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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Sains dan Komunitas JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming International Journal of Health and Pharmaceutical (IJHP) Jurnal Agripet
Meitasari, Annisa Diyan
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Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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The Effectiveness Test Of Natural Hair Growth Tonic: Avemor (Aloe Vera And Moringa Oleifera) For Thickening Hair And Anti-Licknes Suhesti, Iin; Meitasari, Annisa Diyan; Sulistiana, Nila Efa; Azizah , Dinar
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 1 (2024): February 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i1.316

Abstract

Avemor (Aloe vera and Moringa oleifera) is a natural hair growth tonic manufactured with a combination of aloe vera gel and dried moringa leaf extract as its active ingredients. Aloe vera includes a variety of vitamins and minerals, including vitamins A and C, amino acids, copper, inositol, and others. The extract from moringa leaves also includes tanins, vital amino acids, vitamin C, vitamin E, and other nutrients. One of the products with 2% minoxidil is employed as a positive control. Several hair diseases are treated off-label with the powerful arteriol vasoconstrictor minoxidil, which can also promote hair growth. In order to determine the effectiveness of Natural Hair Growth Tonic, tests were done on male New Zealand white rabbit hair. Avemor (Aloe vera and Moringa oleifera) is one of the products containing 2% minoxidil, with variations in the content of dried moringa leaf extracts of 2%, 4%, and 6% in comparison to the positive control. On the backs of five rabbits, six test regions were created, and each area received a different treatment every day using a sample volume of 0.5 ml. Results of the Natural Hair Growth Tonic's physical evaluation: Avemor (Aloe vera and Moringa oleifera) has a liquid shape, a distinct aroma, a pH of 6, and is homogeneous with the yellow-golden color of the formulae 1 and 2 as well as the golden brown in the formula 3. It also varies in the concentration of the dried moringa leaf extracts. Formula 4 (negative control) has the appearance of a liquid, is dazzling white in color, and emits a distinct odor. Additionally, formula 5 (positive control) has a liquid-like consistency, a vivid yellowish color, and a distinguishable scent. The average reserve viscosity for formula 1 was 2.96 ± 0.14 cPs, for formula 2 it was 2.99 ± 0.10 cPs, and for formula 3 it was 4.05 ± 0.07 cPs. Formula 4 (negative control) had a value 2.96 ± 0.10 cPs, and formula 5 (positive control) had a value of 1.82 ± 0.03 cPs. The average result of rabbit hair growth on the seventh day for treatment 1 is 0.22 ± 0.17 cm, treatment 2 is 0.30 ± 0.23 cm, treatment 3 is 0.42 ± 0.42 cm, treatment 4 is 0.58 ± 0.47 cm, treatment 5 is 0.68 ± 0.36 cm, and treatment 6 is 0.90 ± 0.42 cm. On the 14th day of treatment 1, the average result of rabbit hair growth was 0.43 ± 0.06 cm; on the same day, treatment 2, 0.27± 0.18 cm; on the same day, treatment 3, 0.42 ± 0.33 cm; on the same day, treatment 4, 0.77 ± 0.22 cm; on the same day, treatment 5, 0.28 ± 0.24 cm; and on the same day, treatment 6, 0.43 ± 0.38 cm. The average length of rabbit hair on the 21st day for treatment 1 was 0.43 ± 0.26 cm, for treatment 2 was 0.73 ± 0.19 cm, for treatment 3 was 0.32 ± 0.23 cm, for treatment 4 was 0.48 ± 0.31 cm, for treatment 5 was 0.13 ± 0.17 cm, and for treatment 6 was 0,43 ± 0.30 cm.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Ermawati, Dian Eka; Hanuriansyah, Yavi; Susanto, Nindita Clourisa Amaris; Rochmani, Sholichah; Utami, Diyah Tri; Zulpadly, M. Fiqri; Sasongko, Heru; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Untari, Meta Kartika
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
Formulation and Activity of Sunscreen Cream from Ethanol Extract of Calendula officinalis L Flowers Rohmani, Sholichah; Mar’atushsholihah, Luthfia; Darojati, Ulfa Afrinurfadhillah; Meitasari, Annisa Diyan; Susanto, Bela Novita Amaris
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.48-57.2024

