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All Journal Majalah Kedokteran Bandung Althea Medical Journal Nusantara Medical Science Journal Indonesian Journal of Medicine Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) International Journal of Retina Jurnal Medika Malahayati Sehat Masada Narra J IJRETINA - International Journal of Retina Oftalmologi: Jurnal Kesehatan Mata Indonesia Ophthalmologica Indonesiana
Arief S. Kartasasmita
Department Of Ophthalmology, Faculty Of Medicine, Padjadjaran University Cicendo National Eye Center, Bandung, West Java
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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SUCCESS OF INTRAVITREAL RANIBIZUMAB IN ACUTE CENTRAL SEROUS CHORIORETINOPATHY Chalid Kurniawan; Arief Kartasasmita
International Journal of Retina Vol 3 No 2 (2020): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2020.vol003.iss002.106

Abstract

Introduction: Central serous chorioretinopathy (CSC) manifests as neurosensory detachment of the macula and observation has been considered as an appropriate first-line approach. Active treatment is required to prevent recurrences or chronic type. This study aim to evaluate the effectiveness of intravitreal ranibizumab injection (IVRI) for acute CSC. Methods: A single-center retrospective descriptive study. Five files of the patients who had the diagnosis of CSC then treated with IVRI between 2018 and 2019 have been investigated. IVRI were given once every 4 weeks until sub-retinal fluid resolved. Demographic details, best-corrected visual acuity (BCVA), and central macular thickness (CMT) were studied before and after treatment. Results: The mean age of the patients was 57 years (SD= 10.5 years) mostly female (3 patients). The mean duration before treatment was 3.8 weeks (SD= 1.4 weeks). The mean number of IVRI was 1.4 (SD= 0.5). The mean CMT before IVRI was 436.4 μm (SD= 109.1) and decreased to 243 μm (SD= 38.3) at the last visit. The mean BCVA before IVRI was 0.56 logMAR (SD= 0.37) and improved to 0.22 logMAR (SD= 0.29) Conclusion: IVRI appeared to be effective treatment for acute CSC. The mean CMT decreased and BCVA improved after therapy.
Good Outcome In Open Globe Injury With Intraocular Foreign Body Rahayu Widhyasti; Made Indra Widyanatha; Arief S. Kartasasmita; Erwin Iskandar; Rova Virgana; Grimaldi Ihsan
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 6 No 1 (2024): Oftalmologi: Jurnal Kesehatan Mata Indonesia
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v6i1.61

Abstract

Introduction: Intraocular foreign body (IOFB) represents the second most common cause of open globe injury (OGI) and critical ophthalmic emergency that requires urgent diagnosis and treatment to prevent blindness. It can cause direct damage via entry into the eye and causing future damage. The immediate pars plana vitrectomy (PPV) surgery in post-traumatic endophthalmitis is beneficial for optimizing visual prognosis. Case report: A 55-year-old male patient came to the Emergency Room tertiary referral hospital with chief complaints of blurry vision, pain, and red-eye in his right eye 3 days before admission. The patient’s right eye was hit by a fragment of the sickle knife while mowing the grass in the yard without protective eyeglasses. Painful on his right eye is getting worse accompanied by lacrimation. The patient went to Tertiary Eye Hospital because of his complaints getting worse. The patient was diagnosed with Open Globe Injury Type C grade D pupil B zone 1, suspect early endophthalmitis, traumatic cataract of the right eye, and hypertension. Pars plana vitrectomy, vitreous tap, antibiotic intravitreal injection (with Ceftazidime and Vancomycin), IOFB extraction, explore, corneal scraping on the wound, cultural resistance, primary hecting of the cornea were done. The visual acuity improves and the infection was resolved. Conclusion : One of the most common traumas in ophthalmology is IOFB and it is considered an emergency condition. Proper ophthalmology examination and appropriate ancillary testing should be done to reveal this condition. Good management will give a good result of the patient’s visual prognosis.
Characteristics and Management of Pediatric Ocular Trauma Laila Wahyuni; Maya Sari; Arief S Kartasasmita
Majalah Oftalmologi Indonesia Vol 41 No 1 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v41i1.12

