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All Journal Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) Jurnal Penelitian Pendidikan IPA (JPPIPA) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Mandala Pharmacon Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT MONSU'ANI TANO Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy FARMESTRA
Yuniarto, Ari
Universitas Muhammadiyah A.R. Fachruddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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PELATIHAN PEMBUATAN LILIN AROMATERAPI DARI BEBERAPA MINYAK ALAMI DI TIGARAKSA KABUPATEN TANGERANG, BANTEN Hariyanti Hariyanti; Priyanto Priyanto; Ari Yuniarto; Aziz Setiawan; Dina Pratiwi; Nu’aiman Nu’aiman; Tafriani Sucianti Nesha
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 3 (2024): Juni
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i3.21587

Abstract

Abstrak: Penggunaan minyak alami pada lilin sebagai aromaterapi dapat mengatasi penyebaran demam berdarah dengue (DBD). Pelatihan tentang pembuatan lilin aromaterapi sebagai antinyamuk sehingga masyarakat dapat mencegah gigitan dan perkembangbiakan nyamuk dengue serta memproduksi produk kesehatan secara mandiri. Mitra merupakan 20 peserta ibu-ibu PKK Perumahan Grand Metro Sodong 2 RW 9, Tigaraksa Tangerang. Kegiatan ini bertujuan untuk meningkatkan pemahaman masyarakat tentang pentingnya kesadaran kesehatan lingkungan dan pencegahan penyakit DBD dengan memanfaatkan tanaman sekitar menjadi produk kesehatan yang bermanfaat serta bernilai ekonomis. Kegiatan pengabdian ini dilakukan dalam bentuk ceramah edukasi dan pelatihan pembuatan lilin aromaterapi. Pelaksanaan pelatihan dibagi menjadi beberapa tahap yaitu pretest, penyampaian materi, pelatihan, uji hedonik, serta posttest. Pelaksanaan kegiatan telah berlangsung sangat lancer dan baik. Semua peserta sangat antusias selama pemaparan materi dan pelatihan pembuatan lilin aromaterapi. Hasil uji hedonis terpilih lilin aromaterpi minyak sereh yang terpilih sebesar 45% responden. Terjadi peningkatan pemahaman para peserta dilihat dari nilai test pada data interprestasi tinggi (nilai ≥ 80) dari 16,67% meningkat menjadi 36,67%.Abstract: Using natural oils in candles as aromatherapy can overcome the spread of dengue hemorrhagic fever (DHF). Training on making aromatherapy candles as mosquito repellent so people can prevent bites and breeding dengue mosquitoes and independently produce health products. Partners are PKK mothers of Grand Metro Sodong 2 RW 9 Housing, Tigaraksa, Tangerang. This activity aims to increase public understanding of the importance of environmental health awareness and prevention of dengue disease by utilizing surrounding plants in health products that are useful and economically valuable. This service activity is done through educational lectures and training in aromatherapy candles. The implementation of training is divided into several stages, namely, pretest, material delivery, training, hedonic test, and posttest. The implementation of activities has been very smooth and good. All participants were very enthusiastic during the presentation of the material and the training on making aromatherapy candles. The results of the hedonic test selected lemongrass oil aromatherapy candles, which were selected by 45% of respondents. There was an increase in the participants' understanding, as seen from the test scores on high interpretation data (≥ 80) from 16.67% to 36.67%.
Active compounds of fingerroot (Boesenbergia pandurata) for obesity treatment: in silico approaches Yuniarto, Ari; Aji, Abdul; Ramadhani, Anggia Noor; Permatasari, Galuh Wening
MPI (Media Pharmaceutica Indonesiana) Vol. 4 No. 1 (2022): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v4i1.4807

Abstract

Obesity has become increasingly prevalent worldwide each year. Several studies have proven that herbs are effective in preventing obesity. The research delved into the active compounds of Boesenbergia pandurata to reveal their mechanisms of action by utilizing bioinformatics approaches. The research methods included active compounds selection, QSAR analysis, networking analysis, molecular docking, and ADME prediction. The QSAR analysis predicted that the active compounds were correlated with some theoretical activities with more than 0.5 probability, namely vasoprotective, anti-hypercholesterolemic, anti-inflammatory, free radical scavenging, and as a lipid metabolism regulator and TNF expression inhibitor. Furthermore, the results of the networking analysis showed that five compounds (pinocembrin, cardamonin, flavokawain B, flavokawain C, and tectochrysin) had direct interactions with RPS6KB1. Pinocembrin exhibited the highest binding affinityof -7.26 kcal/mol, although not as strong as that of the control ligand (FS9). The ADME prediction indicated that the five compounds were non-toxic and had excellent absorption. It can be concluded that the active compounds of B. pandurata have the ability to improve metabolic syndrome, especially obesity, in silico through several mechanisms, such as suppression of pro-inflammatory cytokine, regulation of lipid metabolism, and those associated with antioxidants.
Antihypertension Activity of Averrhoa bilimbi Fruit Juice on Sodium Chloride and Prednisone-Induced Rats Yuniarto, Ari; Alviolita, Dini; Kurniasukmawati, Ika; Rasydy, La Ode Akbar
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5798

