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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Abdi Insani Jurnal Kesehatan Tambusai
Nugraha, Kadek Nandita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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KARDIOMIOPATI HIPERTROFI: SEBUAH TINJAUAN PUSTAKA Nurhaliza, Siti; Hazaa, Saskia Safarinaa; Nur Rifa'i, Ahmad; Fadila, Amila; Nugraha, Kadek Nandita; Syamsuddin, Muhammad Zaim Muflih; Wenilia, Rosita; Yahya, Najla Aulia; Putra, Rifky Sandya Rakadi; Kadarisma, Sofia; Safira, Siska Dwi
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.36755

Abstract

Kardiomiopati hipertrofi (HCM) adalah kelainan genetik miosit jantung yang mengakibatkan hipertrofi ventrikel kiri, fibrosis dan hiperkontraktilitas jantung. Kelainan ini diduga akibat mutasi gen sarkomer dominan autosomal. dan merupakan penyebab kematian mendadak paling sering pada usia muda. Berdasarkan data ekokardiografi yang berasal dari Amerika Serikat teridentifikasi sebanyak 0.2% dari keseluruhan populasi menderita kardimiopati hipertrofi. Penelitian ini menggunakan pendekatan tinjauan literatur dengan mengumpulkan data dari basis data online seperti PubMed, ScienceDirect, MDPI, dan Google Scholar. Tinjauan literatur ini secara komprehensif membahas definisi, etiologi, epidemiologi, faktor risiko, patofisiologi, diagnosis, tatalaksana, komplikasi dan prognosis kardiomiopati hipertrofi.
Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review Putra, Made Raditya Arhya; Saputri, Legis Ocktaviana; Wicaksono, Teguh Budi; Nugraha, Kadek Nandita; Putri, Ajeng Ayu; Salsabila, Rika Kamila; Fidelia, Puspa Zalika
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7546

Abstract

Alzheimer’s Disease (AD) is a gradually worsening neurodegenerative condition characterized by the build-up of beta-amyloid proteins, resulting in a decline in cognitive abilities. β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is known to play a role in the formation of beta-amyloid plaques. Thus, theoretically, inhibiting BACE1 can potentially prevent and slow down the accumulation of these plaques. This study is a literature review that compiles data from various research examining the inhibitory effects of compounds from marine organisms on the BACE1 enzyme. A comprehensive analysis was conducted on the available literature to evaluate the potential of these compounds.  19 marine organisms and 40 compounds were identified with low IC50 values, five compounds with notably low IC50 values were identified: (1) 8,8’-Bieckol [1.62 µM] from Ecklonia cava, (2) Phlorofucofuroeckol A [2.13 µM] and (3a) Dieckol [2.21 µM] from Eisenia bicyclis, (4) bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether [2.32 µM] from Symphyocladia latiuscula, (3b) another Dieckol [2.34 µM] also from Ecklonia cava and (5) Heparan sulfate [2.89 µM] from Portunus pelagicus. These findings underscore the therapeutic potential of marine compounds as BACE1 inhibitors for AD. However, further research is needed to explore their bioavailability and clinical efficacy for practical application in preventing and treating Alzheimer’s Disease.
The Association of Vitamin D Levels with Monocyte-to-Lymphocyte-Ratio in Pulmonary Tuberculosis Patients Nugraha, Kadek Nandita; Ajmala, Indana Eva; Dirja, Bayu Tirta; Andari, Marie Yuni
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7945

