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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Terapan Abdimas Jurnal Ilmiah Kedokteran Wijaya Kusuma The Indonesian Journal of Infectious Diseases Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Abdidas Jurnal Pengabdian Masyarakat: Humanity and Medicine Berkala Penelitian Hayati Sinnun Maxillofacial Journal Journal of Mandalika Literature Calvaria Medical Journal Jurnal Pengabdian Masyarakat Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran
Lusiani Tjandra
Department Of Pharmacology, Medical Faculty, University Of Wijaya Kusuma Surabaya, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Ilmiah Kedokteran Wijaya Kusuma

 1 
Prednisone USE IN PATIENTS WITH ASTHMA BRONKHIALE linked IgE AND IgG LEVELS PATIENTS Tjandra, Lusiani
Jurnal Ilmiah Kedokteran Wijaya Kusuma 2009: edisi khusus Desember 2009
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Background: There’s been reported that the use of prednisone increase the occurrence of disease caused by viruses. And so, this study was done to find out the IgG and IgE status in asthmatic bronchial patients who used prednisone.Methods: The immunodiagnostic test applied was the precipitation test.Results: Showed that the average of IgG in asthmatic bronchial patients who used prednisone is 1332,09 mg/dl, less than the average IgG in patients who did not use prednisone. The average of IgE in asthmatic bronchial patients who used prednisone is 4224,0.10-5mg/dl, less than the average of IgE in patients who did not use prednisone. The use of prednisone as a therapy for asthma bronchiale does lower the rate of IgG but that rate is still within the range of normal IgG rate in human body (639 – 1349 mg/dl).Conclusions: So, the use of prednisone can’t make human suffers from diseases cause by viruses just because the use of prednison as a therapy in asthma bronchiale.
PROTOONCOGENE Tjandra, Lusiani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2010): Edisi Januari 2010
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Genes that promote autonomous cell growth in cqncer cells are called oncogenes, and their normal cellular counterparts are called protooncogenes. Protooncogenes are physiologic regulators of cell proliferation and differentiation,oncogenes are characterized by the ability to promote cell growth in the absence of normal mitogenic signals. Their products, called oncoproteins, resemble the normal products of protooncogenes with the exception that oncoproteins are devoid of important regulatory elements.Their production in the transformed cells becomes constitutive, that is, not dependent on growth factors or other external signal. Each of the cancer genes has a specific function, the dysregulation of which contributes to the origin or progression of malignancy. It traditional to describe cancer- causing genes on the basis of their presumed function.Mutations in genes that regulate these cellular traits are seen in every cancer. However, the precise genetic pathways that give rise to these attributes differ between cancers, even within the same orhan. It is widely believed that the occurrence of mutations in cancer-causing genes is conditioned by the robustness of the DNA repair machinery of the cell. When genes that normally sense andrepair DNA demage are impaired or lost, thevresultant genomic instability favors mutations in genes that regulate the other acquired capabilities of cancer cells.
PROTOONCOGENE Lusiani Tjandra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2010): Edisi Januari 2010
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.42 KB) | DOI: 10.30742/jikw.v2i1.85

Abstract

Genes that promote autonomous cell growth in cqncer cells are called oncogenes, and their normal cellular counterparts are called protooncogenes. Protooncogenes are physiologic regulators of cell proliferation and differentiation,oncogenes are characterized by the ability to promote cell growth in the absence of normal mitogenic signals. Their products, called oncoproteins, resemble the normal products of protooncogenes with the exception that oncoproteins are devoid of important regulatory elements.Their production in the transformed cells becomes constitutive, that is, not dependent on growth factors or other external signal. Each of the cancer genes has a specific function, the dysregulation of which contributes to the origin or progression of malignancy. It traditional to describe cancer- causing genes on the basis of their presumed function.Mutations in genes that regulate these cellular traits are seen in every cancer. However, the precise genetic pathways that give rise to these attributes differ between cancers, even within the same orhan. It is widely believed that the occurrence of mutations in cancer-causing genes is conditioned by the robustness of the DNA repair machinery of the cell. When genes that normally sense andrepair DNA demage are impaired or lost, thevresultant genomic instability favors mutations in genes that regulate the other acquired capabilities of cancer cells.
Characteristics of Indonesian Wild honey and Cultivited Honey and Their Antibacterial Activity against Staphylococcus aureus and Escherichia coli Lusiani Tjandra; Budhi Setyawan; Masfufatun masfufatun
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.254 KB) | DOI: 10.30742/jikw.v11i1.1795

Abstract

Indonesia's natural wealth is very abundant in the form of flora and fauna that can be developed as raw materials for medicine. Honey in Indonesia is very diverse from Sabang to Merauke. Different types of honey are influenced by regional origin, season at harvest, type of bee, type of plant source of nectar, way of life of bees (cultivated or wild), harvesting method and post-harvest handling. This study aims to determine the characteristics of forest bee honey and cultivated honey and to determine the potential of honey as an antibacterial in the treatment of infectious diseases caused by Staphylococcus aureus and Escherichia Coli bacteria. The materials used were Carisa honey samples from Wild honey [Wild Klanceng and Wild Cerana] and Cultivation [Cerana Cultivation], S. aureus and E. coli bacteria. The characteristic test method is in accordance with the Indonesian National Standard and the honey inhibition test against the growth of S. aureus and E. Coli bacteria using the diffusion method. The results showed that Wild Cerana (WC) and Wild Klanceng (WK) honey demonstrated higher water content, ash content, acidity and glucose from Cerana Cultivated (CC) honey. Carissa Honey (beside Cerana cultivated honey) had antibacterial activity against S. aureus and E. Coli at different concentrations. Wild Wild Honey has the highest antibacterial activity compared to other types of honey. Conclusion Indonesian wild honey showed weak antibacterial activity against Staphylococcus aureus. Meanwhile, honey that is cultivated does not have antibacterial activity. 
Ekspresi Protein P53 Mutan pada melanoma maligna dan Nevus melanositik Lusiani Tjandra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2011): Volume II, Nomor 1, Januari 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2652.054 KB) | DOI: 10.30742/jikw.v2i1.2184

