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All Journal Majalah Kedokteran Bandung KUMPULAN JURNAL DOSEN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA Global Medical and Health Communication JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Muhammadiyah Medical Journal Jurnal Pandu Husada JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Nurfadly, Nurfadly
Universitas Muhammadiyah Sumatera Utara
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Pembinaan Usaha Kesehatan Sekolah (Uks) Di Sekolah - Sekolah Muhammadiyah Kota Medan Nurfadly Nurfadly; Robitah Asfur; Amelia Eka Damayanty
JURNAL PRODIKMAS Hasil Pengabdian Kepada Masyarakat Vol 4, No 1 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.634 KB) | DOI: 10.30596/jp.v4i1.6165

Abstract

AbstrakMuhammadiyah merupakan suatu persyarikatan yang sangat memperhatikan kesejahteraan umat dan mengembangkan amal usaha di banyak bidang diantaranya bidang kesehatan dan pendidikan. Muhammadiyah memiliki amal usaha di bidang pendidikan  hampir di seluruh wilayah Indonesia tersebar secara merata. Di kota Medan terdapat  lebih kurang 50 sekolah dasar Muhammadiyah dan memiliki hampir 15.000  murid.  Sekolah sebagai tempat belajar, harus memiliki lingkungan bersih dan sehat, yang mendukung berlangsungnya proses belajar dan mengajar yang baik, serta  diharapkan mampu membentuk siswa yang memiliki derajat kesehatan yang lebih baik untuk mendukung pencapaian tujuan pendidikan.  Untuk  mencapai tujuan tersebut maka setiap sekolah dianjurkan mempunyai Usaha Kesehatan Sekolah (UKS). Masalah yang dihadapi selama ini adalah sebagian besar sekolah Muhammadiyah belum mempunyai UKS, padahal UKS sangat diperlukan untuk terciptanya sekolah sehat.   Sehingga dilaksanakanlah kegiatan PKPM yang bertujuan untuk membina UKS di sekolah dasar-sekolah dasar Muhammadiyah di Kota Medan.  Kegiatan dilaksanakan di gedung pertemuan Madrasah Tsanawiyah Aisyiah pada pertengahan April dan dihadiri oleh 10 kepala sekolah dasar Muhammadiyah atau perwakilannya.
Anti-Cervical Cancer Study of a Labdane-type Diterpene Obtained from Legundi Fruit (Vitex triolia L.) Targeting the Bcl-2 Gene Humairah Medina Liza Lubis; Emni Purwoningsih; Nurfadly Nurfadly
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11728

Abstract

Abstract: The development and induction of cervical cancer carcinogenesis are linked to sexually transmitted Human Papillomavirus (HPV) infection, and can affect human genes, particularly those involved in the apoptotic process, one of which is the Bcl-2 gene. Several synthetic compounds, including pyrimidineylpiperazine, phenylpyrazole, kendomycin, and navitoclax, have been shown to be effective in inhibiting the antiapoptotic activity of Bcl-2, but it is the labdane-type diterpene content of the natural legundi fruit plant (Vitex trifolia L.) that has anticancer bioactivity, particularly in the process of genetic mutations, Apoptotic inhibition and therapeutic failure have yet to be discovered, particularly in cervical cancer. The study's goal was to investigate the mechanism of interaction (molecular docking) of labdane type-diterpene compounds with the antiapoptotic protein Bcl-2. In silico (docking molecular) research was used to determine the interaction between legundi fruit ligands and the Bcl-2 target protein in cervical cancer. The docking analysis results will then be visualized with the Discovery Studio 4.1, LigPlot+, and Ligand Scout 3.1 software. The interaction of proteins and ligands was studied to determine the number and type of bonds formed, such as hydrogen and hydrophobic bonds. The results were as follows: Gibbs energy -7.8, pKi 1.91 m, 10 hydrophobic bonds, and hydrophobic residues Leu80, Leu82, Thr83, Thr86, Ala87, Cys90, Met118, Glu121, Ser122, and Leu130. The findings presented here suggest that labdane-type diterpenes are powerful anticancer agents capable of inducing apoptosis and inhibiting the antiapoptotic action of the Bcl-2 gene, which should be investigated further in (pre)clinical studies.
Differences in CD95L Levels and Blood Test Results in Primary and Secondary Dengue Infection Patients Nurfadly Nurfadly; Iqrina Widia Zahara; Said Munazar Rahmad
Majalah Kedokteran Bandung Vol 54, No 4 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n4.2822

