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EVALUASI PENGGUNAAN ANTIBIOTIK ISPA PNEUMONIA PASIEN ANAK DI RUMAH SAKIT UMUM KOTA TANGERANG SELATAN TAHUN 2020-2023 Rahajeng, Suny Koswara; Sayyidah, Sayyidah; Dewi, Bheta Sari; Kristiyowati, Anis Dwi; Ismaya, Nurwulan Adi
PHRASE (Pharmaceutical Science) Journal Vol 4, No 2 (2024): Pharmaceutical Science Journal Vol 4 No 2
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i2.910

Abstract

ABSTRAK Seperti halnya di belahan dunia lain, pneumonia merupakan masalah kesehatan utama di Indonesia. Gejala infeksi saluran pernapasan akut (ISPA) dapat berkisar dari yang sama sekali tidak bergejala atau sedang hingga yang sangat parah dan bahkan fatal. ISPA dapat memengaruhi saluran pernapasan atas atau bawah. Iritasi pada sinus, hidung, dan paru-paru yang disebabkan oleh infeksi saluran pernapasan akut (ISPA) biasanya berlangsung sekitar seminggu. Penatalaksanaan pneumonia ISPA sangat bergantung pada penggunaan antibiotik yang tepat untuk mencegah resistensi antibiotik dan menjamin kemanjuran pengobatan. Para peneliti di Rumah Sakit Umum Kota Tangerang Selatan bermaksud untuk melihat seberapa baik antibiotik untuk aspirasi paru salin intravena (ISPA) bekerja pada pasien pneumonia pediatrik mereka. Penelitian ini merupakan studi observasional deskriptif. Informasi dikumpulkan dari rekam medis anak-anak yang didiagnosis dengan pneumonia ISPA antara tahun 2020 dan 2023. Sampel dari pasien dipilih untuk dianalisis menggunakan teknik pengambilan sampel acak. Sebanyak 71 partisipan dalam penelitian ini dipilih menggunakan metode sampel total. Mayoritas pasien ISPA pneumonia adalah laki-laki (36 dari 91), dan mayoritas pasien berusia di bawah lima tahun (54 dari 96; atau 76% dari total). Dari semua antibiotik yang digunakan, 36 pasien (51% dari total) diresepkan makrolida, dengan 36 pasien (51% dari total) menerima azitromisin. Analisis penggunaan antibiotik berdasarkan masing-masing kriteria: Tepat Pasien (100%), Tepat Indikasi (100%), Tepat Obat (96%), dan Tepat Dosis (97%). 
FORMULASI DAN EVALUASI FISIK SEDIAAN SERUM ANTI-AGING YANG MENGANDUNG EKSTRAK TANAMAN DARI BERBAGAI LITERATUR Dewi, Bheta Sari; Werawati, Ayu
KOLONI Vol. 1 No. 4 (2022): DESEMBER 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i4.426

Abstract

Currently, beauty products are developing very fast, especially anti-aging facial care products. One of the most popular products is serum. Serum contains many concentrates that are useful for nourishing and moisturizing the skin. Several plants that have been studied have the potential to be used as serum preparations, namely apuh-apuhan leaves, brown rice, Malacca fruit, gotu kola, jamblang leaves, cempedak leaves, black pepper, and Perilla Frutescens. This study aims to determine the formulation and physical evaluation of serum preparations containing plant extracts in terms of various literatures. The method used is descriptive literature review by collecting various sources from several national journals. The number of national journals used is 7 and 1 international journal. The results of a literature study on serum formulations containing plant extracts can be formulated into serum dosage forms. Evaluation of serum preparations includes organoleptic tests, pH tests, spreadability tests, and viscosity tests. The results of the study concluded that the formulation with the most complete physical evaluation and had good stability without any signs of damage to the dosage form in the serum formulation with a pH value of 5.5, a spreadability of 6.63 cm and a viscosity value of 2900 cP were found in formulations containing the extract. malacca fruit plants. Keywords: anti-aging, serum, formulation, evaluation, extract
UJI EFEKTIVITAS SERUM EKSTRAK DAUN KELOR (Moringa oleifera L.) SEBAGAI ANTIJERAWAT Staphylococcus aureus Dewi, Bheta Sari; Werawati, Ayu; Hasanah, Uswatun; Sayyidah, Sayyidah; Dewantoro, Agung; Saputra, Aldi
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.281