Abstract

One of the conditions associated with pulmonary tuberculosis (TB) is low vitamin D levels. Vitamin D has a role in stimulating antimicrobial peptides in various immune cells to create optimal immune function. Immune function is closely related to pulmonary TB pathophysiology, especially hematology changes. This makes the monocyte-lymphocyte ratio (MLR) a novel, affordable, and easy-to-perform inflammatory marker in pulmonary TB disease. This study aimed to determine whether there is a relationship between vitamin D levels and monocyte-lymphocyte ratio in patients with pulmonary tuberculosis at West Nusa Tenggara Provincial Hospital. This study was cross- sectional. The study subjects were all pulmonary TB patients in the period 2023-2024 in the inpatient installation who met the inclusion and exclusion criteria. Statistical analysis was performed using the Spearman rho correlation test. There were 43 samples in total, the majority of which were male (53.5%), in the productive age range of 18-64 years (74.4%), and body mass index in the underweight category (46.5%). The status category of vitamin D levels in patients was divided into deficiency (<20 ng/mL) (69.8%), insufficiency (21- 29 ng/mL) (20.9%), normal (30-100 ng/mL) (9.3%), and toxicity (>100 ng/mL) (0%). The monocyte-lymphocyte ratio (MLR) level from the patient's blood test results obtained a median of 0.66 with a minimum-maximum of 0.15-6.09. The results of statistical analysis obtained a p-value of >0.05. There is no significant relationship between vitamin D levels and monocyte-lymphocyte ratio in pulmonary tuberculosis patients at West Nusa Tenggara Provincial Hospital.
GANGGUAN KEPRIBADIAN TIPE C Kadarisma, Shofia; Hardyningrat, Baiq Inna Dwi; Kirana, Devi Chandra; Nugraha, Kadek Nandita; Yahya, Najla Aulia; Nuril Islahi, Salsabila Dinda; Nurhaliza, Siti; Elizar, Lale Justin Amelinda
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.37048

Abstract

Organisasi Kesehatan Dunia (WHO) mendefinisikan kesehatan sebagai keadaan keseimbangan fungsi fisik, mental, dan sosial, serta bebas dari penyakit dan kelemahan. Kesehatan mental adalah keadaan seseorang mampu secara penuh mengenali kemampuannya,  mengatasi tekanan normal dalam kehidupan sehari-hari, bekerja secara produktif, dan memberikan kontribusi kepada masyarakat. Gangguan kepribadian umumnya memiliki prognosis yang buruk karena merupakan gangguan psikologis kompleks yang berhubungan dengan penurunan kualitas hidup.  Terdapat 10 gangguan kepribadian berbeda yang dikelompokan ke dalam 3 golongan, yaitu  Kluster A (gangguan kepribadian pada seseorang dengan perilaku aneh atau eksentrik), Kluster B (gangguan kepribadian pada seseorang dengan perilaku dramatis, emosional, atau tidak menentu), dan Kluster C (gangguan kepribadian pada seseorang dengan perilaku cemas atau takut). Prevalensi gangguan kepribadian Cluster A, Cluster B, dan Cluster C diperkirakan oleh WHO masing-masing sebesar 3.6%, 1.5% dan 2.7%. Penelitian ini bertujuan untuk memperoleh gambaran umum terkait gangguan kepribadian, khususnya pada golongan kluster C. Metode penelitian yang digunakan adalah jenis kajian literatur yang membahas mengenai definisi, epidemiologi, etiologi, manifestasi klinis, mekanisme terjadinya pada masing-masing jenis gangguan kepribadian cluster c. sumber data yang diambil dengan cara penelusuran elektronik melalui situs pencarian perpustakaan termasuk Google Scholar, ProQuest, MDPI, dan PubMed. Secara keseluruhan, dalam mengatasi gangguan kepribadian kluster C melalui terapi perilaku kogintif (CBT). Pasien diberi stimulus yang terukur untuk diberi pembiasaan dalam mengatasi ketakutan yang dialami. Prognosis gangguan kepribadian tipe C relatif baik apabila didiagnosa dan ditangani dengan cepat dan tepat. tetapi tidak menutup kemungkinan untuk mengalami prognosis dengan komplikasi gangguan penyakit mental lainnya.
UPAYA PENINGKATAN KESEHATAN SISWA SD NEGERI 2 SENGGIGI MELALUI PROGRAM : “KENALI MAKANMU, JAGA KESEHATANMU” Arhya Putra, Made Raditya; Octora, Metta; Abdiman, I Made Tobias; Putri, Atina Rizki; Hazaa, Saskia Safarinaa; Farras, Afif; Sholihatin, Illiyani; Nurhaliza, Siti; Kadarisma, Shofia; Putra, Yusril Sani Riandika; Ginuluh, Gintis Dhimar; Hayaza, Safira Said; Retnaningsih, Ekawaty; Mujahid, Sabila Izzatina Azmy; Makbul, Ini Hidayat; Hardyningrat, Baiq Inna Dwi; Kirana, Devi Chandra; Nugraha, Kadek Nandita; Ishlahi, Salsabila Dinda Nuril; Yahya, Najla Aulia; Amanullah, Mohammad Sany Rosafi
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1164

