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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Jurnal BALIRESO Window of Health : Jurnal Kesehatan Batoboh : Jurnal Pengabdian Pada Masyarakat Journal of Pharmaceutical and Medicinal Sciences JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Pharmaceutical Reports Journal Microbiology Science JURNAL PENGABDIAN MASYARAKAT YAMASI Jurnal Pengabdian Farmasi dan Sains KOPEMAS MPSJ Jurnal Balireso: Jurnal Pengabdian pada Masyarakat
Masdiana Tahir
Fakultas Farmasi, Universitas Muslim Indonesia, Makassar
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antioxidant Activity Analysis of Endophytic Fungal Isolates IFBZ5, IFBZ6, and IFBZ7 from the Stem of Bidara (Ziziphus mauritiana Lam.) Fitriana, Fitriana; Tahir, Masdiana; Hamdhan, Aulia Nurul Insani; Sumardi, Farah Hikmah Nur; Putri, Adinda
Journal Microbiology Science Vol 5, No 1 (2025)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v5i1.1193

Abstract

Endophytic fungal isolates coded IFBZ5, IFBZ6, and IFBZ7 derived from the stem of the bidara plant (Ziziphus mauritiana Lam.) have shown potential antioxidant properties. This study aims to test the antioxidant activity of endophytic fungal isolates on the bidara plant stem (Ziziphus mauritiana Lam.) by TLC-Autography method and DPPH (1,1-diphenyl-2-picrylhydrazil) free radical silencing. This study used endophytic fungi isolates code IFBZ-5, IFBZ-6 and IFBZ-7 which were fermented for 21 days using MYB medium which was then liquid-liquid extracted with ethyl acetate (1:1) and evaporated. The fermentate extract obtained was then tested for antioxidant activity qualitatively and quantitatively. Qualitative analysis using TLC plates indicated antioxidant activity in all isolates. Quantitative analysis showed that isolate IFBZ7 exhibited strong antioxidant activity with an IC50 value of 50.120 ppm, while IFBZ5 and IFBZ6 showed very weak activity with IC50 values of 2.482.363 µg/mL and 467.847 µg/mL, respectively. The BHT comparator had an IC50 value of 6.778 µg/mL. This shows that the antioxidant power of endophytic fungal isolates coded IFBZ5, IFBZ6 and IFBZ7 is lower than the antioxidant activity of BHT as a comparison.
In Vitro Anti-Inflammatory Activity of Bajakah Tampala Root (Spatholobus littoralis Hassk.) Maskur, Sri Karina; Tahir, Masdiana; Razak, Rais
Pharmaceutical Reports Vol 4, No 1 (2025): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v4i1.358

Abstract

Bajakah tampala root (Spatholobus littoralis Hassk.) contains phenolic compounds, flavonoids, tannins, terpenoids and saponins. Flavonoid compounds have pharmacological effects, namely anti-inflammatory. The purpose of this study was to determine the anti-inflammatory activity of ethanol extract of bajakah tampala root by inhibiting protein denaturation in vitro using UV-Vis spectrophotometer and diclofenac sodium as positive control. The extract was prepared by maceration method using 96% ethanol solvent. The results showed that the ethanol extract of bajakah tampala root had a percentage of inhibition of 31.27% at the lowest concentration (10 ppm) and 43.28% at the highest concentration (50 ppm) with an IC50 value of 77.92 µg/mL and the ic50 value of diclofenac sodium is 12.26 µg/mL. The percentage of inhibition that is more than 20% is considered to have inhibitory power in the protein denaturation process. So, it can be concluded that the ethanol extract of bajakah root has potential as an anti-inflammatory.
Analisis Pektin Albedo Buah Jeruk Pamelo sebagai Adsorben Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu): Pectin Analysis of Pamelo Citrus Albedo (Citrus maxima (Burm.f) Merr.) as Adsorbent of Heavy Metal Plumbum (Pb), Cadmium (Cd) and Copper (Cu) Tahir, Masdiana; Safitri, Ineks; Suhaenah, Asriani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.08 KB) | DOI: 10.22487/j24428744.2019.v5.i2.12134

