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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN MEDISAINS Mutiara Medika: Jurnal Kedokteran dan Kesehatan JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Surya Masyarakat Bantenese Jurnal Pengabdian Masyarakat Medika Kartika : Jurnal Kedokteran dan Kesehatan Science Midwifery Prosiding Seminar Nasional Program Pengabdian Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Alfaina Wahyuni
Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Atherosclerosis in rat PCOS model induced by testosterone propionate combined with high fat high fructose diet Sularto, Dirwan Suryo; Wahyuni, Alfaina
Science Midwifery Vol 11 No 5 (2023): December
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i5.1384

Abstract

Atherosclerosis is closely related to the metabolic syndrome like what occurs to Polycystic Ovary Syndrome (PCOS). The recent increase in prevalence due to high calories diet and high carbohydrate, infrequent exercise, and the escalating obesity trend increased insulin resistance. PCOS is linked to many long term health problems, such as cardiovascular disease, atherosclerosis, and diabetes. How is the potential of atherosclerosis for PCOS model mice induced with testosterone propionate and high fat diet and high fructose? This research is important to conduct in order to determine the potential of atherosclerosis for PCOS through the observation on mice model of PCOS. This research employed Postest Only Control Group Design method. Twenty female Rattus norvegicus strain Wistar mice weighing between 100 and 130 grams, aged 3 months, served as the samples. After observing estrous cycle, 15 mice were randomly chosen to be made PCOS model induced with testosterone propionate 1mg/100 g BW/day intramuscularly combined with high fat diet and high fructose. The treatment was given on day 18, 21, and 24. Afterwards, the mice were sacrificed on day 19, 22, and 25. After 12 hours of fasting the mice, the mice were sacrificed and the coronary arteries attached to the heart were taken to be made histological preparations. Then, the degree of atherosclerosis potential was observed. Statistical analysis used One Way Anova test with significance level of α=0,05. Data analysis was performed using Statistical Product and Servive Solutions (SPSS) program version 24.0 for Windows.
PEMBERIAN PROPOLIS MEMENGARUHI PROFIL LIPID PADA TIKUS MODEL Polycystic Ovary Syndrome (PCOS) Meida, Nur Shani; Wahyuni, Alfaina; Aqdami, Muhammad Tsabit
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 2 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Polycystic Ovary Syndrome (PCOS) adalah suatu kelainan endokrin dan metabolik yang ditandai dengan anovulasi, hiperandrogenisme, dan gambaran polikistik pada ovarium. Etiologi PCOS belum pasti, diduga erat kaitan dengan stres oksidatif, dislipidemia, dan resistensi insulin. Propolis mengandung antioksidan, dapat menghambat proses peroksidasi lipid. Tujuan penelitian ini untuk mengetahui pengaruh propolis terhadap profil lipid. Penelitian ini adalah penelitian eksperimental menggunakan sebanyak 25 ekor tikus Wistar betina, berumur 13 minggu, berat badan 100-130 gram, sehat, usapan vagina normal, dan tidak hamil. Sampel dibagi menjadi lima kelompok yaitu K1 (kontrol negatif/normal), dan K2 (kontrol positif/PCOS), kelompok perlakuan P1, P2, dan P3 (PCOS+ propolis pada masing-masing kelompok dosis 50, 100, dan 200 mg/kgBB sekali per hari secara oral selama 14 hari). Induksi tikus model PCOS dilakukan dengan injeksi intraperitoneal Testosteron Propionat 1,8 mg/kbBB/hari dan diet HFHF selama 21 hari. Tikus dipuasakan 12 jam dilanjutkan dengan pemeriksaan profil lipid serum. Metode uji One Way Anova dan uji Kruskal-Wallis digunakan dalam uji statistik untuk mengetahui perbedaan antar kelompok. Hasil penelitian menunjukkan propolis secara bermakna (p<0,05) memiliki kemampuan menurunkan kadar kolesterol total, Low Density Lipoprotein (LDL) dan trigliserida serta meningkatkan kadar High Density Lipoprotein (HDL). Propolis dosis 100 mg/kgBB sekali per hari paling efektif bermakna (p <0,05) menurunkan kadar kolesterol total, sedangkan pada penurunan kadar LDL dan trigliserida serta peningkatan kadar HDL tidak ada dosis efektif . Propolis mampu menurunkan kadar kolesterol total, LDL dan trigliserida serta menaikkan kadar HDL pada tikus model PCOS. Kata kunci: antioksidan, PCOS, profil lipid, propolis DOI : 10.35990/mk.v7n2.p167-176
Co-Authors - Supriyatiningsih Afifah, Eliana Fairuz Afifatul Latifah Alfun Dhiya An Alfun Dhiya An Anindya, Vita Anna Monita Aqdami, Muhammad Tsabit Arifia, Erina Arsalan, Muhammad Rafi Asmara, Ardhityara Jelfi Astri Kartika Sari Astri Kartika Sari, Astri Kartika Astuti, Yoni Barlianz, Maulana Andree Cahyani, Fitnaningsih Endang Cynthia Dwi Mayayustika Della Lovy Fadillah, Maulana Arif Fadiyah, Nida Fatihi, Fatihi Firma Nur Rachmawati Hayati, Nur Hidayat, M. Fahri Kamila Sedah Kirana Kurniawati, Hidayatul Lakcitadhini, Yayie M Zulfani Najmi M. Rafif Rafif Maryani, Nova Nisrina, Hana Noor, Hafni Zuchra Nur Hayati Nur Hayati Nur Shani Meida Nurrahman, Deni Oktavia, Adinda Oktavia, Dwiana Ferda Permana, Gilang Prayoga Putra Pramono, Nabila A Pratiwi, Zila Putra, Gagah Buana Putri, Angelikha Merha Rachmawati, Firma Nur Rahmalika Fitri Rahmiati, Nurmaita Sanjaya, Jatiyasa Ega Satrio R, Muhammad Keiza Seravine, Salsabillah Sharla, Disya Shifa Noor Amalya Siti Aminah Tri Susila Estri Sularto, Dirwan Suryo Sulistiari Retnowati Tritia Widiantara, I Nyoman Tsabita, Aifa Fahma Wiwik Kusumawati Wiwik Kusumawati, Wiwik Yayie Lakcitadhini Yosy Budi Setiawan