Abstract

Dengue is a disease caused by dengue virus (DENV) that is transmitted mainly by the female Aedes aegypti mosquito. There are four serotypes of DEN, leading to a possibility that a person may be infected four times by this virus, albeit with different serotypes. Recovery from infection with one viral serotype provides lifelong immunity to the same serotype but not to the other serotypes. Secondary infection by other serotypes increases the risk of developing severe dengue. The pathogenesis of severe dengue involves apoptosis of microvascular endothelial cells that leads to plasma leakage. In addition, there is usually a decrease in platelets and leukocytes and an increase in hematocrit. This study aimed to compare the results of the CD95L examination involved in the apoptotic process and the results of blood tests in primary and secondary dengue patients. This was a cross-sectional study performed in a four months period  (September–December 2019) involving several clinics and doctor's private practices in Medan, Indonesia. Subjects were eighty-four dengue patients, consisting of 18 (21%) patients with primary infection and 66 (79%) with secondary infection. Data collected were tested with the Mann Whitney test with p-value of <0.05 considered significant. A significant difference (p value=0.007) was observed in the lymphocyte counts between primary and secondary dengue patients, but no differences were seen in CDL95 level, platelet count, leukocyte count, and hematocrit. In conclusion, except for the lymphocyte count, there is no difference in CD95L level and blood test results between primary and secondary dengue patients.
Sosialisasi Dan Edukasi Pencegahan Covid-19 Dalam Memasuki Pembelajaran Tatap Muka Di Desa Percut Sei Tuan Ceri Permata Ayuni; Nurfadly Nurfadly; Humairah Medina Liza Lubis
JURNAL PRODIKMAS Hasil Pengabdian Kepada Masyarakat Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jp.v7i2.12833

Abstract

Coronavirus Disease (COVID-19) masihmenjadi ancaman di berbagai Negara seluruh dunia, khususnya di Indonesia dan Sumatera Utara. Penyakit ini menyerang semua golongan, anak-anak, dewasa dan lansia. Pembukaaan sekolah yang dilakukan pemerintah, anak-anak serta remaja perlu mendapatkan edukasi yang mudah dipahami mengenai COVID-19 dan cara pencegahannya saat proses pembelajaran dilakukan secara tatap muka. Hal ini yang menjadi dasar penulis dalam melakukan kegiatan Kuliah Kerja Nyata (KKN) dengan memberikan penyuluhan atau sosialisasi tentang COVID-19 dan upaya pencegahannya kepada siswa SD, SMP, dan SMA di Desa Percut dalam melakukan pembelajaran tatap muka.Tujuan kegiatan ini yaitu agar mampu menekan angka positif COVID-19 di Indonesia, khususnya Sumatera Utara. Kegiatan sosialisasi ini dilaksanakan dengan cara memberikan pengetahuan tentang pentingnya memahami dan mengaplikasikan protokol kesehatan pencegahan COVID-19 terutama cuci tangan dan memakai masker pelindung muka dengan baik dan benar, port de entry dari virus tersebut serta memberikan gambaran tentang bahaya jika tidak mematuhi protokol kesehatan pencegahan COVID-19 seperti gejala dan tanda yang akan ditimbulkan dan dilanjutkan dengan praktek secara langsung mengenai cara memakai dan melepaskan masker serta mencuci tangan dengan baik dan benar. Penyampaian materi dilakukan dengan menggunakan media slide power point dan video animasi, tidak lupa pula di sela-sela penyampaian materi diadakannya kegiatan ice breaking, dan diakhir penyampaian materi dilakukan quiz terkait materi yang disampaikan sebelumnya.
KARAKTERISTIK PASIEN MALARIA DI PUSKESMAS SIABU KECAMATAN SIABU KABUPATEN MANDAILING NATAL TAHUN 2019 MIFTAH KHOIRIAH; NURFADLY NURFADLY
JURNAL ILMIAH SIMANTEK Vol 7 No 1 (2023): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Malaria is a disease caused by Plasmodium which is transmitted through female Anophelesmosquitoes as a vector. Malaria is still a public health problem in the world, including Indonesia, with high morbidity and mortality rates. The characteristics of malaria patients can be seen based on age, sex, occupation, level of education, and type of Plasmodium. To determine the characteristics of malaria patients at the Siabu Public Health Center, Siabu District, Mandailing Natal District in 2019. This study was a descriptive observational study with a cross sectional method. The population in this study was all patient data who were diagnosed with malaria at the Siabu Public Health Center, Siabu District, Mandailing Natal District in 2019. The sampling technique used the total sampling method. Retrieval of research data by taking all medical record data of malaria patients at the Siabu Public Health Center, Siabu District, Mandailing Natal District in 2019. The results of this study obtained 174 people diagnosed with malaria in 2019. The highest age group was aged <20 years, as many as 81 people ( 46.6%). Most of the sexes in malaria patients were male as many as 108 people (62.1%). Most jobs for malaria patients are farmers, as many as 68 people (39.1%). The highest level of education among malaria patients is SD, amounting to 102 people (58.6%). The most Plasmodium type in malaria patients was Plasmodium falciparum as much as 132 (75.8%). Malaria patients at the Siabu Public Health Center, Siabu District, Mandailing Natal District, in 2019, were mostly found at <20 years old, most of the sexes were men, the most occupations were farmers, the highest education level was elementary school, the most Plasmodium type was Plasmodium falcifarum.
Soil-Transmitted Helminth Eggs Contamination on Fresh Vegetables in Medan Indonesia Nurfadly, Nurfadly; Zahara, Iqrina Widia; Nasution, Aisyah Khoiriyah
Global Medical & Health Communication (GMHC) Vol 11, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i1.9770

