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Meka Faizal Farabi
Universitas Al-Irsyad Cilacap
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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GAMBARAN STATUS RESISTENSI RIFAMPISIN PASIEN TUBERKULOSIS EKSTRA PARU (TBEP) PEMERIKSAAN TES CEPAT MOLEKULER (TCM) DI RSUD CILACAP PERIODE JANUARI – OKTOBER 2025 Legiana Elza Syariah; Fitri Galih Ramadhani; Junior Dwi Cahyo; Meka Faizal Farabi; Dwi Sulistyowati; Fery Nugroho
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7618

Abstract

Extrapulmonary tuberculosis (EPTB) is tuberculosis that occurs outside the respiratory system and often experiences delays in diagnosis due to the characteristics of low-concentration specimens. The Xpert MTB/RIF-based Molecular Rapid Test (TCM) is recommended as an initial diagnostic method because it can detect Mycobacterium tuberculosis and rifampicin resistance quickly. This study aims to describe the results of TCM examination and rifampicin resistance status in EPTB cases at Cilacap Regional Hospital during January–October 2025. This study used a non-experimental observational design with a retrospective descriptive approach. Data were obtained from TCM examination results on extrapulmonary specimens of EPTB patients. The results showed that of all EPTB samples examined, a small proportion were detected positive for Mycobacterium tuberculosis. The majority of positive samples showed sensitivity to rifampicin, although cases with resistance and intermediate categories were still found. Variations in positive EPTB specimens included biopsy tissue, pleural fluid, feces, gastric lavage, abscess pus, and ultraascites fluid, reflecting the spectrum of extrapulmonary TB infection. The conclusion of this study shows that rifampicin sensitivity in EPTB cases in Cilacap Regency is still dominant, indicating that the effectiveness of the first-line anti-TB regimen is still maintained, but vigilance against the potential for drug-resistant TB is still needed through continuous TCM examination.
Perbandingan Maserasi Daun Pala, Daging Pala dan Biji Pala sebagai Agen Antibakteri Terhadap bakteri Staphylococcus aureus Meka Faizal Farabi; yusuf eko Nugroho
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7761

Abstract

Staphylococcus aureus is a pathogenic bacterium that can cause various infections in humans and has the potential to develop antibiotic resistance. The utilization of medicinal plants as natural antibacterial agents has gained increasing attention, including nutmeg (Myristica fragrans Houtt.), which is known to contain various bioactive compounds. This study aimed to compare the antibacterial activity of nutmeg leaf, seed, and mace infusions against Staphylococcus aureus. The study was conducted using an experimental laboratory design with the agar well diffusion method. Infusions were prepared using a 1:10 (w/v) ratio of simplicia to distilled water and heated at 90°C for 15 minutes. A suspension of S. aureus was inoculated onto Mueller Hinton Agar (MHA), followed by antibacterial activity testing using leaf, seed, and mace infusions. The inhibition zone diameters were measured after incubation at 37°C for 24 hours. The results showed that nutmeg leaf infusion produced an average inhibition zone diameter of 13.67 ± 1.53 mm, whereas seed and mace infusions did not produce any inhibition zones. These findings indicate that only nutmeg leaf infusion exhibited antibacterial activity against S. aureus under the conditions of this study. Therefore, nutmeg leaves have the potential to be developed as a natural antibacterial agent that can be easily applied through a simple infusion method. Further studies are recommended to evaluate the phytochemical profile, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) to support its development as an antibacterial agent.
PERBANDINGAN KADAR HEMOGLOBIN DAN MCV SEBAGAI INDIKATOR ANEMIA DEFISIENSI BESI PADA IBU HAMIL TRIMESTER I DAN TRIMESTER III DI PUSKESMAS MAJENANG I Damara Desiyanti; Yusuf Eko Nugroho; Meka Faizal Farabi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7766

