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All Journal International Journal of Public Health Science (IJPHS) Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Acta Pharmaciae Indonesia : Acta Pharm Indo JCPS (Journal of Current Pharmaceutical Sciences) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Bioscientist : Jurnal Ilmiah Biologi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Masyarakat Bangsa Jurnal Farmasi Indonesia Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Nashihah, Siti
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Antibacterial activity of ethanol extract of limpasu (Baccaurea lanceolata) pericarpium with the ultrasound assisted extraction method against Propionibacterium acne Ulpah, Rusmili; Nashihah, Siti; Zamzani, Irfan
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.6393

Abstract

Background: Acne, a prevalent skin condition, can arise from factors such as an unhealthy lifestyle, dietary habits, hormonal imbalances, and bacterial infections. Propionibacterium acnes is a notable bacterium responsible for acne. In South Borneo, the pericarpium of the limpasu plant (Baccaurea lanceolata) is traditionally used to treat acne. Objective: This study aims to scientifically validate the empirical antibacterial effects of limpasu pericarpium against Propionibacterium acnes, as reported by the communities in South Borneo. Methods: The ultrasound-assisted extraction (UAE) method was utilized to extract compounds from limpasu pericarpium. The antibacterial activity of the limpasu pericarpium extract was evaluated using the disc diffusion method at concentrations of 20%, 40%, 60%, 80%, and 100% w/v. Clindamycin served as the positive control, and 1% DMSO was the negative control. Results: The lowest concentration (20%) fell within the strong activity category, producing a clear zone diameter of 18.76 mm. Higher concentrations (40%, 60%, 80%, and 100%) demonstrated more potent antibacterial effects, with inhibition zones of 23.23 mm, 26.06 mm, 26.93 mm, and 27.33 mm, respectively. Notably, 60% to 100% concentrations exhibited greater inhibitory effects than the positive control, clindamycin, which had an inhibition zone of 25.23 mm. Conclusion: The study confirms the antibacterial properties of limpasu pericarpium against Propionibacterium acnes, supporting the traditional claims of its efficacy by the South Borneo communities.
COMPARISON OF LACTIC ACID BACTERIAL ISOLATES FROM VARIATIONS IN TIME FERMENTATION PROCESS OF CEMPEDAK SKIN Syifa Noorwina; siti nashihah
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2077

Abstract

Cempedak is a tropical native fruit from Indonesia and can be consumed by fermenting the skin fruit using a salt solution. The results of the fermentation called Mandai. Fermentation will be successful if there is a role of Lactic Acid Bacteria (LAB). Therefore, this study was conducted to determine the content of LAB in Mandai and isolates when fermented at different times. This study was carried out by dilution and the Pour Plate method, identifications such as morphological identification by gram staining and biochemical test by catalase t and TSIA test. Identification of this study was the observation of clear zone around the bacteria grown on MRSA media as a selective medium for LAB plus CaCO3. In this study, 5 samples of Mandai were used with different fermentation times. The results of the LAB isolation study in Mandai showed that the longer the Mandai fermentation was carried out, the more colonies there would be. While the LAB type was only found in sample 5 which was fermented within 20 weeks. The results obtained were following the characteristics of LAB, including gram-positive bacteria in the form of bacilli or cocci, not having catalase enzyme, and being able to ferment carbohydrates. 
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN BANGKAL (Nauclea subdita) TERHADAP BAKTERI Staphylococcus aureus Monica, Cahya; Zamzani, Irfan; Siti Nashihah
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2129

