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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Jurnal BALIRESO Window of Health : Jurnal Kesehatan Batoboh : Jurnal Pengabdian Pada Masyarakat Journal of Pharmaceutical and Medicinal Sciences JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Pharmaceutical Reports Journal Microbiology Science JURNAL PENGABDIAN MASYARAKAT YAMASI Jurnal Pengabdian Farmasi dan Sains KOPEMAS MPSJ Jurnal Balireso: Jurnal Pengabdian pada Masyarakat
Masdiana Tahir
Fakultas Farmasi, Universitas Muslim Indonesia, Makassar
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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ANALISIS BAHAN KIMIA OBAT NATRIUM DIKLOFENAK PADA SEDIAAN JAMU PEGAL LINU YANG BEREDAR DI MAKASSAR Tahir, Masdiana; Maryam, St; Wahdania, Andi
Window of Health : Jurnal Kesehatan Vol. 1 No. 4 (Oktober, 2018)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.233 KB)

Abstract

Jamu pegal linu merupakan salah satu produk obat tradisional yang banyak diminati oleh masyarakat, karena dapat menghilangkan nyeri otot dan tulang, memperlancar peredaran darah, memperkuat daya tahan tubuh serta menghilangkan sakit diseluruh badan. Salah satu bahan kimia obat yang sering ditambahkan dalam jamu pegal linu adalah natrium diklofenak. Penelitian ini bertujuan untuk menganalisis kandungan bahan kimia obat natrium diklofenak pada sediaan jamu pegal linu. Jamu pegal linu yang digunakan pada penelitian ini yaitu 7 macam merek jamu pegal linu yang beredar di kota Makassar. Dengan kriteria jamu yang paling banyak diminati oleh masyarakat. Analisis kualitatif bahan kimia obat natrium diklofenak dilakukan dengan kromatografi lapis tipis (KLT), menggunakan fase diam silika gel dan  fase gerak etil asetat : asam asetat glasial : toluen (60:40:1). Hasil analisis menunjukkan sampel A, C dan G positif mengandung natrium diklofenak dengan nilai Rf sama dengan standar natrium diklofenak yaitu Rf= 0,69. Analisis kuantitatif secara spektrofometri UV-Vis pada panjang gelombang 280 nm dengan variasi konsentrasi 4, 6, 8, 10, 12, 14, dan 16 ppm, diperoleh kadar natrium diklofenak untuk sampel jamu A dengan kadar 154 mg/g, sampel C 28,302 mg/g, dan sampel G 6,908 mg/g. Kata kunci :     Natrium diklofenak, jamu pegal linu, Spektrofotometri UV-Vis
StudiIn SilicoSenyawaTurunan8-Tersubtitusi-7-Methoxy-2h-Chromen-2-OneSebagaiPenghambatEnzim Telomerase Tahir, Masdiana; Damayanti, Sophi; Hadi, Daryono; Tjahyono, Tjahyono
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.588

Abstract

Adjustment of telomere length by telomerase is considered as a biological marker which determine the proliferation of cancer cells. The telomerase activity in cancer cells is potential to be targeted for cancer therapies. The aim of this study was QSAR studies to determine the descriptors that affect the anticancer activity of 8-substituted-7-methoxy-2H-chromen-2-one derivatives. The descriptors were calculated by using software MOE® 2009.10. to design new derivative compounds that have anticancer potency, to predict pharmacokinetic properties by using preADMET, and to predict tocixity by ADMET predictorTM and interaction predict to telomerase by using Autodock 4.2.6  The results showed QSAR equation was log IC50 = -1.358 (± 1.149) - 2.957 (± 1.019) × AM1_LUMO + 0.041 (± 0.011) × E_vdw + 2.367 (± 0.748) × glob + 0.487 (± 0.100) × log S. Fourteen of the new derivative compounds were designed based on QSAR equation revealed higher activity prediction than the lead compound and performed good absorption in the intestine. Compound (33) is predicted to have low permeability in Caco-2 cells and weakly bound to plasma proteins. Compound (50) predicted weakly bound to plasma proteins as well. Toxicity prediction showed that 9 derivatives compounds were predicted to have lower nearly equal toxicity to the toxicity of the lead compound. The study of the interaction of compounds with the receptor showed that derivatives (2), (4), (40) and (41) have the highest affinity to the receptor TERT with the binding free energy is −9.60 kcal / mol, −9.39 kcal / mol, −9.20 kcal / mol and -9.08 kcal / mol. Based on QSAR study, pharmacokinetic profile, toxicity, and the study of the interaction, four compounds have the potential to be develop as anticancer with telomerase inhibition.
StudiIn SilicoSenyawaTurunan8-Tersubtitusi-7-Methoxy-2h-Chromen-2-OneSebagaiPenghambatEnzim Telomerase Tahir, Masdiana; Damayanti, Sophi; Hadi, Daryono; Tjahyono, Tjahyono
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2960.084 KB) | DOI: 10.35617/jfi.v10i2.588

