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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Jurnal BALIRESO Window of Health : Jurnal Kesehatan Batoboh : Jurnal Pengabdian Pada Masyarakat Journal of Pharmaceutical and Medicinal Sciences JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Pharmaceutical Reports Journal Microbiology Science JURNAL PENGABDIAN MASYARAKAT YAMASI Jurnal Pengabdian Farmasi dan Sains KOPEMAS MPSJ Jurnal Balireso: Jurnal Pengabdian pada Masyarakat
Masdiana Tahir
Fakultas Farmasi, Universitas Muslim Indonesia, Makassar
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antioxidant Activity Of Hydrolyzed Black Soybean (Glycine Soja Linn. Sieb.) By β-Carotene Bleaching Masdiana Tahir; Zainal Abidin; Nilla Sukmawati
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 1 (2017): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.021 KB)

Abstract

Black soybean (Glycine soja Linn. Sieb.) contain flavonoid compounds known as isoflavones. Isoflavones are kind of flavonoid which is the highest antioxidative activity exhibited by the isoflavones aglycones, especially genistein. Isoflavone glycosides containt in G. soja can be hydrolyzed to be aglycone (genistein) using an acid. The aim if this research was to investigate the antioxidant activity of the hydrolyzed G. soja extract that was obtained by β-carotene bleaching method. The result showed that the hydrolyzed G. soja extract has the value of antioxidant activity 42.8% and 81.1% for the standards solution of quercetin. Therefore, it can conclude that the hydrolyzed G. soja extract has the efficacy as an antioxidant.
Analysis of Lycopene and Vitamin C Levels of Pomelo Citrus Fruit (Citrus maxima (Burm) Merr) Red n White Varieties From South Sulawesi Masdiana Tahir; A. Trihadi Kusuma; Ekawati Ekawati
JCPS (Journal of Current Pharmaceutical Sciences) Vol 2 No 1 (2018): September 2018
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Pomelo citrus (Citrus maxima (Burm) Merr) is a fruit plant that has many chemical ingredients that are beneficial to health, including lycopene, flavonoids, provitamin A, vitamin C, pectin, carbohydrates, retinol, calcium and phosphorus. Lycopene is a bright red carotenoid pigment, which is found in red fruits as well as vitamin C. The purpose of this study was to determine of lycopene and vitamin C levels in pomelo citrus (Citrus maxima (Burm) Merr) red and white varieties from Pangkep Regency, South Sulawesi. The method using UV-Vis Spectrophotometry, at a wavelength of 471 nm for lycopene and 494 nm for vitamin C. The results showed that levels of lycopene pomelo citrus red variety was 32,444 mg/kg and white variety 2,801 mg/kg. Levels of Vitamin C in pomelo citrus red variety was 0,721 mg/g and white variety 0,107 mg /g. The content of lycopene and vitamin C of pomelo citrus red variety is greater than of white variety.
AKTIVITAS SENYAWA FLAVANOID EKSTRAK ETANOL BUNGA KERSEN (Muntingia calabura L) SEBAGAI TABIR SURYA Masdiana Tahir; Rahmawati Rahmawati; St Maryam; Putri Nurfauziah; Naura Nazhifah
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.839

Abstract

Chronic exposure to ultraviolet rays from the sun might result in oxidative stress, changes in the structure and composition of the skin. Sunscreen preparations are recommended to be used to prevent or minimize the harmful effects of UV rays on the skin. Sunscreen can be obtained from natural ingredients, one of which is the flower of cherry (Muntingia calabura L.). This study aims to identify the content of flavonoids and test the sunscreen activity of the ethanol extract of cherry flower (Muntingia calabura L.) in vitro using the UV-Vis spectrophotometric method based on the SPF value. Flavonoids are claimed to be capable to blocking ultraviolet (UV) light-induced radicals that have a protective effect against UV radiation, where the SPF value is a universal measure that describes the potency of a UV defense material. The findings of this study showed that the ethanol extract of cherry flowers positively contained flavonoid compounds including the flavonol, flavanone, and anthocyanidin groups. The results of the sunscreen activity test showed that the ethanol extract of cherry flowers had sunscreen activity at a concentration of 0.01% with an SPF value of 10.9 (moderate SPF), 0.05% with an SPF value of 41.6 (high SPF), 0,15% with an SPF value of 45.5 (high SPF). and 0.25% with an SPF value of 48.7 (high SPF). The higher the extract concentration, the higher the SPF value indicating the greater the activity as sunscreen.
Pembuatan Sabun Padat dan Sosialisasi Hidup Sehat di Desa Kamiri, Kecamatan Balusu, Kabupaten Barru Aminah, Aminah; Tahir, Masdiana; Abidin, Zainal
Batoboh Vol 8, No 1 (2023): BATOBOH : JURNAL PENGABDIAN PADA MASYARAKAT
Publisher : Institut Seni Indonesia Padangpanjang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26887/bt.v8i1.1367