Abstract

Hypertension is a condition where systolic and diastolic blood pressure continuously increases, causing heart disease, kidney disease, hardening of the arteries, eye damage, and stroke (brain damage). Bilimbi (Averrhoa bilimbi L.) is traditionally used to lowering high blood pressure. The research objective was evaluating the activity of A. bilimbi as an antihypertensive. The research was conducted in vivo using rats and the CODA blood pressure analysis instrument. The doses used for A. bilimbi juice were 150, 300, and 600 mg/kg BW, respectively. A. bilimbi juice at a dose of 600 mg/kg BW/day for 14 days can reduce systolic and diastolic blood pressure in male Wistar rats induced by 2.5% NaCl and 1.5 mg/kg BW prednisone. The results of the study showed that A. bilimbi juice at a dose of 600 mg/kg BW. had antihypertensive activity.
Formulation and Hedonic Test of Lemon (Citrus limon L.), Ginger (Zingiber officinale), and Porang (Amorphophallus muelleri Blume) Flour as Health Powder Beverage Nurshiyami, Yusfa; Nuraini, Nuraini; Yuniarto, Ari
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 2 (2024): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i2.6713

Abstract

Health powder drinks are drinks made from powder or granules in a mixture of sugar, fruit, and spices, usually served quickly by brewing, and contain many nutritional and non-nutritional elements. Identify the physical evaluation of powder, quality requirement test (Indonesian National Standard (SNI)), and hedonic test of lemon juice (Citrus limon L.), ginger (Zingiber officinale), and porang flour (Amorphophallus muelleri Blume) health powder beverage. This study was experimental, by making lemon and ginger juice powder using a freeze-drying instrument. Lemon, ginger, and porang flour powders were formulated in 3 formulas. Then, the physical evaluation of the powder involving a quality requirement test (SNI) and hedonic test was conducted. The results of physical evaluation tests which include (organoleptic, flow time, angle of repose, specific gravity, water content, and dissolving time) and quality requirements tests which include (water content and ash content) show that powdered drinks meet the physical requirements of powders and quality requirements (SNI). Hedonic taste, color, aroma, and texture tests differ from the three formulas. Health powder drinks have a good physical evaluation of powders and quality requirements (SNI), and the most favored formula by panelists is formula 3. Submitted: 29-07-2024, Revised: 09-12-2024, Accepted: 11-12-2024, Published regularly: December 2024
Molecular Docking of Pomegranate Peel (Punica granatum L.) Active Compounds by Targeting Tumor Necrosis Factor Alpha (TNF-α) in Diabetes Condition Yuniarto, Ari; Rangkuti, Saru Noliqo; Junaidin
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 2 (2024): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i2.6917

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by increased blood glucose concentration, known as hyperglycemia. Several studies report that diabetes mellitus is associated with the presence of tumor necrosis factor-α (TNF-α). One of the medicinal plants that has the potential to be used to treat diabetes mellitus is pomegranate (Punica granatum L.). Therefore, this study aimed to observe the effect of bioactive compounds of pomegranate peel as antidiabetic against TNF-α using a molecular docking approach. The stages of molecular docking include geometry optimization, validation of the docking program, docking ligand test, and visualization of the docking results. The target compounds analyzed from pomegranate peel were ellagitannin and punicalagin. The macromolecular target wasTNF-α. Redocking between the original ligand and the target TNF-α showed an RMSD value of ≤ 2.0 Å with a value of 0.4902 Å. The hydrophobic interaction was formed between ellagitannin and punicalagin on the TNF-α target shows excellent ligand-receptor interactions, this can be seen from the binding free energy value which is smaller when compared to the co-crystal ligand. These results indicate that the complex formed from tethering ellagitannin and punicalagin to the TNF-α target is more stable than the original ligand complex with the TNF-α target. Based on the research results, it can be concluded that pomegranate peel has excellent potential as an antidiabetic. In silico research shows that pomegranate peel content such as ellagitannin can bind stably with TNF-α (ΔG = -132.44kcal/mol), so it is predicted to be able to suppress TNF-α which is responsible for the emergence of diabetes mellitus. Submitted: 05-10-2024, Revised: 16-11-2024, Accepted: 25-11-2024, Published regularly: December 2024
Review: Zebrafish (Danio Rerio) Sebagai Model Obesitas dan Diabetes Melitus Tipe 2 Hardianti, Mira; Yuniarto, Ari; Hasimun, Patonah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.69-79.2021

