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All Journal Jurnal Biologi Tropis Jurnal Abdi Insani Jurnal Kesehatan Tambusai SALUT: Journal of Social and Education
Nugrahani, Baiq Dwiyan
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Biologi Tropis

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Literature Review : Development of Monoclonal Antibodies Using The Expression System of Nicotiana benthamiana Anugraheni, Audina Filsa Nur; Nuralyza, Imasayu; Maulira, Dinda Ayu; Ramadhani, Aliza Salsabila; Nugrahani, Baiq Dwiyan; Sunarwidhi, Anggit Listyacahyani
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8919

Abstract

Monoclonal antibodies (mAbs) have become a key component in modern biotechnology and healthcare, playing essential roles in the treatment of diseases such as cancer, viral and bacterial infections, asthma, and in diagnostic applications. However, conventional mAb production using mammalian cell systems is costly, time-consuming, and presents scalability limitations. To address these challenges, current technological advances have led to the development of alternative platforms using plant-based expression systems. This review aims to explore the potential and progress in producing monoclonal antibodies through the Nicotiana benthamiana plant-based expression system, which offers several advantages including rapid production, cost efficiency, greater production capacity, and reduced risk of contamination. The method employed in this review is a literature study conducted through database searches (Google Scholar, PubMed, Science Direct, and others) focusing on peer-reviewed articles from 2015 to 2024. The articles were selected and then analyzed thematically was performed to extract relevant data. The results indicate that Nicotiana benthamiana can efficiently produce functional mAbs with glycosylation profiles comparable to mammalian systems. In addition, plant antibodies have also been successfully applied in various therapeutic and diagnostic studies. Further research is needed to ensure the safety and effectiveness of Nicotiana benthamiana plant-based mAb, as well as efforts to develop production scale for wider medical applications.
Antibacterial Activity of Eichornia crassipes Leaf and Eggshell Extracts Against Staphylococcus aureus and Staphylococcus mutans Nugrahani, Baiq Dwiyan; Habibie, Irhas Anugrahadi; Ramadhan, Muhammad Rafi Bintang; Pitaloka, Galuh Suli; Rismawati, Dhity; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9373

Abstract

Dental disease remains a major health concern in Indonesia, with a high prevalence across various age groups. This study aims to formulate and evaluate herbal toothpaste using Eichhornia crassipes (water hyacinth) leaf extract and eggshell powder, and to determine its antibacterial activity against Streptococcus mutans and Staphylococcus aureus. The toothpaste was prepared in three formulations with varying concentrations, followed by evaluation of its physical properties and antibacterial activity using the well diffusion method. Among the formulations, F1 containing 3% water hyacinth extract and 15 g eggshell powder showed optimal results. F1 fulfilled physical quality standards based on SNI 12-3524-1995, including pH, viscosity, and foam formation. Antibacterial testing demonstrated that F1 exhibited very strong inhibition zones of 21.87 mm against S. aureus and 21.50 mm against S. mutans. These findings indicate that a combination of water hyacinth extract and eggshell powder is effective as an active agent in herbal toothpaste. This research supports the utilization of abundant local waste materials as a sustainable alternative in oral health care formulations.
Co-Authors Aini, Siti Rahmatul Ananta, Muhammad Naufal Farras Anugraheni, Audina Filsa Nur Arzaqi, Yazid Maula Arzy, Muhammad Dimas Attaya, Kalisa Bulkis, Nanda Dalila, Virga Fathiya Habibie, Irhas Anugrahadi Hajrin, Wahida Hasina, Raisya Lestari, Dian Fathita Dwi Mahacita Andanalusia Marasabessy, Keysha Nabilla Putri Maulira, Dinda Ayu Nuralyza, Imasayu Nurhidayah, Afifah Nurhidayati Pitaloka, Galuh Suli Ramadhan, Muhammad Rafi Bintang Ramadhani, Aliza Salsabila Rismawati, Dhity Salsabila, Ghina Saputra, Yoga Dwi Sunarwidhi, Anggit Listyacahyani Yasykurah, Malva Marshaniswa