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Tuty yuniarty, Tuty
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Therapeutic Effect of Topical Ointment Ethanol Extract From Patiwala Leaves (Lantana camara) on Histological Profile of Incision Wounds in Diabetic Rat Models Orno, Theosobia Grace; Rosanty, Anita; Atmaja, Ratih Feraritra Danu; Hasan, Zulfikar Ali; Yuniarty, Tuty; Putra, Ahmat Rediansya
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1091-1097

Abstract

Diabetic wounds are one of the neurovascular complications of diabetes. Hyperglycemia complicates the healing of diabetic wounds, which are susceptible to infection and chronic inflammation. Topical treatment using herbal extracts aims to reduce the side effects of surrounding tissue damage. A topical ointment made from ethanol extract of Patiwala (Lantana camara) leaves, which has been tested for product quality, has antibacterial and anti-inflammatory effects that has been proven to help accelerate the healing of diabetic wounds in rats through parameters such as reduced wound diameter, changes in the number of fibroblast cells, and collagen fiber formation seen in the histological profile during 21 days of therapy with a concentration of 15% (p>0.05) compared to the positive control of 10% betadine.
Co-Authors Anita Rosanty, Anita Atmaja, Ratih Feraritra Danu Citranti, Elvia Darmayani, Satya Darmayanti, Setya Fauzi, Ahmad Zil Hasan, Aswiro Hasan, Zulfikar Ali Hasjim, Lisfaresliana Hasnah, Nur Jiarti Kusbandiyah Malik, Handayani Misbah, Sitti Rachmi Naningsih, Hasmia Nuris Kushayati Orno, Theosobia Grace Putra, Ahmat Rediansya Reni Yunus, Reni Sari, Julianti Isma SARI, MULIA SAFRIDA Sarita, Sultina Siti Rachmi Misbach, Siti Rachmi Theosobia Grace Orno Usman, Julianti Isma Sari