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Training Science Process Skills with the SETS Model in Biotechnology Learning: Applications and Future Research Directions Subekti, Hasan; Puspitarini, Sapti; Suwandi, Edi
Jurnal Penelitian Pendidikan IPA Vol 11 No 10 (2025): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i10.11353

Abstract

The purpose of this study is to investigate how biotechnology education focuses on learning implementation, student activities, Science Process Skills (SPS), field constraints, student responses, and to identify future research directions. The study employs descriptive quantitative research involving students at the junior high school Unesa. The data is gathered through observation, test and questionnaire. The data are analysed descriptively. Based on what the observer thought, the data showed that learning went very well. It's mostly made up of talking between students and teachers, like asking questions and having conversations. At most, problem-solving and data collection skills were learned, but things like media, classroom, and time management were not. Student responses were positive to the SETS model, but their understanding of scientific work and evaluation questions needed to be improved. These potentially affect the priority research agenda, which focuses on technology integration, teacher training, contextual learning, interdisciplinary approaches, and the integrated biotechnology of SETS. The study concludes that SETS model learning was carried out very well and received a positive response from students, with active interaction between students and teachers, especially in verbal interaction and SPS, such as formulating problems and data collecting.
Hepatoprotection and Immunomodulation of Natural Killer and CD8 T Cells by Meniran-Turmeric Extract Combination in Mice Injected with 7,12-Dimethylbenz[a] Anthracene Puspitarini, Sapti; Widodo, Nashi; Widyarti, Sri; Azzamuddin, Haidar; Ulinnuha, Maria; Puspitoputri, Alya H.; Khansa, Shafanony; Rifa’i, Muhaimin
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.499-507

Abstract

Combination herbal or polyherbal offers advantages by synergizing multiple plants to address health issues more effectively. Meniran and turmeric are traditionally used medicinal plants with notable pharmacological activities due to their bioactive compounds. This study investigated the curative effect of a meniran-turmeric extract combination on immunocompetent cells, particularly NK and CD8 cells, and on liver histopathology in mice administered 7,12-dimethylbenz[a]anthracene (DMBA). Female BALB/c mice (Mus musculus) were injected subcutaneously with DMBA at 45 mg/kg body weight (BW) in the mammary gland area and maintained for eight weeks. They were then treated with a 1:1 meniran-turmeric extract combination for two weeks at doses of 100, 300, 900, and 1,800 mg/kg BW, followed by liver and immune cell analyses. The results showed a lower CD8+ T-cell population in extract-treated groups (17.53±1.13%-19.79±1.51%) compared with the DMBA group (20.92±4.74%). Conversely, NK+ cell populations increased after extract treatment (0.33±0.01%-0.56±0.13%) compared with DMBA alone (0.27±0.02%). Liver histopathology indicated that extract combination administration did not cause more severe damage than that observed in the DMBA group. An extract combination of meniran and turmeric could modulate the immune system, particularly NK and CD8 cells, in mice injected with DMBA. In addition, the study indicated that the combination of meniran and turmeric extract might play a role as an antihepatotoxic agent. This research could serve as a consideration for future studies developing a combination formulation of meniran and turmeric.