Abstract

Corona merupakan virus terbaru yang sedang melanda dunia saat ini, hal ini mengingatkan kita agar pentingnya menjaga kebersihan diri sebelum melaksanakan kegiatan/rutinitas keseharian kita. Masyarakat saat ini sangat membutuhkan informasi berupa literasi, edukasi terkait cara menangkal virus.  Salah satu cara penangkalan virus ini dengan cara menjaga pola hidup sehat dan bersih dengan rajin mencuci tangan menggunakan sabun. Identifikasi masalah di lapangan desa kemiri bahwa adalah kurangnya kesadaran pola hidup bersih dan sehat yang terjadi di kalangan rumah tangga, dan lingkungannya. Alhasil banyak diantaranya menganggap sepele terkait virus korona ini, kurangnya pembiasaan diri untuk mencuci tangan dengan sabun. Sehingga dilakukan sosialisasi berupa penyuluhan cuci tangan yang benar dan pembuatan sabun padat yang ramah lingkungan dan berbahan dasar rumah tangga serta pemberian poster cuci tangan yang benar.  Kegiatan dihadiri oleh peserta sebanyak ±40 orang terdiri atas warga dan kelompok PKK. Kegiatan ini mulanya diberikan penjelasan tentang virus corona dan penyebarannya, lalu  melakukan demosntrasi cara pembuatan sabun padat berbahan dasar dapur rumah tangga, membuat sabun padat secara langsung dan pemberian poster cuci tangan yang benar.Kata Kunci:    sabun padat;  desa Kamiri; hidup sehat; Barru.
STUDI IN SILICO SENYAWA AKTIF DARI JAHE (Zingiber officinale) DAN KERSEN (Muntingia calabura L.) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) DARI SARS-CoV-2 Tahir, Masdiana; Maryam, St.
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1070

Abstract

Coronavirus disease is an infectious disease caused by the SARS-CoV-2 coronavirus, which is an RNA virus consisting of four structural proteins and sixteen non-structural proteins responsible for viral multiplication. One of the proteins is the main protease (Mpro). Inhibition of Mpro is potentially effective as a COVID-19 drug because it will cause the loss of the virus's replication and transcription abilities, so that the virus is unable to survive. The purpose of this study is to determine what chemical compounds in ginger (Zingiber officinale) and kersen (Muntigia calabura) plants have the potential as COVID-19 drugs with the Mpro inhibition mechanism. This research method is in silico using molecular docking method with PyRX software. The results showed that of the 70 chemical compounds from ginger (Zingiber officinale), there are 3 compounds that have potential because they have better activity than the N3 inhibitor comparison ΔG -8.0 kcal/mol, namely Zingiberoside B (-8.6 kcal/mol), Zingiberoside C (-8.5 kcal/mol) and Shogasulfonic acid D (-8.2 kcal/mol). Meanwhile, of the 10 chemical compounds from Jamaica cherry (Muntigia calabura), there are 4 chemical compounds that have potential as Mpro SARS-CoV-2 inhibitors, namely Kempferol 7-(6''-p-coumarylglucoside) or Biondnoid A (-9. 1 kcal/mol), Hiravanone (-8.4 kcal/mol), 5,7,3',4' - Tetrahydroxy - 6, 8 - di - C -prenylflavanone (-8.4 kcal/mol), and Myrtillin (-8.3 kcal/mol).
KANDUNGAN SENYAWA KIMIA DAN AKTIVITAS FARMAKOLOGI TANAMAN MATOA (Pometia Pinnata J.R. Forster & J.G. Forster) Rahmawati, Rahmawati; Tahir, Masdiana; Amir, A. Hesti Wulandasari
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v13i2.778

