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All Journal CHEMPUBLISH JOURNAL Jurnal Surya Medika JMM (Jurnal Masyarakat Mandiri) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Community Empowerment Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sinteza Borneo Journal of Pharmacy Journal of Pharmascience
Muhammad Priyadi
Universitas Palangka Raya
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Formulasi Pil Kunyit (Curcuma Longa L.) Kombinasi Sari Jeruk Limau Kuit (Citrus Hystrix Dc.) Sebagai Antioksidan Citrariana, Shesanthi; Muhammad Priyadi; Anograh R, Defilia; Rahmman, Sudarman; Febrianto, Yahya; Irawan, Ahmad; June N, Franz; Elphasa H, Shavira; Adistia P, Allaya
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.32965

Abstract

Turmeric contains the active compound curcumin, which has been studied for its various biological activities, including antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties. Kaffir lime is a plant commonly found on the island of Borneo and is used in traditional medicine and culinary flavors. Kaffir lime fruit and leaves contain various bioactive compounds, such as flavonoids (hesperidin, naringenin), essential oils (citronellal, limonene), and vitamin C. Flavonoids are known to have antioxidant and anti-inflammatory effects that can boost the immune system. Pills are one of the oldest dosage forms in the pharmaceutical world and are still relevant, especially for herbal preparations due to their ease of manufacture and stability. This study aims to formulate pill preparations by combining turmeric and lime juice. The method used is wet granulation to make pills with varying turmeric concentrations, namely F1 0.26% and F2 0.52% using polyvinyl alcohol as a binder. Physical evaluations include water content, weight uniformity, pH, and disintegration time tests. The pills were then tested for antioxidant activity against DPPH. The results showed that the water content of F1 pills was 4.06% and F2 pills 3.75%, pill weight uniformity with RSD value criteria of F1 was 0.21% and F2 pills 3.40%, the average pH of F1 was 6.32 and F2 pills 6.22, and the disintegration time of F1 was 30 minutes and F2 pills 8.26 minutes. The results of the antioxidant activity of the pill preparations showed that the F1 IC50 was 6.36 ppm and the F2 IC50 was 5.53 ppm. From the results obtained, it can be concluded that F2 pill preparations have good physical properties and potential antioxidant activity.
Improving Students’ Skills through the Production of Aromatherapy Candles Using a Combination of Cinnamon and Citronella Essential Oils Ayuchecaria, Noverda; Riani, Defilia Anogra; Priyadi, Muhammad; Suprayogi, Thathit; Navirius, Franz June; Galeno, Nathanael Neda; Roselia, Jessica Alexandra; Esterlita, Anggraeni Putri
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 8, No 1 (2026): FEBRUARY 2026
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v8i1.17052

Abstract

Aromatherapy candles are candles made by mixing a base material, such as solid paraffin, with essential oils derived from certain plants. Training activities aimed at increasing knowledge in developing new products are still rarely conducted. This situation also occurs at SMA Negeri 2 Palangka Raya, where there is a lack of practical skills training programs that utilize local potential, as well as limited entrepreneurship development among students. This community service activity was conducted in October 2025 and aimed to provide training in making aromatherapy candles to students of SMA Negeri 2 Palangka Raya. This program employed the Participatory Action Research (PAR) method and focused on producing aromatherapy candles using a combination of cinnamon and citronella essential oils. The main participants were 45 tenth-grade students. The improvement in students’ skills was measured using pre-tests and post-tests, along with questionnaires regarding the aromatherapy candle-making training. The results showed that 53.33% of participants were interested in the skills to be acquired, 55.56% rated the implementation of the activity as very good, and 51.11% considered the theme of the activity to be very beneficial. Evaluation results indicated that 81.2% of participants demonstrated excellent knowledge in the candle-making process. The pre-test and post-test results also showed an improvement in scores after the training was conducted. In conclusion, the aromatherapy candle-making training using a combination of cinnamon and citronella essential oils at SMA Negeri 2 Palangka Raya was successfully implemented and achieved its intended objectives. This was evidenced by the high enthusiasm of participants and the improvement in their knowledge and skills after participating in the activity.
Profil Fitokimia Ekstrak Etil Asetat Temu Kunci (Boesenbergia rotunda L.) dan Serai (Cymbopogon citratus) Muhammad Priyadi; Nurul Chusna; Isnawati Isnawati; Opi Indriani
Journal of Pharmascience Vol. 8 No. 1 (2021): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i1.9725