Abstract

Adjustment of telomere length by telomerase is considered as a biological marker which determine the proliferation of cancer cells. The telomerase activity in cancer cells is potential to be targeted for cancer therapies. The aim of this study was QSAR studies to determine the descriptors that affect the anticancer activity of 8-substituted-7-methoxy-2H-chromen-2-one derivatives. The descriptors were calculated by using software MOE® 2009.10. to design new derivative compounds that have anticancer potency, to predict pharmacokinetic properties by using preADMET, and to predict tocixity by ADMET predictorTM and interaction predict to telomerase by using Autodock 4.2.6  The results showed QSAR equation was log IC50 = -1.358 (± 1.149) - 2.957 (± 1.019) × AM1_LUMO + 0.041 (± 0.011) × E_vdw + 2.367 (± 0.748) × glob + 0.487 (± 0.100) × log S. Fourteen of the new derivative compounds were designed based on QSAR equation revealed higher activity prediction than the lead compound and performed good absorption in the intestine. Compound (33) is predicted to have low permeability in Caco-2 cells and weakly bound to plasma proteins. Compound (50) predicted weakly bound to plasma proteins as well. Toxicity prediction showed that 9 derivatives compounds were predicted to have lower nearly equal toxicity to the toxicity of the lead compound. The study of the interaction of compounds with the receptor showed that derivatives (2), (4), (40) and (41) have the highest affinity to the receptor TERT with the binding free energy is −9.60 kcal / mol, −9.39 kcal / mol, −9.20 kcal / mol and -9.08 kcal / mol. Based on QSAR study, pharmacokinetic profile, toxicity, and the study of the interaction, four compounds have the potential to be develop as anticancer with telomerase inhibition.
PENYULUHAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DI SD INPRES BORISALLO KECAMATAN PARANGLOE KABUPATEN GOWA Tahir, Masdiana; Suhaenah, Asriani; Aminah, Aminah
Jurnal Balireso: Jurnal Pengabdian pada Masyarakat Vol 4, No 2 (2019)
Publisher : Jurnal Balireso: Jurnal Pengabdian pada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.679 KB) | DOI: 10.33096/balireso.v4i2.121

Abstract

The village of Borisallo is a Development Partner Village of UMI in Gowa Regency. One of theeducational facilities is SD Inpres Borisallo where a school is a place of learning that can be athreat of disease transmission if it is not managed properly. Problems with children's healthbehavior are usually related to personal and environmental hygiene. By that, the planting of valuesof health behavior in elementary schools is an absolute necessity and an effort to realize "Healthyand Independent Community" as contained in the health profile of Gowa Regency. As for studentsin SD Inpres Borisallo as many as 102 children with 9 teaching staff. Ideally, the health ofelementary school children is monitored by UKS, but due to various limitations, the role of theUKS SD Inpres Borisallo has not been implemented optimally and there is no special handwashing place for students. The target to be achieved is to increase students' knowledge,awareness, willingness and ability to live clean and healthy lives, and be expected to play an activerole in realizing optimal health degrees, instilling clean and healthy behavioral values (PHBS),improving the practice of handwashing with soap true and became a habit in the daily lives of SDInpres Borisallo students. The approach taken to achieve the target is to provide clean and healthylife behavior counseling (PHBS) and socialization of how to wash hands with soap properly andcorrectly, procure posters on how to wash hands and procure water tap pipe installationinfrastructure for hand washing needs in SD Inpres Borisallo students.
POTENSI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAN FRAKSI N-HEKSAN BUAH JERUK PAMELO (Citrus maxima (Burm) Merr) ASAL KABUPATEN PANGKEP Masdiana Tahir; Asriani Suhaenah; Yulinda Rahim
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.488