Abstract

Zebrafish (Danio rerio) yang sebelumnya disebut Brachydanio rerio merupakan spesies ikan air tawar tropis yang berukuran kecil yang berasal dari Asia Selatan dan Sungai Gangga di India. Zebrafish bisa diaplikasikan pada model obesitas dan diabetes melitus tipe 2 (DMT2). Obesitas merupakan pemicu terjadinya DMT2. Tujuan dari review artikel ini dapat memberikan informasi dan meningkatkan pemahaman pembaca bahwa zebrafish merupakan model yang ideal untuk obesitas dan DMT2. Metode penulisan review artikel ini dilakukan dengan penelusuran artikel ilmiah terpublikasi bertaraf nasional dan internasional dengan menggunakan kata kunci berupa “Obesity, zebrafish, model”, “Hyperglycemia, zebrafish, model” atau “zebrafish for hyperglycemia” dan “Diabetes melitus type 2, zebrafish, model”. Zebrafish model obesitas dan DMT2 yang diinduksi makanan dan obat menunjukkan keunggulan menjadi obesitas seperti pada manusia dan mamalia lain. Selain itu, zebrafish yang diinduksi dengan metode perendaman glukosa diperoleh hasil meningkatnya kadar glukosa darah dan gangguan respon terhadap insulin eksogen. Pemberian alternatif terapi dari bahan alam seperti GTE, palmaria mollis, diosgenin, bubuk kayu manis pada zebrafish memberikan hasil yang cukup baik sehingga bisa dipertimbangkan sebagai alternatif model hewan lain.
Review Artikel : Sediaan Tabir Surya Yang Memiliki Aktivitas SPF Dari Beberapa Ekstrak Tanaman Herbal Jannah, Fadhila Roudhatul; Fauziah Ramadhona, Alfitra; Yuniarto, Ari
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 2 No. 02 (2024): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Paparan cahaya matahari secara terus menerus dapat menyebabkan terjadinya kerusakan pada kulit. Untuk mencegah kerusakan kulit, dibutuhkan tabir surya yang termasuk sediaan kosmetik yang dapat memantulkan atau menyerap secara aktif cahaya matahari sehingga dapat mencegah terjadinya kerusakan kulit karena sinar UV. Sediaan tabir surya yang sudah banyak dipasaran yaitu krim, gel, spray gel dan powder atau bedak tabur. Penentuan nilai sun proction Factor (SPF) dapat dilakukan dengan pengukuran efektivitas sediaan tabir surya untuk melihat kemampuan sediaan terhadap paparan sinar matahari. Review ini diharapkan dapat memberikan informasi kepada pembaca mengenai sediaan tabir surya berbasis tanaman herbal yang memenuhi persyaratan pengujian secara in vitro terkait nilai SPF yang diperuntukkan untuk kulit agar terlindung dari radiasi sinar UV.
Asam mefenamat Efek Rekristalisasi Konvensional dan Dengan Bantuan Ultrasonik terhadap Karakteristik Kristal Asam Mefenamat Rasydy, La Ode Akbar; Damayanti, Hilda; Femalda, Adefia; Yuniarto, Ari; Arrahman, Ikhsan Nazar; Wahid, Rifki Saldi A.
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17164

Abstract

Mefenamic acid is classified as a Biopharmaceutical Classification System (BCS) Class II drug. Crystallisation techniques can significantly influence the critical properties of mefenamic acid crystals, an essential consideration in the pharmaceutical industry. This study investigates the effect of recrystallisation on the morphology and particle size of mefenamic acid crystals using ethyl acetate as the solvent.  Recrystallisation was conducted using both conventional and ultrasonic-assisted methods. The yield was calculated, and characterization was performed to determine the crystal properties, shape, and particle size using polarized microscopy, X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR). The results showed that conventional recrystallisation yielded 25.078%, while ultrasonic-assisted recrystallisation at 50 W, 60 W, 70 W, and 80 W yielded 43.47%, 47.71%, 51.90%, and 50.20%, respectively. Skewness and kurtosis values for the average crystal length and width indicated a normal distribution. XRD analysis revealed that the diffraction peak intensity of conventionally recrystallised crystals became narrow. In contrast, the diffraction peak intensity of ultrasonically assisted crystals broadened. FTIR results demonstrated that the recrystallisation process did not alter the fundamental chemical structure of mefenamic acid. Recrystallisation methods influence crystal shape and size, with ultrasonic-assisted techniques producing crystals of smaller average size than those obtained through conventional methods.
Formulation and Evaluation of Antioxidant Activity of Instant Granules from 70% Ethanol Extract of Single Black Garlic (Allium sativum L.) Setiawan, Abdul Aziz; Yuniarto, Ari; Taptajani, Emir Rizky
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.9059

