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Cortisol levels associated with mortality in children with critical illness: a systematic review Tolibin, Restu Triwulandani; Widiretnani, Septin; Moelyo, Annang Giri
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.472-82

Abstract

Background Critically ill patients, including those with sepsis, have increased cortisol levels due to activation of the hypothalamic-pituitary-adrenal (HPA) axis or critical illness-related corticosteroid insufficiency (CIRCI). Objective To evaluate for a possible association between cortisol levels and mortality from sepsis in pediatric patients by systematic review of the literature. Methods A systematic review was conducted on studies involving critically ill children, including those with sepsis. We included studies published between 2011-2020 analyzing data on cortisol levels (total serum cortisol, serum-free cortisol, salivary cortisol, real-time free cortisol, basal serum cortisol and post-adrenocorticotropin hormone (ACTH) stimulation test, or basal salivary cortisol and post-ACTH stimulation test), the predictive score for mortality (Pediatric Logistic Organ Dysfunction/PELOD), Pediatric Risk of Mortality (PRISM), Pediatric Index of Mortality (PIM), Vasotropic Inotropic Score (VIS), or Pediatric Critical Illness Score (PCIS)], mortality (non-survivor percentage), and CIRCI percentage as an outcome in patients with critical illness, sepsis, and septic shock. Results Twenty-one observational studies were included in our systematic review, with a total of 2,212 subjects, 916 of whom had sepsis. Nineteen studies indicated a positive association between elevated cortisol levels and mortality in critically ill children, but 2 studies stated that there was no association with the CIRCI percentage of 32.3 and 84.3% respectively. The mortality percentage of critically ill patients with elevated cortisol levels and sepsis were 25.81 (2.7-60)% and 35.31 (6-60)%, respectively. The percentages of CIRCI in critically ill and sepsis patients were 21.91 (0-84.3)% and 21.35 (0-84.3)%, respectively. Conclusion Cortisol levels may increase or decrease in critically ill children. Elevated cortisol levels are associated with mortality in septic children. The effect of CIRCI on mortality in critically ill children cannot be concluded.
PENINGKATAN KUALITAS HIDUP PRA LANSIA DAN LANSIA DENGAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DI DESA WONOREJO, SRAGEN Tolibin, Restu Triwulandani
Jurnal Pengabdian Masyarakat Medika Vol 4. No. 2, September 2024
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v4i2.5801

Abstract

ABSTRAK Perilaku Hidup Bersih dan Sehat (PHBS) adalah upaya untuk memperkuat budaya seseorang kelompok maupun masyarakat agar peduli dan mengutamakan kesehatan untuk mewujudkan kehidupan yang lebih berkualitas. Upaya kesehatan Lanjut Usia (Lansia) dilakukan sejak seseorang berusia 60 tahun serta ditujukan untuk menjaga agar tetap hidup sehat, berkualitas, dan produktif sesuai dengan martabat kemanusiaan dan banyak bersinggungan dengan PHBS. Persentase PHBS level rumah tangga dan individu di Kabupaten Sragen pada tahun 2018 sebanyak 40,2% dan 52,2%. Tujuan dari kegiatan ini untuk meningkatkan gerakan masyarakat yang bersifat preventif dan promotif, maka penulis melakukan kegiatan pengabdian masyarakat berupa edukasi PHBS Lansia di Desa Wonorejo, Sragen. Metode penyuluhan mencakup pretest dan post test untuk mengukur pengetahuan peserta, diikuti dengan pemberian materi serta dilanjutkan dengan diskusi tanya jawab. Analisis efektivitas penyuluhan berdasarkan perbedaan nilai pretest dan post test. Nilai pretest dan post test dianalisis menggunakan metode uji Wilcoxon. Hasil penyuluhan didapatkan peningkatan pengetahuan peserta setelah penyuluhan dengan nilai p < 0,001.    ABSTRACT Clean and Healthy Living Behaviour (CHLB) is an effort to strengthen the culture of a group or community to care about and prioritize health to create a better quality life. Health efforts for the elderly are carried out from when a person is 60 years old and are aimed at maintaining a healthy, high-quality and productive life in accordance with human dignity and have a lot of contact with CHLB. The percentage of CHLB at the household and individual levels in Sragen Regency in 2018 was 40.2% and 52.2%. The purpose of this activity is to increase preventive and promotive community movements, the author conducted community service activities in the form of PHBS education for the elderly in Wonorejo Village, Sragen. The counceling method includes a pretest and posttest to measure participants' knowledge, followed by providing materias and continued with question and answer discussion. Analysis of the effectiveness of the extension based on differences in pretest and posttest scores. Pretest and posttest scores were analyzed using the Wilcoxon test method. The results of the counseling showed an increase in participants' knowledge after the counseling with a p value <0.001.
UPAYA PENGUATAN PELAYANAN KESEHATAN BAYI DAN BALITA DI PUSKESMAS COLOMADU II DENGAN MANAJEMEN TERPADU BALITA SAKIT Tolibin, Restu Triwulandani; Mahawan, Yasmin Faradila; Tampan, Yulia
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 1, Maret 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i1.7069