Abstract

Bangkal (Nauclea subdita) is a typical plant in the southern part of the island of Borneo. In everyday life, bangkal leaves are used to treat wounds, ulcers, toothache, fever and diarrhea. The purpose of this study was to measure and determine the antibacterial activity of the ethanol extract of bangkal leaves against Staphylococcus aureus using the Ultrasonic Assisted Extraction (UAE) method. Bangkal leaves were extracted by UAE using 96% ethanol. The antibacterial inhibition test was carried out using the Kirby-Bauer disc diffusion method. Testing of antibacterial inhibition zones of Bangkal leaf extract against Staphylococcus aureus bacteria had an effect or significantly different with concentrations of 40%, 60%, 80%, 100% respectively and produced antibacterial activity with inhibition zones of 12.7±0.06 respectively. mm, 13.9±0.00 mm, 15±0.00 mm, 16±0.00mm. The results of the antibacterial activity examination showed that the ethanolic extract of bangkal leaves could inhibit the growth of Staphylococcus aureus at a concentration of 40% with an inhibition zone diameter of 12.7 mm and the highest concentration at 100% with an inhibition zone diameter of 16.00 mm. This indicates that the extract of bangkal leaves has antibacterial activity against Staphylococcus aureus which has an inhibition zone with a moderate to strong category.
Variability and pharmacological potential of bajakah (Spatholobus sp.) as an indigenous medicinal plant: a review Mahfudh, Nurkhasanah; Utami, Dwi; Nashihah, Siti; Ahda, Mustofa; Andika, Andika; Sabilla, Giriani Ayu
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.23791

Abstract

Bajakah (Spatholobus sp.) is an indigenous Indonesian plant that has been traditionally used as medicine, especially in Kalimantan Island, Indonesia. The variability and potential of bajakah as a traditional Indonesian medicinal plant have attracted research attention. This review article describes the traditional use, distribution, and pharmacological activity of bajakah. An integrative review method was employed, following procedures such as literature search, data analysis, and result presentation. Understanding the variations is important to understand the therapeutic potential and differences in active compound content among different types of bajakah. Furthermore, the chemical composition of bajakah has been identified, including alkaloids, flavonoids, tannins, saponins, and triterpenoids, which can potentially exhibit pharmacological effects and mechanisms of action associated with its traditional use. This review provided additional insights into the potential of bajakah as an herbal medicinal in the future. Therefore, this review article provides an overview of the traditional use distribution, and pharmacological activity of bajakah as a promising traditional medicine. Further research, including clinical studies, is needed to scientifically validate the therapeutic potential of bajakah and further understand the mechanisms of action and potential side effects associated with it.
Identifikasi Daun Sangkareho (Callicarpa longifolia Lam) secara Makroskopis dan Mikroskopis : Macroscopic and Microscopic Identification of Sangkareho (Callicarpa longifolia Lam.) Leaves Helma Novitasari; Siti Nashihah; Irfan Zamzani
Jurnal Sains dan Kesehatan Vol. 3 No. 5 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i5.570

Abstract

The utilization and development of traditional plants is a big investment for the sustainability of Indonesia society. Traditional medicine has its own requirements in order to guarantee the authenticity or correctness of the raw materials used. Sangkareho (Callicarpa longifolia Lam.) Is a family of Lamiaceae and a species of the genus Callicarpa. This study aims to provide scientific information data about the macroscopic and microscopic leaves of Sangkareho. The examination was carried out by observing the fresh leaves and the simplicia powder on the leaves of Sangkareho. The organoleptic results of the fresh Sangkareho leaves are hijua color, the distinctive smell of Sangkareho leaves is weak, and the taste is bitter, while the simplicia powder is slightly brownish in color, the distinctive smell of Sangkareho leaves is strong, and the taste is bitter. Macroscopic obtained by Sangkareho leaves are dark green on the upper surface and light green on the underside of the leaves, bitter taste, distinctive smell of Sangkareho leaves, oval elongated leaf shape, slightly hairy leaf surface, 11-17 cm long, 3 5-6 cm, the leaves are rather thin, the edges of the leaves are serrated, and the tips of the leaves are tapered, while for the simplicia powder it has a dense, smooth, non-stringy and dry texture, slightly brownish green, bitter taste, and has a distinctive smell of sangkareho leaves.
Apoteker Mengabdi: Apoteker Mendampingi Pemanfaatan Tanaman Obat Keluarga Sebagai Antihipertensi Yulisa, Ika; Wandi, Halifah Risma; Muliyati, Imas; Damayanti, Indira; Wardana, Kevin Febrian; Nashihah, Siti
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 8 (2024): Oktober
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i8.1462

