant relationship between the use of facial moisturizers and the incidence of acne vulgaris due to masks with a p-value = 0.722 (p>0.05).Conclusion: There is no relationship between the use of facial moisturizers with the incidence of acne vulgaris due to masks.

The Effect of Espresso and Drip Brewing Coffee Methode to The Hardness of Bulk-Fill Composite Resin Rahmadani Widya Atmani; Diah Ajeng Purbaningrum; Faizah Fulyani; Lusiana Batubara
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.31162

Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin.

THE EFFECT OF CARBONATED, ISOTONIC AND YOGHURT DRINKS IMMERSION ON THE ROUGHNESS OF BULK-FILL COMPOSITE RESIN Ayu Khoirun Nisa; Diah Ajeng Purbaningrum; Lusiana Batubara; Faizah Fulyani
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30521

Background: Composite resins are dental restorative materials that are widely used and have high aesthetic value compared to other materials. However, acidic environmental conditions can degrade the composite resins, resulting in increased surface roughness of the resin, and consequently lead to an increased risk of caries.Objective: the purpose of this study was to evaluate the effect of immersion in acidic drinks on the surface roughness of composite resins,Method: In this study 24 samples of bulk fillTM composite resins were used. Samples were divided into four groups. Each sample was immersed for 5 seconds in either artificial saliva (control), carbonated beverage, isotonic, or yogurt, and followed by 5 seconds immersion in saliva. This cycle was repeated for 20 times for 14 consecutive days. The roughness of composite resin before and after 14 days immersion was measured by using a profilometer. Microscopic structures were analyzed by Scanning electron Microscope (SEM). Statistical analysis was used paired t-test, Anova and Post Hoc LSD.Results: Data from each sample group was normally distributed- with p > 0.05. The paired t-test for each group showed a p-value < 0.05, which indicates there was a significant difference between surface roughness before and after immersion. ANOVA analysis revealed that there was a difference in the surface roughness between groups LSD test, showed that there was difference in the surface roughness between artificial saliva with carbonated drink, isotonic drink with carbonated drink, yoghurt drink with carbonated drink (p<0.0001), between artificial saliva group with yoghurt drink, yoghurt drink with carbonated drink, yoghurt drink with isotonic drink (p <0.05) which means there was a significant difference between group. Meanwhile, the isotonic drinks with artificial saliva obtained results (p>0.05), which means there is no significant difference.Conclusion: Exposure of carbonated drinks, yoghurt drinks, and isotonic drinks can significantly increase the roughness of the surface Bulk Fill resin composite compared to exposure of artificial saliva.Keywords: Composite resin, Bulk Fill, Surface Roughness, Acid

Effectiveness of Brown Algae Extract to Reduce Serum Malondialdehyde and Protein Carbonyl Levels in Streptozotocin-Induced Sprague Dawley Rats Batubara, Lusiana; Kristina, Tri N.; Rachmawati, Banundari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Brown algae (Sargassum duplicatum) contains bioactive compound with natural antioxidant that may potentially decrease lipid peroxidation and protein oxidation process in diabetes mellitus. Objective: to prove the effectiveness of brown algae extract administration (150mg/kgBW; 300mg/kgBW and 450 mg/kGBW respectively) in reducing serum MDA and PCO levels in streptozotocin-induced sprague dawley rat. Methods: This experiment study used the post test only control group design. Twenty eight (28) Sprague dawley rats induced with Streptozotocin (STZ) 40 mg/kgBW (i.p) were divided into four groups (n=7). The first group was diabetic non treated group (control). The second to fourth groups were the diabetic rats which given brown algae extract (150mg/kgBW; 300mg/kgBW and 450 mg/kgBW respectively) for 30 days. Serum MDA and PCO levels were examined by using ELISA method. Data were analyzed using one way ANOVA.Results: There were no significant differences in serum MDA levels among groups (p=0,405). However, serum PCO level in group administered with 450mg/kgBW of brown algae extract decreased significantly compared to control group (p=0.001), group administered with 150mg/kgBW (p=0.001) and 300mg/kgBW (p=0,037). Conclusion: Administration of brown algae extract did not decrease serum MDA levels significantly. Administration of 450mg/kgBW brown algae extract is effective to decrease serum PCO level significantly.

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