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All Journal HAYATI Journal of Biosciences The Journal of Experimental Life Sciences (JELS) BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Jurnal Penelitian Pendidikan IPA (JPPIPA) Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Abdi: Media Pengabdian Kepada Masyarakat BIOCHEPHY: Journal of Science Education Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Triwikrama: Jurnal Ilmu Sosial Jurnal Penelitian Pendidikan Indonesia (JPPI) MERDEKA: Jurnal Ilmiah Multidisiplin Sasambo: Jurnal Abdimas (Journal of Community Service) Reflektif: Jurnal Pendidikan dan Kebudayaan
Sapti Puspitarini
Universitas Negeri Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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Hepatoprotection and Immunomodulation of Natural Killer and CD8 T Cells by Meniran-Turmeric Extract Combination in Mice Injected with 7,12-Dimethylbenz[a] Anthracene Puspitarini, Sapti; Widodo, Nashi; Widyarti, Sri; Azzamuddin, Haidar; Ulinnuha, Maria; Puspitoputri, Alya H.; Khansa, Shafanony; Rifa’i, Muhaimin
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.499-507

Abstract

Combination herbal or polyherbal offers advantages by synergizing multiple plants to address health issues more effectively. Meniran and turmeric are traditionally used medicinal plants with notable pharmacological activities due to their bioactive compounds. This study investigated the curative effect of a meniran-turmeric extract combination on immunocompetent cells, particularly NK and CD8 cells, and on liver histopathology in mice administered 7,12-dimethylbenz[a]anthracene (DMBA). Female BALB/c mice (Mus musculus) were injected subcutaneously with DMBA at 45 mg/kg body weight (BW) in the mammary gland area and maintained for eight weeks. They were then treated with a 1:1 meniran-turmeric extract combination for two weeks at doses of 100, 300, 900, and 1,800 mg/kg BW, followed by liver and immune cell analyses. The results showed a lower CD8+ T-cell population in extract-treated groups (17.53±1.13%-19.79±1.51%) compared with the DMBA group (20.92±4.74%). Conversely, NK+ cell populations increased after extract treatment (0.33±0.01%-0.56±0.13%) compared with DMBA alone (0.27±0.02%). Liver histopathology indicated that extract combination administration did not cause more severe damage than that observed in the DMBA group. An extract combination of meniran and turmeric could modulate the immune system, particularly NK and CD8 cells, in mice injected with DMBA. In addition, the study indicated that the combination of meniran and turmeric extract might play a role as an antihepatotoxic agent. This research could serve as a consideration for future studies developing a combination formulation of meniran and turmeric.
Training Science Process Skills with the SETS Model in Biotechnology Learning: Applications and Future Research Directions Hasan Subekti; Sapti Puspitarini; Edi Suwandi
Jurnal Penelitian Pendidikan IPA Vol 11 No 10 (2025): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i10.11353

Abstract

The purpose of this study is to investigate how biotechnology education focuses on learning implementation, student activities, Science Process Skills (SPS), field constraints, student responses, and to identify future research directions. The study employs descriptive quantitative research involving students at the junior high school Unesa. The data is gathered through observation, test and questionnaire. The data are analysed descriptively. Based on what the observer thought, the data showed that learning went very well. It's mostly made up of talking between students and teachers, like asking questions and having conversations. At most, problem-solving and data collection skills were learned, but things like media, classroom, and time management were not. Student responses were positive to the SETS model, but their understanding of scientific work and evaluation questions needed to be improved. These potentially affect the priority research agenda, which focuses on technology integration, teacher training, contextual learning, interdisciplinary approaches, and the integrated biotechnology of SETS. The study concludes that SETS model learning was carried out very well and received a positive response from students, with active interaction between students and teachers, especially in verbal interaction and SPS, such as formulating problems and data collecting.
PENDAMPINGAN PENGEMBANGAN INSTRUMEN PENILAIAN OTENTIK YANG MENDUKUNG PEMBELAJARAN MENDALAM UNTUK GURU-GURU IPA MTS KABUPATEN TUBAN Sabtiawan, Wahyu Budi; Sudibyo, Elok; Subekti, Hasan; Sari, Dhita Ayu Permata; Purnomo, Aris Rudi; Roqobih, Fikky Dian; Puspitarini, Sapti; Aprilia, Gita Bella
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol. 11 No. 2 (2026): JURNAL ABDI : Media Pengabdian Kepada masyarakat
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/abdi.v11i2.46770