Abstract

ABSTRAK Masalah kematian bayi dan balita masih menjadi tantangan besar di Indonesia. Sebagian besar kematian bayi disebabkan oleh komplikasi saat lahir, sedangkan diare dan pneumonia menjadi penyebab utama kematian balita. Pemerintah telah berupaya mengatasi masalah ini dengan menerapkan program Manajemen Terpadu Balita Sakit (MTBS) yang memberikan pelatihan kepada tenaga kesehatan di puskesmas. Puskesmas Colomadu II, sebagai salah satu fasilitas kesehatan di tingkat pertama, turut berperan dalam upaya penurunan angka kematian bayi dan balita. Tim pengabdian masyarakat mengajukan penguatan MTBS bagi tenaga kesehatan agar lebih siap dalam melakukan perawatan pada bayi dan balita sakit. Metode pelaksanaan pengabdian masyarakat berupa penyuluhan dan diskusi interaktif, diikuti dengan pemberian materi tentang MTBS, serta analisis efektivitas penyuluhan berdasarkan perbedaan nilai pretest dan posttest untuk mengukur pengetahuan tenaga kesehatan. Nilai pretest dan posttest dianalisis menggunakan metode uji Wilcoxon. Analisis statistik didapatkan peningkatan pengetahuan peserta setelah penyuluhan dengan nilai p<0,01 yang mengindikasikan keberhasilan peningkatan pengetahuan peserta.    ABSTRACT Infant and toddler mortality remains a major challenge in Indonesia. Most infant mortality is caused by complications at birth, while diarrhea and pneumonia are still the leading causes of toddler mortality. The government has attempted to address this issue by implementing the Manajemen Terpadu Balita Sakit (MTBS) program which provides training to health workers at community health centers. Puskesmas Colomadu II, as one of the first-level health facilities, plays a role in efforts to reduce infant and toddler mortality rates. Community service team proposed strengthening MTBS for health workers to prepare and provide care for sick infants and toddlers. The method for implementing community service is in the form of counseling and interactive discussions, followed by providing material about MTBS, as well as analysis of the effectiveness of counseling based on differences in pretest and posttest scores to measure the knowledge of health workers. Pretest and posttest scores were analyzed using the Wilcoxon test method. Statistical analysis showed an increase in participant’s knowledge after counseling with a p value <0.001, which indicated the success of increasing participant’s knowledge.
Correlation between Socioeconomic Level and Nutritional Status with The Incidence of Helminthiasis in Elementary Students Rahmah, Maulida; Nurhayani, N; Bestari, Rochmadina Suci; Tolibin, Restu Triwulandani; Najmii, Muhammad Firoos Allaam
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5520

