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All Journal HAYATI Journal of Biosciences Hemera Zoa Jurnal Sains Materi Indonesia Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Biota Jurnal Sumberdaya Hayati Jurnal Pembelajaran dan Biologi Nukleus Journal of Health and Nutrition Research Molekul: Jurnal Ilmiah Kimia Jurnal Sains Materi Indonesia Biodiversitas Journal of Biological Diversity
Berry Juliandi
Department Of Biology, Faculty Of Mathematics And Natural Science, IPB University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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RAT BLOOD PROFILE EVALUATION AFTER Fe3O4/CHITOSAN COLLOID INJECTION Aloma Karo Karo; Irham Abdul Azis; Wildan Z.L.; Grace Tj. Sulungbudi; Mujamilah Mujamilah; Berry Juliandi
Jurnal Sains Materi Indonesia Vol. 20 No. 3 (2019): Jurnal Sains dan Materi Indonesia
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jsmi.2019.20.3.5479

Abstract

RAT BLOOD PROFILE EVALUATION AFTER Fe3O4/CHITOSAN COLLOID INJECTION. The application of iron oxide (Fe3O4) magnetic nanoparticles in the biomedical field is still being explored, mainly related to its toxicity and side effects. This article reported results of the study aimed at analyzing the effect of chitosan-coated magnetic nanoparticles (NPM-C) on rat blood profiles. Magnetic colloid as much as 1 ml (concentration of 5 mg NPM-C / mL aquabidest) for 1 kG rat body weight was injected through intra-venous to the treated rat group (4 Wistar rats aged 6 months; weight ± 275 grams; male sex) while another four rats injected with sterile aquabidest used as a control group. The blood taking from each group of rats was carried out on 1 day before injection and several days after injection (days 1, 7, 14, 21, 28) through veins in the tail. To these blood samples, a series of blood profile analyzes is carried out including basic hematology, blood chemistry, and fragility of the erythrocyte membrane. The results of the analysis showed no significant differences between blood profiles after treatment and control, which indicated that chitosan-coated magnetic nanoparticles did not trigger cellular stress responses in the blood. The stability of blood magnetism analyzed by VSM (Vibrating Sample Magnetometer) also shows that magnetic nanoparticles are detected in the blood and tend to decrease in number with increasing time, so it is thought that these nanoparticles can be degraded or have been distributed into organs. These stable properties are analyzed due to an existence of chitosan coating around magnetic nanoparticles. Based on this study it can be concluded that up to the given concentration limit, iron oxide nanoparticles coated by chitosan are not toxic and have the potential to be used as drug carriers, MRI contrast agents, and other biomedical applications.
Co-Authors Ahmad Sulaiman Alwahdy Ahmed, Ifty AKBAR, MUHAMMAD AZHARI Alfarisi, Hamzah ALFIYAN, ACHMAD Aloma Karo Karo Alwahdy, Ahmad S. Anggi Nurhardiyanti Munawaroh Araz Meilin Arief Boediono Boenjamin Setiawan Budiariati, Vista Cahayadi, Sigit Daru Desmina Kristiani Hutabarat Dian Anggraini Dwi Budiono Fahri Fahri FITMAWATI FITMAWATI Fitmawati Fitmawati Grace Tj. Sulungbudi HANIM, NISFA Harry Murti Huda Shalahudin Darusman Imam Taufik Indra Bachtiar Innayah Zahara Irham Abdul Azis Jasmi Jasmi Jauharlina Jauharlina Johan Iskandar Kartika Marta Djakaria Kelvin Yaprianto Kinichi Nakashima Kukuh Nirmala Kurniawan, Mohammad Lamerkabel, J. S. A. Mahardika Gama Pradana Mardilah Meilisha Putri Pertiwi MEYLA SUHENDRA Meyla Suhendra Mokhamad Fahrudin Mujamilah Mujamilah Nisfia Rakhmatun Nisa Nunung Yuniarti Nurhayati, Retno Wahyu Nurinsiyah, Ayu Savitri Nuzulia, Nur Aisyah Puji Lestari Puji Rianti Puspaningsih, Dewi Puspita E. Wuyung Puspita Eka Wuyung Qashiratuttarafi Qashiratuttarafi Quraisy Zakky Ratih Rinendyaputri Ratih Rinendyaputri Ratih Rinendyaputri RIKA RAFFIUDIN Rizkiya, Iffi Ruhama Maya Sari Siti Sa'diah Siti Sa'diah Siti Sadiah SRI BUDIARTI Subangkit, Mawar Susanto, Yayi D.B. Tri Atmowidi Tsukasa Sanosaka Tutik Wresdiyati WIDYASTUTI, SALMAH Wildan Mubarok Wildan Z.L. WINDRA PRIAWANDIPUTRA, WINDRA Yayi Dwina Bilianti Susanto Yessie Widya Sari Yetty Ramli Yulia Pujiastuti