Abstract

Pamelo citrus is a fruit plant having the potential to be developed in Indonesia. One of the centers for producing large oranges or Pamelo citrus in South Sulawesi is Pangkep Regency. One of the components of the Pamelo citrus is pectin. Pectin is a polysaccharide compound with a high molecular weight which is widely found in plants and it can absorb metals because they contain carboxylic groups. This study aimed to analyze pectin from albedo pamelo citrus fruit as an adsorbent for heavy metal plumbum (Pb), cadmium (Cd) and copper (Cu). The method used was atomic absorption spectrophotometer with the equation analysis of heavy metal adsorption by pectin of pamelo citrus determined by Langmuir and Freundlich adsorption isothermal method. The results showed that pectin of albedo pamelo citrus following the isothermal of Freundlich adsorption which showed the adsorbent capacity of Pb, Cd and Cu with the KF values 0.561 mg/g, 0.010 mg/g and 0.066 mg/g, respectively. Meanwhile, n values were 0.823 for Pb, 0.321 for Cd and 1.121 for Cu, and in commercial pectin following the isothermal of Freundlich adsorption with the KF values of Pb, Cd and Cu were 0.650 mg/g, Cd 0.015 and Cu of 0.77 mg/g, respectively. Then the n values were 0.641 for Pb, 0.811 for Cd and 1.183 for Cu.
PENGUJIAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BUNGA KERSEN (Muntingia calabura L.) MENGGUNAKAN METODE FRAP Kaisupy, Siti Sumayya; Maryam, St; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 3 No 1 (2025)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v3i1.324

Abstract

Kersen Flower (Muntingia calabura L.) contains several chemical compounds, including flavonoids, tannins, triterpene, saponins and polyphenols that play a role in antioxidant activity. This study aims to determine the antioxidant activity and determine the antioxidant activity value of ethanol extract Muntingia Flower (Muntingia calabura L.) using FRAP (Ferry Reducing Antioxidant Power) method. Extraction was done using maceration method and measurement was done using UV-Vis spectrophotometry method at wavelength of 715 nm. The comparator used was quercetin. The results showed that the concentration of antioxidant activity Muntingia Flower using FRAP method was 684.209 mgQE/g which showed high activity.
Determination of Tannin in Ethanol Extract of Bajakah Tampala Root (Spatholobus littoralis Hassk) as an Anticholesterol Saskia, Eka Putri; Tahir, Masdiana; Suhaenah, Asriani
Pharmaceutical Reports Vol 4, No 2 (2025): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v4i2.377

Abstract

The root of Bajakah Tampala (Spatholobus littoralis Hassk.) is known to contain several bioactive secondary metabolites, including saponins, flavonoids, phenolics, and tannins, which contribute to its broad pharmacological potential. Among these compounds, tannins play an important role in various therapeutic applications such as hemostasis, burn treatment, and the management of diarrhea, dysentery, and tumors. In addition, tannins possess anticholesterol properties by precipitating mucosal proteins on the surface of the small intestine, thereby reducing the absorption of cholesterol and lipids into the bloodstream. This study aimed to determine the tannin content in the ethanol extract of Bajakah Tampala root as part of an investigation into its potential as a natural anticholesterol agent. The extraction process was carried out using the maceration method with 96% ethanol as the solvent to ensure efficient recovery of phenolic compounds. Quantitative analysis of tannin content was performed using the UV-Visible spectrophotometric method at a wavelength of 750 nm, with gallic acid employed as the standard reference compound. The results showed that the tannin concentration in the ethanol extract of Bajakah Tampala root was 91.699 mg GAE/g extract (milligrams of gallic acid equivalent per gram of extract). These findings suggest that Bajakah Tampala root possesses a high tannin content, supporting its potential development as a natural anticholesterol agent and contributing to the growing evidence of its pharmacological benefits in traditional medicine.
PENYULUHAN DAN PELATIHAN PEMBUATAN PRODUK NANO SPRAY FACEMIST BERBAHAN DASAR LEMON PADA IBU-IBU PKK DI DESA PADDINGIN, KEC. SANROBONE. KAB. TAKALAR Suhaenah, Asriani Suhaenah; Tahir, Masdiana; Afifah Amdar, Andi; Isrananda, Dwi
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 1 No. 2 (2023): April 2023
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2023.v1.i2.16199

