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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Terapan Abdimas Jurnal Ilmiah Kedokteran Wijaya Kusuma The Indonesian Journal of Infectious Diseases Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Abdidas Jurnal Pengabdian Masyarakat: Humanity and Medicine Berkala Penelitian Hayati Sinnun Maxillofacial Journal Journal of Mandalika Literature Calvaria Medical Journal Jurnal Pengabdian Masyarakat Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran
Lusiani Tjandra
Department Of Pharmacology, Medical Faculty, University Of Wijaya Kusuma Surabaya, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Biology, Medicine,

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Synergistic Anti-Biofilm Activity of Klanceng Honey and Probiotics against Candida albicans Setiawan, Budhi; Masfufatun, Masfufatun; Tjandra, Lusiani; Ishartadiati, Kartika
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.123-127

Abstract

Candida albicans is a common cause of fungal infections, especially in hospitals. Biofilm formation by this fungus is a significant problem as it leads to increased drug resistance and complications in treatment. The biofilm's extracellular matrix protects the fungal cells, making it difficult for antifungal drugs to penetrate and clear the infection. Aim: This study investigates the potential of honey and probiotic formulations to inhibit the biofilm matrix formation in Candida albicans. Result: Klanceng honey showed the strongest inhibition of Candida albicans biofilm formation, reducing it by 89.39% (OD = 0.34 ± 0.10), compared to yogurt (29.43%, OD = 2.25 ± 0.16) and Yakult (67.95%, OD = 1.02 ± 0.25) (p < 0.05). When mixed with yogurt in a 5:1:2 ratio (honey:yogurt: water), Klanceng honey reduced biofilm formation by 84.92% (OD = 0.50 ± 0.12). Manuka and Melifera honey in the same ratio also showed strong inhibition, reducing biofilm formation by 77.84% (OD = 0.73 ± 0.08) and 90.52% (OD = 0.31 ± 0.07), respectively. This performance exceeded fluconazole’s, which achieved a 65.52% reduction (OD = 1.14 ± 0.02). For all three honey types, the 4:1:3 and 2:1:5 ratios (honey:Yakult: water) were more effective, with reductions of up to 80.96% for Melifera and 75.64% for Klanceng (p < 0.05). Conclusion: This research suggests that honey and probiotic formulations hold promise as natural alternatives in combating Candida albicans infections. The study found that the ratio of honey to probiotics in the formulations significantly influenced their effectiveness.
Co-Authors Aisyah Najmah Chayani akhmad sudibya, akhmad Ali Husen Alif Setijono Andra Agnez Al Aska Aritania, Putu Oky Atik Sri Wulandari Atik Sri Wulandari Ayly Soekanto Budhi Setiawan Budhi Setyawan Che Che Karina Putri Komarudin Cikal Septy Buana Dania Putri Devi Dwi Rianti, Emilia Dorta Simamora Efendi, Wiyoga Agung Enny Wilianti Febtarini Rahmawati Furkani, Agusniar Haru Setiawan Herliani, Olivia Ibrahim Njoto Indahasari, Noer Kumala Kartika Ishartadiati Listyawati, Agusniar Furkani Masfufatun Masfufatun Masfufatun Meivy Isnoviana Michael Djajanto Mirin, Anike Novita D. Muhammad Abdul Malik Muhammad Fadhlurrohman Narotama, Harya Noer Kumala Indahsari, Noer Kumala Nugroho Eko Wirawan Budianto Nur Fadiana Fadila Prada Marwah Al kamilah Pramita Laksitarahmi Isrianto Pratika Yuhyi Hernanda Putra, I Made Bimantara Febryan Putu Oky Ari Tania Ratnasari, Diana Tri Rini Purbowati Sugiharto Sukma Sahadewa, Sukma Theodora THEODORA Tiara Nandita Putri Tri Ratnasari, Diana Wahyuni Dyah Parmasari, Wahyuni Dyah