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All Journal Journal of Islamic Pharmacy JFL : Jurnal Farmasi Lampung Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Borneo Journal Of Pharmascientech Jurnal Buana Farma Sciences of Pharmacy Jurnal Pengabdian Kepada Masyarakat Kalam Medical Sains : Jurnal Ilmiah Kefarmasian
Soemarie, Yulistia Budianti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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IN SILICO IDENTIFICATION OF BREADFRUIT PLAN COMPOUNDS (Artocarpus atilis) AGAINST ANGIOTENSIN-CONVERTING ENZYME 2 AS A CANDIDATE MODEL OF COVID-19 INHIBITORS Fauzi, Muhammad; Soemarie, Yulistia Budianti; Hasniah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1275

Abstract

The spread of COVID-19 has continued to grow rapidly worldwide. This disease is characterized by the presence of severe respiratory syndrome disorders in humans. The ACE2 receptor is the gateway for the COVID-19 virus to target cells, where it is expressed in airway epithelial and vascular endothelial cells. Breadfruit (Artocarpus altilis) contains active flavonoids. Flavonoid derivatives found in breadfruit include artonin-E, cycloaltilisin-7, cycloaltilisin, isocyclomorusin, cyclomorusin, cyclomulberrin, isocyclomulberrin, cyclocommunal, morusin, quercetin and artocarpin. This study aimed to determine the flavonoid derivative of breadfruit (Artocarpus altilis), which has the most effective potential against the ACE2 receptor, as a candidate inhibitor of the COVID-19 virus in silico. The results showed that of the eleven flavonoid derivatives of breadfruit (Artocarpus altilis) tested, 3 compounds gave the lowest binding affinity value, namely cycloaltilisin -8.79 kcal/mol, cyclomulberrin -8.95 kcal/mol, and artocarpin -9.30. kcal/mol compared to Chloroquine -7.67 kcal/mol and Hydroxychloroquine -7.22 kcal/mol. The predicted results of the Lipinski Rule of Five showed that the 3 compounds and the comparison drug met the Ro5 rule. The compounds cycloaltilisin, cyclomulberin, and artocarpine have antiviral activity, as indicated by the Pa value in the range of 0.5<Pa<0.7. Cycloaltilisin, cyclomulberin and artocarpine are the most effective compounds to be developed as candidates for COVID-19 inhibitors. Keywords: Breadfruit, ACE-2, Covid-19, In Silico
UJI AKTIVITAS ANTIBAKTERI DAUN JUKUT PENDUL (Kyllinga nemoralis) YANG DIPEROLEH DARI KOTABARU, KALIMANTAN SELATAN, INDONESIA Soemarie, Yulistia Budianti; Niasti, Ignalia; Hasniah
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1763

Abstract

The use of antibiotics as acne treatment is often used as the main treatment by the community. Natural acne treatments that are easily available should be developed to replace chemical products, such as the jukut pendul plant (Kyllinga nemoralis). The purpose of this study was to determine the antibacterial activity of jukut pendul leaves against Propionibacterium acnes. The sample was determined, extracted by maceration method using 70% ethanol, then fractionated with water, ethyl acetate, and n-hexane solvents. Phytochemical screening on ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction. Antibacterial activity tests were conducted on extracts and fractions of jukut pendul leaves with concentrations of 5%, 10%, and 15%. Antibacterial activity testing of 5% concentration ethanol extract produced inhibition of 9.5 mm (medium), 10% 9.6 mm (medium), 15% 10.16 mm (strong). The n-hexane fraction of 5%, 10% and 15% concentration was 6 mm (medium). Ethyl acetate fraction of 5% concentration was 9 mm (medium), 10% 9.6 mm (medium), 15% 11.2 mm (strong). Water fraction of 5% and 10% concentration was 6 mm (medium), 15% concentration was 8.3 mm (medium). Keywords: Antibacterial, Jukut Pendul (Kyllinga nemoralis), Propionibacterium acnes
POTENSI EKSTRAK ETANOL DAUN KELAKAI (Stenochlaena Palustris (Burm.f) Bedd) SEBAGAI AKTIVITAS ANTIFUNGI TERHADAP Candida albicans: POTENTIAL ETANOL EXTRACT OF KELAKAI LEAVES (Stenochlaena Palustris (Burm.f) Bedd) AS ANTIFUNGI ACTIVITY AGAINST Candida albicans Wahyudi, Achmad Nur; Soemarie, Yulistia Budianti; Fauzi, Muhammad
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1808