Abstract

Pregnancy is a condition in which the ovum and sperm meet. Changes during pregnancy include changes in erythrocyte mass, plasma volume, and blood volume, resulting in low hemoglobin (Hb) levels due to a decrease in erythrocyte in the blood. Anemia is a global health problem, especially in developing countries, with an estimated 30% of the world’s population suffering from anemia. Anemia is common in the community, especially among pregnant women. Anemia in pregnant women that is not treated properly can increase the risk of dangerous complications, such as premature labor. In addition, anemia can also increase the risk of low birth weight in babies. On the mother’s side, anemia can increase the risk of postpartum depression and postpartum maternal mortality. The purpose of this study was to determine the comparison of hemoglobin and MCV levels as indicators of iron deficiency anemia in pregnant women in the first and third trimesters at the Majenang I Community Health Center. This was an observational analytical study with a cross-sectional approach, with samples taken at the Majenang I Community Health Center from September 2024 to April 2025 according to the inclusion and exclusion cricetria, totalling 33 samples. The results showed a significant difference in hemoglobin levels between at first trimester (average 11.97 g/dL) and the third trimester (11.00 g/dL). Additionally, there was a significant difference in MCV values between the two groups. The average MCV value increased from 82.75 in the first trimester to 84.12 in the third trimester. The increase in MCV values was still within the normocytic range and reflected the adaptation of erythropoiesis during pregnancy. The conclusion of this study is that there are differences in hemoglobin and MCV levels in pregnant women in the first and third trimesters at the Majenang I Community Health Center. Both hemoglobin and MCV levels undergo significant changes and can be used as early indicators in detecting iron deficiency anemia in pregnant women.
HUBUNGAN KADAR MIKROALBUMIN TERHADAP KADAR UREUM DAN KREATININ PADA PASIEN DIABETES MELLITUS TIPE 2 DI PUSKESMAS CILACAP TENGAH 1 Hastuti Budi Rahayu; Meka Faizal Farabi; Dini Puspodewi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.7882

Abstract

Diabetes Mellitus is a serious, long-term condition that occurs when a person's blood glucose levels rise because the body cannot produce enough insulin. According to the International Diabetes Federation (IDF), there were approximately 20.4 million adults aged 20-79 years old with diabetes in Indonesia in 2024, and this number is expected to increase to 28.6 million by 2050. Diabetic nephropathy is a complication of diabetes mellitus that begins with microalbuminuria, which can be detected before kidney function declines, indicated by increased blood urea and creatinine levels. This study aims to determine the relationship between microalbuminuria and serum urea and creatinine levels in patients with type 2 diabetes mellitus  Method: This research is descriptive with a cross-sectional research design using medical record data from patients participating in the Chronic Disease Management Program (Prolanis) at the  Central Cilacap 1 Puskesmas in the period of April 2025. Data were analyzed using the Kolmogorov-Smirnov normality test and continued using the Spearman non-parametric correlation test. Result: The results of the study showed that the average microalbumin level was 122.9491 mg/g creatinine, the average urea level was 28.60 mg/dL and the average creatinine level was 0.91 mg/dL. The results of the Spearman correlation test showed a significant value (ρ-value) between microalbumin and urea levels of 0.003 and between microalbumin and creatinine levels of 0.003. he ρ-value of each is <0.05 Conclusion: can be concluded that there is a relationship between microalbumin levels and urea and creatinine levels in type 2 Diabetes Mellitus patients at the Central Cilacap 1 Puskesmas  
PERBANDINGAN KADAR UREUM DARAH SEBELUM DAN SESUDAH HEMODIALISA PADA PENDERITA GAGAL GINJAL DI RSUD MAJENANG Sri Lestari; Dini Puspodewi; Meka Faizal Farabi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 14 No. 1 (2026): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v14i1.8028

