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Najmah Najmah
Department Of Biochemistry, IPB University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Engineering Environmental Science Immunology & microbiology Mathematics Physics Public Health Social Sciences Other

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Journal : Current Biochemistry

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Antioxidant Activity, Inhibition α-Glucosidase of Cymbopogon nardus (L.) Rendle and Identification of Active Compounds Najmah Najmah; Hasim Hasim; Didah Nur Faridah
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.3

Abstract

Diabetes mellitus (DM) has become a health problem in various countries, even in Indonesia, multiple of Covid-19 sufferers have DM as comorbid. Treatment of DM can be conducted by delaying glucose intake performed by the α-glucosidase enzyme in the intestine. Treatment using synthetic drugs often causes side effects. Instead to overcome these problems, herbal medicine is a choice. Cymbopogon nardus (L.) Rendle served as a potential candidate as seen from prior research but related to DM drugs, further exploration needs to be performed. This study aims to acquire a DM medicine by using Cymbopogon nardus (L.) Rendle . The leaves were macerated using 96% concentration of ethanol followed by multilevel fractionation with n-hexane, water and ethyl acetate as solvents. The test results showed that the n-hexane fraction was the best for antioxidant activity and α -glucosidase inhibition with IC50 values of 8,23 ppm and 311,87 ppm while the identification of the compound by using Liquid Chromatograph-Mass Spectrometry (LC-MS/MS) suspected compounds that have a role were ar-turmerone, beesioside N and notohamosin A. Based on the test, the n-hexane fraction was found as a source of antioxidants as well as α -glucosidase inhibitors. Keywords: Antioxidant, α -glucosidase, Cymbopogon nardus (L.) Rendle, LC-MS/MS.
Co-Authors Aris, Ayub Pratama Arviani Arviani Auli Irfah Bambang Pontjo Priosoeryanto Chairunnisah J Lamangantjo Deasy Natalia Botutihe Devi Bunga Pagalla Djarot Sasongko Hami Seno Elfrida Ratnawati Erga Kurniawati Erni Mohamad Haris Munandar Hasim Hasim Hermin Utami Jusna Ahmad Kostiawan Sukamto, Kostiawan La Ode Aman Masrid Pikoli Masruroh Masruroh Moch Rio Pambudi Mohammad Alex Firdaus Netty Ino Ischak Ninasafitri, Ninasafitri Nurlaida Nurlaida Opir Rumape Rizki Fitria Saadatul Husna Sasmita Pomuato Siti Afdianti Domu Thayban, Thayban Vivi Dia Afrianti Sangkota Waras Nurcholis Yuszda K Salimi