Abstract

Background: To describe the characteristics of patients with ocular trauma in Cicendo Eye Hospital (CEH) Bandung, West Java.Methods: Data was taken from medical record of patients aged 0-14 between January to December 2011. The patient age, gender, visual acuity (before and after treatment), onset, types of trauma, laterality, location of trauma, causes and treatment were documented and analyzedResults: We found 188 children recorded with eye injury, 130 boys (69.1%) and 58 girls(30.9%) . Based on age distribution, eye trauma was mostly in group 2-7 years in 83 children (44.14%). The initial visual acuity obtained was mostly > 0.5 (Snellen chart) in 89 children (53,7%) and 0,02 – LP of 11 children (50%) of closed globe injury and open globe injury respectively. Most patient came to CEH between 1-3 days of onset. Laterality of ocular trauma was mostly on the rigth eye (53,2%) and occur at out door (53,2%). The most causes of injury was blunt trauma 166 cases (88,3%). Medical management was needed in 141 cases, 46 cases had to been operated, and 1 cases just conservative.Conclusions: Ocular trauma was a common injury in preschool children, boys and right eye, mostly occur at out door, but those were no significant difference in both open and closed ocular trauma. Prognosis for visual function are mostly good in closed globe injury. We need more intensive supervision in the home especially outdoor enviroment, for that group of children. Key word: open globe injury, closed globe injury, Children, Cicendo eye hospital
Measurement of the Cut Off Score of Visual Function Questionnaire on Vision Related Quality of Life to Predict Severity of Diabetic Retinopathy Fauziah Hayati; Arief Kartasasmita; Mayang Rini; Feti Karfiati
Majalah Oftalmologi Indonesia Vol 41 No 3 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v41i3.46

Abstract

Background: Diabetic retinopathy has a negative impact on quality of life. In order to investigate the effects of visual impairment in self-perception of quality of life, vision related questionnaires such as the National Institute Visual Function Questionnaire (NEI-VFQ-25) has been developed. The aim of this study is to predict severity of diabetic retinopathy using NEI-VFQ-25 Version 2000 by measuring the cut off score of visual function questionnaire on vision related quality of life Methods: Cross Sectional study by examining 49 diabetic retinopathy patients who meet the inclusion criteria. All patients requested to answer the questionnaire. All question have a score and all question scores then categorized into a number of subscales that can be averaged to yield the subscale scores (lowest to highest range 0-100). Higher score on the VFQ–25 indicates better visual function and health related quality of life. Average scoring then being analyzed by ROC curve in order to gain the cut off score value between retinopathy and sight threatening diabetic retinopathy. Results: The cut off score value between retinopathy and sight threatening diabetic retinopathy is 90.90. The VFQ-25 classification score is in the range of <90.90 consider threatening diabetic retinopathy and ≥90.90 consider retinopathy. Conclusion: VFQ-25 is one of the instruments to confirm that diabetic retinopathy significantly impair quality of life. The cut off score value between retinopathy and sight threatening diabetic retinopathy is 90.90. Keywords: Diabetic retinopathy, NEI-VFQ-25
Effects of SGLT2 inhibitor administration on blood glucose level and body weight in type 1 diabetes rat model Syukri, Maimun; Zaini, Lia M.; Kartasasmita, Arief S.; Gondhowiardjo, Tjahjono D.; Lesmana, Ronny
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.194