Abstract

Snacks in the school environment have an important role in fulfilling good nutrition and nutrition for elementary school students. Currently, there are still many traders who do not pay attention to the snacks sold both in terms of health, composition, and hygiene. Based on data from BPOM or the Food and Drug Supervisory Agency, around 39.96% of snacks that are not eligible for consumption are spread throughout Indonesia. This shows how important it is for school students to pay more attention to their health in choosing snacks in the school area. This also underlies the conduct of counseling on healthy food and snacks in the elementary school environment in the Senggigi area, West Lombok Regency as a target elementary school from the Faculty of Medicine, University of Mataram. The counseling was carried out for grade 1 and 2 students of SDN 2 Senggigi and was carried out on Friday, September 1, 2023 at 09.00 – 10.00 WITA. Counseling activities include providing counseling materials about healthy snacks, singing healthy snack songs, pre and post-tests, healthy snack games, and ending with giving fruits to students as participants in counseling. Furthermore, pre and post-test result data was processed using the SPSS application and there was a change in the average value of students' knowledge before and after the delivery of healthy snack counseling materials.
Cholangiocarcinoma: A Comprehensive Review and Update Guideline Nugraha, Kadek Nandita; Hardyningrat, Baiq Inna Dwi; Kirana, Devi Chandra; Yahya, Najla Aulia; Ishlahi, Salsabila Dinda Nuril; Kadarisma, Shofia; Djannah, Fathul
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.8419

Abstract

Cholangiocarcinoma is a rare cancer of the gastrointestinal system. However, the prognosis for people with this disease has not improved in the last decade. CCA has a poor prognosis because most cases are diagnosed at an advanced stage and the availability of treatment options is limited.  This literature review aims to provide information regarding the current understanding and guidelines for cholangiocarcinoma. In this literature review, we searched the National Center for Biotechnology Information (NCBI) and Google Scholar using the search keywords "Cholangiocarcinoma", "cholangiocarcinoma management", "cholangiocarcinoma guidelines" taken ScienceDirect, Researchgate, National Comprehensive Cancer Network, and PubMed published in the last 10 years. From various databases, the literature used and according to the selection criteria amounted to 50 articles In the latest articles and the Cancers NCCN Guidelines for Biliary Tract Cancer in 2023, CCA treatment is carried out based on the patient's profile. Targeted therapy is an additional treatment option today by targeting the molecular profile involved in the pathogenesis of CCA. The diagnosis of cholangiocarcinoma is made through histology, radiography, and laboratory examination. Based on the Cancers NCCN Guidelines for Biliary Tract Cancer in 2023, the treatment carried out consists of determining cancer staging, surgery, radiation therapy, and systemic therapy.
Co-Authors Abdiman, I Made Tobias Ajmala, Indana Eva Amanullah, Mohammad Sany Rosafi Andari, Marie Yuni Arhya Putra, Made Raditya Dirja, Bayu Tirta Elizar, Lale Justin Amelinda Fadila, Amila Farras, Afif Fathul Djannah Fidelia, Puspa Zalika Ginuluh, Gintis Dhimar Hardyningrat, Baiq Inna Dwi Hayaza, Safira Said Hazaa, Saskia Safarinaa Ishlahi, Salsabila Dinda Nuril Kadarisma, Shofia Kadarisma, Sofia Kirana, Devi Chandra Makbul, Ini Hidayat Metta Octora Mujahid, Sabila Izzatina Azmy Nur Rifa'i, Ahmad Nuril Islahi, Salsabila Dinda Ocktaviana Saputri, Legis Putra, Made Raditya Arhya Putra, Rifky Sandya Rakadi Putra, Yusril Sani Riandika Putri, Ajeng Ayu Putri, Atina Rizki Retnaningsih, Ekawaty Safira, Siska Dwi Salsabila, Rika Kamila Sholihatin, Illiyani Siti Nurhaliza Syamsuddin, Muhammad Zaim Muflih Teguh Budi Wicaksono Wenilia, Rosita Yahya, Najla Aulia