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All Journal Universa Medicina Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Jurnal Bakti Masyarakat Indonesia Jurnal Kesehatan Tambusai NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Tarumanagara Medical Journal Jurnal Rumpun Ilmu Kesehatan Journal of Global Pharma Technology
Twidy Tarcisia
Fakultas Kedokteran Universitas Tarumanagara
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Mekanisme Seluler dan Molekuler Cedera Miokard Tipe 2 serta Peningkatan Troponin Pasca Henti Jantung: Tinjauan Literatur Neshya Ruriana Putri; Siska Yulianti; Luluk Hermawati; Twidy Tarcisia; Ni Luh Putu Eka Kartika Sari
Jurnal Rumpun Ilmu Kesehatan Vol. 6 No. 2 (2026): Juli: Jurnal Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v6i2.6676

Abstract

Cardiac arrest causes global ischemia followed by reperfusion injury, resulting in diffuse myocardial damage and cardiac troponin release. This condition is commonly associated with type 2 myocardial injury caused by an imbalance between myocardial oxygen supply and demand rather than acute coronary occlusion. This article summarizes evidence on the cellular and molecular mechanisms of type 2 myocardial injury and troponin release after cardiac arrest. A narrative literature review was conducted using articles published between 2015 and 2025 from PubMed and Google Scholar. The findings indicate that ischemia causes ATP depletion, ionic imbalance, intracellular calcium overload, and mitochondrial dysfunction. Reperfusion further aggravates myocardial injury through reactive oxygen species generation, inflammasome activation, pro-inflammatory cytokine release, apoptosis, and pyroptosis. These processes impair cardiomyocyte membrane integrity and cause structural damage, leading to troponin release. Troponin elevation may reflect reversible membrane permeability changes or irreversible cardiomyocyte injury. Therefore, high-sensitivity cardiac troponin levels should be interpreted according to pathophysiological mechanisms and clinical context to distinguish type 2 myocardial injury from myocardial infarction caused by acute coronary occlusion.
Co-Authors Agnestina Agnestina Arlends Chris Chrismerry Song Denny Denny Dewi Sukmawati Hadisono Hadisono I Made Nasar Irmawati Hassan Jeanne A. Pawitan Jeanne Adiwinata Pawitan Karjadidjaja, Idawati Kevin Pratama Diliano Siswoto Lia Damayanti Liem, Isabella Kurnia Luluk Hermawati Maharani, Fauziah Dea Ratna Melisa Leviana Neshya Ruriana Putri Ni Luh Putu Eka Kartika Sari Radiana D. Antarianto Ria Margiana Santoso Cornain Santoso, Alexander Halim Sari Mariyati Dewi Nataprawira Siska Yulianti Siswoto, Kevin Pratama Diliano Tasdin, Willy Wahyuni, Octavia Dwi Yefta Moenadjat