Abstract

The current challenge is requiring teachers to be able to implement authentic assessments that support in-depth learning. One of the tools in this implementation is assessment. The problem is that the partner, the MGMP Science Teachers of MTs in Tuban Regency, is not yet accustomed to implementing authentic assessments that support in-depth learning and therefore requires training and mentoring. Based on this, training and mentoring are needed to implement assessments that support in-depth learning. Through this activity, it is hoped that partners can improve their skills in implementing authentic assessments that support in-depth learning. The implementation method is divided into four stages, namely preparation, material presentation, training and mentoring, and evaluation. Participants in this PKM activity were 67 MTs science teachers in Tuban Regency. The results of the mentoring and training showed that (1) there was an increase in the PKM participants' understanding regarding authentic assessments based on pre- and post-test scores; (2) the level of skills of the training participants in planning and implementing authentic assessments was still lacking (thus, more intensive mentoring for participants regarding planning and implementing authentic assessments was needed); and (3) the training participants showed a positive response to the PKM activity.
PEMBELAJARAN TEAMS GAMES TOURNAMENT CHALLENGE RELAY PADA MATERI SISTEM PERNAPASAN UNTUK MENINGKATKAN HASIL BELAJAR DAN KETERAMPILAN SOSIAL SISWA SMP Fernanda Putri, Kamelia; Puspitarini, Sapti
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 01 (2026): Volume 11 No. 01 Maret 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v11i01.43001

Abstract

Science learning outcomes at UPT SMP Negeri 12 Gresik are still relatively low. This study aims to see the effect of Teams Games Tournament learning to improve students' learning outcomes and social skills. The method used in this study is a pre-experimental One Group Pretest-Posttest Design, where there is only one group without a control group. The data analysis technique used in this study is supported by SPSS software, namely the normality test with the Shapiro-Wilk test, the Paired Sample t-Test if the data is normally distributed and the Wilcoxon test if the data is detected to have an abnormal distribution and the N-Gain test. The results of this study are that Teams Games Tournament Challenge Relay learning is able to improve science learning outcomes and students' social skills at UPT SMP Negeri 12 Gresik.
PENERAPAN HUKUM TERMODINAMIKA PERTAMA DALAM PENGGUNAAN ENERGI PANEL SURYA TERHADAP PENERANGAN JALAN UMUM (PJU) Nur Fitria, Rieke; Aulia Fadila, Pramudya; Hanin; A’yunin Nafi’ah, Qurrotul; Putri Syahida, Avina; Puspitarini, Sapti
Jurnal Reflektif Vol 2 No 3 (2025): Reflektif: Jurnal Pendidikan dan Kebudayaan
Publisher : YAYASAN PADHANG MANAH SIBYAN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In general, street lights that use solar power are converted to electricity. The conversion of solar heat into electrical energy that causes the street lights to turn on uses the principles of the First Law of Thermodynamics. This article aims to identify the process and challenges in applying the First Law of Thermodynamics to renewable energy technologies, especially in the context of using solar energy for street lighting. The method applied is Literature Review from various journals both at national and international levels. The first law of thermodynamics is related to the creation of renewable energy which is currently the focus of efforts to create sustainable energy. This topic discusses the concept of the first law of thermodynamics, and the mechanism of converting sunlight into electrical energy and then into street lighting. Various challenges are affected in the form of heat management, the use of environmentally unfriendly materials in solar panels, expensive investment costs, energy conversion efficiency. This article reinforces the importance of applying the first law of thermodynamics to the development of renewable energy, and the challenges resolved in its implementation.
Co-Authors Agresza, Churnelia Ahmad Fauzi Hendratmoko Aini, Ika Nur AN NURIL MAULIDA FAUZIAH Annastasya Shofi Muliani Aprilia, Gita Bella Arika Nadia Zalfa Aulia Fadila, Pramudya Aulia, Lintang Metha Azzamuddin, Haidar A’yunin Nafi’ah, Qurrotul Dinia Rizqi Dwijayanti Dwi Santika, Annyla DYAH ASTRIANI Edi Suwandi ELOK SUDIBYO Enny Susiawati Enny Susiyawati Erman Erman Eva Widya Puspita Sari Fasih Bintang Ilhami, Fasih Bintang Fauziyah, Iffah Nur Fernanda Putri, Kamelia Fikky Dian Fikky Dian Roqobih Hanin HASAN SUBEKTI Jannah, An-Nisa Mutiara Rizky Khansa, Shafanony KIKI SEPTARIA Lia Yuliati, Lia Liliana, Sal Sabila MOHAMMAD BUDIYANTO Muhamad Arif Mahdiannur Nabila Hanin Fitriani Nashi Widodo Naurah Fakhrina Nisa, Alyyah Fikrotun Novita Azzahra Ramadhina Nur Fitria, Rieke Prisca Putri Anjani Purnomo, Aris Rudi Puspitoputri, Alya H. Putri Syahida, Avina Rachma Firdauzi, Aliya Rahman, Nanang Rifa’i, Muhaimin Roqobin, Fikky Dian Sabtiawan, Wahyu Budi Sari, Dhita Ayu Permata Shalkha Hanifi Siti Marpuah, Siti Sri Widyarti Susiawati, Enny Susiyawati, Enny TUTUT NURITA Ulinnuha, Maria Wardhani, Raden Eliza