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All Journal Jurnal Kebidanan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB Medical Laboratory Technology Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Asian Journal of Health Research
Tri Yudani Mardining Raras
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Tinjauan Literatur: KEFIR: MIKROBIOLOGI, SENYAWA BIOAKTIF, DAN MANFAATNYA PADA PENYAKIT NONINFEKSI Tri Yudani Mardining Raras
Majalah Kesehatan Vol. 9 No. 4 (2022): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2022.009.04.7

Abstract

  Kefir semakin populer sebagai produk makanan fermentasi. Secara makroskopis butiran kefir memiliki struktur warna yang ireguler, multilobular, lengket dan berwarna kekuningan. Simbiosis mikrobiota antara bakteri dan khamir merupakan komponen utama dalam biji kefir. Bakteri yang paling banyak ditemukan pada butir kefir adalah Lactobaccilus sp. dan Lactococcus sp. sedangkan khamirnya didominasi oleh Saccharomyces sp. dan Kluveromyces sp. Kefir mengandung senyawa bioaktif seperti eksopolisakarida, bioaktif peptida, bacteriocin dan biosurfaktan yang berpotensi meningkatkan manfaat kesehatan dari kefir. Tinjauan literatur ini bertujuan untuk mengulas kefir dari aspek mikrobiologi, kandungan senyawa bioaktif kefir dan pengaruhnya sebagai agen imunomodulator atau imunostimulan pada artritis, antialergi, antikolesterol dan penyakit noninfeksi lain. Kefir berpotensi untuk dikembangkan sebagai produk kesehatan dan nutraseutikal sesuai dengan pengaruhnya terhadap stimulasi respons imun, antiartritis, aktivasi imunitas mukosa intestinal, perlindungan dari ulkus peptikum, antikanker, antimutagenesis, antialergi, menurunkan kadar kolesterol, mengurangi obesitas, dan antihipertensi. Oleh karena itu, kefir sangat potensial untuk dieksplorasi lebih lanjut dalam penelitian translasional sebagai salah satu bahan aditif dalam produk pangan fungsional yang memberikan manfaat untuk kesehatan.  
Effectiveness of Rosmarinus officinalis and Centella asiatica Nanoemulsions Against Caspase 3 Gestational Diabetes Mellitus Expression Sutini Lamadi; Fajar Dwi Prastiwi; Tri Yudani Mardining Raras; Husnul Khotimah; I Wayan Arsana Wiyasa
Medical Laboratory Technology Journal Vol. 9 No. 2 (2023): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v9i2.537

Abstract

Gestational diabetes mellitus (GDM) is closely related to oxidative stress conditions in insulin resistance conditions that increase Reactive Oxygen Species (ROS) against the body's defense antioxidant mechanism. Chronic complications due to hyperglycemia in patients with GDM increase BAX / BCL2 levels which then activates the change of procaspase 3 to caspase 3, an activator of apoptosis. This study aims to determine the effect of the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions on caspase 3 expressions in zebrafish models of gestational diabetes mellitus, with a posttest-only controlled group design. The samples were divided into five groups, namely K- (EM), K+(EM+3% Glucose), P1, P2 and P3 (3% Glucose + Combination of Rosmarinus officinalis and Centella asiatica 2.5μg/ml, 5μg/ml and 10μg/ml), which will be tested for PEPCK and Caspase expression at the age of 3dpf using Real Time-PCR. The results of the correlation test of the group with caspase 3 obtained (p = 0.045) negative direction. These results show that the combination of Rosmarinus officinalis and Centella asiatica nanoemulsion decreased Caspase 3 expression in zebrafish models of gestational diabetes mellitus. The combination of Rosmarinus officinalis and Centella asiatica nanoemulsion has the potential to reduce blood glucose levels and reduce the risk of apoptosis in gestational diabetes mellitus patients.
Probiotics Lactobacillus reuteri increase levels of β-Defensin1, sIgA and decrease number of Staphylococcus aureus bacteria colonies in vaginal mucosa on puerperal mice model infected with Staphylococcus aureus Nur Azizah; Umu Qonitun; Tri Yudani Mardining Raras; Sumarno Reto Prawiro
Jurnal Kebidanan Vol 9, No 1 (2020): February 2020
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.9.1.2020.71-80

Abstract

Puerperal Infection is a bacterial infection in the genitalia and female reproduction system, which cause the highest mortality among women who post give birth in recent years. The causative agent of this infection is Staphylococcus aureus (S. aureus). Alternative therapy using probiotics such as Lactobacillus reuteri was developed to reduce the increasing incidence of antibiotic resistance. This article studies the effect of probiotics L. reuteri increasing β-defensin1 levels, sIgA levels, and decreasing the number of bacteria S. aureus colonies in the vaginal mucosa on puerperal mice model that induced with S. aureus bacteria. Mice BALB/c were used as an animal model and divided into four different groups. The measurement β-defensin1 levels, sIgA levels, and the number of bacteria S. aureus colonies were conducted in one and three days postpartum. Enzyme-Linked Immunosorbent Assay (ELISA) method was to measure performed for β-defensin1 levels, and sIgA levels, Total plate count was used for the quantity of bacteria S. aureus colonies. β-defensin1 and sIgA levels showed a similar pattern and elevated significantly in all treated group compared to control. The highest value was obtained from a group that administered with L. reuteri and induced with S. aureus in all measurements. The levels of β-defensin1 and sIgA in three days postpartum were higher than that day one. The number of S. aureus colonies was lower in the treated group compare that of the positive control. The average number of bacteria in one day postpartum was higher than three days. The administration of L. reuteri and or induction of S. aureus could increase the level of β-defensin1 and sIgA but reduced decrease in the number of bacteria S. aureus colonies/
Co-Authors Achmad Rudijanto Achmad Rudijanto Aina Angelica Antiek Primardianti Ati Rastini August Boeck Aunillah Hamid Sholeh David Christianto Diana Lyrawati Didit T Setyo Budi Dwi Yuni Nur Hidayati Edy Widjajanto Ema Pristi Yunita Ema Pristi Yunita, Ema Pristi Eviana Norahmawati Fajar Dwi Prastiwi Francisca S Tanoerahardjo Francisca S. Tanoerahardjo Francisca Tanoerahardjo, Francisca Galih Puspita Citra Mahardhika Hendy Setyo Yudhanto herdian fitria widyanto putri HMS Chandra Kusuma Husnul Khotimah Husnul Khotimah Iin Trilistiyanti Nugrahani, Iin Trilistiyanti Karyono Mintaroem Kenty Wantri Anita Kusworini Handono Maimun Z Arthamin Maimun Zulhaidah Arthamin, Maimun Zulhaidah Melati Puspita Sari Ni Ketut Devy Kaspirayanthi Noni Fidya Ayu Anandasari Novalia Kridayanti Nunuk S Muktiati Nunuk Sri Muktiati Nur Azizah Qatrunnada Naqiyyah Khusmitha S, Noorhamdani A Sardjono, Teguh Wahyu Singgih Pujo Wahono Sri Winarsih Subandi Subandi Sumarno . Sumarno Reto Prawiro Sutini Lamadi Tatit Nurseta Tri Wahju Astuti Tri Wahju Astuti, Tri Wahju Triwahju Astuti Triwahju Astuti Umu Qonitun VALENTINA YURINA VALENTINA YURINA Wibi Riawan Wiyasa, I Wayan Arsana