Abstract

ABSTRAK Kegiatan pengabdian masyarakat dilakukan di desa paddingin, kecamatan sanrobone. Mata pencaharian penduduk tergolong lebih beragam, mulai petani, peternak, wirausaha, hingga PNS. Pekerjaan sebagai petani menempati persentase paling tinggi di daerah tersebut. Dalam seminggu petani rata-rata menghabiskan waktu sekitar 33 jam untuk bekerja atau sekitar 4,7 jam per harinya. Pekerjaan dimulai sejak pagi hari dan berakhir saat siang atau sore hari sehingga saat bekerja petani akan terpapar sinar matahari. Paparan sinar matahari terus-menerus dan berkelanjutan bisa menyebabkan beberapa masalah pada kulit, sinar ultraviolet akan menyebabkan kulit menjadi lebih gelap, keriput, kusam , kering, timbul bercak kecokelatan (melasma) hingga kanker kulit. Tujuan pengabdian ini untuk memberikan penyuluhan dan pelatihan pembuatan facemist berbahan dasar lemon sehingga masyarakat mampu membuat sendiri dan dapat dimanfaatkan untuk keluarga dekat. Mitra pengabdian adalah Ibu-Ibu PKK di desa paddingin, dan hasil dari kegiatan ini, masyarakat mampu memahami dan bisa mengimplementasikan pembuatan facemist berbahan dasar lemon sehingga dapat dimanfaatkan oleh masyarakat khusunya yang bekerja sebagai petani sehingga dapat terlindungi dari paparan sinar matahari. Kata Kunci : Facemist, lemon, nano spray ABSTRACT Community service activities are carried out in Paddinding village, Sanrobone district. The livelihoods of the population are classified as more diverse, from farmers, ranchers, entrepreneurs, to civil servants. Employment as a farmer occupies the highest percentage in the area. In a week the average farmer spends about 33 hours working or about 4.7 hours per day. Work starts in the morning and ends in the afternoon or evening so that when working farmers will be exposed to sunlight. Continuous and continuous exposure to sunlight can cause several problems with the skin, ultraviolet light will cause the skin to become darker, wrinkles, dull, dry, brown spots (melasma) to skin cancer. The purpose of this service is to provide counseling and training in making face mist made from lemon so that people are able to make their own and can be used for their close families. The service partners are PKK women in Paddinding village, and as a result of this activity, the community is able to understand and can implement making face mist made from lemon so that it can be used by the community, especially those who work as farmers so they can be protected from sun exposure.
UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT DAUN KARET KEBO (Ficus elastica) DENGAN MENGGUNAKAN METODE FRAP Hasyim, Amita; Suhaenah, Asriani; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.76

Abstract

Free radicals are atoms, molecules or compounds that can stand alone, having one or more unpaired electrons in their outermost orbitals. Antioxidants are molecules that are able to deactivate or stabilize free radicals. The kebo rubber leaf plant is known to have benefits as an antioxidant because it contains ingredients such as glycosides, flavonoids, phenolic acids, alkaloids, steroids, saponins, coumarins, tannins, and triterpenoids. The aim of this research was to test the antioxidant activity of the ethyl acetate fraction of kebo rubber leaves (Ficus elatica) using the FRAP (Ferric Reducing Antioxidant Power) method. The rubber kebo leaf extraction method uses the maceration method with 96% ethanol solvent. The ethanol extract was fractionated using the liquid-liquid partition method to obtain the ethyl acetate fraction. the sample fraction was added with several FRAP reagents and then measured using a UV-Vis spectrophotometer at a maximum wavelength of 712 nm with quercetin as a comparison. The results showed that the ethyl acetate fraction of kebo rubber leaves for antioxidant activity was 26.692 mgQE/g fraction.
AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE DARI EKSTRAK BUNGA KERSEN (Muntingia calabura L.) SECARA IN VITRO Azzahra, Resqinah; Maryam, St.; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 3 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i3.80

Abstract

The cherry tree is one of the plants that has great potential to be utilized because it contains several beneficial bioactive compounds, one of which is flavonoids.. The purpose of this research is to determine the alpha-glucosidase enzyme inhibition activity of an ethanol extract of cherry blossoms (Muntingia calabura L.) in vitro using a microplate reader instrument. The research method begins with preparing the sample by maceration using 96% ethanol as a solvent, followed by testing the inhibition of alpha-glucosidase enzyme activity using p-nitrophenyl- α-D-glucopyranoside (PNPG) substrate and acarbose as a comparison. The potential of a compound to inhibit enzyme activity can be determined by calculating the IC50. The results showed that the ethanol extract of cherry blossoms (Muntingia calabura L.) has an IC50 value of 135.53 µg/mL, higher than the IC50 value of acarbose at 41.17 µg/mL.
Analisis Kadar Senyawa Polifenol Dari Teh Daun Tanaman Cacao (Theobroma cacao L.) Secara Spektrofotometri UV-Vis Desi, Nilma Sri; Maryam, St.; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.242