Abstract

Purpose: To examine the relationship between socioeconomic status and nutritional condition with the prevalence of helminthiasis among students at SDN 02 Selokaton. Methodology: This research employs a quantitative observational analytic approach with a cross-sectional design. A total of 130 fifth- and sixth-grade students were selected using total sampling. The independent variables (socioeconomic status and nutritional status) were assessed through questionnaires and anthropometric measurements, respectively. The dependent variable, helminth infection incidence, was determined through microscopic stool analysis. Data were analyzed using Spearman's test. Results: Among the 65 students who met the inclusion criteria, 20% (13 students) tested positive for helminth infections. Poor nutritional status was found in 6.2% of students, while 43.1% had low nutritional status. Most students came from families with a middle socioeconomic status (78.5%). No significant correlation was found between socioeconomic status or nutritional status and the incidence of helminth infections (p > 0.05). Applications/Originality/Value: Despite the lack of a significant correlation, the high prevalence of helminth infections suggests that factors like environmental hygiene and hygienic behaviors may play a more influential role. Health education and improved sanitation are needed to reduce the prevalence of helminth infections in the area.
Risk Factors for Early Weight Loss in Breastfed Term Infants: Biomedical Perspective Tolibin, Restu Triwulandani; Herdhiyanti Siwi, Dinar; Anggitaratri, Zakia Novi
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i1.8422

Abstract

Infants can lose some of their birth weight in the first weeks of life. Identification of the risk factors associated with breastfed infant weight loss in the few weeks following the birth can increase the success of exclusive breastfeeding. The aim of this research was to determine the risk factors in breastfed full-term infants that cause early weight loss at a hospital. This study was retrospective study, which analyzes weight loss in breastfed term infants born between July 1, 2024, and October 31, 2024, at hospital in Boyolali, Central Java. A total of 194 infants were included in the study. The variables studied the maternal age, method of delivery, infant’s birth weight, infant’s gender, and maternal parity.  Pearson Chi-Square test was used to compar categorical data. Logistic Regression with the Backward Stepwise method was used to analyze multivariate data. Caesarean section was statistically significant risk factor for early weight loss in breastfed term infants that increases the chance of weight loss by 1.56 times. We concluded that caesarean section increased the chance of early weight loss in breastfed term infants.
PENGUATAN KETAHANAN KELUARGA MELALUI PROGRAM KELUARGA BAKOH (BAHAGIA, KOKOH, DAN SEHAT) Andrianie, Prilya Shanty; Habiby, Wahdan Najib; Inayati, Nurul Latifatul; Tolibin, Restu Triwulandani; Dhani, Sheena Ramadhia Asmara; Salsabila , Hasna; Hernanda, Shakira Amarillis; Suryono, Yusuf Ade
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.9085

