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Profil Pengobatan Dan Efektivitas Obat Tuberkulosis Paru Pada Pasien Tuberkulosis Paru Di Puskesmas Kebayoran Lama Rahajeng, Suny Koswara; Sayyidah, Sayyidah; Fadhilah, Humaira; Dewantoro, Agung; Dewi, Bheta Sari; Ardiansyah, Muhammad Rivan
PHRASE (Pharmaceutical Science) Journal Vol 5, No 2 (2025): Pharmaceutical Science Journal Vol 5 No 2, 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i2.1180

Abstract

Pulmonary tuberculosis (TB) is a serious health problem in Indonesia. A treatment profile that meets guidelines and patient compliance is crucial for successful therapy. To determine the treatment profile and effectiveness of TB drugs in patients at the Kebayoran Lama Community Health Center. This descriptive study used secondary data from the medical records of 78 pulmonary TB patients selected by purposive sampling from July to December 2024. Analysis was based on patient characteristics, treatment profiles, and drug effectiveness. The results the majority of patients were aged 17-25 years (38%), female (51%), had a high school education (54%), and worked as private sector workers (27%). In the intensive phase, most patients (72%) weighing 55-70 kg received a regimen of 4 tablets of 4FDC; the continuation phase used 4 tablets of 2FDC. The effectiveness of therapy was demonstrated by 54% of patients with negative AFB conversion accompanied by clinical improvement (reduced cough, increased appetite, decreased shortness of breath). The Conclusion is Pulmonary TB treatment at the Kebayoran Lama Community Health Center is in accordance with national guidelines with weight-based dosage. Regular evaluation is still needed to improve the success of therapy.
PENGARUH EKSTRAK JAHE MERAH (Zingiber officinale Var. Rubrum TERHADAP KADAR KOLETSEROL PADA MENCIT PUTIH JANTAN Fadhilah, Humaira; Dewi, Bheta Sari; Utami, Sheila Meitania
PHRASE (Pharmaceutical Science) Journal Vol 6, No 1 (2026)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v6i1.1299

Abstract

Hiperkolesterol merupakan faktor risiko utama penyakit jantung dan pembuluh darah. Penggunaan statin sebagai terapi konvensional memiliki keterbatasan karena efek samping dan biaya. Oleh karena itu, alternatif bahan alam seperti jahe merah (Zingiber officinale var. Rubrum) yang mengandung flavonoid dan gingerol dengan aktivitas antioksidan dan hipolipidemik menjadi perhatian. Penelitian ini bertujuan mengevaluasi pengaruh ekstrak jahe merah terhadap kadar kolesterol pada mencit putih jantan. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak jahe merah (Zingiber officinale var. Rubrum) terhadap kadar kolesterol total pada mencit putih jantan. Penelitian menggunakan 18 ekor mencit putih jantan yang dibagi menjadi 6 kelompok: kontrol negatif, kontrol positif, control pembanding (simvastatin), dan tiga kelompok perlakuan dengan dosis ekstrak jahe merah 1000, 1500, dan 2000 mg/kgBB. Induksi hiperkolesterol dilakukan dengan pakan lemak tinggi dan PTU. Ekstrak dibuat dengan metode maserasi menggunakan etanol 96%. Hasil uji fitokimia menunjukkan kandungan flavonoid dan alkaloid. Hasil menunjukkan penurunan kadar kolesterol signifikan pada kelompok perlakuan dibanding kelompok positif. Kesimpulan: ekstrak jahe merah efektif menurunkan kadar kolesterol, terutama pada dosis 1000 mg/kgBB dan 1500 mg/kgBB.
FORMULASI DAN EVALUASI FISIK SEDIAAN SERUM ANTI-AGING YANG MENGANDUNG EKSTRAK TANAMAN DARI BERBAGAI LITERATUR Bheta Sari Dewi; Ayu Werawati
KOLONI Vol. 1 No. 4 (2022): DESEMBER 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i4.426

Abstract

Currently, beauty products are developing very fast, especially anti-aging facial care products. One of the most popular products is serum. Serum contains many concentrates that are useful for nourishing and moisturizing the skin. Several plants that have been studied have the potential to be used as serum preparations, namely apuh-apuhan leaves, brown rice, Malacca fruit, gotu kola, jamblang leaves, cempedak leaves, black pepper, and Perilla Frutescens. This study aims to determine the formulation and physical evaluation of serum preparations containing plant extracts in terms of various literatures. The method used is descriptive literature review by collecting various sources from several national journals. The number of national journals used is 7 and 1 international journal. The results of a literature study on serum formulations containing plant extracts can be formulated into serum dosage forms. Evaluation of serum preparations includes organoleptic tests, pH tests, spreadability tests, and viscosity tests. The results of the study concluded that the formulation with the most complete physical evaluation and had good stability without any signs of damage to the dosage form in the serum formulation with a pH value of 5.5, a spreadability of 6.63 cm and a viscosity value of 2900 cP were found in formulations containing the extract. malacca fruit plants. Keywords: anti-aging, serum, formulation, evaluation, extract