Abstract

Indonesian people habitually consume fresh vegetables as companions to other foods. We can find soil-transmitted helminths (STH) eggs in fresh vegetables that are not washed clean. This study determines whether there was STH egg contamination in fresh vegetables in several stalls selling fried chicken in Medan. This study was a descriptive study with a cross-sectional design. Research samples were four types of fresh vegetables: lemon basil (Ocimum africanum), lettuce (Lactuca sativa), cucumber (Cucumis sativus), and cabbage (Brassica oleracea var. capitata) collected from 88 fried chicken stalls in Medan in January 2019. All samples were examined by the sedimentation method to ensure STH egg contamination at the Parasitology Laboratory of the Faculty of Medicine Universitas Muhammadiyah Sumatera Utara. The types of fresh vegetables that were most contaminated by STH eggs were lemon basil leaves (Ocimum africanum), and the most abundant STH eggs found were Ascaris lumbricoideseggs. In conclusion, there is egg contamination in fresh vegetables in several stalls selling fried chicken in Medan. 
Effect of Ketapang Leaf Extract on HDL Levels of Rattus norvegicus Induced by High-fat Foods Nurfadly, Nurfadly; Fajar, Muhammad; Thristy, Isra; Yenita, Yenita
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14070

Abstract

High-density lipoprotein (HDL) functions to transport cholesterol from the blood vessel endothelium to the liver and excreted through the digestive tract so that it does not cause dyslipidemia, which is a risk factor for cardiovascular disease. Current treatment for dyslipidemia uses long-term statin drugs, which can cause various side effects, so herbal alternatives such as ketapang leaves (Terminalia catappa L.), which contain flavonoids and have the effect of increasing HDL levels, needed to be evaluated to achieve that reason. This study aims to evaluate whether ketapang leaf extract has an effect on increasing blood HDL levels. This research used experimental animals with a pretest and a posttest with a control group design. It was conducted at the Biochemistry Laboratory and Laboratory Animal Management Unit, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Medan, from September to December 2023. This study used Wistar strain male white rats (Rattus norvegicus) that were induced on a high-fat diet, divided into five groups: negative control, positive control (given simvastatin), treatment 1 (given 21 mg/kgBW ketapang leaf extract), treatment 2 (given 42 mg/kgBW ketapang leaf extract) and treatment 3 (given 84 mg/kgBW ketapang leaf extract). The study results showed a significant difference (p<0.05) in the average HDL levels before and after treatment in the positive control, treatment 2, and therapy three groups. Thus, the study concluded that ketapang leaf extract affected increasing HDL levels of male white rats (Rattus norvegicus).
Correlation between Soil Transmitted Helminth Infection with Nutritional Status in Elementary School at Deli Serdang Regency North Sumatera Andini, Leni; Nurfadly, Nurfadly
Muhammadiyah Medical Journal Vol 2, No 1 (2021): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1383.952 KB) | DOI: 10.24853/mmj.2.1.7-14

Abstract

Background: The prevalence of Soil Transmitted Helminth (STH) infections in Indonesia is still high, especially in elementary school children in North Sumatra Province.  STH infection is thought to cause harm to nutrient requirements due to lack of calories, causing health and nutritional conditions to decline. Purposes: To determine the relationship of STH infection with nutritional status in 105926 State Elementary School students. Method: Analytic observational with cross sectional design.  Sampling uses a total sampling method, with a total sample of 87 people.  Nutritional status was determined by the CDC-NCHS 2000 growth curve and the determination of the STH infection used the Kato-Katz examination method.  Results: 26 samples (29,9%) were positive and 61 samples (70,1%) were negative for STH infections.  Positive samples infected with STH have nutritional status that is dominated by moderate and good nutritional status. Conclusion: There is no correlation between STH infection and nutritional status in 105296 State Elementary School students in Percut Sei Tuan District, Deli Serdang Regency, North Sumatra.
Faktor-Faktor Yang Mempengaruhi Tingkat Pengetahuan Dan Perilaku Pencegahan Leptospirosis Pada Petugas Sampah Di Kelurahan Teladan Timur Kota Medan Ramadhani, Muhammad; Nurfadly, Nurfadly; Pudiyanti, Pinta; Murlina, Nelli
JURNAL PANDU HUSADA Vol 6, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v6i2.22051

