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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Science and Technology Indonesia Majalah Farmaseutik BULETIN AL-RIBAATH Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Sasambo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Rise Desnita, Rise
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Science and Technology Indonesia

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Development and Validation of the RP-HPLC Method for Dexamethasone Sodium Phosphate Determination in Nasal Chitosan Microsphere Preparations Desnita, Rise; Noviana, Eka; Zai, Khadijah; Sulaiman, Teuku Nanda Saifullah
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.165-172

Abstract

The purpose of this work was to provide a robust, sensitive, accurate, and straightforward analytical method for measuring dexamethasone sodium phosphate (DSP) in chitosan microspheres preparedn using the spray drying method. DSP was quantitatively analyzed using RP-HPLC with an ultraviolet detector at 254 nm, a mobile phase that contained a mixture of acetonitrile and 0.1% sodium dihydrogen phosphate monohydrate (50:50) operating isocratically at a flow rate of 1.0 mL/min, and a stationary phase that was a C18 PrincetonSPHER-100 C18-QB 100A HPLC Column (250 × 4.6 mm, 5 um). The ICH recommendations were followed in the validation of the analytical method. DSP had a retention duration of 2.899 minutes and a tailing factor of 0.827. The RP-HPLC method was linear (R = 0.9992) in the 15-60 ug/mL concentration range. The limits of quantitation (LOQ) and detection (LOD) were 4.425 ug/mL and 1.327 ug/mL, respectively. The relative standard deviations for the intra-day and inter-day precisions were 0.057-0.876% and 0.780-0.949%, respectively. The recovery percentages at 50, 100, and 200% concentration levels were within the 99.269-100.980% range. The validated method has been successfully applied to determine DSP entrapment efficiency in chitosan microspheres. A linear, sensitive, accurate, precise, and robust technique of determining DSP in chitosan microsphere preparations is offered by the established RP-HPLC method.
Co-Authors ., Saraswati Anastasia, Desy Siska Anggraini, Silvana Anugrah, Gusti Alfi Apridamayanti, Pratiwi Arianda, Muhammad Fikri Arief Nurrochmad Dea Pertiwi Dean Vuai, Felix Ryan Eka Kartika Untari Eka Noviana Hairunnisa, Syarifah Halim, Clara Maretta Hariyanto IH Herlina, Tutun Isnindar Isnindar Kasim, Zainab kasim, zainab Kurniawan, Uray Sandy Luliana, Sri Mariasy, Henny Muhammad Akib Yuswar Mutiara Dinda Putri Nera Umilia Purwanti, Nera Umilia Nora Nurlina Sinaga Novi Yana Santika Nur Atikah Oktavia, Ayu Diah Pratiwi Apridamayanti Putri, Mutiara Dinda Ronny Martien Salim, Suaina Sari, Putri Kemala Sehro Sehro Sehro, Silvana Anggraini Siska Anastasia, Desy Sulaiman, Teuku Nanda Saifullah Tamara, Olivia Utia Mufliha Variandini Aldhila Kharis Variandini Aldhila Kharis, Variandini Aldhila VENI LESTIAWATI Yuswar, Muhammad Akib zai, Khadijah Zainab Kasim