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All Journal Health and Medical Journal JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Journal of Social Research
Alia, Vrenda
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : JOURNAL LA MEDIHEALTICO

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Sukralfat as a Therapy for Reducing Itching and Repairing the Skin Barrier: A Systematic Review Alia, Vrenda; Widhiati, Suci; Oktavriana, Triasari; Lidjaja, Lifesia Natali; Noviani, Laura
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1508

Abstract

Sucralate is an aluminum salt from sucrose octasulfate that is known for its anti-ulcer activity, mucosal protection, and anti-mucositis potential. Recently, sucralfat has been used topically for the healing of various epithelial wounds, including ulcers, inflammatory dermatitis, mucositis, and burns. This systematic review aimed to evaluate the effectiveness of sucralfat as a topical therapy in reducing itching (pruritus) and improving the skin barrier. The analysis method used is Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). A literature search was conducted on studies from 2004 to 2024 using keywords such as "sucralfate", "pruritus", "dermatitis", and "skin barrier" on PubMed, ProQuest, Science Direct, and Scopus databases. Inclusion criteria include topic relevance, research design, human subjects, and United Kingdom-speaking studies. Of the 141 articles found, 7 articles met the inclusion criteria. These studies involved a total of 605 subjects from different countries and used clinical trial methods and randomized controlled trials. The results showed that topical sucralfat was effective in reducing itching and improving the skin barrier in various skin conditions such as diaper dermatitis, chronic ulcers, and postoperative wounds. Sukralfat shows great potential in wound healing and skin barrier repair through the mechanism of protective layer formation, increased expression of epidermal growth factors, and anti-inflammatory properties. This effect indirectly helps reduce pruritus which often occurs due to damage to the skin barrier. Topical succulthate is effective in reducing itching and repairing the skin barrier, making it a promising therapy for a variety of inflammatory and ulcerative skin conditions.
Retrospective Study of Seborrhoic Dermatitis Patients at the Dermatology and Venereology Outpatient Installation Hidayati, Nurul; Irawanto, Muhammad Eko; Alia, Vrenda; Ivani, Ivani
Journal La Medihealtico Vol. 6 No. 1 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i1.1892

Abstract

Seborrheic dermatitis is a chronic superficial skin disorder occurs in 1-5% of the world's population with the symptom of erythematous plaque with slightly yellowish scaling and without clear border, it caused by multifactorial etiopathogenesis includes sebaceous gland secretion, Malassezia fungi colonization, and immune response. This study aims to determine the profile of seborrheic dermatitis patients in Dermatology and Venereology Outpatient Installation of Dr. Moewardi Surakarta General Hospital in January 2021 - December 2023 period. This study is a retrospective study using medical record data from seborrheic dermatitis patients who visited the Dermatology and Venereology Outpatient Installation of Dr. Moewardi Surakarta General Hospital from January 2021 to December 2023. The data collected included the number of cases, age group, gender, occupation, lesion location, and therapy options. Seborrheic dermatitis affected 76 people. Men are more likely to have seborrheic dermatitis than women; up to 43 patients (56.6%) and 30 patients (39.5%) are adults, the oldest age group with the condition. Up to 27 patients (35.5%) who suffer from this disease are private employees, 43 patients (56.6%) with comorbidities, and up to 65 patients (85.5%) frequently have lesion in their head. The most common therapy given was topical corticosteroid combined with anti-fungal in 38 patients (50.0%). In this study, the topical corticosteroids that were widely used were mometasone 0.1% cream and desoxymetasone 0.25% cream, topical antifungal that were widely used were ketoconazole 2% shampoo and ketoconazole 2% cream. Male adults are most likely to develop seborrheic dermatitis.
Co-Authors Esa Putri, Osdatilla Esa Irawanto, Muhammad Eko Ivani, Ivani Kariosentono, Harijono Lidjaja, Lifesia Natali Murasmita, Alamanda Murastami, Ammarilis Nila Kusumasari Noviani, Laura Nurul Hidayati Pradestine, Sesia Prasetyadi Mawardi Putri, Osdatilla Esa Triasari Oktavriana Widhiati, Suci