Abstract

                                                       ABSTRACTAcne is among the most prevalent dermatological issues caused by the bacterium Staphylococcus aureus. Moringa leaf extract (Moringa oleifera L.) is known to contain bioactive compounds such as flavonoids, tannins, and alkaloids, which serve as anti-acne agents. This research seeks to assess the efficacy of a serum formulated with moringa leaf extract in inhibiting the growth of acne-causing Staphylococcus aureus. The extraction of moringa leaves was carried out using the maceration technique with 96% ethanol serving as the solvent. The extract was then formulated into a serum preparation with concentrations of 4%, 7%, and 10%, using Clindamycin as the positive control and the serum base as the negative control. The antibacterial efficacy was evaluated through the agar well diffusion technique to determine the inhibition zone against Staphylococcus aureus. Each treatment was conducted in triplicate. Additionally, the physical stability of the serum was assessed, covering organoleptic characteristics, homogeneity, pH, spreadability, and adhesion. The findings revealed that moringa leaf extract exhibited inhibitory effects on the growth of Staphylococcus aureus, as evidenced by the presence of inhibition zones. The inhibition zone diameters were 14.21 mm at 4% concentration, 17.30 mm at 7%, and 19.20 mm at 10%. In comparison, the positive control showed a diameter of 30.78 mm, while the negative control showed no inhibition (0 mm). This research suggests that serum formulated with moringa leaf extract holds promise as an effective topical solution for treating acne.                                                  ABSTRAKJerawat ialah satu diantara masalah kulit yang umum disebabkan oleh bakteri Staphylococcus aureus. Ekstrak daun kelor (Moringa oleifera L.) dikenal punya senyawa bioaktif seperti flavonoid, tanin, dan alkaloid sebagai agen antijerawat. Kajian ini memiliki tujuan guna melakukan uji efektivitas serum berbahan dasar ekstrak daun kelor dalam menghambat pertumbuhan bakteri jerawat Staphylococcus aureus. Ekstrak daun kelor diperoleh lewat metode maserasi dengan pelarut etanol 96%. Ekstrak ini kemudian diformulasi ke sediaan serum dengan konsentrasi 4%, 7%, dan 10% serta digunakan Clindamycin sebagai kontrol positif dan basis serum menjadi kontrol negatif. Uji aktivitas antibakteri memakai metode difusi sumuran agar, guna mengukur zona hambat pada Staphylococcus aureus. Perlakuan diulang sebanyak 3 kali. Stabilitas fisik serum juga diuji meliputi organoleptis, homogenitas, pH, daya sebar dan daya lekat. Hasilnya diperoleh bahwa ekstrak daun kelor mempunyai kemampuan menghambat pertumbuhan Staphylococcus aureus bisa diamati dengan adanya zona hambat yang dibentuk. Diameter zona hambat di konsentrasi 4% senilai 14,21 mm, konsentrasi 7% sebesar 17,30 mm, konsentrasi 10% senilai 19,20 mm, kontrol positif senilai 30,78 mm, dan kontrol negatif sebesar 0 mm. Kajian ini memberi indikasi jika serum ekstrak daun kelor punya potensi jadi sediaan topikal yang efektif bagi pengobatan jerawat.
Peningkatan Literasi Penggunaan Obat melalui Edukasi Pengenalan Logo Obat bagi Siswa SMP Muhammadiyah 04 Pangkatrejo Aditya Sindu Sakti; Bheta Sari Dewi; Nurul Izzah H. L. Pasi; Marhamah Marhamah; Amalia Puspa Wahyu; Deta Hilar Nurrohmah; M. Ahsanul Farihin; Nur’aini Al Wahida
Nusantara: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 4 (2025): November: NUSANTARA Jurnal Pengabdian Kepada Masyarakat
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/nusantara.v5i4.6982