Abstract

Hipertensi merupakan kondisi ketika tekanan darah tinggi dengan tekanan sistolik lebih dari 130 mmHg dan tekanan diastolik lebih dari 90 mmHg. Tekanan darah tinggi apabila tidak terkontrol atau tidak diberi perhatian khusus dapat menyebabkan berbagai komplikasi. Sebagian besar pasien hipertensi menggunakan obat bahan alam selain obat hipertensi konvensional. Pasien yang menggunakan obat bahan alam memang terbukti menurunkan tekanan darah. Namun, hanya 15,2% yang menggunakan obat bahan lama sesuai dengan peraturan BPOM tentang kriteria jamu. Sehingga dapat disimpulkan perlunya edukasi mengenai penggunaan obat bahan alam di masyarakat sebagai terapi komplementer untuk hipertensi. Tujuan kegiatan ini yaitu untuk memberikan edukasi mengenai tanaman obat keluarga (TOGA) sebagai antihipertensi dan menjelaskan bagaimana cara menggunakan, juga cara mengolahnya.  Metode yang digunakan dalam kegiatan adalah berupa pemaparan materi mengenai definisi, gejala, tanaman obat keluarga yang berpotensi sebagai antihipertensi dan juga cara pengolahannya. Setelah kegiatan ini diharapkan dapat membantu masyarakat untuk mengetahui, memberikan informasi dan penerapan tanaman obat keluarga (TOGA) sebagai terapi yang bersifat tradisional disamping penggunaan obat-obat konvensional. Dan juga diharapkan akan berdampak pada penurunan kasus hipertensi dan peningkatan derajat kesehatan masyarakat.
UJI DAYA HAMBAT EKSTRAK ETANOL DAUN RAMBAI (Sonneratia Caseolaris (L) Engl) TERHADAP BAKTERI Propionibacterium acnes DAN Staphylococcus epidermidis Fitriani, Tiya; Nashihah, Siti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.714 KB) | DOI: 10.35617/jfionline.v13i1.65

Abstract

Currently there are many anti-acne preparations on the market but not a few of these drugs give side effects to the user. The need for alternatives from nature that can act as antibacterial in the treatment of acne that has a smaller risk of side effects. This study aims to determine the inhibition of ethanol extract of rambai leaves (Sonneratia caseolaris (L) Engl) against acne-causing bacteria Propionibacterium acnes and Staphylococcus epidermidis. Extraction was carried out by the UAE method and a yield of 9.21% was obtained. Phytochemical screening obtained positive results containing flavonoids, triterpenoids, tannins, saponins and phenol compounds. Antibacterial activity test was conducted using the well diffusion method with 4 different concentrations of 15%, 25%, 50% and 75% with positive control of clindamycin 0.03% and negative control of DMSO 1%. The results of antibacterial activity testing on Propionibacterium acnes bacteria obtained inhibition zone diameters of 3.3 mm; 4.43 mm; 6.48 mm; and 8.45 mm, respectively, while on Staphylococcus epidermidis bacteria 11.08 mm; 12.27 mm; 15.38 mm; and 16.78 mm, respectively. The results of the One Way ANOVA statistical test obtained a significance value of 0.000 (p<0.05) which indicates that the treatment of each group is significantly different.
Uji Aktivitas Antibakteri Ekstrak Daun Karamuntin (Rhodomyrtus tomentosa (Aiton) Hassk.) terhadap Bakteri Streptococcus mutans Ramadhanty, Dewi Alfisyah; Lestari, Yulianita Pratiwi Indah; Nashihah, Siti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (858.701 KB) | DOI: 10.35617/jfionline.v15i1.112

Abstract

Abstract: Indonesia has many medicinal plants that can used to treat various diseases. One of the plants is the leaves of karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.). Traditionally, karamunting leaves are used as a treatment in dental caries, wound care, and scabies. This study was aimed to determine the antibacterial effect of karamunting leaves ethanol extract against Streptococcus mutans by the well method. The design of this study was experimental laboratory research. The sample was karamunting leaves ethanol extract. The extracts were evaluated for antibacterial activity against Streptococcus mutans using the well method with a concentration of 6,25%; 12,5%; 25%; and 50% w/v. The result showed karamunting leaves ethanol extract provided an antibacterial activity against Streptococcus mutans with an inhibition zone diameters of 17,7±0,0577; 22,6±0,2516; 25,3±0,1527; and 28,3±0,0577 mm. at the concentration of 6,25% w/v, 12,5% w/v, 25% w/v, and 50% w/v, respectively. karamunting leaves ethanol extract had significant antibacterial activity against Streptococcus mutans at the concentration 50% w/v with inhibition zone diameters of 28,3 mm.
Pemanfaatan Bahan Alam Sebagai Terapi Hipertensi Rizqiannoor, Muhammad; Khairunnisa, Khairunnisa; Mahmudah, Mahmudah; Maulana, Rafli; Napisah, Siti; Nashihah, Siti
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 7 (2025): September
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i7.2901