Abstract

Pomelo citrus (Citrus maxima (Burm) Merr) is a fruit plant that has the potential to be developed for health. Pomelo fruit contains lycopene, flavonoids and vitamin C which can provide antioxidant activity. The purpose of this study was to determine the potential antioxidant activity of ethanol extract and fraction of n-hexane of pomelo citrus using quercetin as a comparison. Extraction of pomelo citrus fruit using the maceration method with liquid-liquid fractionation using water and n-hexane (1: 3 v / v). Testing of antioxidant activity using the DPPH (1,1-Diphenyl-2-picrylhidrazil) method is based on the ability of the sample to capture DPPH free radicals which are characterized by purple to yellow discoloration and a decrease in the absorbance value of DPPH which has reacted with samples in certain concentrations. Absorbance measurements using a UV-Vis spectrophotometer at a wavelength of 514,942 nm. The results showed that the IC50 value of quercetin was 6.55 µg / mL which was a strong antioxidant, while the IC50 value of the ethanol extract of pomelo citrus fruit was 2882.26 µg / mL and IC50 value of the n-hexane fraction of pomelo orange was 3668,44 µg / mL which is a weak antioxidant category. Kata kunci : Antioxidants, Ethanol Extract, n-Hexane Fraction, Pomelo citrus (Citrus maxima (Burm) Merr
PENENTUAN KADAR FENOLIK TOTAL EKSTRAK ETANOL DAUN NILAM (Pogostemon cablin Benth.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Masdiana Tahir; A. Muflihunna; Syafrianti Syafrianti
Jurnal Fitofarmaka Indonesia Vol 4, No 1 (2017): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (815.41 KB) | DOI: 10.33096/jffi.v4i1.231

Abstract

One of the plants that is well known in the community and is used as a traditional medicine is patchouli (Pogostemon cablin Benth.). It contains essential oils, flavonoids, saponins, tannins, glycosides, terpenoids and steroids. The alcohol content, such as patchouli alcohol and its derivatives, phenol, and a group of terpenoids in patchouli oil has antibacterial activity. The aim at this research to determine the total phenolic condition the ethanol extract from the patchouli leaves. The extract obtained was analyzed ist content using UV-Vis spectrophotometer. The measurements were done at the maximum wavelength of 662,85 nm. The result showed that the total phenolic in patchouli leave is 327,84 mgGAE /gram of extract.
ANALISIS KANDUNGAN VITAMIN C DAN β- KAROTEN DALAM DAUN KELOR (Moringa oleifra Lam.) DENGAN METODE SPEKTROFOTOMETRI UV–VIS Masdiana Tahir; Nurul Hikmah; Rahmawati Rahmawati
Jurnal Fitofarmaka Indonesia Vol 3, No 1 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1241.839 KB) | DOI: 10.33096/jffi.v3i1.173

Abstract

This research aimed to analyze the levels of vitamin C and β-carotene in Moringa leaves extract (Moringa oleifera Lam.) using UV-Vis spectrophotometry. Vitamin C on Moringa leaves are extracted with ethanol 96%. The extracts obtained was qualitatively analyzed of levels of vitamin C using specific reagents an iodine 1% and ammonium molybdate 5%. Than quantitatively using UV-Vis spectrophotometry at wavelength of 570 nm, obtained an verage grade of 7,96 mg/g. For β-carotene, Moringa leaves were extracted with acetone. The extract obtained was extracted again with ether, then saponified with KHO solvent 15% w/v in methanol, allowed to stand overnight. The extract obtained was extracted again with ether, then freed from wet with distilled water. Extracts were analyzed qualitatively using thin layer chromatography and quantitatively using UV-Vis spectrophotometry at wavelength of 450 nm and obtained an average grade of 3,31 mg/g.
Peningkatan Pemahaman Mengenai Menstruasi Melalui Penyuluhan Serta Pemeriksaan Golongan Darah Di Usia Dini Sukmawati Syarif; A. Muflihunna; Zainal Abidin; Masdiana Tahir
LOYALITAS: Jurnal Pengabdian Kepada Masyarakat Vol 3 No 2 (2020): November 2020
Publisher : IAI Darussalam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30739/loyal.v3i2.397