Abstract

Abstrak: Leptospirosis merupakan salah satu penyakit zoonosis yang menjadi masalah kesehatan masyarakat di Indonesia. Penyakit ini diakibatkan oleh infeksi bakteri Leptospira yang ditularkan secara langsung maupun tidak langsung dari hewan ke manusia. Kejadian leptospirosis dapat terjadi di seluruh dunia, namun lebih sering pada daerah iklim tropis atau subtropis dengan curah hujan yang tinggi. Petugas sampah merupakan pekerjaan yang berisiko terinfeksi leptospirosis. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi tingkat pengetahuan dan perilaku pencegahan leptospirosis pada petugas sampah di Kelurahan Teladan Timur. Penelitian ini merupakan deskriptif analitik dengan desain cross-sectional, Uji hipotesis yang digunakan adalah uji Chi Square. Pengambilan data menggunakan kuesioner dengan jumlah responden sebanyak 88 sampel. Hasil uji hipotesis tingkat pengetahuan berdasarkan usia didapatkan nilai p = 0,003 dan berdasarkan pendidikan didapatkan nilai p = 0,000. Hasil uji hipotesis perilaku pencegahan berdasarkan usia didapatkan nilai p = 0,183 dan berdasarkan pendidikan didapatkan nilai p = 0,018. Dapat disimpulkan bahwa faktor yang mempengaruhi tingkat pengetahuan yaitu faktor usia dan pendidikan, sedangkan faktor yang mempengaruhi perilaku pencegahan leptospirosis pada petugas sampah yaitu faktor pendidikan dan tingkat pengetahuan. 
PREVALENSI INFEKSI SOIL TRANSMITTED HELMINTH PADA MURID SEKOLAH DASAR NEGERI 105296 KECAMATAN PERCUT SEI TUAN, KABUPATEN DELI SERDANG, SUMATERA UTARA Muhammad Jabbar Rahman Tapiheru; Nurfadly Zain
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.249

Abstract

Background: Soil Transmitted Helminths infection is the most common worm infection found in humans. The prevalence of STH infections in Indonesia is generally still high, mostly in populations with poor sanitation, with varying data of 2.5% - 62% and the highest intensity obtained among preschoolers and primary schools. Objective: This study aims to determine the prevalence of STH infections in public elementary school students 105296 in Percut Sei Tuan sub-district, Deli Serdang District, North Sumatra. Method: This type of research uses descriptive analytic research methods with cross sectional approach. Results: The prevalence of STH infections in grade I-VI students of SD Negeri 105296 Percut Sei Tuan in 2019 is 29.9%. The types of worms that infect are Ascaris lumbricoides worms at 23.1%, Trichuris trrichiura with a percentage of 65.4%, Hookworm not found and mixed infections 11.5% of all samples. Conclusion: The prevalence of STH infections in grade I-VI students of SD Negeri 105296 Percut Sei Tuan in 2019 is 29.9%. The infection is rather high, which should have been greatly reduced or even no more STH infections.
Co-Authors ALYA LAILATU ASSZIVA Amelia Eka Damayanty Ance Roslina Andini, Leni Br Ginting, Heni Sry Wahyuni Ceri Permata Ayuni ELMAN BOY Faried Lubis, Taufik Akbar Harahap, Sevani Ayu Humairah Medina Liza Lubis Iqrina Widia Zahara Isra Thristy MIFTAH KHOIRIAH Muhammad Fajar Muhammad Jabbar Rahman Tapiheru MURLINA, NELLI Nasution, Aisyah Khoiriyah Pudiyanti, Pinta Purwoningsih, Emni R. MUHAMMAD ZIKRI PRANOTO Ramadhani, Muhammad RIDO RAIS HUTABARAT Robitah Asfur SAID MUNAZAR RAHMAT Sarirah, Munauwarus Siregar, Nur Fitriani Syafrin Lubis, Riri Arisanty Yenita . Yenita Yenita Yulfi, Hemma Zahara, Iqrina Widia Zahir Husni Lubis ZIMLY KHATIF VALDIVIA RITONGA