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All Journal Science and Technology Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Insan Farmasi Indonesia Jurnal Pengabdian Farmasi dan Sains
Farida Ifadotunnikmah
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Journal : Science and Technology Indonesia

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Effect of Sodium Alginate-Carrageenan Concentration in Rifampicin Pulmospheres on Physical Characteristics, Release, and Anti-Tuberculosis Activity Liempepas, Angelika; Rahmadi, Mahardian; Ifadotunnikmah, Farida; Hariyadi, Dewi Melani
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.817-825

Abstract

Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which mostly attacks the lungs, but can also affect other organs. Tuberculosis is one of the biggest health problems worldwide. Conventional oral rifampicin preparations have several limitations, such as poor bioavailability, low solubility, and drug instability in the gastrointestinal fluid. Only a small portion of the tuberculosis drug can reach the alveoli, the main target of the tuberculosis drug. Drug delivery Systems are one of the solutions to this problem. They are a formulation or system that can mediate the delivery of therapeutic substances in the body to increase therapeutic effects, reduce drug side effects, increase bioavailability, and improve patient compliance. Pulmonary drug delivery requires a small dose and particle size, so microspheres are selected for lung delivery. This research aims to study the effect of sodium alginate concentration and carrageenan (0.75%, 1%, 1.25%) with a ratio of 1:1 on physical characteristics, in vitro release, and anti-tuberculosis activity. Preparation of Rifampicin Sodium Alginate-Carageenan Pulmospheres with Ionotropic Gelation-Aerosolization. Pulmospheres were evaluated for entrapment efficiency, morphology, yield, particle size, drug loading, in vitro release, and Mycobacterium smegmatis activity. Increasing concentrations of sodium alginate and carrageenan produce rifampicin pulmospheres with good physical characteristics, increase rifampicin release, and result in inhibitory activity against Mycobacterium smegmatis
Co-Authors Abdul Rahem Abdul Rahem, Abdul Afandi, Ryan Arie Sulistyarini Bambang Tri Purwanto Bastiana Bastiana Bermawi, Bastiana Budiatin, Aniek Setiya Chrismawan Ardianto Dewi Melani Hariyadi Dewi Melani Hariyati Etik Wahyuningsih Febrianti, Winanda Rizki Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hartono, Thalia Vanessa Hermansyah, Andi I NYOMAN WIJAYA Ichsanto, Farhan Hanang Isnalita Isnalita, Isnalita Juni Ekowati Kholis Amalia Nofianti Liempepas, Angelika Mahardian Rahmadi Melanny Ika Sulistyowaty Mochammad Yuwono Muhammad Faris Adrianto, Muhammad Faris Neny Purwitasari Noorma Rosita Pratama, Adam Prawitasari, Neny Prayoga, Adistiar Priyandani, Yuni Purwitasari, Neny Retno Widyowati Rianti, Dian Ratna Setiawan, Albertus Aditya Shihab, Fawaz Sukorini, Anila Impian Sumarno . Susanto, Julian Dwi SUZANA, SUZANA Toetik Aryani Tutik Sri Wahyuni Ulvan, Angkasa Megistra Umi Athiyah, Umi Wiwied Ekasari Yuda, Ana Zulkarnain, Bambang Subakti