Abstract

ABSTRAK Permasalahan menurut mitra yang didapat dari kepala Puskesmas Colomadu II, kasus pernikahan dini dan kehamilan di luar nikah cukup tinggi. Tahun 2023 terdapat 11 kasus hamil di luar nikah yang dilaporkan dan diperkirakan masih banyak kasus serupa namun tidak dilaporkan. Solusi yang diberikan dalam pengabdian ini adalah kegiatan Penguatan Ketangguhan Keluarga Melalui Program Keluarga Bakoh (Bahagia, Kokoh, Dan Sehat): Perspektif Agama, Kesehatan, Psikologis, dan Pendidikan yang akan dilakukan bersama mitra yaitu Puskesmas Colomadu II. Program Keluarga BAKOH ini mengintegrasikan psikoedukasi dan juga pelatihan dari berbagai perspektif yaitu Agama, Medis/Kesehatan, Psikologi, dan Pendidikan. Bentuk program yang akan diberikan antara lain: psikoedukasi pra nikah bagi kader remaja, edukasi kesehatan reproduksi bagi kader remaja, psikoedukasi membangun ketangguhan keluarga: perspektif agama, kesehatan, psikologis, dan pendidikan. Metode kegiatan yang dilakukan berupa psikoedukasi kesehatan reproduksi remaja, psikoedukasi ketahanan remaja, pemberian pelatihan menjaga kesehatan mental remaja, dan konseling. Hasil evaluasi menunjukkan bahwa peningkatan pemahaman informasi para kader meningkat, 68,9% peserta merasa sangat puas dengan fasilitas yang diberikan dan 26,7% merasa puas. Kemudian terkait dengan materi yang diberikan, 75,6% peserta merasa sangat puas dan menilai materi yang diberikan sangat menarik, sementara 24,4% lainnya menilai materinya menarik. Kualitas narasumber pun dinilai oleh 88,9% peserta sangat kompeten dan 11,1% kompeten. Sehingga secara umum, seluruh peserta merasa puas dan sangat puas dengan kegiatan pengabdian Program Keluarga BAKOH.   ABSTRACT Issues identified by partners, particularly the Head of Puskesmas Colomadu II, reveal a significant prevalence of early marriage and premarital pregnancies. In 2023, there were 11 reported cases of premarital pregnancies, with many similar cases likely remaining unreported. The solution in this community service initiative is the implementation of the Family Resilience Strengthening Program through the BAKOH (Happy, Strong, and Healthy) approach, involving perspectives from religion, health, psychology, and education. This program carried out in collaboration with Puskesmas Colomadu II. The BAKOH Family Program integrates psychoeducation and training from various perspectives: religious, medical/health, psychological, and educational. The program activities include Pre-Marriage Psychoeducation for Adolescent Peer Educators, Reproductive Health Training for Adolescent Peer Educators, and Psychoeducation on Building Family Resilience: Perspectives from Religion, Health, Psychology, and Education. The methods utilized encompass reproductive health psychoeducation for adolescents, psychoeducation on adolescent resilience, mental health training for adolescents, and counseling services. Evaluation results indicate a significant improvement in participants' understanding, with 68.9% expressing high satisfaction with the provided facilities and 26.7% reporting satisfaction. Regarding the materials presented, 75.6% of participants rated them as highly satisfying and very engaging, while 24.4% found them engaging. Additionally, 88.9% of participants assessed the quality of the facilitators as highly competent, while 11.1% rated them as competent. Overall, all participants reported feeling satisfied or very satisfied with the activities conducted under the BAKOH Family Program.
PENCEGAHAN, DETEKSI DINI, DIAGNOSIS DAN TATA LAKSANA STUNTING PADA BALITA DAN KADER BALITA DI WILAYAH KERJA PUSKESMAS COLOMADU II, KABUPATEN KARANGANYAR Agustina, Tri; Tolibin, Restu Triwulandani; Aisyah, Riandini; Lestari, Nining; Bestari, Rochmadina; Maylafaiza, Annisa; Nafisa, Balqis; Rahayu, Destri; Arrohma, Farah; Fauzi, Favian; Setiani, Hilda; Ramadhani, Marsyanda; Sukardi, Nadya; Pratama, Nur; Ayyasi, Quanta
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.12255

Abstract

  ABSTRAK Stunting merupakan gangguan pertumbuhan linier yang ditandai dengan panjang atau tinggi badan menurut umur di bawah -2 SD. Kondisi ini mencerminkan masalah gizi kronik dan masih menjadi tantangan besar di Indonesia. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman dan keterampilan kader serta orang tua balita dalam pencegahan stunting melalui edukasi, pelatihan antropometri, promosi pemberian ASI eksklusif, MPASI bergizi seimbang, dan pemahaman tentang pangan olahan untuk keperluan medis khusus (PKMK). Metode pelaksanaan mencakup survei awal, koordinasi dengan Puskesmas Colomadu II, pelatihan kader, edukasi kepada orang tua, serta evaluasi menggunakan pretest dan posttest. Hasil analisis dengan uji Wilcoxon Signed-Rank menunjukkan tidak terdapat perbedaan signifikan secara statistik, namun terdapat peningkatan nilai deskriptif yang menunjukkan adanya dampak positif terhadap peningkatan pengetahuan. Hasil ini mengindikasikan bahwa pendekatan edukatif berbasis komunitas berpotensi efektif untuk pencegahan stunting bila dilaksanakan secara berkelanjutan dan adaptif.   ABSTRACT Stunting is a linear growth disorder characterized by height or length below -2 SD for age. This condition reflects chronic malnutrition and remains a major challenge in Indonesia. This community service activity aims to improve the understanding and skills of cadres and parents of toddlers in preventing stunting through education, anthropometry training, promotion of exclusive breastfeeding, nutritionally balanced complementary foods, and understanding of processed foods for special medical purposes (PKMK). The implementation methods included an initial survey, coordination with the Colomadu II Community Health Center, cadre training, education for parents, and evaluation using pre-tests and post-tests. The results of the analysis using the Wilcoxon Signed-Rank test showed no statistically significant differences, but there was an increase in descriptive values, indicating a positive impact on knowledge improvement. These results indicate that a community-based educational approach has the potential to be effective in preventing stunting when implemented in a sustainable and adaptive manner.