Abstract

. Cocoa leaves (Theobroma cacao L.) contain secondary metabolites such as polyphenol compounds, flavanoids, saponins and tannins which are the largest group of phenolic compounds that act as antioxidant compounds. This study aims to determine the levels of polyphenolic compounds produced from cocoa leaf tea preparations (Theobroma cacao L.) based on the comparison of growing places, namely the Wajo, Jeneponto and Malino regions. Quantitative analysis using UV-Vis spectrophotometric method. based on qualitative analysis by Thin Layer Chromatography method using mobile phase n- hexanes: ethyl acetate: methanol with a ratio (2: 7: 2). Based on the results showed that the preparation of cocoa leaf tea (Theobroma cacao L.). As well as quantitative analysis measured at a maximum wavelength of 768 nm with gallic acid comparator standard. Tea samples contain polyphenolic compounds based on the Rf value equivalent to gallic acid comparator of 0.6. based on the analysis of levels from the Wajo area of 16.238 mgGAE/g, Jeneponto area 18.102 mg/GAE/g, and Malino area 6, 752 mgGAE/g and rf value of gallic acid comparator 0.630; rf value of samples from Jeneponto area 0.6; Wajo 0.6 and Malino 0.615. From the above results, it can be concluded that there are polyphenol compounds in tea samples from each region and the largest polyphenol content is found in the Jeneponto area.
UJI AKTIVITAS ANTIOKSIDAN PADA EKSTRAK ETANOL DAUN KAKAO (Theobroma cacao L.) DENGAN PERBANDINGAN BERDASARKAN TEMPAT TUMBUH DENGAN METODE PEREDAMAN RADIKAL BEBAS DPPH Salahuddin, Muthia Amaliah; Maryam, St.; Tahir, Masdiana
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 2 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i2.268

Abstract

Kakao (Theobroma cacao L.) merupakan salah satu tanaman yang mengandung senyawa metabolit sekunder yaitu flavonoid, saponin dan tanin. Secara empiris daun kakao digunakan sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol daun kakao (Theobroma cacao L.) dengan perbandingan berdasarkan tempat tumbuh menggunakan metode peredaman radikal bebas DPPH (2,2-Difenil-1-Pikrilhidrazil) dengan parameter nilai IC50. Berdasarkan hasil yang diperoleh, hasil uji kualitatif menunjukkan adanya metabolit sekunder yang terkandung dalam esktrak etanol daun kakao seperti alkaloid, fenolik, flavonoid, saponin, dan tanin serta diperoleh nilai IC50 ekstrak etanol daun kakao daerah Jeneponto sebesar 24,658 µg/mL kategori sangat kuat, daerah Malino 59,742 µg/mL kategori kuat, serta Wajo 56,898 µg /mL kategori kuat dengan perbandingan baku pembanding yaitu kuersetin dengan nilai IC50 sebesar 1,882 µg/mL kategori sangat kuat. keyword: Theobroma cacao L., antioksidan, IC50;
Co-Authors A. Muflihunna A. Muflihunna A. Trihadi Kusuma Afifah Amdar, Andi Aminah Aminah Aminah Aminah Amir, A. Hesti Wulandasari Amula, Andi Tenri Anak Agung Istri Sri Wiadnyani Anda Cahya Heluth arniati, arniati Asriani Suhaenah Azzahra, Resqinah Desi, Nilma Sri Ekawati Ekawati Evatiara, Nur Fitriana Fitriana Hadi, Daryono Hamdhan, Aulia Nurul Insani Harti Widiastuti Hasyim, Amita ISRANANDA, DWI Kaisupy, Siti Sumayya Mamat Pratama, Mamat Maskur, Sri Karina Mochammad Imron Awalludin mondo, zhafira anggraini Muammar Fawwaz Musdalifah, A. Muzakkir Baits, Muzakkir Nasra Nasra Naura Nazhifah Nilla Sukmawati Nurlina Permatasari, Andi Pratama, Shinta Indah Putri Nurfauziah Putri, Adinda Rahmawati Rahmawati Rahmawati, Rahmawati Rais Razak, Rais Safitri, Ineks Safruddin Salahuddin, Muthia Amaliah Sari, Wina Astri Saskia, Eka Putri Seniwati Seniwati, Seniwati Sophi Damayanti St Maryam St Maryam, St St. Maryam, St. Suhaenah, Asriani Suhaenah Sukmawati Sukmawati Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Sumardi, Farah Hikmah Nur Syafrianti Syafrianti Tjahyono Tjahyono Wahdania, Andi Yulinda Rahim Zainal Abidin Zainal Abidin Zainal Abidin