Abstract

Chronic kidney disease (CKD) is a progressive and irreversible decline in kidney function that leads to the accumulation of metabolic waste products, including urea. Hemodialysis is a renal replacement therapy that functions to remove metabolic waste and maintain fluid balance in the body. Measurement of blood urea levels before and after hemodialysis is important to evaluate the effectiveness of the therapy. This study aimed to determine the comparison of blood urea levels before and after hemodialysis in patients with chronic kidney disease at Majenang Regional General Hospital. This study was a quantitative study with an observational analytic design using secondary data obtained from medical records of chronic kidney disease patients undergoing hemodialysis at Majenang Regional General Hospital during June–November 2025. A total of 103 patients who met the inclusion and exclusion criteria were included in the study. Data were analyzed using the Kolmogorov-Smirnov normality test and Paired Sample t-Test with a 95% confidence level. The results showed that the mean blood urea level before hemodialysis was 133.54 ± 38.13 mg/dL, with a minimum value of 29 mg/dL and a maximum value of 244 mg/dL. After hemodialysis, the mean blood urea level decreased to 46.51 ± 21.61 mg/dL, with a minimum value of 6 mg/dL and a maximum value of 102 mg/dL. The Kolmogorov-Smirnov test indicated that the data were normally distributed (p>0.05). The Paired Sample t-Test revealed a statistically significant difference between blood urea levels before and after hemodialysis (p=0.000). In conclusion, hemodialysis is effective in reducing blood urea levels in patients with chronic kidney disease. Measurement of blood urea levels before and after hemodialysis can be utilized as a laboratory parameter to evaluate treatment effectiveness and assist in monitoring the clinical condition of patients with chronic kidney disease..
Analisis Mutu Sediaan Dan Pembacaan Mikroskopis Tuberkulosis Di Cilacap Tahun 2024 : Quality Of Tuberculosis Smear Preparation And Reading In Cilacap, 2024 Fitria Nur Kartika; Imam Agus Faizal; Ira Pangesti; Meka Faizal Farabi
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 2 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i2.1932

Abstract

Pemeriksaan mikroskopis Basil Tahan Asam (BTA) merupakan metode yang tetap digunakan dalam pemantauan pengobatan tuberkulosis (TBC) di fasilitas pelayanan kesehatan yang belum memiliki akses ke Tes Cepat Molekuler (TCM). Kualitas pemeriksaan sangat dipengaruhi oleh mutu pembuatan dan pembacaan sediaan. Penelitian ini bertujuan untuk mengevaluasi kualitas sediaan mikroskopis TBC di Kabupaten Cilacap tahun 2024 berdasarkan enam indikator standar, serta menilai akurasi pembacaan melalui uji silang sebagai bagian dari Pemantapan Mutu Eksternal (PME). Penelitian menggunakan desain deskriptif evaluatif menggunakan pendekatan evaluasi program secara retrospektif. Data uji silang triwulan I–IV dianalisis secara deskriptif kuantitatif. Hasil menunjukkan tingkat partisipasi yang tinggi (91,67–97,92%), peningkatan kualitas spesimen, serta akurasi pembacaan yang sangat tinggi (99,23–100% tanpa kesalahan besar). Namun, indikator ketebalan, ukuran, dan kerataan masih belum optimal pada sebagian fasilitas. Kesimpulannya, mutu pembuatan dan pembacaan sediaan mikroskopis TBC di Kabupaten Cilacap telah memenuhi standar nasional, namun masih diperlukan peningkatan kompetensi teknis dan penguatan pembinaan serta pemantapan mutu untuk menjaga konsistensi hasil pemeriksaan.
Co-Authors Adzani Azhar, Fadlilah Afrilla, Rananda Ana Hidayati Mukaromah Asiva Khoirunisa BUDIYANTO Damara Desiyanti Desika Dewi Dinah Fauziyyah Dini Puspodewi Dwi Sulistyowati Elisa Issusilaningtyas Endang Tri Wahyuni Maharani Fery Nugroho Fitri Galih Ramadhani Fitria Nur Kartika Ginanjar Triyono, Heru Hastuti Budi Rahayu Imam Agus Faizal Iqbal Tamimi Ira Pangesti Ira Pangesti Iskandar, Drajat Junior Dwi Cahyo Kartika Palupi Legiana Elza Syariah Lestari, Tika Lisa Savitri mala aulia hapsari Mubarok, Akhmad Mulyani, Eti Nikmah Nuur Rochmah Nugroho, Yusuf Eko Pepi Febrianti Putri, Reza Amelia Raafi R, Muhammad Raden Bagus Muhamad Tsabitul Fikriyansyah Reja Rafli, Afan Risma Adzkia Putri Sari, Windia Arta Sa’if Revallindo Mirza Sri Lestari Stalis Norma Ethica Tajudin, Tatang wahid, wahyumuttaqin Wahyu, Wahyu Wahid Muttaqin Yasinta Aritonang Yuhansyah Nurfauzi Yusuf Eko Nugroho Yusuf Eko Nugroho