Abstract

Sunscreen made of natural ingredients is an alternative to protect the skin from excess UV radiation and a substitute for chemical products that have side effects. It was reported that Calendula officinalis L. has flavonoid and saponin metabolite compounds which function as photoprotective agents. This research aims to formulate sunscreen cream and examine the effect of variations in Calendula officinalis L flower extract (5%;7%;10% w/v) on physicochemical properties, stability, and values of the Sun Protecting Factor (SPF) in vitro using UV-Vis spectrophotometry and in vivo using wistar line rat test animals to see the time of formation of Minimum Erythema Dose (MED). It has been proven that variations in the concentration of Calendula officinalis L. extract affected the physicochemical properties, such as pH value, viscosity, spreadability, and adhesion strength. However, the overall results of the physicochemical properties still met the requirements. Variations in extract concentration affected the SPF value. In vitro SPF test showed the minimum protection category for F1, extra protection for F2, maximum protection for F3, and no protection for F0. Meanwhile, the in vivo SPF test showed the minimal protection category for F1, medium protection for F2, extra protection for F3, and no protection for F0.
Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment Meitasari, Annisa Diyan; Ermawati, Dian Eka; Rohmani, Sholichah; Sasongko, Heru; Zulpadly, Muhammad Fiqri; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Untari, Meta Kartika; Darojati, Ulfa Afrinurfadhilah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007064

Abstract

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.
Pelatihan Pembuatan Lulur Tradisional Berbahan Dasar TOGA di Kelompok Wanita Tani (KWT) Bagas Waras Boyolali: Training on Making Traditional Scrubs Based on TOGA at KWT Bagas Waras Boyolali Darojati, Ulfa Afrinurfadhilah; Rohmani, Sholichah; Sasongko, Heru; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyan; Untari, Meta Kartika; Ermawati, Dian Eka; Artanti, Anif Nur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 9 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i9.8562

Abstract

The Bagas Waras Women's Farmers Group (KWT) is one of the women's groups that cultivates a lot of TOGA in Banyuanyar Village, Boyolali. Their seriousness in cultivating TOGA is proven by the establishment of Omah TOGA, which has become an educational tourism destination. KWT members also have high enthusiasm for developing TOGA's potential and have produced many processed food products from TOGA. KWT Bagas Waras needs innovations in TOGA products, namely traditional cosmetic products. The service team provides scientific insight through training on developing traditional cosmetic products, namely body scrubs made from various types of TOGA. This activity involves 40 KWT members who will participate in a series of stages: preparation, training, practice, and evaluation. This training activity can increase the scientific insight of KWT members and help them develop traditional body scrubs made from TOGA and good packaging methods. This training has gone well, with all participants very enthusiastically listening to material related to traditional cosmetics and demonstrating how to make body scrubs. The results obtained are traditional body scrubs with various variants originating from TOGA.
Diversifikasi Minyak Atsiri Sereh Wangi Sebagai Bisnis KUB Aroma Alam Desa Sruni Boyolali Suhesti, Iin; Purwanto, Diyan Sakti; Meitasari, Annisa Diyan; Permadi, Dedi Setyo; Kurniawan, Marcela Lexi Putri
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 6, No 2 (2023): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v6i2.4051

Abstract

KUB Aroma Alam merupakan suatu kelompok usaha bersama yang didirikan oleh bapak Sriyanto Broto Suseno yang terletak di Dk. Watesari, Desa Sruni, Kec. Musuk, Boyolali, Jawa Tengah. KUB Aroma Alam memproduksi minyak atsiri dari berbagai jenis tumbuhan dan air mawar yang telah disalurkan ke beberapa kota besar di Indonesia seperti Sulawesi, Surabaya, Bogor dan beberapa kota lainnya. Pemasaran yang dilakukan di kota-kota besar hanya dilakukan jika mendapatkan permintaan, tetapi belum mengalami penjualan yang signifikan. Hal ini masih menjadi permasalahan yang dialami oleh KUB Aroma Alam, karena kurangnya pemahaman tentang cara pembuatan sediaan farmasi ataupun kosmetik yang berasal dari minyak atsiri. Salah satu minyak atsiri yang dibuat yaitu minyak atsiri sereh wangi atau dikenal dengan Citronella Oil. Tujuan kegiatan pengabdian kepada masyarakat ini yaitu untuk memberikan peluang bisnis kepada KUB Aroma Alam dan masyarakat sekitar dengan memberikan pengetahuan tentang cara pembuatan sediaan kosmetik yang berasal dari minyak atsiri yaitu berupa spray anti nyamuk. Metode pelaksanaan pengabdian ini dilakukan dengan 3 tahap yaitu ceramah, demonstrasi dan pelatihan, serta dilanjutkan dengan diskusi. Kegiatan ini diikuti oleh 40 Orang Warga Dk. Watesari. Peserta sangat antusias memperhatikan dan bertanya mengenai cara pengolahan minyak atsiri menjadi spray anti nyamuk. Target luaran yang dicapai dari kegiatan ini yaitu berupa produk spray anti nyamuk yang dapat diproduksi oleh masyarakat guna meningkatkan taraf ekomomi keluarga.
Physicochemical Characterization, Cytotoxic Activity, and Caspase-9 Expression of Nanogold-Parijoto (Medinilla Speciosa Reinw .Ex, Bl ) in Hela Cell Lines Artanti, Anif Nur; Rohmani, Sholichah; Prihapsara, Fea; Utami, Diyah Tri; Amaris Susanto, Nindita Clourisa; Zulphadly, M.Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp175-185