Abstract

Senyawa bahan alam yang terdapat pada tanaman memiliki banyak khasiat bagi kesehatan yang telah dibuktikan melalui pengobatan tradisional secara empiris. Identifikasi senyawa kimia sangat penting untuk mengetahui kemungkinan adanya senyawa yang dapat memiliki aktivitas farmakologi. Tanaman yang telah banyak digunakan oleh masyarakat termasuk pengobatan adalah temu kunci (Boesenbergia rotunda L.) dan serai (Cymbopogon citratus). Temu kunci dan serai diekstraksi menggunakan pelarut etil asetat. Uji fitokimia pada ekstrak etil asetat temu kunci dan serai dilakukan dengan uji kualitatif pereaksi warna dan pengendapan serta kromatografi lapis tipis untuk melihat gambaran pemisahan senyawa kimia yang terkandung. Ekstrak etil asetat temu kunci dan serai mengandung senyawa golongan alkaloid, terpenoid, flavonoid, fenol, dan kuinon. Senyawa pada temu kunci dan serai dapat dipisahkan menggunakan kromatografi lapis tipis dengan fase gerak etil asetat : n-heksan (8:2).    Kata Kunci: Fitokimia, Temu Kunci, Serai, Ekstrak Etil Asetat, Kromatografi Lapis Tipis Natural compounds found in plants have many health benefits that have been proven through empirically traditional medicine. Identification of chemical compounds is very important to determine the possibility of compounds having pharmacological activity. Plants that have been widely used by the community, including medicinal plants, are Temu Kunci (Boesenbergia rotunda L.) and serai or lemongrass (Cymbopogon citratus). Temu Kunci and lemongrass were extracted using ethyl acetate as a solvent. Phytochemical test on ethyl acetate extract of temu Kunci and lemongrass was carried out by qualitative test using color reagent and deposition and thin layer chromatography to see the description of the separation of the chemical compounds contained. Temu Kunci and lemongrass ethyl acetate extracts contain alkaloids, terpenoids, flavonoids, phenols, and quinones. Compounds in Temu Kunci and lemongrass can be separated using thin layer chromatography with ethyl acetate: n-hexane (8: 2) as mobile phase.
Uji Aktivitas Antibakteri Kombinasi Minyak Kelapa Murni dan Arang Aktif terhadap Streptococcus mutans Nurul Chusna; Muhammad Priyadi
Journal of Pharmascience Vol. 9 No. 1 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.12704

Abstract

Streptococcus mutans merupakan bakteri penyebab masalah pada karies gigi. Penggunaan bahan alami dipercaya menjadi salah satu terapi infeksi yang dapat digunakan sebagai antibakteri. Beberapa penelitian menunjukkan adanya potensi bahan alami seperti minyak kelapa murni dan mineral arang aktif dapat mengobati karies gigi. Hal ini mendorong untuk mengetahui aktivitas antibakteri kombinasi antara minyak kelapa murni dan arang aktif terhadap S. mutans. Pengujian antibakteri dilakukan dengan metode difusi cakram dengan mengukur diameter zona hambat. Kelompok sampel uji terdiri dari kombinasi minyak kelapa murni : arang aktif (konsentrasi 10% v/v : 5% b/v, 5% v/v : 5% b/v, dan 5% v/v : 10% b/v) dan amoksisilin 30 µg sebagai kontrol positif. Hasil menunjukkan kombinasi minyak kelapa murni : arang aktif (10% v/v : 5%b/v, 5% v/v : 5% b/v, dan 5% v/v : 10% b/v) dan amoksisillin memiliki besaran zona hambat berturut-turut sebesar  8,50 mm; 6,90 mm; 6,90 mm dan 30,04 mm. Hasil uji penelitian yang dilakukan menunjukkan bahwa kombinasi antara minyak kelapa murni dan arang aktif memiliki aktivitas antibakteri yang lemah terhadap bakteri S. mutans. Selanjutnya, perlu dilakukan penelitian lanjutan aktivitas minyak kelapa murni maupun bahan-bahan alami lainnya pada penanganan infeksi gigi dan mulut. Kata Kunci: Antibakteri, Minyak Kelapa Murni, Arang Aktif, Karies Gigi, Streptococcus mutans   Streptococcus mutans is bacteria that causes problems in dental caries. The use of natural ingredients is believed to be one of the infection therapies that can be used as antibacteria. Several studies have shown the potential of natural ingredients such as virgin coconut oil and activated charcoal minerals to treat dental caries. It is encouraging to know the antibacterial activity of the combination of virgin coconut oil and activated charcoal against S. mutans. Antibacterial testing was carried out by disc diffusion method to know the diameter of the inhibition zone. The test sample group consisted of a combination of virgin coconut oil: activated charcoal (10% v/v : 5% w/v, 5% v/v : 5% w/v, and 5% v/v : 10% w/v ) and amoxicillin as a positive control. The results showed that the combination of virgin coconut oil: activated charcoal (10% v/v : 5% w/v, 5% v/v : 5% w/v, and 5% v/v : 10% w/v) and amoxicillin 30 µg had the size of the inhibition zone was 8.50 mm, 6.90mm, 6.90 mm and 30.04 mm, respectively. The results of the research conducted showed that the combination of virgin coconut oil and activated charcoal had weak antibacterial activity against S. mutans. Furthermore, it is necessary to conduct further research on the activity of virgin coconut oil and other natural ingredients in the treatment of dental and oral infections.
Gambaran Histopatologi Hati dan Ginjal Mencit (Mus musculus) Setelah Pemberian Ekstrak Daun Bajakah Kalalawit (Uncaria gambir Roxb.) Yohanes Edy Gunawan; Muhammad Priyadi; Shesanthi Citrariana; Rizki Rachmad Saputra; Decenly Decenly; Anisa Rahma Fauziah; Yahya Febrianto; Thathit Suprayogi
Journal of Pharmascience Vol. 11 No. 2 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.17733