Abstract

This community service program aimed to enhance students’ pharmaceutical literacy through the introduction of drug classification logos at SMP Muhammadiyah 04 Pangkatrejo. The background of this activity was the low level of drug-use literacy among adolescents, often leading to irrational self-medication. The activity employed a quantitative descriptive design with a one-group pretest–posttest approach. Educational interventions included interactive counseling, PowerPoint presentations, visual media using logo sticks, and pretest–posttest evaluation. Data were analyzed using the Wilcoxon Signed Rank Test. The results showed a significant improvement in students’ knowledge (p = 0.000), with mean scores increasing from 58% to 81% after the intervention. The highest gain was observed in the recognition of logo colors and drug classifications. Satisfaction analysis revealed that 96% of participants expressed satisfaction with the learning process, especially regarding material clarity and the presenters’ readiness to answer questions. The study concludes that participatory educational methods and visual media effectively improve rational drug-use awareness among junior high school students. Future programs are recommended to expand similar activities to other schools and integrate digital media for sustained impact on public health literacy.
FORMULASI DAN EVALUASI SEDIAAN LIP BALM DARI EKSTRAK KULIT BUAH DELIMA (Punica granatum L.) Werawati, Ayu; Romlah, Siti Novy; Dewi, Bheta Sari; Sopian, Ahmad; Aulia, Gina; Manuruyah, Phuja Arinda
PHRASE (Pharmaceutical Science) Journal Vol 5, No 1 (2025): Vol 5 No 1 : Pharmaceutical Science Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i1.996

Abstract

Lips are a part of the body that is easily damaged by environmental factors so that it requires special care, such as lip balm. Natural lip balm products are preferred because they are safe and effective for lip health. Pomegranate peel has high antioxidant and tannin content, but is still rarely used in cosmetics such as lip balm. The purpose of this study was to formulate and evaluate lip balm preparations from pomegranate peel extract (Punica granatum L.) with concentrations of 10%, 15% and 20%. The research method in this study is an experimental method with stages of lip balm preparation formulation and continued with examination of the physical quality of the preparation, namely homogeneity test, organoleptic test, pH test, adhesion test, and spreadability test.. The results showed that the observation of the color of the preparation was peach red, semi-solid in shape and had a distinctive odor of oleum cacao, pH 5.92-6.45 which had met the specification range. The conclusion of this study is that F1, F2 and F3 have met the requirements of organoleptic test, homogeneity, spreading power, adhesion, pH test. 
PROFIL PERESEPAN OBAT ASMA PADA PASIEN ANAK DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT “X” JAKARTA PERIODE JANUARI – MARET 2023 Dewantoro, Agung; Fahriati, Andriyani Rahmah; Galih Pratiwi, Rekiyan Tuhu; Dewi, Bheta Sari; Rahajeng, Suny Koswara; Ismaya, Nurwulan Adi
PHRASE (Pharmaceutical Science) Journal Vol 4, No 1 (2024): Pharmaceutical Science Journal Vol 4 No 1, 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i1.730

Abstract

Asma merupakan penyakit inflamasi (peradangan) kronis saluran napas yang ditandai dengan adanya mengi episodik, batuk, dan rasa sesak di dada akibat penyumbatan saluran napas. Asma pada bayi dan anak-anak memiliki angka kejadian yang lebih tinggi dibandingkan pada orang dewasa. Asma pada anak juga memiliki angka morbiditas dan mortalitas yang lebih tinggi dibandingkan orang dewasa. Penyakit asma tidak dapat disembuhkan namun dapat di kontrol sehingga pasien anak yang menderita asma akan mengkonsumsi atau menggunakan obat obatan asma dalam kurun waktu yang cukup panjang. Disamping itu serangan asma yang tidak dapat terprediksi serta munculnya sesak napas pada pasien asma dapat menyebabkan kematian apabila tidak ditangani dengan cepat. Oleh karenannya obat asma harus selalu tersedia dan tidak boleh terjadi kekosongan disarana pelayanan kesehatan sehingga pola peresepan obat asma pada pasien anak perlu diketahui agar data yang diperoleh dapat digunakan sebagai evaluasi pengadan obat asma pada pasien anak agar tidak terjadi kekosongan  Tujuan : Penelitian ini bertujuan untuk mengetahui profil peresepan obat asma pada pasien anak di instalasi farmasi rawat jalan Rumah Sakit “X” di wilayah Jakarta Selatan. Metode : Penelitian ini merupakan penelitian non eksperimental dengan rancangan penelitian bersifat deskriptif. Metode penelitian ini dilakukan dengan pendekatan kuantitatif dengan pengambilan data secara retrospektif dengan menggunakan data rekam medis pasien asma anak secara retrospektif pada periode Januari – Maret 2023 di instalasi farmasi rawat jalan Rumah Sakit “X” di wilayah Jakarta Selatan. Hasil :  penelitian ini menunjukkan bahwa mayoritas pasien asma adalah anak laki-laki sebanyak 56 orang (57,73%) dengan usia 0 – 4 tahun sebanyak 53 (54,64%). Jenis obat bronkodilator yang paling banyak digunakan adalah salbutamol (54,69%), golongan kortikostreroid menggunakan obat jenis budesonide (46,47%), antihistamin yaitu cetirizine (68,18%), mukolitik yaitu acetylcysteine (36%), dan analgetik antipiretik yaitu paracetamol (100%). Golongan obat asma yang paling banyak digunakan yaitu golongan bronkodilator (46,21%). Bentuk sediaan obat yang paling banyak diresepkan adalah nebulizer (35%). Jumlah obat asma dalam 1 resep yang paling banyak diresepkan yaitu 2 macam obat (34,02%).
PROFIL PRESEPAN OBAT PADA PASIEN PEMBESARAN PROSTAT JINAK ATAU BPH (BENIGN PROSTATIC HYPERPLASIA) TAMSULOSIN DAN DUTASTERIDE DI INSTALASI RAWAT JALAN RUMAH SAKIT “X” CIPUTAT PERIODE OKTOBER-DESEMBER 2024 Dewantoro, Agung; Dewi, Bheta Sari; Rahajeng, Suny Koswara
PHRASE (Pharmaceutical Science) Journal Vol 5, No 1 (2025): Vol 5 No 1 : Pharmaceutical Science Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i1.1003

