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All Journal Journal of Islamic Pharmacy Jurnal Ilmiah Manuntung JFL : Jurnal Farmasi Lampung Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Borneo Journal Of Pharmascientech Jurnal Buana Farma Sciences of Pharmacy Jurnal Pengabdian Kepada Masyarakat Kalam Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Soemarie, Yulistia Budianti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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FORMULASI SEDIAAN SALEP EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill.) SEBAGAI ANTIACNE Soemarie, Yulistia Budianti; Astuti, Tri; Rochmah, Nur
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.339 KB) | DOI: 10.51352/jim.v2i2.70

Abstract

Currently, the development of acne drugs (antiacne) use  many natural materials because the natural materials can minimize the side effect if compared with synthetic chemicals drugs. Acne can caused by propionibacterium acnes, staphylococcus epidermis and staphylococcus aureu. One of plants that can be used for acne treatment is leaves of Avocado (Persea americana Mill). The aim of this study was to know whether the ethanol extract of leaves of avocado (Persea americana Mill.) can be made into an ointment preparations that fulfill the requirements. Sample in this research was extract of avocado leaves which used maceration method. The ointment formulations were made into some variation concentrations of PEG 400 and PEG 4000: Formula I (30%:70%); Formula II (50%:50%) and Formula III (70%:30%). The results show that the ointment of avocado leaves which fulfilled the requirements of physical properties is formula III with concentration of PEG 400 70 % and PEG 4000 30 %
FORMULASI ORALLY DISINTERGRATING TABLET (ODT) EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB® Soemarie, Yulistia Budianti; Sa'adah, Hayatus; Marginingsih, Tri
Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.042 KB)

Abstract

Bad breath is usually caused by bacteria and leftovers in the mouth. Utilization of natural ingredients that can be used to overcome the problem of bad breath one of them by using basil leaves (Ocimum americanum L.), which has activity as an antibacterial. The development of the preparations was done on basil leaves to overcome bad breath is by formulating the basil leaves ethanol extract into the Orally Disintegrating Tablet (ODT) preparation. The purpose of this study was to investigate the effect of explotab® concentration variations on the physical properties of ODT and to determine the best of concentrations of Explotab® that fulfill the physical properties of ODT. The type of research conducted was an experimental study. Research object was basil leaves ethanol extract formulated into ODT with Explotab® 2% w/b, 4% w/w, 6% w/b and 8% w/w variation. Physical evaluations test then conducted including : the uniformity of weight evaluation, the hardness test, the friability test, and the dissolved time. The results showed that the explotab® concentration variations had an effect on the physical properties of tablets and the formula with the Explotab® 8% b/b concentration was the best formula that could produce the best ODT tablet with physical properties.   Keywords    :    Basil leaves (Ocimum americanum L.), Explotab®, Orally Disintegrating Tablet (ODT)
UJI MUTU FISIK GRANUL EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB® Soemarie, Yulistia Budianti; Sa'adah, Hayatus; Fatimah, Nurul; Ningsih, Tri Marga
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.096 KB)

Abstract

Bad breath is usually caused by bacteria and food debris left in the mouth. Development of preparations using herbal ingredients, to overcome the problem of bad breath one of them is with utilization basil leaves (Ocimum americanum L.) which have anti bacterial activity. The method of wet granulation is a single method for use in granulation of large doses of active substances because if using direct induced method will require again the addition of a large number of fillers to make it easier forging, but cause the tablet to be not feasible as it will resulting in an increase in tablet size. The type of research conducted is an experimental study. Object the study was basil leaf extract formulated. This formulation was prepared by wet granulation method with variation Explotab® ss crusher ie 2%, 4%, 6% and 8%. Performed wet granulation on each formulation. Granul evaluated the flow time, mass density test, silent angle and fixed assay test. Based on research result the physical quality of ethanol extract granule of basil leaves (Ocimum americanum L.) with explotab® concentration variation it can be concluded that all the formula fulfill the good quality of granule characteristic, because it meets the requirements of parameters of time flow, rest angle, compressibility and density mass
IN SILICO IDENTIFICATION OF BREADFRUIT PLAN COMPOUNDS (Artocarpus atilis) AGAINST ANGIOTENSIN-CONVERTING ENZYME 2 AS A CANDIDATE MODEL OF COVID-19 INHIBITORS Fauzi, Muhammad; Soemarie, Yulistia Budianti; Hasniah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1275

