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Rahajeng, Bangunawati
School Of Pharmacy Faculty Of Medicine And Health Sciences University Of Muhammadiyah Yogyakarta, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Hubungan Kepatuhan Terapi terhadap Risiko Memulai Dialisis dan Kualitas Hidup pada Pasien Penyakit Ginjal Kronis Rawat Inap di Rumah Sakit Salsabila, Arini; Supadmi, Woro; Yuniarti, Endang; Rahajeng, Bangunawati
Indonesian Journal of Clinical Pharmacy Vol 15, No 2 (2026)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2026.v15i2.69628

Abstract

Penyakit ginjal kronis (PGK) merupakan kondisi progresif yang menyebabkan penurunan fungsi ginjal secara permanen serta berdampak pada kualitas hidup dan peningkatan risiko memulai dialisis. Prevalensi PGK di Indonesia tercatat sebesar 0,38% berdasarkan Riskesdas 2018 dan diperkirakan masih lebih rendah dari kejadian sebenarnya. Ketidakpatuhan terhadap terapi dapat memperburuk kondisi klinis dan mempercepat progresivitas penyakit. Penelitian ini bertujuan untuk menganalisis hubungan kepatuhan terapi terhadap risiko memulai dialisis dan kualitas hidup pasien PGK rawat inap di Rumah Sakit PKU Muhammadiyah Kota Yogyakarta. Penelitian ini menggunakan desain observasional dengan potong lintang prospektif. Subjek penelitian diambil pada periode Oktober–Desember 2025 sesuai dengan kriteria inklusi. Data diperoleh dari karakteristik pasien dan penggunaan obat berdasarkan rekam medik elektronik. Kepatuhan terapi diukur menggunakan Medication Adherence Report Scale-5 (MARS-5), kualitas hidup menggunakan Kidney Disease Quality of Life-36 (KDQOL-36), sementara risiko memulai dialisis ditentukan berdasarkan rekam medis. Analisis data dilakukan secara univariat dan bivariat menggunakan uji chi-square. Jumlah responden dalam penelitian ini sebanyak 70 pasien. Sebanyak 38 pasien (54,3%) tergolong patuh terhadap terapi, sedangkan 36 pasien (51,4%) menjalani hemodialisis selama perawatan. Kualitas hidup yang baik ditemukan pada 59 pasien (84,3%). Hasil analisis menunjukkan terdapat hubungan yang signifikan antara kepatuhan terapi dengan kualitas hidup (p<0,001), namun tidak terdapat hubungan yang signifikan antara kepatuhan terapi dengan risiko memulai dialisis (p=0,278). Kepatuhan terapi berhubungan signifikan dengan kualitas hidup, tetapi tidak berhubungan dengan risiko memulai dialisis pada pasien PGK rawat inap. Oleh karena itu, kepatuhan terapi dapat dipertimbangkan sebagai salah satu faktor yang berkaitan dengan kualitas hidup pasien.Kata kunci: kepatuhan terapi, kualitas hidup, penyakit ginjal kronis, risiko memulai dialisis The Relationship between Therapy Adherence and the Risk of Starting Dialysis and Quality of Life in Hospitalized Chronic Kidney Disease PatientsAbstractChronic kidney disease (CKD) is a progressive condition characterized by irreversible deterioration of kidney function, leading to impaired quality of life and an increased risk of initiating dialysis. According to the 2018 Indonesian Basic Health Research (Riskesdas), the prevalence of CKD in Indonesia was 0.38%, although the actual prevalence is likely higher. Poor medication adherence may worsen clinical outcomes and accelerate disease progression. This study aimed to analyze the association between medication adherence, the risk of initiating dialysis, and quality of life among hospitalized patients with CKD at PKU Muhammadiyah Hospital, Yogyakarta City. A prospective cross-sectional observational study was conducted among eligible patients recruited between October and December 2025. Patient characteristics and medication data were obtained from electronic medical records. Medication adherence was assessed using the Medication Adherence Report Scale-5 (MARS-5), quality of life was measured using the Kidney Disease Quality of Life-36 (KDQOL-36), and the risk of initiating dialysis was determined based on medical records. Data were analyzed using descriptive statistics and Chi-square tests. A total of 70 patients were included in the study. Of these, 38 patients (54.3%) were adherent to therapy, while 36 patients (51.4%) underwent hemodialysis during hospitalization. Good quality of life was reported in 59 patients (84.3%). Medication adherence was significantly associated with quality of life (p<0.001), but not with the risk of initiating dialysis (p=0.278). Medication adherence was significantly associated with quality of life but not with the risk of initiating dialysis among hospitalized patients with CKD. Therefore, medication adherence may be considered an important factor associated with patients’ quality of life.Keywords: chronic kidney disease, risk of starting dialysis, therapy adherence, quality of life
Co-Authors A.A. Ketut Agung Cahyawan W Abadi, Barnabas Bagus Aditya Andy Eko Wibowo Aris Widayati Azizah Khoiriyati Charismawati, Erlinda Mimbar Cindy Soraya Devi Puspitasari Diastri, Hanna Dyani Primasari Sukamdi Endang Yuniarti Erna Tri Wulandari Fathurrohmah, Fitriannisa Fitriannisa Fathurrohmah Indriastuti Cahyaningsih, Indriastuti Ingenida Hadning Ingenida Hadning Ingenida Hadning Ingenida Hadning Iwan Dwiprahasto Kuman, Nuryati Muhammad Fariez Kurniawan Muhammad Fariez Kurniawan Muhammad Ridwan Muhammad Ridwan Muhammad Thesa Ghozali Nanang Munif Yasin Noviya Wardhani Nuariska Laila Ramadhani Nugrahaningtyas, Odilia Danti Nurul Hikmah Nurul Maziyyah Octavia, Mega Pinasti Utami Pinasti Utami, Pinasti Prameswara, Annisaa Bella Putri, Claryza Amelia Ramadhani, Firda Ratnasari Sabtanti Harimurti Salma Khoirunnisa Akbar Salsabila, Arini Siti Martini Khairiati Susana, Yolanda Putri Tri Murti Andayani Vella Lailli Damarwati Widyati Widyati Woro Supadmi Zullies Ikawati