Abstract

Thrush is caused by various factors, one of which is the growth of Candida albicans fungus in the mouth area. Many antifungal drugs available to treat Candida albicans fungal infections are made from synthetic chemicals that have the risk of side effects. The objective of this research is to determine the antifungal activity of ethanol extract of kelakai leaves (Stenochlaena palustris (Burm.) Bedd against Candida albicans. The research process begins with testing the concentration of ethanol extract of kelakai leaves (Stenochlaena palustris (Burm.f.) Bedd by 50%, 55%, 60%, and 65%. In addition, phytochemical screening tests, specific and non-specific parameter tests were carried out. Phytochemical screening results show that ethanol extract of kelakai leaves is positive for alkaloids, saponins, tannins, and flavonoids. The specific parameter test shows that the water soluble extract content and ethanol soluble extract content are 83.3% and 85.7%, respectively. Non-specific parameter tests showed ash content of 0.25%, drying shrinkage of 0.27%, and specific gravity of 0.798 g/mL. The results of the antifungal activity test indicate that ethanol extracts of kelakai leaves at concentrations of 50%, 55%, 60%, and 65% cannot inhibit the growth of Candida albicans fungi. Keywords: Stenochlaena palutris, Candida albicans, Kelakai, Antifungal
UJI AKTIVITAS ANTIOKSIDAN RUMPUT JUKUT PENDUL (Kyllinga nemoralis) Nabila, Regina Syifa; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1267

Abstract

Antioxidants are compounds that play an important role in preventing the impact of free radicals that cause various degenerative diseases. Synthesized antioxidants have carcinogenic properties over a long period of time, hence the need for natural sources of antioxidants that have fewer side effects. Jukut pendul grass (Kyllinga nemoralis) is one of the wild plants that has potential as a natural antioxidant. This study aims to compare the antioxidant activity of ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction of jukut pendul grass (Kyllinga nemoralis). The steps of this research were samples of jukut pendul grass (Kyllinga nemoralis) obtained from Kota Baru, South Kalimantan in maceration with 70% ethanol then fractionated using 3 solvents of different polarity. Antioxidant activity testing was performed with a Uv-Vis spectrophotometer using the DPPH method at a wavelength of 515 nm. The results showed that the IC50 value of ethanol extract was 79,842 + 14,275 µg/mL, n-hexane fraction 95,632 + 8,152 µg/mL, ethyl acetate fraction 42,616 + 1,972 µg/mL and water fraction 67,384 + 11,678 µg/mL. Based on the IC50 value, jukut pendul grass (Kyllinga nemoralis) has antioxidant activity with the highest activity in the ethyl acetate fraction.
Rasionalitas Penggunaan Obat Pada Pasien Diabetes Melitus Tipe II Di Puskesmas Kota Martapura Tahun 2023 Normila, Normila; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32341