Abstract

Benign prostatic hyperplasia (BPH) is a term used in histopathology to describe the presence of enlarged stromal and epithelial cells in the prostate gland.  In essence, BPH mostly affects elderly men whose testes are still capable of making testosterone. According to earlier research, using dutasteride and tamsulosin together may have greater therapeutic results for BPH and significantly lower the chance that symptoms may worsen. Purpose:  The objective of this study was to identify salient features of Tamsulosin and Dutasteride prescriptions for benign prostatic enlargement (BPH) at Ciputat "X" Hospital's outpatient clinic from October to December 2024.. Methods: This research method is descriptive, the data is taken restropectively, namely research that looks back, meaning data collection from medical records of outpatients with BPH diagnoses. Results: This study showed that, 101 samples of BPH patients were obtained, the most BPH patients occurred at the age of 56-65 (47.5%), the most work status was self-employed (44.6%), the mosttypes oftherapy were combination therapy oftamsulosin with dutasteride (56.4%), α1-blocker drug classes that got a percentage (100%), the most length of therapy was 1 month (98.0%), and other groups of drugs prescribed Antibiotics (37.5%).
PROFIL PERESEPAN OBAT ANTI TUBERKULOSIS PADA PASIEN ANAK DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT X BOGOR PERIODE JANUARI – MARET 2023 Dewantoro, Agung; Andriati, Riris; Haryani, Setianti; Sakinah, Nur; Dewi, Bheta Sari; Rahajeng, Suny Koswara; Ismaya, Nurwulan Adi
PHRASE (Pharmaceutical Science) Journal Vol 3, No 2 (2023): Pharmaceutical Science Journal Vol 3 No 2, 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v3i2.609

Abstract

Childhood tuberculosis is a disease caused by Mycobacterium tuberculosis at the age of 0-11 years. In Indonesia, tuberculosis is the third leading cause of death after cardiovascular disease and respiratory disease in all age groups. Tuberculosis in children is the most important factor in developing countries because the number of children aged 15 years is 40-50% of the total population. Objective: To find out the Prescribing Profile of Anti-Tuberculosis Drugs in Pediatric Patients at the Bogor X  Hospital Outpatient Pharmacy Installation for the January – March 2023 period. Methods: The type of research conducted was a non-experimental study with a descriptive research design. This research method was carried out using a quantitative approach and retrospective data collection. The retrospective approach is a study that looks backwards, which means collecting data from medical records with a diagnosis of tuberculosis. Results: This study showed that of the 94 tuberculosis patients at Bogor X  Hospital, the dominant sex was male (55.4%), with an age range of 0-5 years (65.9%), with an anatomical location of the disease in pulmonary tuberculosis (91.4%), with treatment for 6 months (95.7%) with comorbid dyspepsia (29.6%), with an intensive treatment phase, namely anti-tuberculosis drugs (66%), with an advanced treatment phase, namely anti-tuberculosis drugs (72.8%) and the use of other drugs, namely vitamins (72.8%).
INOVASI SPRAY GEL KOMBINASI SAMBILOTO, BROTOWALI, KUNYIT, DAN LADA HITAM SEBAGAI ALTERNATIF NON-STEROID UNTUK PEMULIHAN EKSIM TOPICAL STEROID WITHDRAWAL Bachtiar, Wahyu; Dewi, Bheta Sari; Werawati, Ayu
Edu Masda Journal Vol 9, No 2 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i2.277