Abstract

Free radicals contribute to various diseases by inducing oxidative stress. Single black garlic (Allium sativum L.) is recognized for its phenolic compounds, which possess radical-scavenging properties. This study aimed to develop and evaluate instant granules containing black A. sativum extract for their antioxidant activity and physicochemical characteristics. An instant granule formulation was developed using a 70% ethanol extract of a single black A. sativum, with three distinct formulas containing 5%, 7.5%, and 10% extract (Formulas 1, 2, and 3, respectively). The granules were subjected to comprehensive physical quality assessments, including organoleptic properties, moisture content, angle of repose, flow rate, dissolution time, and tapped density. Antioxidant activity was quantified using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, reporting IC50 values. All instant granule formulations successfully met the established physical quality requirements across all evaluated parameters. Furthermore, the antioxidant activity demonstrated a concentration-dependent effect, with IC50 values of 119.576 ppm for Formula 1, 82.000 ppm for Formula 2, and 59.962 ppm for Formula 3. This study confirms that instant granules formulated with a single black A. sativum extract exhibit significant antioxidant potential and possess desirable physical characteristics, indicating their promise as a natural antioxidant supplement.
Formulation And Activity Tests of Anti-Acne Toner 70% Ethanol Extract Black Garlic (Allium sativum L.) Setiawan, Abdul Aziz; Megawati, Sefi; Yuniarto, Ari; Abdulloh
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.10093

Abstract

Black Garlic (BG) is a fermented product of garlic heated at 60-70ᵒC for 14 days. Black garlic has a black color and has an aroma and taste that is not too pungent like garlic. In Black Garlic S-allylcysteine helps the absorption of allicin making metabolism against bacterial infections easier. The purpose of this study was to determine the physical evaluation and antibacterial activity of 70% ethanol extract Black Garlic (EEBG) as well as the optimum concentration of Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes. The study used Single Black Garlic (Allium sativum L.) from Lumajang, East Java, fermented for 30 days at a temperature of 70°C and humidity of 90%. Single black garlic extract is formulated in 3 formulas, including formula 1 (0,5% extract), formula 2 (1% extract), formula 3 (1,5% extract), negatif control (base) and Wardah Acnederm Pure Refining Toner as a comparison. Toner were evaluated by organoleptic testing, pH, homogeneity, and antibacterial activity. The physical results of the toner preparation meet the physical quality requirements which include (organoleptic testing, pH, and homogeneity). The results of the antibacterial activity of toner preparations in formula 1 (0,5% extract), formula 2 (1% extract), formula 3 (1,5% extract), and Commercial toner for antibacterial. The conclusion of this study shows that EEBG has promising antibacterial effects and the evaluation of all instant granules has met the specified requirements.
Co-Authors Abdul Latif Junaedi ABDULLOH Ade Zam-zam J Aji, Abdul Alighita, Widhya Alviolita, Dini Ariadin Nurfi arrahman, ikhsan nazar Aziz Setiawan Dadang Juanda Dadang Juanda Damayanti, Hilda Dina Pratiwi Elin Yulinah Sukandar Elis Susilawati Fauziah Ramadhona, Alfitra Femalda, Adefia Finna Setiawan Hardianti, Mira Hariyanti Hariyanti Hasimun, Patonah I Ketut Adnyana Ika Kurnia Sukmawati Ika Kurnia Sukmawati Irda Fidrianny Jannah, Fadhila Roudhatul Juanda, Dadang Junaidin, Junaidin Kurniasukmawati, Ika Megawati, Sefi Mira Hardianti Nisa Nur Afifah Nita Selifiana Nuraini Nuraini Nurshiyami, Yusfa Nu’aiman Nu’aiman PERMATASARI, Galuh Wening Priyanto Priyanto Rahman, Toni Abdul Ramadhani, Anggia Noor Rangkuti, Saru Noliqo Rasydy, La Ode Akbar Saru Noliqo Rangkuti Sembiring, Rinawati Setiawan, Abdul Aziz Setiawan, Finna Sukmawati, Ika Kurnia Susilawati, Elis Tafriani Sucianti Nesha Taptajani, Emir Rizky Toni Abdul Rahman Wahid, Rifky Saldi A. Widhya Alighita Yani Mulyani Zam-zam J, Ade