Abstract

melanoma maligna merupakan tumor ganas el melanosa dengan pertumbuhan agresif dan resisten terhadap terapi konvensional.
Profile of The Use of Antihypertension Drug and Blood Pressure Evaluation at Gresik Hospital Prada Marwah Al kamilah; Lusiani Tjandra; Meivy Isnoviana; Ibrahim Njoto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 2 (2023): September 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i2.2974

Abstract

A potentially fatal non-communicable disease is hypertension. Important organs like the brain, heart, kidneys, retina, big blood vessels (aorta), and peripheral blood vessels are in danger for harm as a result. Heart attacks and even death can result from hypertension. By avoiding and managing risk factors like smoking, sedentary lifestyles, a lack of fruits and vegetables, and obesity, it is crucial to work towards lowering the risk of hypertension. This study's objectives were to assess blood pressure and establish the profile of antihypertensive medicine use. Methods: Data for this retrospective analysis were gathered based on information from patient pharmacy records and medical records. Results: 33.7% hypertension sufferers aged 65-74 years, 62.2% women and 37.8% men, 38.9% The beta-blocker drug group with the drug that is often used Bisoprolol dose of 2.5 mg as much as 26.9 %, 88% in tablet dosage form, which is used in combination form with the rule of using once a day and 64.3% controlled hypertension. This is a retrospective study that obtained data based on medical record information and patient pharmacy data. Conclusion: Hypertension patients are usually aged between 65-74 years, mostly female. Antihypertensive drugs that are often used are in the beta blocker class which is a Bisoprolol dose of 2.5 mg in tablet, used in a single dose or/and combination. Sixty-four point three percent (64.3%) of patients have controlled hypertension.
Antibacterial Effectiveness of White Champaca Flower (Michelia alba dc) Against Growth of Corynebacterium diphtheriae Tiara Nandita Putri; Nugroho Eko Wirawan Budianto; Lusiani Tjandra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.3923

Abstract

Background: Corynebacterium diphtheriae is a bacterium that attacks the respiratory tract, especially the larynx, tonsils, and throat. These bacteria can release toxins that can cause diphtheria. One of the nutritious plants that people often use is the white Champaca flower, or Michelia alba. Objective: This study aimed to examine the antibacterial effectiveness of white champaca flower (Michelia alba dc) against the growth of Corynebacterium diphtheriae. Methods: Experimental research method with post-test only control group design using Cup-plate technique of ethanol extract of white Champaca flower (Micheia alba) in various concentrations (20%, 40%, 60%, 80%, and 100%) and Erythromycin as a positive control and aquades as a negative control. Results: The results of this research are that the minimum inhibitory concentration against the growth of Corynebacterium diphtheriae bacteria at a 20% concentration is 42.16 mm, the concentration of 40% is 47.21 mm, the concentration of 60% is 51.66mm, while at the concentration of 80% the average diameter of the inhibitory zone is 54.49 mm and also at the concentration of 100% the average diameter of the inhibition zone is 54.69 mm which is the average diameter of the largest inhibition zone. The negative control with an inhibitory zone diameter of 0 mm, while the positive control with an inhibitory zone diameter of 44.21 mm. Conclusion: White Champaca flower extract (Michelia alba dc) had antibacterial effectiveness against the growth of Corynebacterium diphtheriae and at a concentration of 100% it is the most effective concentration in inhibiting the growth of Corynebacterium diphtheriae bacteria. 
Co-Authors Aisyah Najmah Chayani akhmad sudibya, akhmad Ali Husen Alif Setijono Andra Agnez Al Aska Aritania, Putu Oky Atik Sri Wulandari Atik Sri Wulandari Ayly Soekanto Budhi Setiawan Budhi Setyawan Che Che Karina Putri Komarudin Cikal Septy Buana Dania Putri Devi Dwi Rianti, Emilia Dorta Simamora Efendi, Wiyoga Agung Enny Wilianti Febtarini Rahmawati Furkani, Agusniar Haru Setiawan Herliani, Olivia Ibrahim Njoto Indahasari, Noer Kumala Kartika Ishartadiati Listyawati, Agusniar Furkani Masfufatun Masfufatun Masfufatun Meivy Isnoviana Michael Djajanto Mirin, Anike Novita D. Muhammad Abdul Malik Muhammad Fadhlurrohman Narotama, Harya Noer Kumala Indahsari, Noer Kumala Nugroho Eko Wirawan Budianto Nur Fadiana Fadila Prada Marwah Al kamilah Pramita Laksitarahmi Isrianto Pratika Yuhyi Hernanda Putra, I Made Bimantara Febryan Putu Oky Ari Tania Ratnasari, Diana Tri Rini Purbowati Sugiharto Sukma Sahadewa, Sukma Theodora THEODORA Tiara Nandita Putri Tri Ratnasari, Diana Wahyuni Dyah Parmasari, Wahyuni Dyah