Abstract

Island lychee (Pometia pinnata J.R.Forster & J.G.Forster) is a plant species from the Sapidaecae family used as a medical plant that plays a role in healing or improving health condition of the community. This research aimed to determine the content of chemicah compound and pharmacologycal activity of several types of island lychee extract. The review on the study of the chemical content and pharmacologycal activity of island lychee was conducted by searching the literature related to chemical and pharmacologyal review accessed on several journal provide sites (google scholar). Then it was proceeded with screening on these journal to obtain sources that fall with in the inclution criteria. Island lychee has many properties that have been scientifically proven. Several types of the extract are reported to have pharmacologycal activity that can be develop as antioxidans, antibacterials, antimicrobials, antiperusemia, antihyperglycemic/antidiabetic, anticancer and diuretic. The pharmacologycal activity is due to the compound group of alkaloids, flavonoids, phenols, coumarin, polyphenol, saponin, steroids, tannins and terpenoids
Analysis of Artificial Sweeteners, Sodium Cyclamate, in Packaged Beverages and Powders by the Gravimetric Method Pratama, Shinta Indah; Suhaenah, Asriani; Tahir, Masdiana
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.267

Abstract

Most people like instant beverage products because of their practical processing and superior taste and creative packaging, thus attracting consumers to consume them. One of the food additives that is often used in instant beverage products is artificial sweeteners such as sodium cyclamate which has a sweetness level of 3.94 kcal/g or 30 times that of sucrose. This study aims to determine the levels of sodium cyclamate in packaged and powdered drinks circulating on the campus of the Indonesian Muslim University using the gravimetric method. The sampling method used a purposive technique and obtained 6 test samples, qualitative analysis used the precipitation method and obtained all positive samples containing sodium cyclamate. The results of the quantitative analysis obtained the levels of sodium cyclamate for each sample A; B; C; D; E; F as much as 37.07 mg/kg; 30.17 mg/kg; 12.93 mg/kg; 4.31 mg/kg; 340 mg/kg; 258 mg/kg. Thus, these results indicate that all samples do not exceed the levels set by BPOM regulation No. 11 of 2019 concerning food additives, namely 350 mg/kg, so they are safe for consumption.
Kersen (Cherry) (Muntingia calabura L) Leaves as an Alternative Plant Free Radical Scavenger in Improving the Immune System St. Maryam; Baits, Muzakkir; Tahir, Masdiana
Window of Health : Jurnal Kesehatan Vol 6 No 4 (October 2023)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.703

Abstract

Kersen (Cherry) (Muntingia calabura L) leaves are empirically used to treat various diseases because they contain flavonoid and tannin compounds. Based on previous research, it was reported that phenolic compounds, tannins, and flavonoids can potentially counteract free radicals so that they can improve the body's immune system. The purpose of this study was to determine the antioxidant activity of extracts of methanol, ethyl acetate, and n-hexane from cherry leaves (Muntingia calabura L.). The DPPH free radical scavenging method is based on the reduction of the colored DPPH free radical methanol solution by free radical inhibition. The extraction process of a compound is carried out to separate the material from the mixture using a suitable solvent. The existence of a level of polarity of a solvent used to attract the components of active compounds in plants is a guide for the search for new compounds in a plant. The potential of a compound to counteract free radicals can be determined by calculating the IC50. The results showed that the extract of methanol, ethyl acetate, and n-hexane of the cherry leaf (Muntingia calabura L.) had inhibitory activity against DPPH free radicals with IC50 values of 8.67; 9,097, and 18.17 g/mL. Meanwhile, gallic acid has inhibitory activity with an IC50 value of 1.77 g/mL. Methanol and ethyl acetate extracts of cherry leaves were able to inhibit DPPH activity in a very strong category, which was almost comparable to gallic acid, while n-hexane extract had antioxidant activity in a strong category.
PKM PEMBUATAN HAND SANITIZER PERASAN BUAH JERUK NIPIS (Citrus Aurantifolia S.) DAN GEL LIDAH BUAYA (Aloe vera L.) DI DESA KAMIRI KAB. BARRU SULAWESI SELATAN Masdiana Tahir; Aminah Aminah; Sukmawati Sukmawati
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) 2020
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Di awal tahun 2020, dunia digemparkan dengan adanya wabah virus Corona yang ditetapkan oleh WHO sebagai pandemik global. Virus ini menular dengan cepat dan telah menyebar ke beberapa negara, termasuk Indonesia. Sampai saat ini, belum ada vaksin untuk mencegah infeksi virus corona. Oleh sebab itu, cara pencegahan yang terbaik adalah menghindari faktor-faktor yang bisa menyebabkan kita terinfeksi virus tersebut. Salah satu pencegahannya adalah rajin mencuci tangan dengan air dan sabun atau menggunakan hand sanitizer. Sejak mewabahnya virus ini, penggunaan dan permintaan masyarakat Indonesia khususnya di Sulawesi Selatan terhadap sediaan hand sanitizer melonjak dan akhirnya langka dipasaran. Program ini bertujuan sebagai upaya preventif melalui pemanfaatan buah jeruk nipis dan lidah buaya yang ada sekitar masyarakat mitra dalam pembuatan handsanitizer. Masyarakat mitra PKM adalah ibu-ibu PKK desa Kamiri Kec. Balusu kab. Barru Sulawesi Selatan. Metode pelaksanaan program ini adalah metode ceramah atau peyuluhan dan pelatihan pembuatan handsatizer. Kegiataan PKM ini memberikan dampak positif yaitu menambah pengetahuan masyarakat desa Kamiri tentang penggunaan hand sanitizer dan memberikan keterampilan untuk membuat sendiri sediaan hand sanitizer dengan memanfaatkan bahan alam yang ada disekitar masyarakat
Antioxidant Activity of Water and Ethyl Acetate Fractions of Qust Al Hindi Root (Saussurea lappa) Using DPPH Inhibition Method Musdalifah, A.; Sukmawati, Sukmawati; Tahir, Masdiana
Pharmaceutical Reports Vol 3, No 2 (2024): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i2.312