Abstract

Menstruation is a physiological change in a woman's body that occurs periodically and is influenced by reproductive hormones either FSH-Estrogen or LH-Progesterone. In women, this usually occurs every month between teens to menopause, and lasts around 7-28 days. Knowing the characteristics of menstruation early is a very important thing to know because it is an early learning about the reproductive system and their health. Blood type is an inherited antigen on the surface of red blood cells. The two most important types of blood classification to know are the classification of ABO and Rhesus (Rh factor). Blood type examination is an activity that is sometimes overlooked by the community, in this case the needs of the Blood Type are carried out for clinical purposes such as: blood transfusions, preventing transfusion complications, and for pregnant women. According to empirical data obtained in 2017 the level of understanding of menstruation and blood type in primary schools is very low. For this reason, efforts are made to provide education and information as well as checks on children from an early age as a starting point for character building in improving education and knowledge in general and specifically regarding health
PENENTUAN NILAI SPF (SUN PROTECTING FACTOR) EKSTRAK ETANOL JAMUR KANCING (Agaricus bisporus) SECARA IN VITRO DENGAN METODE SPEKTROFOTOMETRI UV-VIS Asriani Suhaenah; Masdiana Tahir; Nasra Nasra
As-Syifaa Jurnal Farmasi Vol 11, No 1 (2019): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.156 KB) | DOI: 10.33096/jifa.v11i1.523

Abstract

Chronic exposure to ultraviolet light from the sun will cause changes in skin structure and oxidative stress on the skin. The effects can be in the form of acute changes such as erythema, pigmentation and photosensitivity, as well as long-term effects of premature aging and skin damage. Sun Protection Factor (SPF) is a universal indicator that explains the effectiveness of a product or substance that is UV protection. Natural ingredients that can be used as UV protection are button mushrooms (Agaricus bisporus). This study aims to determine UV light protection activity in the ethanol extract of button mushrooms (Agaricus bisporus) based on the SPF values analyzed by UV-Vis spectrophotometry at wavelengths of 290-320 nm. The results showed that at concentrations of 1% and 2% had a medium SPF category with SPF values of 17,762 and 28,643. For concentrations of 3% and 4% it has a high SPF category with SPF values of 30,592 and 31,325. The higher the concentration used, the better the SPF value.
UJI AKTIVITAS ANTIOKSIDAN BUAH SEMANGKA (Citrullus lanatus) DENGAN METODE FRAP Masdiana Tahir; Anda Cahya Heluth; Harti Widiastuti
As-Syifaa Jurnal Farmasi Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.358 KB) | DOI: 10.33096/jifa.v8i1.155

Abstract

Have been conducted a research about antioxidant activity assay at watermelon (Citrullus lanatus) using FRAP method. Watermelon is known contains vitamin A, B, C, and lycopene. The aim of research were to determine the antioxidant activity relationship between watermelon juice and vitamin C with FRAP method using ascorbic acid as a comparative standard measure by UV-Vis spectrophotometer at a wavelength of 692 nm. The research result was obtained the antioxidant capacity on the watermelon red meat juice 0,1329 mg AAE/g.
Co-Authors A. Muflihunna A. Muflihunna A. Trihadi Kusuma Afifah Amdar, Andi Aminah Aminah Aminah Aminah Amir, A. Hesti Wulandasari Amula, Andi Tenri Anak Agung Istri Sri Wiadnyani Anda Cahya Heluth arniati, arniati Asriani Suhaenah Azzahra, Resqinah Desi, Nilma Sri Ekawati Ekawati Evatiara, Nur Fitriana Fitriana Hadi, Daryono Hamdhan, Aulia Nurul Insani Harti Widiastuti Hasyim, Amita ISRANANDA, DWI Kaisupy, Siti Sumayya Mamat Pratama, Mamat Maskur, Sri Karina Mochammad Imron Awalludin mondo, zhafira anggraini Muammar Fawwaz Musdalifah, A. Muzakkir Baits, Muzakkir Nasra Nasra Naura Nazhifah Nilla Sukmawati Nurlina Nurwijayanti Permatasari, Andi Pratama, Shinta Indah Putri Nurfauziah Putri, Adinda Rahmawati Rahmawati Rahmawati, Rahmawati Rais Razak, Rais Safitri, Ineks Salahuddin, Muthia Amaliah Sari, Wina Astri Saskia, Eka Putri Seniwati Seniwati, Seniwati Sophi Damayanti St Maryam St Maryam, St St. Maryam, St. Suhaenah, Asriani Suhaenah Sukmawati Sukmawati Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Sumardi, Farah Hikmah Nur Syafrianti Syafrianti Tjahyono Tjahyono Wahdania, Andi Yulinda Rahim Zainal Abidin Zainal Abidin Zainal Abidin