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All Journal Journal of Dentomaxillofacial Science YARSI Medical Journal MDJ (Makassar Dental Journal) Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Irene E. Rieuwpassa, Irene E.
Department Of Oral Biology, Faculty Of Dentistry, Hasanuddin University, Makassar, Indonesia
Dentistry Medicine & Pharmacology Public Health

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Extraction of keratinase enzyme from marine Actinomycetes and its antibacterial againts S.aureus : Ekstraksi enzim keratinase dari Actinomycetes laut dan potensi antibakterinya terhadap S.aureus Rieuwpassa, Irene Edith; Khatimah, Amraida Khusnul; Gunawan, Muh. Chaerul; Maulana, Lalu Novan; Makkawaru, Fadhlan Isnan; Sa, Salsabyila Wahyuni; Amin., Zalzabila M.
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i3.1333

Abstract

Staphylococcus aureus is an important pathogen often associated with serious infections and antibiotic resistance. In the search for alternative treatments, marine Actinomycetes are a potential source due to their ability to produce bioactive enzymes, one of which is keratinase. In addition to its function in keratin degradation, this enzyme is also known to have potential as an antibacte-rial agent. This article explores the extraction of keratinase enzymes from marine Actinomycetes isolates and tests their antibac-terial activity against S.aureus, as a first step in the utilisation of marine biotechnology for medical and pharmaceutical purposes. This systematic review was compiled based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Initial search results of 135 articles were then excluded, yielding four articles that showed that marine Ac-tinomycetes have antibacterial potential against S.aureus. It was concluded that the extraction of keratinase enzymes from ma-rine Actinomycetes showed significant antibacterial activity against S.aureus, indicating the potential of keratinase as an alter-native agent for treating gram-positive bacterial infections, especially amid increasing resistance to antibiotics.
Extraction of keratinase enzyme from marine Actinomycetes and its antibacterial againts S.aureus: Ekstraksi enzim keratinase dari Actinomycetes laut dan potensi antibakterinya terhadap S.aureus rene Edith Rieuwpassa; Amraida Khusnul Khatimah; Muh. Chaerul Gunawan; Lalu Novan Maulana; Fadhlan Isnan Makkawaru; Salsabyila Wahyuni Sa; Zalzabila M. Amin
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Staphylococcus aureus merupakan patogen penting yang sering dikaitkan dengan infeksi serius dan resistensi antibiotik. Dalam upaya mencari alternatif pengobatan, Actinomycetes laut menjadi sumber potensial karena kemampuannya menghasilkan enzim bioaktif, salah satunya keratinase. Selain fungsinya dalam degradasi keratin, enzim ini juga diketahui memiliki potensi sebagai agen antibakteri. Artikel ini mengeksplorasi ekstraksi enzim keratinase dari isolat Actinomycetes laut serta menguji potensi aktivitas antibakterinya terhadap S.aureus, sebagai langkah awal dalam pemanfaatan bioteknologi laut untuk keperluan medis dan farmasi. Systematic review ini disusun berdasarkan pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Hasil pencarian awal sebanyak 135 artikel kemudian dieksklusikan dan diperoleh 4 artikel yang menunjukkan bahwa Actinomycetes laut berpotensi antibakteri terhadap S.aureus. Disimpulkan bahwa ekstraksi enzim keratinase dari Actinomycetes laut menunjukkan aktivitas antibakteri yang signifikan terhadap S.aureus yang berarti potensi keratinase sebagai agen alternatif untuk mengatasi infeksi bakteri gram positif, terutama di tengah meningkatnya resistensi terhadap antibiotik.
Co-Authors Al Fikriyani Amani Fajri Khairunnisa Amin., Zalzabila M. Amraida Khusnul Khatimah Amru, Muh Akmal Andi M. Farhan Andi M. Rizal Andi Muhammad Fahruddin Andi Muhammad Irfan M. Amir Andi Zaky Hanifan Ansyari Muis Anwar, Vina Maulydia Arsyad, Muhammad Aryadi Asmawati Asmawati Asmawati Asmawati Astriani Benyamin, Roland Deavid Budiawan, Utami Putri Chanifah T. Maulita Dian Rafika Sari D Donald R. Nahusona Dwi P. Wulansari Dyan Megasari Eddy Heriyanto Habar Ema Yusuf Erwin Gunawan Fadhlan Isnan Makkawaru Fajriani Fatimah Azzahra Febriansyah M. Ashar Fitrian Riksavianti Fransiske Tatengkeng Fuad Husain Akbar Gabriel SA. Matongan Gunawan, Muh. Chaerul Hamka, Dinda Cindrahati Harun Achmad Harun H. Lala Hasanuddin Thahir, Hasanuddin I Wayan Suka Arsana Ika, Khaerunnisa Ilhamsyah, Salsabyla Tamara Putri Indah Ramadhani Izzah, Agnes Dea Ugie Wihdatul J. I. Lisal Karlina Karlina Khatimah, Amraida Khusnul Lalu Novan Maulana Lenni Indriani M. Iqbal Basri Makkawaru, Fadhlan Isnan Marhamah Masruroh, Bihaeri Itsna Maulana, Lalu Novan Megatriani Matandung Megumi, A. Apriliiqa Melinda Herman Meuthia Narissa Azzahra Mochammad Hatta Muh. Chaerul Gunawan Muliaty Yunus N, Nur Syabina Octavia Gamal Nur Ain latjompoh Nurlindah Hamrun Nurul Fitri Nusaly, Tiara Rezqi Megautama Pharadiba Pharadiba Purnamasari, Daranisa Wulan Putri, Nabilah Atikah Rafikah Hasyim Rahmat Rahmat Ramadhan, Bagas Karunia Reski Y. S Rifqiyanti Ismi Risnanda Thamrin Sa, Salsabyila Wahyuni Salamah, Ummi Salsabyila Wahyuni Sa Sasmita Sherly Horax Siti Rachmatiara Sitti Rafiah Soelistia Ramadhani Sri Dian Haerawati St. Rahma Lukman Sumintarti Sumintarti Surianti Alimin Syamsiar Toppo Syamsiar Toppo Uleng Bahrun Ummi Salmiah Sari Wahyu Aji Ramadhan Wahyuningrat, Mitha Wijaya Yu-Ri Kim Zakiyah, A. Fadhilah Putri Zalzabila M. Amin