Abstract

Secara empiris Bajakah Kalalawit (Uncaria gambir Roxb.) telah digunakan oleh masyarakat lokal Kalimantan karena dipercaya dapat menyembuhkan berbagai macam penyakit. Beberapa penelitian telah menunjukkan potensi aktivitas farmakalogis bajakah kalalawit dimulai dari bagian batang, akar dan lainnya. Namun, apabila tidak digunakan dengan tepat maka berpotensi dapat membahayakan penggunanya. Tujuan dari penelitian ini adalah menganalisis aspek toksikologi konsumsi ekstrak air daun bajakah kalalawit melalui gambaran histopatologi organ hati dan ginjal. Ekstraksi daun bajakah kalalawit menggunakan metode refluks dengan pelarut air dan uji histopatologi menggunakan pengamatan mikroskopis histologi pada organ hati dan ginjal mencit jantan (Mus musculus) melalui pemberian dosis ekstrak air daun bajakah kalalawit sebanyak 52,5 mg/KgBB, 105 mg/KgBB, dan 210 mg/KgBB selama 30 hari. Hasil penelitian menunjukkan bahwa pemberian ekstrak air daun bajakah kalalawit selama 30 hari dapat menimbulkan terjadinya degenerasi sel dan nekrosis sel pada organ hati maupun ginjal mencit. Dapat disimpulkan bahwa pemberian ekstrak air daun bajakah kalalawit dengan dosis 52,5 mg/KgBB, 105 mg/KgBB dan 210 mg/KgBB dapat menyebabkan perubahan histologi pada organ hati dan ginjal. Kata Kunci: Histologi, Ekstrak, Toksikologi, Mikroskopis, Nekrosis   Empirically, Bajakah Kalalawit (Uncaria gambir Roxb.) has been used by local Kalimantan communities because it is believed to cure various diseases. Several studies have shown the potential pharmacalogical activity of bajakah kalalawit starting from the stem, root and other parts. However, if not used properly, it can potentially harm the user.. The purpose of this study was to determine the toxicology aspects of consumption of bajakah kalalawit leaf water extract through histopathological images of liver and kidney organs. Extraction of bajakah kalalawit leaves using reflux method with water solvent and histopathology test using microscopic observation of liver and kidney histology of male mice (Mus musculus) which were treated with doses of bajakah kalalawit leaf water extract 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW for 30 days.  The results showed that the administration of bajakah kalalawit leaf water extract for 30 days can cause cell degeneration and cell necrosis in the liver and kidney organs of mice. It can be concluded that the administration of bajakah kalalawit leaf water extract at doses of 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW may contribute to histologic changes in the liver and kidney.
Co-Authors Ade Irawati Adistia P, Allaya Ahmad Irawan, Ahmad Amaliyah Dina Anggraeni Andra Ari P., Eko Marwanto Heru Mulyantoro Dwi Hermayantiningsih Anisa Rahma Fauziah Anograh R, Defilia Ayuchecaria, Noverda Betrand Fernando Citrariana, Shesanthi Decenly Decenly Decenly Decenly Decenly Decenly Decenly, Decenly Defilia Anogra Riani Drenikha Sikhe R Elphasa H, Shavira Esterlita, Anggraeni Putri Evi Mulyani Fauziah, Anisa Rahma Franz June Navirius Galeno, Nathanael Neda Gunawan, Yohanes E Gunawan, Yohanes Edy Guntur Satrio Pratomo Haryoto Haryoto Heng Yen Khong Isnawati Isnawati Jonathan Kaharati June N, Franz Mohammad Bimo Prakosa Nurul Chusna Nurul Chusna Opi Indriani Putri, Alayya Adistia Rahmman, Sudarman Reny Rosalina, Reny Rian Ka Praja Rismadani Safitri Rizki Rachmad Saputra Roselia, Jessica Alexandra Rts Sherly Dwi Jayanti Sametri, Ni Wayan Septia Shesanthi Citrariana Thathit Suprayogi Thathit Suprayogi Yahya Febrianto Yahya Febrianto Yohanes Edy Gunawan