Abstract

The prevalence of diabetes worldwide is increasing and 629 million people are projected to have diabetes by 2045, and the most significant burden of the disease being concentrated in low- and middle-income countries (LMICs). Type 2 diabetes is mainly treated with insulin adjunctive therapies such as metformin to improve insulin sensitivity and sodium-glucose co-transporter 2 (SGLT2) inhibitors to lower blood glucose levels. However, there was limited study on the application of SGLT2 inhibitors on type 1 diabetes, particularly empagliflozin. Therefore, this study aimed to determine the effect of SGLT2 inhibitors on blood glucose levels and body weights in a rat model of type 1 diabetes. To mimic type 1 diabetes, the rats were injected with streptozotocin 60 mg intra-peritoneally. Twenty-four rat models were randomly divided into four groups: normal rat group (negative control), untreated diabetic rat group (positive control), type 1 diabetic rats treated with metformin, and type 1 diabetic rats treated with empagliflozin. Blood glucose levels and body weight were recorded before and after induced with streptozotocin and on weeks 4, 6, 8 and 10 of the treatment with anti-diabetic drugs. This study found that the blood glucose levels before and after treatment significantly decreased in all groups (p<0.05), except in the negative control group. Similar results were observed in body weight of the rats, which all groups experienced weight loss, except the negative control. These results suggested that apart from being used in type 2 diabetes, SGLT2 inhibitors may also be used as a treatment for type 1 diabetes.
Short-term outcomes of implanting a retropupillary iris-claw intraocular lens in patients with lens and intraocular lens drops Kurniawan, Chalid; Kartasasmita, Arief S.; Harley, Ohisa
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.892

Abstract

Lens drop and intraocular lens (IOL) drop can occur after cataract or phacoemulsification surgery, where the IOL is dislocated from the capsular bag into the vitreous cavity. The aim of this study was to investigate the short-term outcomes of implanting a retropupillary iris claw in patients with IOL drop and lens drop after phacoemulsification. A cross-sectional study was conducted at Santosa Hospital, Bandung, West Java, Indonesia, from January 2020 to December 2023. Patients were divided into two groups: IOL drop and lens drop groups. Total sampling was used, involving 51 patients in the present study, with 27 patients in the IOL drop group and 24 patients in the lens drop group. Data collected included age, sex, eye laterality, the onset of IOL drop or lens drop, intraocular pressure (IOP), uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), record of astigmatism change preoperative and postoperative, and postoperative pars plana vitrectomy (PPV) complications. Our data indicated that the UDVA significantly improved in both IOL drop and lens drop groups after PPV surgery (p<0.001). However, there were no significant changes in IOP or astigmatism following the surgery in either group. Over one month, both groups showed improved UDVA, decreased IOP, and changes in astigmatism, with no significant differences between groups. Similarly, there was no significant difference in CDVA between IOL drop and lens drop groups. Only four complications were recorded in the present study. Comparing IOL drop and lens drop groups, only an increase in IOP showed a significant difference (p=0.018). Corneal edema, IOL decentration, and pupil ovalization were not significantly different. In conclusion, retropupillary iris-claw IOL implantation is safe and effective for aphakic patients with complications from phacoemulsification, regardless of whether it is lens drop or IOL drop.
REVIEW 5 TAHUN KARAKTERISTIK KLINIS PASIEN BENDA ASING INTRAOKULAR DI PMN RS MATA CICENDO Desrina; Virgana, Rova; Kartasasmita, Arief S.; Iskandar, Erwin; Ihsan , Grimaldi; Widyanatha, Made Indra
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 5 No 1 (2023): Jurnal Oftalmologi
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v5i1.46