Abstract

Diabetes melitus tipe 2 dikatakan sebagai gangguan metabolisme yang umum di dunia, penyakit ini disebabkan oleh rusaknya sekresi insulin oleh sel ẞ pankreas serta ketidakmampuan jaringan tubuh dalam merespon insulin. Tujuan studi ini agar mengetahui rasionalitas pengobatan diabetes melitus tipe 2 pada pasien di Puskesmas  Kota Martapura di Kabupaten Banjar tahun 2023.  Metode yang dimanfaatkan agar studi ini ialah non-eksperimental observasional bersama rancangan studi deskriptif serta pengambilan data secara retrospektif. Sampel penelitian sebanyak 173 dengan menggunakan rekam medis pasien diabetes melitus tipe 2 yang dianalisis kesesuaiannya dengan standar PERKENI 2019 penelitian ini juga menggunakan probability sampling dalam pengambilan sampel.  Hasil penelitian berdasarkan demografi pasien pada jenis kelamin yang paling banyak ialah perempuan, sebanyak 64%, pekerjaan pasien terdapat Ibu rumah tangga 29%, paling tinggi dan rentang umur pasien ditemui 47,89% pada rentang 56-65 tahun. Jumlah penyakit penyerta pasien yang banyak ditemui DM Tipe 2 dengan  Hipertensi 46%.  Hasil evaluasi rasionalitas  ditemukan di Puskesmas Kota Martapura memiliki tepat indikasi (99%) serta  tidak tepat (1%), tepat pasien 100%, tepat obat 100%. Tepat dosis 100%,  cara pemberian obat  sebesar 100%, tepat interval waktu pemberian  98 % tidak tepat 2%, tepat lama pemberian obat sebesar 100% tepat.  
Characterization of Lactococcus garvieae Isolated from Wadi Papuyu (Anabas testudineus Bloch) Fermentation of Indonesian Origin as a Probiotic Candidate Soemarie, Yulistia Budianti; Pratama, Rizki Rahmadi; Milanda, Tiana; Barliana, Melisa Intan
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402317

Abstract

Lactococcus garvieae was isolated from the traditional fermented food Wadi Papuyu (Anabas testudineus Bloch) and characterized for its potential as a probiotic candidate. Growth assays demonstrated that L. garvieae could proliferate in MRS medium, reaching cell counts exceeding 107 CFU/mL after 72 h of anaerobic incubation. The isolate exhibited optimal growth at both 30 °C and 37 °C, as indicated by significant increases in absorbance at these temperatures. However, in the bile salt tolerance test using 0.5% (w/v) bile salts, L. garvieae showed a marked decline in growth, with absorbance values decreasing substantially after 24 and 48 h, indicating insufficient bile tolerance. The autoaggregation assay revealed values below 10%, suggesting limited autoaggregation capability and reduced potential for colonization in the gastrointestinal tract. In contrast, the co-aggregation assay showed that L. garvieae was able to coaggregate with pathogenic bacteria such as Escherichia coli, Salmonella spp., and Shigella spp., with co-aggregation percentages exceeding 40% after 5 h. Antimicrobial activity tests demonstrated that L. garvieae produced strong inhibition zones (diameters >10–20 mm and >20 mm) against Gram-positive and Gram-negative pathogenic bacteria. These findings indicate that while L. garvieae exhibits promising antimicrobial activity and co-aggregation ability, its limited bile salt tolerance and autoaggregation capacity are significant constraints in its development as a probiotic candidate.
STANDARISASI DAN UJI AKTIVITAS ANTIOKSIDAN FRAKSI AIR DAUN MURBEI (Morus alba L.) DENGAN METODE DPPH Maulida, Rizqi Noor; Soemarie, Yulistia Budianti; Fauzi, Muhammad
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 1 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i1.236

