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All Journal Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Edu Masda Journal NUSANTARA: Jurnal Pengabdian Kepada Masyarakat KOLONI Pharmaceutical Science Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Kefarmasian Indonesia Jurnal Pengabdian Ikifa
Bheta Sari Dewi
STIKes Widya Dharma Husada Tangerang
Chemistry Civil Engineering, Building, Construction & Architecture Health Professions Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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PENGARUH EKSTRAK JAHE MERAH (Zingiber officinale Var. Rubrum TERHADAP KADAR KOLETSEROL PADA MENCIT PUTIH JANTAN Fadhilah, Humaira; Dewi, Bheta Sari; Utami, Sheila Meitania
PHRASE (Pharmaceutical Science) Journal Vol 6, No 1 (2026)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v6i1.1299

Abstract

Hiperkolesterol merupakan faktor risiko utama penyakit jantung dan pembuluh darah. Penggunaan statin sebagai terapi konvensional memiliki keterbatasan karena efek samping dan biaya. Oleh karena itu, alternatif bahan alam seperti jahe merah (Zingiber officinale var. Rubrum) yang mengandung flavonoid dan gingerol dengan aktivitas antioksidan dan hipolipidemik menjadi perhatian. Penelitian ini bertujuan mengevaluasi pengaruh ekstrak jahe merah terhadap kadar kolesterol pada mencit putih jantan. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak jahe merah (Zingiber officinale var. Rubrum) terhadap kadar kolesterol total pada mencit putih jantan. Penelitian menggunakan 18 ekor mencit putih jantan yang dibagi menjadi 6 kelompok: kontrol negatif, kontrol positif, control pembanding (simvastatin), dan tiga kelompok perlakuan dengan dosis ekstrak jahe merah 1000, 1500, dan 2000 mg/kgBB. Induksi hiperkolesterol dilakukan dengan pakan lemak tinggi dan PTU. Ekstrak dibuat dengan metode maserasi menggunakan etanol 96%. Hasil uji fitokimia menunjukkan kandungan flavonoid dan alkaloid. Hasil menunjukkan penurunan kadar kolesterol signifikan pada kelompok perlakuan dibanding kelompok positif. Kesimpulan: ekstrak jahe merah efektif menurunkan kadar kolesterol, terutama pada dosis 1000 mg/kgBB dan 1500 mg/kgBB.
FORMULASI DAN EVALUASI FISIK SEDIAAN SERUM ANTI-AGING YANG MENGANDUNG EKSTRAK TANAMAN DARI BERBAGAI LITERATUR Bheta Sari Dewi; Ayu Werawati
KOLONI Vol. 1 No. 4 (2022): DESEMBER 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i4.426

Abstract

Currently, beauty products are developing very fast, especially anti-aging facial care products. One of the most popular products is serum. Serum contains many concentrates that are useful for nourishing and moisturizing the skin. Several plants that have been studied have the potential to be used as serum preparations, namely apuh-apuhan leaves, brown rice, Malacca fruit, gotu kola, jamblang leaves, cempedak leaves, black pepper, and Perilla Frutescens. This study aims to determine the formulation and physical evaluation of serum preparations containing plant extracts in terms of various literatures. The method used is descriptive literature review by collecting various sources from several national journals. The number of national journals used is 7 and 1 international journal. The results of a literature study on serum formulations containing plant extracts can be formulated into serum dosage forms. Evaluation of serum preparations includes organoleptic tests, pH tests, spreadability tests, and viscosity tests. The results of the study concluded that the formulation with the most complete physical evaluation and had good stability without any signs of damage to the dosage form in the serum formulation with a pH value of 5.5, a spreadability of 6.63 cm and a viscosity value of 2900 cP were found in formulations containing the extract. malacca fruit plants. Keywords: anti-aging, serum, formulation, evaluation, extract
Formulation and Antioxidant Activity of Syrup Preparation Containing Saga Leaf Extract (Abrus precatorius L.) Bheta Sari Dewi; Sheila Meitania Utami; Sayyidah Sayyidah; Salwa Season Alamsyah; Novita Tri Rahmadani
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Saga leaf (Abrus precatorius L.) have tannins, saponins, alkaloids, and flavonoids that have functions as antioxidants. The plant belongs to the Fabaceae family and is widespread in the tropics and subtropics. Syrup is one form of pharmaceutical preparation used in providing drugs in liquid form so that it is easily drunk by patients, especially children. The purpose of this study was to obtain the best syrup preparation formulation physically and its antioxidant activity. Saga leaf are extracted in ethanol and then syrup preparations by adding saga leaf extract with concentration variations of 0.5% (FI), 1% (FII), and 2% (FIII). Evaluation of syrup preparations includes organoleptic, pH, homogeneity, and antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) measured by UV-Vis spectrophotometer at wavelength 516 nm. The results showed that Formula III had the best results, namely clear dark brown organoleptic, slightly viscous shape, distinctive smell and slightly bitter taste, pH 6.15, homogeneous, and the preparation was stable in storage for 12 days and showed the best IC50 value of 116.94 g/mL compared to FI (132.65 g/mL) and FII (118.03 g/mL). The antioxidant activity of saga leaf extract is categorized as moderate. In conclusion, saga leaf can be formulated as a syrup preparation with an extract concentration of 2% in formula III showing effectiveness as the best IC50 value of 116.94 g/mL and the best formulation.
Co-Authors Aditya Sindu Sakti Afif Ramadhan, Afif Agung Dewantoro Ahmad Sopian Ahmad Sopian, Ahmad Amalia Puspa Wahyu Andriyani Rahmah Fahriati Anis Dwi Kristiyowati Ardiansyah, Muhammad Rivan Aryanti, Fitriya Yuni Aulia Nadya Rizki Imansari Ayu Werawati Bachtiar, Wahyu Beny Maulana Satria Catur Budi Susilo, Catur Budi Deta Hilar Nurrohmah Euis Sumiati Firdha Senja Maelaningsih Galih Pratiwi, Rekiyan Tuhu Gina Aulia Humaira Fadhilah Kristiyowati, Anis Dwi M. Ahsanul Farihin Manuruyah, Phuja Arinda Marhamah Marhamah Mochammad Hasan, Mochammad MS, Dewi Sartika Neneng Sri Purwaningsih Novita Tri Rahmadani Nur Hasanah Nur Sakinah Nurul Izzah H. L. Pasi Nurwulan Adi Ismaya Nur’aini Al Wahida RIRIS ANDRIATI Salwa Season Alamsyah Saputra, Aldi Sayyidah Sayyidah Sayyidah Sayyidah Sayyidah Sayyidah, Sayyidah Setianti Haryani Sheila Meitania Utami Siti Novy Romlah Suny Koswara Rahajeng Taufik Kurrohman Uswatun Hasanah Zahra, Annisa Fairuz