Abstract

Introduction: Intraocular foreign bodies (IOFBs) are defined as intraocularly retained, unintentional projectiles that require urgent diagnosis and treatment to prevent blindness or globe loss. IOFBs account for 18–41% of open globe injuries, and frequently cause severe visual loss in patients with ocular trauma.The purpose of this study are is to describe the characteristics of open-globe injuries with posterior segment intraocular foreign bodies (IOFB). Subject and Methods: Retrospective data of all patients with posterior segment IOFBs from 2017 to 2022 was conducted. Data including demographics, mechanism of injury, type of IOFB, method of diagnosis, presenting examination, medical and surgical treatment, visual outcomes, and complications were recorded. Result: There were 39 patients (eyes) with IOFB, 38 (97,4%) were male, 10 (25,6%) were 46-55 years old. The most common IOFB occurred at workplace 30 patient (85,7%), 29 (74,3%) were insuranced, surgery were performed 1- 4 days in 15 (38,5%. The most Ocular trauma score were 3 (38,5%) and 2 (35,9%) initial VA were light perception – hand movement (25 or 64,1%), final VA with BCVA were > 20/40 (30,8%) patients and 6/60-6/15 (25,6%). The posterior segment IOFB (51,3%, metallic IOFB 25 (61,5%). Cataract 74,3% and Endophthalmitis (20,5%) were found in initial examination patient with IOFB (13 or 37,1%). Late complication in post surgery IOFB patient was glaucoma 14,4%. Conclusions: The IOFB occurred most commonly in adults, men, at the workplace. The IOFB mostly was metallic, found in the posterior segment. Cataract and endoftalmitis were common in initial finding IOFB patients.
Ocular Manifestations of Aplastic Anemia: Rare Case of Anemic Retinopathy Juanarta, Pieter; Ihsan, Grimaldi; Iskandar, Erwin; Kartasasmita, Arief; Virgana, Rova; Indra, Made
International Journal of Retina Vol 8 No 1 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss001.280

Abstract

Incidence of aplastic anemia was 1-2 cases per million population per years, and showed higher rate in Asia and 10-25 years old. Anemic retinopathy can occur in 28% of patient with severe anemia, especially if accompanied by thrombocytopenia. Most cases were asymptomatic, however decrease visual acuity were also commonly found caused by haemorrhage and Macular edema. A 65 years old female patient came with blurry vision ten days prior admission accompanied with loss of consciousness, recurrent bleeding from nose, gum, and bluish discoloration in her extremities four years ago. Visual acuity was 1/60 on the right eye and 0.4 log on the left eye. Funduscopic examination showed vitreous haemorrhage, dot blot, hard exudate, and tortuosity of vein. Laboratory Examination showed anemia and thrombocytopenia, and peripheral blood morphology showed normochromic anisopoikilocytosis caused by chronic disease. She was scheduled to underwent anti VEGF and showed improvement in her visual acuity after injection. Fundoscopic examination later shows sub-hyaloid haemorrhage, dot blot, hard exudate, and tortuosity of vein. She was scheduled to undergo pars plana vitrectomy and were consulted to internal medicine. Aplastic anemia is a rare disease that usually asymptomatic, thus causing late intervention and a high mortality rate. Early manifestation can be seen in retinal structure as anemic retinopathy thus ophthalmologist have valuable impact in early detection of this disease. Haemorrhage overlying the macula and macular edema is the most common cause of visual impairment. Anti VEGF treatment, transfusion of blood component, and immunosuppressive therapy is needed to prevent complication and increase patient survival rate. Patient visual acuity usually imporved after early transfusion and anti VEGF injection, however delayed intervention may cause irreversible vision loss.
A Rare Case Of Retinal Arterial Microaneurysm: Clinical Features And Diagnostic Insights Yuna, Uray Nabila; Ihsan, Grimaldi; Virgana, Rova; Kartasasmita, Arief S.; Iskandar, Erwin; Widyanatha, Made Indra
Indonesian Journal of Medicine Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.1.773