Abstract

The spread of COVID-19 has continued to grow rapidly worldwide. This disease is characterized by the presence of severe respiratory syndrome disorders in humans. The ACE2 receptor is the gateway for the COVID-19 virus to target cells, where it is expressed in airway epithelial and vascular endothelial cells. Breadfruit (Artocarpus altilis) contains active flavonoids. Flavonoid derivatives found in breadfruit include artonin-E, cycloaltilisin-7, cycloaltilisin, isocyclomorusin, cyclomorusin, cyclomulberrin, isocyclomulberrin, cyclocommunal, morusin, quercetin and artocarpin. This study aimed to determine the flavonoid derivative of breadfruit (Artocarpus altilis), which has the most effective potential against the ACE2 receptor, as a candidate inhibitor of the COVID-19 virus in silico. The results showed that of the eleven flavonoid derivatives of breadfruit (Artocarpus altilis) tested, 3 compounds gave the lowest binding affinity value, namely cycloaltilisin -8.79 kcal/mol, cyclomulberrin -8.95 kcal/mol, and artocarpin -9.30. kcal/mol compared to Chloroquine -7.67 kcal/mol and Hydroxychloroquine -7.22 kcal/mol. The predicted results of the Lipinski Rule of Five showed that the 3 compounds and the comparison drug met the Ro5 rule. The compounds cycloaltilisin, cyclomulberin, and artocarpine have antiviral activity, as indicated by the Pa value in the range of 0.5<Pa<0.7. Cycloaltilisin, cyclomulberin and artocarpine are the most effective compounds to be developed as candidates for COVID-19 inhibitors. Keywords: Breadfruit, ACE-2, Covid-19, In Silico
UJI AKTIVITAS ANTIBAKTERI DAUN JUKUT PENDUL (Kyllinga nemoralis) YANG DIPEROLEH DARI KOTABARU, KALIMANTAN SELATAN, INDONESIA Soemarie, Yulistia Budianti; Niasti, Ignalia; Hasniah
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1763

Abstract

The use of antibiotics as acne treatment is often used as the main treatment by the community. Natural acne treatments that are easily available should be developed to replace chemical products, such as the jukut pendul plant (Kyllinga nemoralis). The purpose of this study was to determine the antibacterial activity of jukut pendul leaves against Propionibacterium acnes. The sample was determined, extracted by maceration method using 70% ethanol, then fractionated with water, ethyl acetate, and n-hexane solvents. Phytochemical screening on ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction. Antibacterial activity tests were conducted on extracts and fractions of jukut pendul leaves with concentrations of 5%, 10%, and 15%. Antibacterial activity testing of 5% concentration ethanol extract produced inhibition of 9.5 mm (medium), 10% 9.6 mm (medium), 15% 10.16 mm (strong). The n-hexane fraction of 5%, 10% and 15% concentration was 6 mm (medium). Ethyl acetate fraction of 5% concentration was 9 mm (medium), 10% 9.6 mm (medium), 15% 11.2 mm (strong). Water fraction of 5% and 10% concentration was 6 mm (medium), 15% concentration was 8.3 mm (medium). Keywords: Antibacterial, Jukut Pendul (Kyllinga nemoralis), Propionibacterium acnes
POTENSI EKSTRAK ETANOL DAUN KELAKAI (Stenochlaena Palustris (Burm.f) Bedd) SEBAGAI AKTIVITAS ANTIFUNGI TERHADAP Candida albicans: POTENTIAL ETANOL EXTRACT OF KELAKAI LEAVES (Stenochlaena Palustris (Burm.f) Bedd) AS ANTIFUNGI ACTIVITY AGAINST Candida albicans Wahyudi, Achmad Nur; Soemarie, Yulistia Budianti; Fauzi, Muhammad
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1808