Abstract

Hipertensi merupakan masalah kesehatan global dengan prevalensi yang terus meningkat, termasuk di Indonesia. Penggunaan obat antihipertensi jangka panjang dapat menimbulkan efek samping, sehingga diperlukan alternatif terapi yang aman dan mudah diakses, seperti bahan alam. Mentimun (Cucumis sativus L.) mengandung kalium dan bersifat diuretik, sedangkan seledri (Apium graveolens L.) memiliki senyawa vasodilator seperti apiin dan mannitol, yang berpotensi menurunkan tekanan darah. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi dan demonstrasi pembuatan sari mentimun serta rebusan daun seledri sebagai terapi pendukung hipertensi. Metode pelaksanaan meliputi penyuluhan kesehatan, pengecekan tekanan darah gratis, pemaparan materi, dan sesi tanya jawab interaktif di wilayah Kuin Cerucuk, Banjarmasin, dengan peserta sebanyak 20 orang. Hasil kegiatan menunjukkan peningkatan pemahaman masyarakat mengenai hipertensi dan pemanfaatan herbal sebagai terapi pendukung. Peserta juga diajarkan cara pengolahan bahan alam secara higienis. Kesimpulan dari kegiatan ini adalah edukasi berbasis bukti ilmiah mengenai mentimun dan seledri dapat menjadi solusi alternatif dalam manajemen hipertensi, mengurangi ketergantungan pada obat sintetis, serta meningkatkan kesadaran akan gaya hidup sehat. Dukungan tindak lanjut berupa monitoring dan publikasi diharapkan dapat memperluas dampak positif kegiatan ini.
Antibacterial activity of Sappan (Caesalpinia sappan L.) wood methanol extract against Staphylococcus epidermidis Atunnisa, Waro; Zamzani, Irfan; Nashihah, Siti
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21900

Abstract

The entry and proliferation of microorganisms, such as bacteria, cause skin infections. One of the bacteria that causes skin infections is Staphylococcus epidermidis. Sappan (Caesalpinia sappan L.) wood has been known to have various pharmacology activities, one of which is antibacterial, so its activities need to be developed and improved. This study aimed to determine the activity of the methanol extract of Sappan (C. sappan L.) wood as an antibacterial against S. epidermidis. This research was conducted by extracting Sappan wood powder with 96% methanol as solvent using the Ultrasound-Assisted Extraction (UAE) method and testing for antibacterial activity with concentrations of 25%, 50%, 75% and 100% using the disc method. Results showed that the methanol extract of Sappan wood had an antibacterial activity; the highest inhibition zone at a concentration of 75% was 29.25 mm. Sappan wood was expected to be a promising alternative therapy for overcoming acne problems and can increase economic value for the wider community. 
Co-Authors Ahmad Mahdi Mar'ie Ahsana, Dina Andika Andika Andika Andika Andika Andika Atunnisa, Waro Damayanti, Indira Diah Safitri Dina Ahsana Dwi Utami Fajeriyati, Nurul Fitriah Fitriah Fitriani, Tiya Helma Novitasari Islan Nor Khairunnisa Khairunnisa Mahmudah Mahmudah Mar'ie, Ahmad Mahdi Maulana, Rafli Monica, Cahya Muhammad Yusron Maulana El-Yunusi Muliyati, Imas Murdi, Habib Basyanur Mustofa Ahda Nurkhasanah Mahfudh Ramadhanty, Dewi Alfisyah Rizka Mulya Miranti rizki rahmadi Rizqiannoor, Muhammad Sabilla, Giriani Ayu Siti Napisah Siti Rahmita Syifa Noorwina Ulpah, Rusmili Wandi, Halifah Risma Wardana, Kevin Febrian Waro Atunnisa Yulianita Pratiwi Indah Lestari Yulisa, Ika Zamzani, Irfan Zamzani, Irfan