Abstract

Free radicals are molecules that do not have an electron pair in the outer shell, making them highly reactive. Oxidation due to free radicals can be prevented and inhibited by substances, namely antioxidants. Natural antioxidants are obtained from plants or fruits, one of which is Qust al hindi (Saussurea lappa).  Qust al hindi is a plant native to India that is used as a traditional medicine. Qust al hindi contains various phytochemical compounds, one of which is flavonoid compounds that function as antioxidants. The purpose of this study was to analyze the antioxidant activity of water and ethyl acetate fractions of qust al hindi plant roots by 1,1-diphenyl-2picrylhydrazyl (DPPH) silencing method using UV-Vis spectrophotometry based on the calculation of IC50 value using GraphPad Prism Application. The results of this study indicate that the water and ethyl acetate fractions of qust al hindi plant roots have antioxidant activity against DPPH free radicals with IC50 values of 203.5 µg/mL; 193.3 µg/mL, respectively, which are included in the very weak and weak antioxidant groups.
Co-Authors A. Muflihunna A. Muflihunna A. Trihadi Kusuma Afifah Amdar, Andi Aminah Aminah Aminah Aminah Amir, A. Hesti Wulandasari Amula, Andi Tenri Anak Agung Istri Sri Wiadnyani Anda Cahya Heluth arniati, arniati Asriani Suhaenah Azzahra, Resqinah Desi, Nilma Sri Ekawati Ekawati Evatiara, Nur Fitriana Fitriana Hadi, Daryono Hamdhan, Aulia Nurul Insani Harti Widiastuti Hasyim, Amita ISRANANDA, DWI Kaisupy, Siti Sumayya Mamat Pratama, Mamat Maskur, Sri Karina Mochammad Imron Awalludin mondo, zhafira anggraini Muammar Fawwaz Musdalifah, A. Muzakkir Baits, Muzakkir Nasra Nasra Naura Nazhifah Nilla Sukmawati Nurlina Nurwijayanti Permatasari, Andi Pratama, Shinta Indah Putri Nurfauziah Putri, Adinda Rahmawati Rahmawati Rahmawati, Rahmawati Rais Razak, Rais Safitri, Ineks Salahuddin, Muthia Amaliah Sari, Wina Astri Saskia, Eka Putri Seniwati Seniwati, Seniwati Sophi Damayanti St Maryam St Maryam, St St. Maryam, St. Suhaenah, Asriani Suhaenah Sukmawati Sukmawati Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Sumardi, Farah Hikmah Nur Syafrianti Syafrianti Tjahyono Tjahyono Wahdania, Andi Yulinda Rahim Zainal Abidin Zainal Abidin Zainal Abidin