Abstract

Thrush is caused by various factors, one of which is the growth of Candida albicans fungus in the mouth area. Many antifungal drugs available to treat Candida albicans fungal infections are made from synthetic chemicals that have the risk of side effects. The objective of this research is to determine the antifungal activity of ethanol extract of kelakai leaves (Stenochlaena palustris (Burm.) Bedd against Candida albicans. The research process begins with testing the concentration of ethanol extract of kelakai leaves (Stenochlaena palustris (Burm.f.) Bedd by 50%, 55%, 60%, and 65%. In addition, phytochemical screening tests, specific and non-specific parameter tests were carried out. Phytochemical screening results show that ethanol extract of kelakai leaves is positive for alkaloids, saponins, tannins, and flavonoids. The specific parameter test shows that the water soluble extract content and ethanol soluble extract content are 83.3% and 85.7%, respectively. Non-specific parameter tests showed ash content of 0.25%, drying shrinkage of 0.27%, and specific gravity of 0.798 g/mL. The results of the antifungal activity test indicate that ethanol extracts of kelakai leaves at concentrations of 50%, 55%, 60%, and 65% cannot inhibit the growth of Candida albicans fungi. Keywords: Stenochlaena palutris, Candida albicans, Kelakai, Antifungal
UJI AKTIVITAS ANTIOKSIDAN RUMPUT JUKUT PENDUL (Kyllinga nemoralis) Nabila, Regina Syifa; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1267

Abstract

Antioxidants are compounds that play an important role in preventing the impact of free radicals that cause various degenerative diseases. Synthesized antioxidants have carcinogenic properties over a long period of time, hence the need for natural sources of antioxidants that have fewer side effects. Jukut pendul grass (Kyllinga nemoralis) is one of the wild plants that has potential as a natural antioxidant. This study aims to compare the antioxidant activity of ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction of jukut pendul grass (Kyllinga nemoralis). The steps of this research were samples of jukut pendul grass (Kyllinga nemoralis) obtained from Kota Baru, South Kalimantan in maceration with 70% ethanol then fractionated using 3 solvents of different polarity. Antioxidant activity testing was performed with a Uv-Vis spectrophotometer using the DPPH method at a wavelength of 515 nm. The results showed that the IC50 value of ethanol extract was 79,842 + 14,275 µg/mL, n-hexane fraction 95,632 + 8,152 µg/mL, ethyl acetate fraction 42,616 + 1,972 µg/mL and water fraction 67,384 + 11,678 µg/mL. Based on the IC50 value, jukut pendul grass (Kyllinga nemoralis) has antioxidant activity with the highest activity in the ethyl acetate fraction.
RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN DIABETES MELITUS DENGAN ULKUS DIABETIKUM DI BANJARMASIN, KALIMANTAN SELATAN, INDONESIA Annida Mujahidah Nurul Azmi; Soemarie, Yulistia Budianti; Juwita Ramadhani
Jurnal Ilmiah Manuntung Vol 11 No 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.901

Abstract

otential to cause serious complications. Antibiotic therapy is one of the treatment options for patients with diabetic ulcers. Overuse of antibiotics can lead to resistance, which can make therapy less successful. This study aims to determine the percentage of rational antibiotic use and its effect on therapy outcomes in diabetic ulcer patients. This study aims to identify the percentage of rational antibiotic use and its effect on therapeutic outcomes in diabetic ulcer patients in Banjarmasin Hospital. This study was an observational study with a cross-sectional method and data collection in this study was carried out retrospectively during the period July-December 2023. The rationality of antibiotic use was evaluated using the Gyssens method and the correlation of rationality with therapeutic outcomes was analyzed using the chi square test. The study subjects were 94 patients with diabetic ulcers who met the inclusion criteria. The rationality of antibiotic use with the Gyssens category was in category 0 (appropriate) for 65 patients (69%), category IIb (inappropriate interval) for 3 patients (3%), category IIIa (too short) for 10 patients (11%), category IIIb (too long) for 6 patients (6%), category IVa (more effective) for 3 patients (3%), and category IVc (cheaper alternative) for 7 patients (7%). The results of the Chi-Square Test state that there is a significant correlation between the rationality of antibiotic use and therapeutic outcomes in the form of a decrease in the degree of diabetic ulcers. 69% of patients received rational antibiotic therapy and 31% received irrational therapy based on the Gyssens method and there was a correlation between the rationality of antibiotic use and therapeutic outcomes in the form of a decrease in the degree of diabetic ulcers.
Rasionalitas Penggunaan Obat Pada Pasien Diabetes Melitus Tipe II Di Puskesmas Kota Martapura Tahun 2023 Normila, Normila; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32341