Abstract

Parijoto (Medinilla speciosa, Reinw. ex. Bl.), a tropical plant native to Southeast Asia, contains flavonoids, tannins, and saponins, which have the potential as an anticancer. Gold nanoparticle-based drug formulations are applied to increase the anticancer effectiveness of herbal medicines. The compounds in the stalk of parijoto have the potential to be bioreductor in the biosynthesis of gold nanoparticles. This study aims to determine the physicochemical characterization, cytotoxic activity, and expression of protein caspase-9 after treatment with nanogold parijoto (AuNPs-PR) on HeLa cell. The nanogold biosynthesis process was done by reacting 1 mM HAuCl4 with parijoto aqueous extract (EP). Physicochemical characterization measure of particle size, Polydisperse Index (PdI), and zeta potential of AuNPs-PR was carried out using a particle size analyzer. The cytotoxic effect and viability cell of AuNPs- PR were carried out using the MTT assay. The expression of caspase-9 was observed by immunocytochemistry assay. Physicochemical characterization of AuNPs-PR shows that the particle size value is 160.8 nm with PdI and zeta potential values of 0.430 and -4.56 mV respectively. In the MTT assay, both AuNPs-PR and EP demonstrated a reduction in the viability of Hela cells after 24 h in a dose-dependent manner, yielding IC50 values of 3.28 μg/mL and 19.22 μg/mL, respectively. AuNPs-PR and EP showed low cytotoxic activity against Vero normal cells, with IC50 values of over 500 μM. Further, the immunocytochemistry assay indicated that there was upregulation of caspase-9 by their expression. These results indicate that AuNPs-PR could effectively induce apoptosis in HeLa cells by upregulating caspase-9.Keywords: caspase-9, HeLa cells, MTT, nanogold, parijoto.
The Impact of Turmeric, Curcuma, and Ginger Feed Additives on the Productivity of Kaur Cattle as a Genetic Resource in Bengkulu Zulpadly, M. Fiqri; Meitasari, Annisa Diyan
Jurnal Agripet Vol 24, No 2 (2024): Volume 24, No. 2, October 2024
Publisher : Faculty of Agriculture

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17969/agripet.v24i2.33489

Abstract

Kaur cattle, a local breed in Bengkulu, represent a valuable genetic resource that requires preservation and effective utilization to enhance livestock production. Turmeric, curcuma, and ginger are plants known for their essential oils and curcumin content, which offer numerous proven benefits. This study aimed to evaluate the impact of these feed additives on the productivity of Kaur cattle. A quantitative research method employing a completely randomized design was used, consisting of four treatments and four replications. The diet comprised wild grass (10% of body weight) and palm kernel meal in an 80:20 ratio. The treatments were as follows: P0 (control: wild grass and palm kernel meal), P1 (wild grass, palm kernel meal, and turmeric powder Curcuma xanthorrhiza Roxb.), P2 (wild grass, palm kernel meal, and curcuma powder Curcuma longa L.), and P3 (wild grass, palm kernel meal, and ginger powder Zingiber officinale Rosc.). The study involved 16 male Kaur cattle aged 1.5-2 years, with an average body weight of 160-180 kg, observed over 60 days. The variables measured included average daily weight gain, forage consumption, total feed consumption, feed efficiency, and cost efficiency. Data were analyzed using a one-way ANOVA. The results showed that the mean daily weight gain (kg/head/day) was P0=0.352.57, P1=0.472.39, P2=0.502.46, and P3=0.492.88, with no significant differences between treatments. The mean feed efficiency (%) was P0=0.124.44, P1=0.254.71, P2=0.275.22, and P3=0.264.38, also showing no significant differences. The mean cost efficiency for feed use was P0=35,8697.47, P1=34,2817.08, P2=33,2207.39, and P3=35,4107.21, with no significant differences observed. Overall, the addition of turmeric, curcuma, and ginger powders to the feed did not significantly impact the productivity of Kaur cattle.
Co-Authors Amaris Susanto, Nindita Clourisa Anif Nur Artanti, Anif Nur Azizah , Dinar Darojati, Ulfa Afrinurfadhilah Darojati, Ulfa Afrinurfadhillah ERMAWATI, DIAN EKA Fea Prihapsara, Fea Hanuriansyah, Yavi Heru Sasongko Kurniawan, Marcela Lexi Putri Mar’atushsholihah, Luthfia Permadi, Dedi Setyo Purwanto, Diyan Sakti Rochmani, Sholichah Sholichah Rohmani, Sholichah suhesti, iin Sulistiana, Nila Efa Susanto, Bela Novita Amaris Susanto, Nindita Clourisa Amaris untari, meta kartika Utami, Diyah Tri Zulpadly, M. Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri