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All Journal JMM (Jurnal Masyarakat Mandiri) Borneo Journal Of Pharmascientech International Journal of Community Service
Su'aida, Nily
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Journal : Borneo Journal Of Pharmascientech

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Karakterisasi Fitokimia dan Uji Daya Hambat Senyawa Daun Kelakai (stenochlaena palustris) Khas Kalimatan Terhadap Bakteri Propionibacterium acnes Secara In Vitro Apriliyana, Nafisah Sofia; Su'aida, Nily; Fadillah, Aris; Abdi, Muhammad; Azkya, Nurizka; Nadiati, Nadiati; Halimah, Siti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.576

Abstract

Several acne therapy modalities have been widely used to eradicate Propionibacterium acnes, the causative pathogen of acne. However, it cannot treat acne optimally and has adverse effects. Kelakai (Stenochlaena palustris) possesses antibacterial activity. Based on the antibacterial activity of S. palustris, its leaf can be utilized as an alternative acne therapeutic substance. Therefore, this study investigated the effects of the ethanol extract of S. palustris leaf on P. acnes. The extraction of S. palustris was performed using maceration with 96% ethanol. The antibiotic activity test was divided into five groups: a positive control group (Clindamycin), a negative control group (Propionibacterium acnesATCC®6919), and three test groups with concentration gradients. Phytochemical analysis was positive for the identification of saponins, tannins, alkaloids, steroids and flavonoids. The inhibitory diameter of P. acnes at 75% extraction concentration was closest to that of the positive control group and has inhibition zone of diameter 13,99 + 0,77 (strong inhibition) indicating its effectiveness in inhibiting the growth of P. acnes. Based on the antibacterial activity of the ethanol extract of S. palustris leaf, the leaf extract has the potential to be used as a medicinal substance in acne therapy.
Karakteristik dan Uji Aktivitas Antiosidan Ekstrak Kolagen Sisik Ikan Gabus (Channa sp.) Su'aida, Nily; Ridha, ainur; Soemarie, Yulistia Budianti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.652

Abstract

This study aims to isolate collagen from the scales of snakehead fish (Channa sp.) and evaluate the antioxidant activity of the extracted collagen. Collagen was isolated using a 0.5 M acetic acid method, involving dissolution and purification procedures. The collagen extract was characterized using FTIR analysis to detect functional groups and phytochemical tests to identify active compounds. Antioxidant activity was assessed using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method to measure free radical scavenging potential. The results indicated that the collagen extract from snakehead fish scales contains bioactive compounds with significant antioxidant activity. The IC₅₀ values demonstrated a strong ability to neutralize free radicals, showing higher potency than the control. FTIR analysis detected hydroxyl (3330.21 cm⁻¹), methyl (2111.83 cm⁻¹), and carbonyl (1635.85 cm⁻¹) groups as characteristic phytochemical components of Channa sp. collagen extract. The IC₅₀ values at different concentrations were classified as very strong at low concentrations (25%), strong at moderate concentrations (50%), and moderate at higher concentrations (75%). The antioxidant activity of snakehead fish scale extract was very strong at lower concentrations but decreased as the concentration increased
Co-Authors Apriliyana, Nafisah Sofia Ariessanti Alicia Kusuma Wardhani, RR Aris Fadillah Azkya, Nurizka Erlianti, Karina Hasniah Hasniah Juwita Ramadhani Lusiana, Herlina M. Yogi Riyantama Isjoni Mardiana, Lia Muhammad Abdi, Muhammad Muliyani Muliyani Nadiati, Nadiati Ridha, ainur Riza, Yeni Rizki Rahmadi Pratama Siti Halimah Soemarie, Budianti Soemarie, Yulistia Budianti