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All Journal Jurnal Biologi Tropis Jurnal Kesehatan Tambusai
Nugraha, Kadek Nandita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KARDIOMIOPATI HIPERTROFI: SEBUAH TINJAUAN PUSTAKA Nurhaliza, Siti; Hazaa, Saskia Safarinaa; Nur Rifa'i, Ahmad; Fadila, Amila; Nugraha, Kadek Nandita; Syamsuddin, Muhammad Zaim Muflih; Wenilia, Rosita; Yahya, Najla Aulia; Putra, Rifky Sandya Rakadi; Kadarisma, Sofia; Safira, Siska Dwi
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.36755

Abstract

Kardiomiopati hipertrofi (HCM) adalah kelainan genetik miosit jantung yang mengakibatkan hipertrofi ventrikel kiri, fibrosis dan hiperkontraktilitas jantung. Kelainan ini diduga akibat mutasi gen sarkomer dominan autosomal. dan merupakan penyebab kematian mendadak paling sering pada usia muda. Berdasarkan data ekokardiografi yang berasal dari Amerika Serikat teridentifikasi sebanyak 0.2% dari keseluruhan populasi menderita kardimiopati hipertrofi. Penelitian ini menggunakan pendekatan tinjauan literatur dengan mengumpulkan data dari basis data online seperti PubMed, ScienceDirect, MDPI, dan Google Scholar. Tinjauan literatur ini secara komprehensif membahas definisi, etiologi, epidemiologi, faktor risiko, patofisiologi, diagnosis, tatalaksana, komplikasi dan prognosis kardiomiopati hipertrofi.
Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review Putra, Made Raditya Arhya; Saputri, Legis Ocktaviana; Wicaksono, Teguh Budi; Nugraha, Kadek Nandita; Putri, Ajeng Ayu; Salsabila, Rika Kamila; Fidelia, Puspa Zalika
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7546

Abstract

Alzheimer’s Disease (AD) is a gradually worsening neurodegenerative condition characterized by the build-up of beta-amyloid proteins, resulting in a decline in cognitive abilities. β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is known to play a role in the formation of beta-amyloid plaques. Thus, theoretically, inhibiting BACE1 can potentially prevent and slow down the accumulation of these plaques. This study is a literature review that compiles data from various research examining the inhibitory effects of compounds from marine organisms on the BACE1 enzyme. A comprehensive analysis was conducted on the available literature to evaluate the potential of these compounds.  19 marine organisms and 40 compounds were identified with low IC50 values, five compounds with notably low IC50 values were identified: (1) 8,8’-Bieckol [1.62 µM] from Ecklonia cava, (2) Phlorofucofuroeckol A [2.13 µM] and (3a) Dieckol [2.21 µM] from Eisenia bicyclis, (4) bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether [2.32 µM] from Symphyocladia latiuscula, (3b) another Dieckol [2.34 µM] also from Ecklonia cava and (5) Heparan sulfate [2.89 µM] from Portunus pelagicus. These findings underscore the therapeutic potential of marine compounds as BACE1 inhibitors for AD. However, further research is needed to explore their bioavailability and clinical efficacy for practical application in preventing and treating Alzheimer’s Disease.
The Association of Vitamin D Levels with Monocyte-to-Lymphocyte-Ratio in Pulmonary Tuberculosis Patients Nugraha, Kadek Nandita; Ajmala, Indana Eva; Dirja, Bayu Tirta; Andari, Marie Yuni
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7945

Abstract

One of the conditions associated with pulmonary tuberculosis (TB) is low vitamin D levels. Vitamin D has a role in stimulating antimicrobial peptides in various immune cells to create optimal immune function. Immune function is closely related to pulmonary TB pathophysiology, especially hematology changes. This makes the monocyte-lymphocyte ratio (MLR) a novel, affordable, and easy-to-perform inflammatory marker in pulmonary TB disease. This study aimed to determine whether there is a relationship between vitamin D levels and monocyte-lymphocyte ratio in patients with pulmonary tuberculosis at West Nusa Tenggara Provincial Hospital. This study was cross- sectional. The study subjects were all pulmonary TB patients in the period 2023-2024 in the inpatient installation who met the inclusion and exclusion criteria. Statistical analysis was performed using the Spearman rho correlation test. There were 43 samples in total, the majority of which were male (53.5%), in the productive age range of 18-64 years (74.4%), and body mass index in the underweight category (46.5%). The status category of vitamin D levels in patients was divided into deficiency (<20 ng/mL) (69.8%), insufficiency (21- 29 ng/mL) (20.9%), normal (30-100 ng/mL) (9.3%), and toxicity (>100 ng/mL) (0%). The monocyte-lymphocyte ratio (MLR) level from the patient's blood test results obtained a median of 0.66 with a minimum-maximum of 0.15-6.09. The results of statistical analysis obtained a p-value of >0.05. There is no significant relationship between vitamin D levels and monocyte-lymphocyte ratio in pulmonary tuberculosis patients at West Nusa Tenggara Provincial Hospital.
Co-Authors Ajmala, Indana Eva Andari, Marie Yuni Dirja, Bayu Tirta Fadila, Amila Fidelia, Puspa Zalika Hazaa, Saskia Safarinaa Kadarisma, Sofia Nur Rifa'i, Ahmad Ocktaviana Saputri, Legis Putra, Made Raditya Arhya Putra, Rifky Sandya Rakadi Putri, Ajeng Ayu Safira, Siska Dwi Salsabila, Rika Kamila Siti Nurhaliza Syamsuddin, Muhammad Zaim Muflih Teguh Budi Wicaksono Wenilia, Rosita Yahya, Najla Aulia