Abstract

                                                        ABSTRACTsynergistically for the treatment of Topical Steroid Withdrawal by inhibiting the main inflammatory pathways (TNF-α and IL-6, IL-17, NF-κB, and MAPK pathways). The objective of this study was to determine the optimal formulation of a spray gel containing extracts of sambiloto, brotowali, turmeric, and black pepper based on physical characteristics (organoleptic properties, pH, and viscosity). The optimal formulation was analysed using Design Expert software version 13 and the Mixture D-Optimal method. The independent variables in this study were brotowali extract, sambiloto extract, and turmeric extract. The dependent variables were black pepper extract 1%, carbopol 0.5%, TEA 1%, citric acid 1%, ethanol 15%, phenoxyethanol 0.5%, and propylene glycol 5%. The results obtained indicate that the optimal formulation is based on the highest desirability value from the analysis using the Design Expert program, which is 0.867. The optimal formulation for the spray gel formulation is 3% brotowali extract, 4% sambiloto extract, and 3% turmeric extract.                                                ABSTRAKSambiloto, Brotowali, Kunyit, Dan Lada Hitam merupakan tanaman yang bekerja sinergis untuk pengobatan Topical Steroid Withdrawal dengan aktivitas menekan jalur-jalur inflamasi utama ( jalur TNF-α dan IL-6, IL-17, NF-κB, dan MAPK). Tujuan penelitian ini adalah untuk menentukan formula optimal sediaan spray gel yang mengandung ekstrak sambiloto, brotowali, kunyit, dan lada Hitam berdasarkan karakteristik fisik (organoleptis, pH dan viskositas). Formula optimal dianalisis menggunakan perangkat lunak Design Expert versi 13 dan melalui metode Mixture D-Optimal. Variabel independen dalam penelitian ini adalah ekstrak brotowali, ekstrak sambiloto dan ekstrak kunyit. Variabel dependen adalah ekstrak lada hitam 1%, carbopol 0,5%, TEA 1%, Asam sitrat 1%, Etanol 15%, Fenoksietanol 0,5% dan Propilenglikol 5%. Hasil yang diperoleh menunjukkan bahwa formulasi optimal didasarkan pada nilai keinginan tertinggi dari hasil analisis menggunakan program Design Expert sebesar 0,867. Formulasi optimal untuk sediaan spray gel adalah ekstrak brotowali 3%, ekstrak sambiloto 4% dan ekstrak kunyit 3%.  
Formulation and Antioxidant Activity of Syrup Preparation Containing Saga Leaf Extract (Abrus precatorius L.) Dewi, Bheta Sari; Utami, Sheila Meitania; Sayyidah, Sayyidah; Alamsyah, Salwa Season; Rahmadani, Novita Tri
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Saga leaf (Abrus precatorius L.) have tannins, saponins, alkaloids, and flavonoids that have functions as antioxidants. The plant belongs to the Fabaceae family and is widespread in the tropics and subtropics. Syrup is one form of pharmaceutical preparation used in providing drugs in liquid form so that it is easily drunk by patients, especially children. The purpose of this study was to obtain the best syrup preparation formulation physically and its antioxidant activity. Saga leaf are extracted in ethanol and then syrup preparations by adding saga leaf extract with concentration variations of 0.5% (FI), 1% (FII), and 2% (FIII). Evaluation of syrup preparations includes organoleptic, pH, homogeneity, and antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) measured by UV-Vis spectrophotometer at wavelength 516 nm. The results showed that Formula III had the best results, namely clear dark brown organoleptic, slightly viscous shape, distinctive smell and slightly bitter taste, pH 6.15, homogeneous, and the preparation was stable in storage for 12 days and showed the best IC50 value of 116.94 g/mL compared to FI (132.65 g/mL) and FII (118.03 g/mL). The antioxidant activity of saga leaf extract is categorized as moderate. In conclusion, saga leaf can be formulated as a syrup preparation with an extract concentration of 2% in formula III showing effectiveness as the best IC50 value of 116.94 g/mL and the best formulation.