Abstract

Excessive exposure to sunlight can lead to various skin health issues, including premature aging, as the skin serves as the body’s primary external protector. Mulberry leaves (Morus alba L.) are recognized for their content of anthocyanins and phenolic compounds, which act as antioxidant agents. This study aimed to evaluate the antioxidant effectiveness of the water fraction extracted from mulberry leaves. The research process involved collecting samples, followed by remaceration with 70% ethanol, standardization tests, and fractionation through a liquid-liquid method using n-hexane, ethyl acetate, and distilled water. The water fraction yield obtained was 6.23g. In the specific standardization tests, all parameters met the required standards; however, in the non-specific tests, the ash content exceeded the requirements, registering 10.5% above the acceptable threshold of less than 42%. Antioxidant activity was assessed using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, with quercetin as a reference. Measurement via a UV-Vis spectrophotometer revealed an IC50 value of 25.020 ± 0.223 μg/mL for the mulberry leaf water fraction, compared to an IC50 of 0.012 ± 0.009 μg/mL for quercetin, indicating that the water fraction exhibits lower antioxidant potency.
Karakteristik dan Uji Aktivitas Antiosidan Ekstrak Kolagen Sisik Ikan Gabus (Channa sp.) Su'aida, Nily; Ridha, ainur; Soemarie, Yulistia Budianti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.652

Abstract

This study aims to isolate collagen from the scales of snakehead fish (Channa sp.) and evaluate the antioxidant activity of the extracted collagen. Collagen was isolated using a 0.5 M acetic acid method, involving dissolution and purification procedures. The collagen extract was characterized using FTIR analysis to detect functional groups and phytochemical tests to identify active compounds. Antioxidant activity was assessed using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method to measure free radical scavenging potential. The results indicated that the collagen extract from snakehead fish scales contains bioactive compounds with significant antioxidant activity. The IC₅₀ values demonstrated a strong ability to neutralize free radicals, showing higher potency than the control. FTIR analysis detected hydroxyl (3330.21 cm⁻¹), methyl (2111.83 cm⁻¹), and carbonyl (1635.85 cm⁻¹) groups as characteristic phytochemical components of Channa sp. collagen extract. The IC₅₀ values at different concentrations were classified as very strong at low concentrations (25%), strong at moderate concentrations (50%), and moderate at higher concentrations (75%). The antioxidant activity of snakehead fish scale extract was very strong at lower concentrations but decreased as the concentration increased
Sosialisasi Penggunaan Antibiotik Yang Rasional Pada Pengunjung MTQ Kalsel 2023 Hasniah, Hasniah; Su’aida, Nily; Soemarie, Yulistia Budianti; Erlianti, Karina
Jurnal Pengabdian Kepada Masyarakat Kalam Vol. 3 No. 3 (2024): Pemberdayaan Potensi Masyarakat Untuk Peningkatan Kemampuan Hidup Sehat
Publisher : Prisani Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70704/jpk.v3i3.296

Abstract

Infectious diseases are one of the many health problems that occur in society, especially in Indonesia. The drugs commonly prescribed by doctors for the general public to overcome this problem are antibiotics. Antibiotics are drugs used by health to inhibit, kill or treat bacterial infections. However, the use of antibiotics is often misused, such as using antibiotics without a doctor's prescription, not finishing antibiotics, not using according to dosage, to treatment that should not require antibiotics. This poses a risk of antibiotic resistance. One of the factors causing this is the lack of education to the public regarding the use of drugs, especially antibiotics. The target of this activity is the people of South Kalimantan, precisely to the visitors of MTQ South Kalimantan 2023 where not a few of these people understand the use of antibiotics. This activity was carried out with the hope of educating the public about the use of good and correct antibiotics so as to prevent the development of antibiotic resistance. Based on the results of these activities, the people of South Kalimantan, namely visitors to MTQ South Kalimantan 2023, have received information on how to use antibiotics properly, correctly and rationally.
Co-Authors Erlianti, Karina Hasniah Hasniah Juwita Ramadhani Marginingsih, Tri Maulida, Rizqi Noor Melisa Intan Barliana, Melisa Intan Muhammad Fauzi Nabila, Regina Syifa Niasti, Ignalia Ningsih, Tri Marga Normila, Normila Nur Rochmah, Nur Nurul Fatimah Nurwijayanti Ridha, ainur Sa'adah, Hayatus Su'aida, Nily Su’aida, Nily TIANA MILANDA Tri Astuti Wahyudi, Achmad Nur