Abstract

Background: In Retinal Arterial Macroaneurysms (RAM), the central retinal artery suffers from acquired focal hypertension. Clinical manifestations of the disease are diverse and easily misdiagnosed. Several imaging modalities may be used in order to confirm the diagnosis of RAM. This article aims to describe the clinical features and method of diagnosis of an uncommon case of retinal artery microaneurysm. Case report: A 57-year-old woman presented with a progressive loss of vision in her right eye months prior. Visual acuity in the right eye was 0.8 log 13. Upon funduscopic inspection of the right eye, firm exudates with low tortuosity and submacular hemorrhage were observed. The right eye’s OCTA revealed a localized expansion and significant constriction with twisted blood vessels on the reverse side of the deformed vessel, while the OCT of the macula revealed submacular hemorrhage. The patient was diagnosed with ruptured retinal Arterial Macroaneurysm or Macular Telangiectasia Type I and Retinopathy Hypertensive Grade II of both eyes, No Diabetic Retinopathy of both eyes with Diabetes Mellitus and Hypertension. The right eye of the patient received concentrated laser photocoagulation and an intravitreal injection of anti-VEGF. Conclusion: RAM is an acquired vascular disease defined by restricted, fusiform, or saccular dilation in the first three arteries of the main retinal artery. Retinal microaneurysms can be diagnosed with various imaging modalities. Ram may be treated with intravitreal anti-VEGF drugs, combination therapy, or laser photocoagulation.
GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF DIABETIC RETINOPATHY AND DIABETIC MACULAR EDEMA IN INDONESIA Harley, Ohisa; Hertanto, Martin; Sembiring, Sindy Boru; Yustiarini, Ima; Susilo, Teguh; Dharma, Andhika Guna; Sjahreza, Emil; Firmansyah, M; Iskandar, Erwin; Agustiawan, Referano; Andayani, Ari; Dewi, Nadia Artha; Andayani, Gitalisa; Djatikusumo, Ari; Elvioza, Elvioza; Ichsan, Andi M; Kartasasmita, Arief S
International Journal of Retina Vol 7 No 2 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss002.300

Abstract

Diabetic retinopathy (DR) and diabetic macular edema (DME) are among the microvascular complications in individuals with diabetes mellitus (DM) that can lead to blindness if not diagnosed early and managed appropriately. Both disorders can be diagnosed and treated using a variety of techniques. Treatment modalities include laser photocoagulation therapy, vitrectomy surgery, intraocular steroid injections, and anti-vascular endothelial growth factor (anti-VEGF) injections. These methods can help avoid blindness when used in conjunction with metabolic control. These recommendations were created with the use of evidence-based medicine principles to help medical professionals—particularly ophthalmologists—identify and treat cases of DR and DME.The primary objective is to provide consensus recommendations and hopefully reduce the incidence of blindness caused by DR and DME in Indonesia.
Co-Authors A M Ichsan Agustiawan, Referano Andayani, Gitalisa Andika Prahasta Anita Deborah Anwar Ari Andayani Chalid Kurniawan Dainty Maternity Deni K Sunjaya Desrina Dewi Marhaeni Diah Herawati Dharma, Andhika Guna Dinan S Bratakoesoma Djatikusumo, Ari Dwijayanti, Sindi effendi, yulia Elsyanty, Firda Muthia Elvioza Elvioza, Elvioza Endang Sri Wahyuni Erni Mayor Erwin Iskandar Erwin Iskandar Farid Husin Farid Husin Fauziah Hayati Feti Karfiati Memed Firmansyah, M Graziani, Gabriella Grimaldi Ihsan Grimaldi Ihsan Habibah S. Muhiddin Hadyana Sukandar Harley, Ohisa Ichsan, Andi M Ihsan , Grimaldi Ihsan, Grimaldi Ihsan, Grimaldi Indra, Made Iriani, Oktarina Sri Iskandar, Erwin Iwan Sovani Iwan Sovani Juanarta, Pieter Juliati Juliati Juliati, Juliati Kurniawan, Chalid Laila Wahyuni Made Indra Widyanatha Maimun Syukri, Maimun Marliana Rahma Marsha Rayfa Pintary Martin Hertanto Maya Sari Mayang Rini Mega Wulan Purnama Sari Metita, Mirza Mia Purnama Mirza Metita Nadia Artha Dewi Nauli, Rizki Rahma Nurul Aini Pintary, Marsha Rayfa Ponpon S Idjradinata Ponpon S Idjradinata Prettyla Yollamanda Purnama Sari, Mega Wulan Purnama, Mia Rahayu Widhyasti Rizki Rahma Nauli Ronny Lesmana Rova Virgana Rova Virgana Sembiring, Sindy Boru Setiawan . Setyohadji, Bambang Sindi Dwijayanti Sjahreza, Emil Susiarno, Hadi Susilo, Teguh Tjahjono D. Gondhowiardjo Vita Murniati Tarawan Widyanatha, Made Indra Yollamanda, Prettyla Yuna, Uray Nabila Yustiarini, Ima Zaini, Lia M.