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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) ABDINE Jurnal Pengabdian Masyarakat Jurnal Masyarakat Madani Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Farida Lanawati Darsono
Fakultas Farmasi, Universitas Katolik Widya Mandala Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Formulation and In vitro Evaluation of Kaffir Lime Fruit Peel Extract-Containing Gel for Sunscreen, Antioxidant, and Moisturizing Activity Darsono, Farida Lanawati; Soegianto, Lisa
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Kaffir lime peel waste (Citrus hystrix) has antioxidant effects that have the potential to protect the skin from exposure to UV-A and UV-B rays, as well as moisturize the skin. This study aims to determine the effect of increasing the concentration of condensed extract of kaffir lime fruit peel on its effectiveness as an antioxidant, sunscreen activity, and moisturizer. The condensed extract was obtained by maceration using 96% ethanol. In this study, we tested hydrophilic gels consisting of 4 extract concentrations in their formula: F1 (7.5%), F2 (10%), F3 (15%), and F4 (20%). The research phase begins with the extract standardization process and gel formulation, followed by testing physical quality and efficacy as an antioxidant, sunscreen, and moisturizing activity. Experimental data from different batches and formulas were analyzed using the One-Way ANOVA statistical method. The condensed extract (20%) provides an IC50 value of 15.51 mg/mL. The results of the experiment showed that increasing the concentration of kaffir lime fruit peel extract could reduce the pH value, viscosity and increase the spreadability of the gel preparation. The SPF value increased with increasing extract concentration. It is included in the maximum protection category, while based on the % Erythema Transmission Value ≤ 1 and % Transmission Pigmentation of 3-40, it falls under the total block category. Increasing the concentration of a condensed extract of kaffir lime fruit peel in a hydrophilic gel base can increase its effectiveness as a UV protector and a moisturizer, with F3 (15%) as the best formula.
Co-Authors Achmad Noerkhaerin Putra Agustina Chriswinda Bura Mare Bindharawati, Nina Bindharawati, Nina Chomariyah, Nur Chomariyah, Nur Diana Diana Dwiwulandari, Fransisca Yunita Dwiwulandari, Fransisca Yunita Ekayanti, Ni Luh Putu Serly Ekayanti, Ni Luh Putu Serly Foe, Kuncoro Indra Gunawan Ivonne Soeliono Jati, Ignasius Radix A.P. Jessica, Maria Anabella Lannie Hadisoewignyo Letelay, Yulia Riani Liliek S. Hermanu, Liliek S. Lisa Soegianto Lisa Soegianto Lisa Soegianto Maria Anabella Jessica Maria Anabella Jessica Maria Manungkalit Martha Ervina Mellisa Laura Mintoro Ningsih, Kadek Sri Utami Ningsih, Kadek Sri Utami Prasetyo, Jefri Sari, Dwi Augusnita Shinta Marito Sinansari, Restry Stephanie Devi Artemisia Sumi WIjaya, Sumi Vania Denise Djunaidy Wijaya, Andre Wijayanti, Luh Putu Widiasih Wuryanto Hadinugroho