Abstract

Diabetes melitus tipe 2 dikatakan sebagai gangguan metabolisme yang umum di dunia, penyakit ini disebabkan oleh rusaknya sekresi insulin oleh sel ẞ pankreas serta ketidakmampuan jaringan tubuh dalam merespon insulin. Tujuan studi ini agar mengetahui rasionalitas pengobatan diabetes melitus tipe 2 pada pasien di Puskesmas  Kota Martapura di Kabupaten Banjar tahun 2023.  Metode yang dimanfaatkan agar studi ini ialah non-eksperimental observasional bersama rancangan studi deskriptif serta pengambilan data secara retrospektif. Sampel penelitian sebanyak 173 dengan menggunakan rekam medis pasien diabetes melitus tipe 2 yang dianalisis kesesuaiannya dengan standar PERKENI 2019 penelitian ini juga menggunakan probability sampling dalam pengambilan sampel.  Hasil penelitian berdasarkan demografi pasien pada jenis kelamin yang paling banyak ialah perempuan, sebanyak 64%, pekerjaan pasien terdapat Ibu rumah tangga 29%, paling tinggi dan rentang umur pasien ditemui 47,89% pada rentang 56-65 tahun. Jumlah penyakit penyerta pasien yang banyak ditemui DM Tipe 2 dengan  Hipertensi 46%.  Hasil evaluasi rasionalitas  ditemukan di Puskesmas Kota Martapura memiliki tepat indikasi (99%) serta  tidak tepat (1%), tepat pasien 100%, tepat obat 100%. Tepat dosis 100%,  cara pemberian obat  sebesar 100%, tepat interval waktu pemberian  98 % tidak tepat 2%, tepat lama pemberian obat sebesar 100% tepat.  
Characterization of Lactococcus garvieae Isolated from Wadi Papuyu (Anabas testudineus Bloch) Fermentation of Indonesian Origin as a Probiotic Candidate Soemarie, Yulistia Budianti; Pratama, Rizki Rahmadi; Milanda, Tiana; Barliana, Melisa Intan
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402317

Abstract

Lactococcus garvieae was isolated from the traditional fermented food Wadi Papuyu (Anabas testudineus Bloch) and characterized for its potential as a probiotic candidate. Growth assays demonstrated that L. garvieae could proliferate in MRS medium, reaching cell counts exceeding 107 CFU/mL after 72 h of anaerobic incubation. The isolate exhibited optimal growth at both 30 °C and 37 °C, as indicated by significant increases in absorbance at these temperatures. However, in the bile salt tolerance test using 0.5% (w/v) bile salts, L. garvieae showed a marked decline in growth, with absorbance values decreasing substantially after 24 and 48 h, indicating insufficient bile tolerance. The autoaggregation assay revealed values below 10%, suggesting limited autoaggregation capability and reduced potential for colonization in the gastrointestinal tract. In contrast, the co-aggregation assay showed that L. garvieae was able to coaggregate with pathogenic bacteria such as Escherichia coli, Salmonella spp., and Shigella spp., with co-aggregation percentages exceeding 40% after 5 h. Antimicrobial activity tests demonstrated that L. garvieae produced strong inhibition zones (diameters >10–20 mm and >20 mm) against Gram-positive and Gram-negative pathogenic bacteria. These findings indicate that while L. garvieae exhibits promising antimicrobial activity and co-aggregation ability, its limited bile salt tolerance and autoaggregation capacity are significant constraints in its development as a probiotic candidate.
Co-Authors Annida Mujahidah Nurul Azmi Erlianti, Karina Hasniah Hasniah Juwita Ramadhani Marginingsih, Tri Maulida, Rizqi Noor Melisa Intan Barliana, Melisa Intan Muhammad Fauzi Nabila, Regina Syifa Niasti, Ignalia Ningsih, Tri Marga Normila, Normila Nur Rochmah, Nur Nurul Fatimah Nurwijayanti Ridha, ainur Sa'adah, Hayatus Su'aida, Nily Su’aida, Nily TIANA MILANDA Tri Astuti Wahyudi, Achmad Nur