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All Journal Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) JMM (Jurnal Masyarakat Mandiri) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Mandala Pharmacon Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT MONSU'ANI TANO Jurnal Pengabdian Masyarakat Makara Journal of Science Borneo Journal of Pharmacy FARMESTRA
Yuniarto, Ari
Universitas Muhammadiyah A.R. Fachruddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Identification of Xanthine Oxidase Inhibitors in Single-Clove Black Garlic using Metabolomics and Molecular Docking Approaches Setiawan, Abdul Aziz; Kumala, Shirly; Laksmitawati, Dian Ratih; Yuniarto, Ari; Yuliana, Nancy Dewi
Makara Journal of Science Vol. 30, No. 1
Publisher : UI Scholars Hub

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Abstract

Black garlic is produced through controlled fermentation under specific temperature and humidity conditions, during which the Maillard reaction enhances its sensory properties and bioactivity. The anti-hyperuricemic potential of single-clove black garlic (SBG) remains unexplored. This study combined Ultra High-Performance Liquid Chromatography–High Resolution Mass Spectrometry-based metabolomics and an in-silico approach to identify the potential xanthine oxidase inhibitors (XOI) in SBG. Methanolic extracts (10 ppm) exhibited xanthine oxidase inhibition ranging from 50.09% to 68.01%, which is comparable to allopurinol (78.74%) at the same concentration. Metabolomic profiling tentatively identified 45 compounds, and orthogonal partial least squares analysis revealed seven metabolites as strongly correlated with XOI activity, namely α-(1-deoxy-D-fructose-1-yl)-L-arginine, alliin, 2-amino-2-deoxy-D-glucose, S-allyl-L-cysteine, quercetin, and m-coumaric acid. Molecular docking showed that these compounds exhibited binding energies comparable to allopurinol, thus indicating favorable interactions within the xanthine oxidase active site. Molecular dynamics simulations confirmed the stability of ligand–enzyme complexes, with consistent hydrogen bond interactions, which support their stable binding conformations. ADMET analysis revealed that most compounds demonstrated acceptable pharmacokinetic profiles, high intestinal absorption, low blood–brain barrier permeability, and non-hepatotoxic and non-mutagenic properties. The integration of metabolomics, molecular docking, molecular dynamics, and ADMET prediction supports the potential of SBG-derived compounds as safe and effective XOIs, thereby highlighting SBG as a promising functional food candidate for the management of hyperuricemia
Evaluasi Kualitatif dan Kuantitatif Penggunaan Antibiotik Pada Pasien Pneumonia Di Instalasi Rawat Inap RSUP Dr. Sitanala Sefi Megawati; Ulis Ulis; Ari Yuniarto
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 01 Juli 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v22i1.20802

Abstract

Pneumonia adalah penyakit infeksi yang serius, yang disebabkan oleh berbagai faktor, dan untuk mencegah berkembangnya resistensi bakteri berdasarkan hal tersebut perlu dilakukan penelitian penggunaan antibiotik yang tepat dan rasional. Penelitian ini bertujuan untuk mengetahui ketepatan penggunaan antibiotik dan untuk mengetahui jenis dan jumlah penggunaan antibiotik dengan metode ATC/DDD pada pasien pneumonia rawat inap RSUP Dr. Sitanala Kota Tangerang. Dengan jumlah sampel 106 dari 145 populasi pasien, data dikumpulkan secara retrospektif dari laporan rekam medis dan dihitung berdasarkan rumus slovin. Dari hasil penelitian menunjukkan ketepatan penggunaan antibiotik pasien pneumonia RSUP Dr. Sitanala Kota Tangerang tahun 2019-2021 yaitu ketepatan indikasi 100%, pemilihan obat 100%, dosis 99,1%,  cara pemberian obat 100%, interval waktu pemberian obat 100%, dan lama pemberian antibiotik 11,32%, kemudian terdapat 8 macam antibiotik sebagai terapi penyakit pneumonia dimana kuantitas penggunaan 3 terbesar adalah Ceftriaxone 67,28 DDD/100 patient-days  (56,12%), Azithromycin 29,55 DDD/100 patient-days (24,65%), dan Levofloxacin 18,93 DDD/100 patient-days (15,79%).
Co-Authors Abdul Latif Junaedi Ade Zam-zam J Aji, Abdul Alighita, Widhya Alviolita, Dini Ariadin Nurfi Asyila, Nadia Dinda Aziz Setiawan Dadang Juanda Dadang Juanda Dian Ratih Laksmitawati Dina Pratiwi Elin Yulinah Sukandar Elis Susilawati Fauziah Ramadhona, Alfitra Hardianti, Mira Hariyanti Hariyanti Hasimun, Patonah I Ketut Adnyana Ika Kurnia Sukmawati Ika Kurnia Sukmawati Irda Fidrianny Jannah, Fadhila Roudhatul Juanda, Dadang Junaidin, Junaidin Kurniasukmawati, Ika Megawati, Sefi Mira Hardianti Nancy Dewi Yuliana Nisa Nur Afifah Nita Selifiana Nuraini Nuraini Nurshiyami, Yusfa Nu’aiman Nu’aiman PERMATASARI, Galuh Wening Priyanto Priyanto Rahman, Toni Abdul Ramadhani, Anggia Noor Rangkuti, Saru Noliqo Rasydy, La Ode Akbar Roudhatul Jannah, Fadhila Saru Noliqo Rangkuti Sembiring, Rinawati Setiawan, Abdul Aziz Setiawan, Finna Shirly Kumala Sukmawati, Ika Kurnia Susilawati, Elis Tafriani Sucianti Nesha Taptajani, Emir Rizky Toni Abdul Rahman Ulis Ulis Widhya Alighita Yani Mulyani Zam-zam J, Ade